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| 1 | Influence of Heat Treatment on Microstructure and Mechanical Properties of Plasma Sprayed FeCrMoCBY Amorphous Coatings显示文摘The changes of the microstructure and the mechanical properties of FeCrMoCBY amorphous coatings prepared by plasma spraying after heat treatment were investigated.300,400,500 and 600℃were selected as the heat treatment temperature,and the crystallization phenomenon occurred after the heat treatment at 600℃.The crystallization products of the coating heat-treated at 600℃were a-Fe and Fe23(C,B)6.Heat treatment was beneficial to the microhardness and the bonding strength of the coatings.The microhardness of the coating heat-treated at 600℃increased obviously,and the strongest bonding strength occurred in the coating heat-treated at 500℃.The improvement of the wear resistance of the coatings could attribute to heat treatment as well,and the wear resistance of the coating heat-treated at 600℃was the optimum,compared with the coating heat-treated at 500℃. | 吴林涛 周泽华 DEND Yong ZHANG Xin WANG Miqi WANG Zehua ZHANG Kaicheng YANG Guangheng | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，5： | 1 |
| 2 | Inducible immortality in hTERT‐human mesenchymal stem cells显示文摘 | Samantha L. Piper Miqi Wang Akira Yamamoto Farbod Malek Andrew Luu Alfred C. Kuo Hubert T. Kim | 2012 | J. Orthop. Res2012，，12： | 1 |
| 3 | Natural variation in the transcription factor REPLUMLESS contributes to both disease resistance and plant growth in Arabidopsis显示文摘When attacked by pathogens,plants need to reallocate energy from growth to defense to fend off the invaders,frequently incurring growth penalties.This phenomenon is known as the growth–defense tradeoff and is orchestrated by a hardwired transcriptional network.Altering key factors involved in this network has the potential to increase disease resistance without growth or yield loss,but the mechanisms underlying such changes require further investigation.By conducting a genome-wide association study(GWAS)of leaves infected by the hemi-biotrophic bacterial pathogen Pseudomonas syringae pv.tomato(Pst)DC3000,we discovered that the Arabidopsis transcription factor REPLUMLESS(RPL)is necessary for bacterial resistance.More importantly,RPL functions in promoting both disease resistance and growth.Transcriptome analysis revealed a cluster of genes in the GRETCHEN HAGEN 3(GH3)family that were significantly upregulated in rpl mutants,leading to the accumulation of indole-3-acetic acid-aspartic acid(IAA-Asp).Consistent with this observation,transcripts of virulence effector genes were activated by IAA-Asp accumulated in the rpl mutants.We found that RPL protein could directly bind to GH3 promoters and repress their expression.RPL also repressed flavonol synthesis by directly repressing CHI expression and thus activated the auxin transport pathway,which promotes plant growth.Therefore,RPL plays an important role in plant immunity and functions in the auxin pathway to optimize Arabidopsis growth and defense. | Miqi Xu Xuncheng Wang Jing Liu Aolin Jia Chao Xu Xing Wang Deng Guangming He | 2022 | Plant Communications2022，3，5： | 0 |
| 4 | An integrative profiling of metabolome and transcriptome in the plasma and skeletal muscle following an exercise intervention in diet-induced obese mice显示文摘Exercise intervention at the early stage of type 2 diabetes mellitus(T2DM)can aid in the maintenance of blood glucose homeostasis and prevent the development of macrovascular and microvascular complications.However,the exercise-regulated pathways that prevent the development of T2DM remain largely unclear.In this study,two forms of exercise intervention,treadmill training and voluntary wheel running,were conducted for high-fat diet(HFD)-induced obese mice.We observed that both forms of exercise intervention alleviated HFD-induced insulin resistance and glucose intolerance.Skeletal muscle is recognized as the primary site for postprandial glucose uptake and for responsive alteration beyond exercise training.Metabolomic profiling of the plasma and skeletal muscle in Chow,HFD,and HFD-exercise groups revealed robust alterations in metabolic pathways by exercise intervention in both cases.Overlapping analysis identified nine metabolites,including beta-alanine,leucine,valine,and tryptophan,which were reversed by exercise treatment in both the plasma and skeletal muscle.Transcriptomic analysis of gene expression profiles in the skeletal muscle revealed several key pathways involved in the beneficial effects of exercise on metabolic homeostasis.In addition,integrative transcriptomic and metabolomic analyses uncovered strong correlations between the concentrations of bioactive metabolites and the expression levels of genes involved in energy metabolism,insulin sensitivity,and immune response in the skeletal muscle.This work established two models of exercise intervention in obese mice and provided mechanistic insights into the beneficial effects of exercise intervention on systemic energy homeostasis. | Shuang Han Qingqian Wu Mengying Wang Miqi Yang Chen Sun Jiaqi Liang Xiaozhen Guo Zheyu Zhang Jingya Xu Xinyuan Qiu Cen Xie Siyu Chen Yue Gao Zhuo-Xian Meng | 2023 | Journal of Molecular Cell Biology2023，15，3： | 0 |
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