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| 1 | The potential of bone morphogenetic protein 2 as a neurotrophic factor for Parkinson’s disease显示文摘Parkinson’s disease is the second most common neurodegenerative disorder;it affects 1%of the population over the age of 65.The number of people with Parkinson’s disease is set to rapidly increase due to changing demographics and there is an unmet clinical need for disease-modifying therapies.The pathological hallmarks of Parkinson’s disease are the progressive degeneration of dopaminergic neurons in the substantia nigra and their axons which project to the striatum,and the aggregation ofα-synuclein;these result in a range of debilitating motor and non-motor symptoms.The application of neurotrophic factors to protect and potentially regenerate the remaining dopaminergic neurons is a major area of research interest.However,this strategy has had limited success to date.Clinical trials of two well-known neurotrophic factors,glial cell line-derived neurotrophic factor and neurturin,have reported limited efficacy in Parkinson’s disease patients,despite these factors showing potent neurotrophic actions in animal studies.There is therefore a need to identify other neurotrophic factors that can protect againstα-synuclein-induced degeneration of dopaminergic neurons.The bone morphogenetic protein(BMP)family is the largest subgroup of the transforming growth factor-βsuperfamily of proteins.BMPs are naturally secreted proteins that play crucial roles throughout the developing nervous system.Importantly,many BMPs have been shown to be potent neurotrophic factors for dopaminergic neurons.Here we discuss recent work showing that transcripts for the BMP receptors and BMP2 are co-expressed with several key markers of dopaminergic neurons in the human substantia nigra,and evidence for downregulation of BMP2 expression at distinct stages of Parkinson’s disease.We also discuss studies that explored the effects of BMP2 treatment,in in vitro and in vivo models of Parkinson’s disease.These studies found potent effects of BMP2 on dopaminergic neurites,which is important given that axon degeneration is increasingly recognized as a key early event in Parkinson’s disease.Thus,the aim of this mini-review is to give an overview of the BMP family and the BMP-Smad signalling pathway,in addition to reviewing the available evidence demonstrating the potential of BMP2 for Parkinson’s disease therapy. | Susan R.Goulding Aideen M.Sullivan Gerard W.O’Keeffe Louise M.Collins | 2020 | Neural Regeneration Research2020，15，8： | 7 |
| 2 | Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease显示文摘Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson's disease. In Parkinson's disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinson's disease. Several neurotrophic factors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5. | Shane V.Hegarty Gerard W.O’Keeffe Aideen M.Sullivan | 2014 | Neural Regeneration Research2014，9，19： | 6 |
| 3 | Neurotrophic factor therapy for Parkinson's disease: past, present and future显示文摘One of the greatest unmet needs in the treatment of Parkinson’s disease(PD)is a disease-modifying therapy,which can halt the ongoing degeneration of dopaminergic neurons that is characteristic of this disorder.Current therapies focus on managing symptoms,rather than on addressing their cause.Promising candidates for disease-modifying therapies are the dopaminergic neurotrophic factors(NTFs).NTFs are | Aideen M.Sullivan Gerard W.O'Keeffe | 2016 | Neural Regeneration Research2016，11，2： | 2 |
| 4 | Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”显示文摘 | Chris H.Polman Stephen C.Reingold GillesEdan MassimoFilippi Hans‐PeterHartung LudwigKappos Fred D.Lublin Luanne M.Metz Henry F.McFarland Paul W.O’Connor MagnhildSandberg‐Wollheim Alan J.Thompson Brian G.Weinshenker Jerry S.Wolinsky | 2005 | Ann Neurol2005，，6： | 2 |
| 5 | Impact of angina class on inhibition of platelet aggregation following clopidogrel loading in patients undergoing coronary intervention: Do we need more aggressive dosing regimens in unstable angina?显示文摘 | DanielSoffer IssamMoussa Kishore J.Harjai Judith A.Boura Simon R.Dixon Cindy L.Grines William W.O’Neill Gary S.Roubin Jeffrey W.Moses | 2003 | Cathet Cardiovasc Intervent2003，，1： | 1 |
| 6 | Corporate Philanthropic Practices显示文摘 | Brown W.O Helland E Smith J.K | | 0，，05： | 1 |
| 7 | Reference group influence on product and brand purchase decisions显示文摘 | Bearden W.O Etze''''l M.J | | 0，，09： | 1 |
| 8 | Quantitative Evaluation of Third Year Medical Students' Perception and Satisfaction from Problem-Based Learning in Anatomy:A Pilot Study of the Introduction of Problem Based Learning into the Traditional Didactic Medical Curriculum in Nigeria显示文摘 | Saalu L.C Abraham A.A Aina W.O | | 0，，04： | 1 |
| 9 | Iatrogenic coronary artery dissections extending into and involving the aortic root显示文摘 | Dennis W.Dunning Joel K.Kahn Earl T.Hawkins William W.O’Neill | 2000 | Cathet. Cardiovasc. Intervent2000，，4： | 1 |
| 10 | The effects of salinity on reproductive performance in Florida red tilapia显示文摘 | Watanabe W.O Burnett K.M Olla B.L | | 0，，： | 1 |
| 11 | Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”显示文摘 | Chris H.Polman Stephen C.Reingold GillesEdan MassimoFilippi Hans‐PeterHartung LudwigKappos Fred D.Lublin Luanne M.Metz Henry F.McFarland Paul W.O’Connor MagnhildSandberg‐Wollheim Alan J.Thompson Brian G.Weinshenker Jerry S.Wolinsky | 2005 | Ann Neurol2005，，6： | 1 |
| 12 | Application of a Cardiac Arrest Score in Patients with Sudden Death and ST Segment Elevation for Triage to Angiography and Intervention显示文摘 | PETER A.MCCULLOUGH RAJATPRAKASH KENNETH J.TOBIN WILLIAM W.O’NEILL RICHARD J.THOMPSON | 2007 | Journal of Interventional Cardiology2007，，4： | 1 |
| 13 | Optimizing Use of Relaimed Asphalt Pavement with the Superpave System显示文摘 | Kennedy T.W Tam W.O Solaimanian M | | 0，，： | 1 |
| 14 | Efficient finite element techniques for limit analysis of suction caissons under lateral loads显示文摘 | B Sukumaran W.O McCarron P Jeanjean H Abouseeda | 1999 | Computers and Geotechnics1999，，2： | 1 |
| 15 | Salt water culture of Florida red tilapia and other saline-tolerant tilapias:a review显示文摘 | Watanabe W.O | | 0，，： | 1 |
| 16 | Adolescent risk-taking behavior:A review of the role of parental involvement显示文摘 | Hindelang R.L Dwyer W.O Leeming F.C | | 0，，03： | 1 |
| 17 | FIBERSIM~在无人机复合材料部件开发中的优点显示文摘高空无人机的机身约占起飞总重的三分之一.任何对机身的减重都直接转化成增加传感器或有效载荷、飞行持续时间.因此制造者专注于采用工业定义的工程过程来设计新的机身,这些新设计的机身开发费用更少同时比以前的机身更轻. | John W.O'Connor 石庆华 | 2011 | 航空制造技术2011，0，15： | 1 |
| 18 | Aneurysms of the hepatic artery after liver transplantation显示文摘 | B Stange U Settmacher M Glanemann N.C Nuessler W.O Bechstein P Neuhaus | 2000 | Transplantation Proceedings2000，，3： | 1 |
| 19 | Adolescent risk-taking behavior:A review of the role of parental Involvement显示文摘 | Hindelang R.L Dwyer W.O Leeming F.C | | 0，，03： | 1 |
| 20 | Separation of thiosulfate and the polythionates in gold thiosulfate leach solutions by capillary electrophoresis显示文摘 | John W.O’Reilly Greg W.Dicinoski YasuyukiMiura Paul R.Haddad | 2003 | ELECTROPHORESIS . 2003 (12‐)2003，，： | 1 |
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