|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genomic prediction of fruit texture and training population optimization towards the application of genomic selection in apple显示文摘Texture is a complex trait and a major component of fruit quality in apple.While the major effect of MdPG1,a gene controlling firmness,has already been exploited in elite cultivars,the genetic basis of crispness remains poorly understood.To further improve fruit texture,harnessing loci with minor effects via genomic selection is therefore necessary.In this study,we measured acoustic and mechanical features in 537 genotypes to dissect the firmness and crispness components of fruit texture.Predictions of across-year phenotypic values for these components were calculated using a model calibrated with 8,294 SNP markers.The best prediction accuracies following cross-validations within the training set of 259 genotypes were obtained for the acoustic linear distance(0.64).Predictions for biparental families using the entire training set varied from low to high accuracy,depending on the family considered.While adding siblings or half-siblings into the training set did not clearly improve predictions,we performed an optimization of the training set size and composition for each validation set.This allowed us to increase prediction accuracies by 0.17 on average,with a maximal accuracy of 0.81 when predicting firmness in the‘Gala’בPink Lady’family.Our results therefore identified key genetic parameters to consider when deploying genomic selection for texture in apple.In particular,we advise to rely on a large training population,with high phenotypic variability from which a‘tailored training population’can be extracted using a priori information on genetic relatedness,in order to predict a specific target population. | Morgane Roth Hélène Muranty Mario Di Guardo Walter Guerra Andrea Patocchi Fabrizio Costa | 2020 | Horticulture Research2020，7，1： | 4 |
| 2 | Object-oriented protocol hierarchies for distributed workflow systems显示文摘 | Lockemann P C Walter H D | 1995 | Theory and Practice of Object Systems1995，1，4： | 2 |
| 3 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 4 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 5 | Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett’s oesophagus显示文摘 | Florine Kastelein Katharina Biermann Ewout W Steyerberg Joanne Verheij Marit Kalisvaart Leendert H J Looijenga Hans A Stoop Laurens Walter Ernst J Kuipers Manon C W Spaander Marco J Bruno | 2013 | Gut2013，，12： | 2 |
| 6 | Balancing cell adhesion and Wnt signaling, the key role of β-catenin显示文摘 | Felix H Brembeck Marta Rosário Walter Birchmeier | 2006 | Current Opinion in Genetics & Development2006，，1： | 2 |
| 7 | Childhood Allergic Rhinitis Predicts Asthma Incidence and Persistence to Middle Age: A Longitudinal Study显示文摘 | Burgess J A Walters E H Byrnes G B | 2007 | J Allergy Clin Immunol2007，120，4： | 1 |
| 8 | More progress towarda taxonomy of managerial performance requirements显示文摘 | WALTER C BORMAN H BRUSH DONALD | 1993 | Human performance1993，，6： | 1 |
| 9 | A role for mammalian Ubc6 homo- logues in ER-associated protein degradation 显示文摘 | LENK U YU H WALTER J | 2002 | J Cell Sci2002，115，： | 1 |
| 10 | Nonlinear normal modes of buckled beams: three-to-one and one-to-one International resonance显示文摘 | Nayfeh A H Walter Lacarbonara Char-ming Chin | 1999 | Nonlinear Dynamics1999，18，： | 1 |
| 11 | Cellular composition and viability of demi-and quarter-embryos made from bisected bovine morulae and blastocysts显示文摘 | Gyu-Jin R Walter H J | 1998 | Theriogenology1998，50，： | 1 |
| 12 | The cellulolytic system of Streptomyces reticuli显示文摘 | Schremp f H Walter S | 1995 | Biol Macromol1995，17，： | 1 |
| 13 | The York acupuncture safety study: prospective survey of 34 000 treatments by traditional acupuncturists显示文摘 | MacPherson H Thomas K Walters S | 2001 | BMJ2001，323，7311： | 1 |
| 14 | Matured-endritic cells pulsed with freeze-thaw cell lysates define an effective in vitro vaccine designed to elicitEBV-specific CD4+ and CD8T lymphocyte responses 显示文摘 | WOLFGANG H ELENA R WALTER O | 2000 | Blood2000，7，96： | 1 |
| 15 | Gray matter reduction associated with psychopathology and cognitive dysfunction in unipo- lar depression : a voxel - based morphometry study 显示文摘 | VASIC N WALTER H HOSE A | 2008 | J Affect Disord2008，109，12： | 1 |
| 16 | Characterization of reuterocyclin produced by Lactobacillus reuteri LTH2584 显示文摘 | G?nzle M G H?ltzel A Walter J | 2000 | Applied and Environmental Microbiology2000，66，： | 1 |
| 17 | Inhibition of nitrification by acetylene显示文摘 | Walter H M Keeney D R Fillery I R | 1979 | Soil Science Society of America Journal1979，43，1： | 1 |
| 18 | Secretoneurinan angiogenic neuropeptide,induces postnatal vasculogenesis显示文摘 | Kirchmair R Egger M Walter D H | 2004 | Circulation2004，110，9： | 1 |
| 19 | Object representation and recognition in shape spaces 显示文摘 | ZHANG J ZHANG X KRIM H WALTER G G | 2003 | Pattern recognition2003，36，： | 1 |
| 20 | The effect of mild hypothermia on plasma fentanyl concentration and biotransformation in juvenile pigs显示文摘 | Fritz H G Holzmayr M Walter B | 2005 | Anesth Analg2005，100，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员