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| 1 | Plant-derived nanovesicles as an emerging platform for cancer therapy显示文摘Plant-derived nanovesicles(PDNVs)derived from natural green products have emerged as an attractive nanoplatform in biomedical application.They are usually characterized by unique structural and biological functions,such as the bioactive lipids/proteins/nucleic acids as therapeutics and targeting groups,immune-modulation,and long-term circulation.With the rapid development of nanotechnology,materials,and synthetic chemistry,PDNVs can be engineered with multiple functions for efficient drug delivery and specific killing of diseased cells,which represent an innovative biomaterial with high biocompatibility for fighting against cancer.In this review,we provide an overview of the state-of-theart studies concerning the development of PDNVs for cancer therapy.The original sources,methods for obtaining PDNVs,composition and structure are introduced systematically.With an emphasis on the featured application,the inherent anticancer properties of PDNVs as well as the strategies in constructing multifunctional PDNVs-based nanomaterials will be discussed in detail.Finally,some scientific issues and technical challenges of PDNVs as promising options in improving anticancer therapy will be discussed,which are expected to promote the further development of PDNVs in clinical translation. | Hanzhe Liu Guo-Feng Luo Zhengjun Shang | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 2 | 基于微纳米技术的细胞内递送的物理方法显示文摘随着生物医药学的发展,向细胞内递送外源性大分子在基础生物学和临床应用中至关重要,但基于病毒载体的传统生物方法存在通量低、毒性大、递送性能低以及耗时长等问题。文章综述了电穿孔、声穿孔、微注射和细胞挤压等基于细胞膜破坏实现胞内物质递送的技术,这些通过微纳米技术完成的高通量胞内物质递送的物理方法,可以弥补传统生物方法的很多缺陷,实验证明了其在保证细胞活性的基础上具有可观的转染效率。文章重点描述了基于细胞挤压实现细胞内递送的微流控操作平台及其机理,并讨论各种通过膜破坏技术完成细胞药物或分子递送技术的优势、局限性和发展前景。 | 袁子群 毛志宇 高兴华 胡国辉 巫金波 张萌颖 | 2024 | 自然杂志2024，46，1： | 0 |
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