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| 1 | Hepatitis B surface antigen and hepatitis B core-related antigen kinetics after adding pegylated-interferon to nucleos(t)ids analogues in hepatitis B e antigen-negative patients显示文摘BACKGROUND Hepatitis B e antigen-negative chronic hepatitis B patients under nucleos(t)ids analogues(NAs)rarely achieve hepatitis B surface antigen(HBsAg)loss.AIM To evaluate if the addition of pegylated interferon(Peg-IFN)could decrease HBsAg and hepatitis B core-related antigen(HBcrAg)levels and increase HBsAg loss rate in patients under NAs therapy.METHODS Prospective,non-randomized,open-label trial evaluating the combination of Peg-IFN 180μg/week plus NAs during forty-eight weeks vs NAs in monotherapy.Hepatitis B e antigen-negative non-cirrhotic chronic hepatitis B patients of a tertiary hospital,under NAs therapy for at least 2 years and with undetectable viral load,were eligible.Patients with hepatitis C virus,hepatitis D virus or human immunodeficiency virus co-infection and liver transplanted patients were excluded.HBsAg and HBcrAg levels(log10 U/mL)were measured at baseline and during ninety-six weeks.HBsAg loss rate was evaluated in both groups.Adverse events were recorded in both groups.The kinetic of HBsAg for each treatment group was evaluated from baseline to weeks 24 and 48 by the slope of the HBsAg decline(log10 IU/mL/week)using a linear regression model.RESULTS Sixty-five patients were enrolled,61%receiving tenofovir and 33%entecavir.Thirty-six(55%)were included in Peg-IFN-NA group and 29(44%)in NA group.After matching by age and treatment duration,baseline HBsAg levels were comparable between groups(3.1 vs 3.2)(P=0.25).HBsAg levels at weeks 24,48 and 96 declined in Peg-IFN-NA group(-0.26,-0.40 and-0.44)and remained stable in NA group(-0.10,-0.10 and-0.10)(P<0.05).The slope of HBsAg decline in Peg-IFN-NA group(-0.02)was higher than in NA group(-0.00)(P=0.015).HBcrAg levels did not change.Eight(22%)patients discontinued Peg-IFN due to adverse events.The HBsAg loss was achieved in 3(8.3%)patients of the Peg-IFN-NA group and 0(0%)of the NA group.CONCLUSION The addition of Peg-IFN to NAs caused a greater and faster decrease of HBsAg levels compared to NA therapy.Side effects of Peg-IFN can limit its use in clinical practice. | Teresa Broquetas Montserrat Garcia-Retortillo Miquel Mico Lidia Canillas Marc Puigvehi Nuria Canete Susana Coll Ana Viu Juan Jose Hernandez Xavier Bessa JoseA Carrion | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 2 | Cost-effect clinical analysis in choice of methods of coronary heart disease diagnosis显示文摘 | KALASHNIKOV VIU MITRIAGINA S N SYRKIN A L | 2008 | Ter Arkh2008，80，： | 1 |
| 3 | Granular Vulvovaginitis Syndrome in Nelore pubertal and post pubertal replacement heifers under tropical conditions: role of Mycoplasma spp., Ureaplasma diversum and BHV-1显示文摘 | M. L. Gambarini T. L. Kunz B. D. Oliveira Filho R. N. G. Porto C. M. G. Oliveira W. M. E. D. Brito M. A. O. Viu | 2009 | Tropical Animal Health and Production2009，，7： | 1 |
| 4 | The early diagnostic of chorionic-amnionitic and intrauterine infection on content of nitrite and non-tiolate nitrosocompounds in plasma under premature discharge of amniotic fluid显示文摘 | Titov VIu Osipov AN Balitskii SP | 2013 | Klin Lab Diagn2013，12，： | 1 |
| 5 | Comparative evaluation of proximal resections in rectal cancer 显示文摘 | Lytkin MI Klur VIu Chalisov IA | 1989 | Vestn Khir Ira I I Grek1989，144，8： | 1 |
| 6 | The combination of chronic myeloid leukemia and multiple myeloma in one patient显示文摘 | Romanenko NA Bessmel'tsev SS Udal'eva VIu | 2013 | Vopr Onkol2013，59，2： | 1 |
| 7 | Endogenous and exogenous poly- amines in the organogenesis in Curcuma longa 显示文摘 | Alessandra F M Viu Marco A O Viu Armando R Tavares | 2009 | Sci Hortieulturae2009，121，4： | 1 |
| 8 | The role of inflammatory factors in pathogenesis of ischemic heart disease显示文摘 | Tatenkulova SN Mareev VIu Zykov KA | 2009 | Kardiologiia2009，49，1： | 1 |
| 9 | Pathogenetic characteristics of trigger mechanisms of preterm birth显示文摘 | Holota Via Beniuk V O Chemenko VIu | 2000 | Lik Sprava2000，，78： | 1 |
| 10 | Role of GroEL/GroES chaperonin system and Lon protease in regulation of expression Vibrio fischeri lux genes in Escherichia coli cells 显示文摘 | Manukhov I V Kotova VIu Zavil' genskii G B | 2006 | Mol Biol (Mosk)2006，40，2： | 1 |
| 11 | The use of minimally invasive procedures for diagnosis and therapy of patients with spinal tumors 显示文摘 | Valiev AK Karpenko VIu Setdikov RA | 2005 | Vopr Onkol2005，51，3： | 1 |
| 12 | The effect of ozone therapy on the activity of the autonomic nervous system显示文摘 | Kuz'mina VIu Khokhlov IuK Savin AA | 2012 | Zh Nevrol Psikhiatr Im S S Korsakova2012，112，10： | 1 |
| 13 | ]显示文摘 | Zavodilenko L A Bobrinskaia I G Sluvis VIu | 2007 | Anesteziol Reanimatol2007，，4： | 1 |
| 14 | Long-term resultsof xenoscleroplasty of the posterior Pole of the eyeball in the treatmentof patients with progressive myopia显示文摘 | Cheglakov IuA Ioshin IE Cheglakov VIu | 2005 | Vestn Oftalmol2005，121，6： | 1 |
| 15 | The use of minimally invasive procedures for diagnosis and therapy of patients with spinal tumors显示文摘 | Valiev AK Karpenko VIu Setdikov RA | 2005 | Vopr Onkol2005，51，3： | 1 |
| 16 | Understanding fault-Tolerant distributed systems显示文摘 | Fla Viu Cri Stian | 1991 | Communications of Acm1991，，1： | 1 |
| 17 | Morphologic analysis of reparative osteogenesis in cases of immediate dental implantation in experiments on rabbits 显示文摘 | Nikol'skii VIu | 2005 | Stomatologiia ( Mosk)2005，84，3： | 1 |
| 18 | Molecular- genetic characteristics of Mycobacterium tuberculosis strains isolated from patients with tuberculous spondylitis显示文摘 | Viazovaia AA Solov'eva NS Zhuravlev VIu | 2013 | Zh Mikrobiol Epidemiol Immunobiol2013，，5： | 1 |
| 19 | New-onset pul- monary tuberculosis patients with schizophrenia: course and effi- ciency of treatment 显示文摘 | Mishin VIu Shevchuk EIu Tsygankov BD | 2008 | Probl Tuberk Bolezn Legk2008，6，： | 1 |
| 20 | The architectonics of the lymphatic networks in the sheep heart 显示文摘 | Chumakov VIu | 1996 | Morfologiia1996，110，5： | 1 |
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