|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Endoclips vs large or small-volume epinephrine in peptic ulcer recurrent bleeding显示文摘AIM:To compare the recurrent bleeding after endoscopic injection of different epinephrine volumes with hemoclips in patients with bleeding peptic ulcer.METHODS:Between January 2005 and December 2009,150 patients with gastric or duodenal bleeding ulcer with major stigmata of hemorrhage and nonbleeding visible vessel in an ulcer bed(Forrest Ⅱa) were included in the study.Patients were randomized to receive a small-volume epinephrine group(15 to 25 mL injection group;Group 1,n = 50),a large-volume epinephrine group(30 to 40 mL injection group;Group 2,n = 50) and a hemoclip group(Group 3,n = 50).The rate of recurrent bleeding,as the primary outcome,was compared between the groups of patients included in the study.Secondary outcomes compared between the groups were primary hemostasis rate,permanent hemostasis,need for emergency surgery,30 d mortality,bleeding-related deaths,length of hospital stay and transfusion requirements.RESULTS:Initial hemostasis was obtained in all patients.The rate of early recurrent bleeding was 30%(15/50) in the small-volume epinephrine group(Group 1) and 16%(8/50) in the large-volume epinephrine group(Group 2)(P = 0.09).The rate of recurrent bleeding was 4%(2/50) in the hemoclip group(Group 3);the difference was statistically significant with regard to patients treated with either small-volume or large-volume epinephrine solution(P = 0.0005 and P = 0.045,respectively).Duration of hospital stay was significantly shorter among patients treated with hemoclips than among patients treated with epinephrine whereas there were no differences in transfusion requirement or even 30 d mortality between the groups.CONCLUSION:Endoclip is superior to both small and large volume injection of epinephrine in the prevention of recurrent bleeding in patients with peptic ulcer. | Neven Ljubicic Ivan Budimir Alen Biscanin Marko Nikolic Vladimir Supanc Davor Hrabar Tajana Pavic | 2012 | World Journal of Gastroenterology2012，18，18： | 11 |
| 2 | 国际糖尿病足工作组:糖尿病足溃疡周围动脉病变诊断、预后与管理指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分显示文摘1999年以来,国际糖尿病足工作组(IWGDF)已经多次发表循证医学基础上的糖尿病足预防与管理指南。该指南是有关糖尿病足溃疡合并周围动脉病变(PAD)患者的诊断、预后和管理指南,更新了以前IWGDF指南的内容。高达50%的糖尿病足溃疡患者同时患有PAD,这种病变使得患者截肢和心血管病变的风险明显增加。这类患者的诊断、预后和治疗明显地不同于那些没有PAD的糖尿病患者,但仅有很少的关于这类患者的高质量的研究强调了这点。我们遵循GRADE方法来提出临床问题并以至少包括患者-干预-比较-结局(PICO)形式说明重要结局,进行了系统的医学科学文献评价,写出推荐意见及其合理性。这类推荐是建立在系统文献评价的循证医学基础上的,没有证据时则在权衡利弊和患者选择、便宜性和干预的费用等因素后,采用专家的观点。这里我们发布更新的2019年糖尿病足溃疡合并PAD患者的有关PAD诊断、预后和管理的指南,以及一些需要未来特别关注的研究课题。 | Robert J.Hinchliffe Rachael O.Forsythe Jan Apelqvist Ed J.Boyko Robert Fitridge Joon Pio Hong Konstantinos Katsanos Joseph L.Mills Sigrid Nikol Jim Reekers Maarit Venermo R.Eugene Zierler Nicolaas C.Schaper 无 许樟荣(译) 冉兴无(审校) | 2019 | 感染.炎症.修复2019，20，4： | 10 |
| 3 | Silicon acquisition and accumulation in plant and its significance for agriculture显示文摘Although silicon(Si) is ubiquitous in soil and plant, evidence is still lacking that Si is essential for higher plants. However, it has been well documented that Si is beneficial for healthy growth of many plant species. Si can promote plant mechanical strength, light interception, as well as resistance to various forms of abiotic and biotic stress, thus improving both yield and quality. Indeed, application of Si fertilizer is a rather common agricultural practice in many countries and regions. As the beneficial effects provided by Si are closely correlated with Si accumulation level in plant, elucidating the possible mechanisms of Si uptake and transport in plants is extremely important to utilize the Si-induced beneficial effects in plants. Recently, rapid progress has been made in unveiling molecular mechanisms of Si uptake and transport in plants. Based on the cooperation of Si influx channels and efflux transporters, a model to decipher Si uptake, transport and distribution system in higher plants has been developed, which involves uptake and radial transport in root, xylem and inter-vascular transport and xylem unloading and deposition in leaf. In this paper, we overviewed the updated knowledge concerning Si uptake, transport and accumulation and its significance for the major crops of agricultural importance and highlighted the further research needs as well. | YAN Guo-chao Miroslav Nikolic YE Mu-jun XIAO Zhuo-xi LIANG Yong-chao | 2018 | Journal of Integrative Agriculture2018，17，10： | 8 |
| 4 | Mitotic crossover- an evolutionary rudiment which promotes carcinogenesis of colorectal carcinoma显示文摘Mitotic crossover is a natural mechanism that is a main source of the genetic variability of primitive organisms.In complex organisms such as mammals,it represents an evolutionary rudiment which persisted as one of the numerous DNA repair mechanisms,and results in the production of homozygous allele combinations in all heterozygous genes located on the chromosome arm distal to the crossover.This event is familiar as loss of heterozygosity,which is one of the key mechanisms responsible for the development and progression of almost all cancers.We propose the hypothesis in which mitotic crossover is a principal source of the increased loss of heterozygosity that leads to the initiation and progression of colorectal carcinoma.The hypothesis could be tested by in vitro inhibition of Rad51 protein,orthotopic grafting of human colon cancer tissue into the gut of mice,and treatment with potential inhibitors.After these procedures,the frequency of mitotic crossover would be estimated.The development of selective inhibitors of mitotic crossover could stop further carcinogenesis of colorectal carcinoma,as well as many other neoplastic events.Loss of heterozygosity is an event responsible for carcinogenesis,its reduction by selective inhibitors of mitotic crossover could have a positive effect on cancer chemoprevention,as well as on growth reduction and a cessation in the progression of earlier developed tumors. | Branislav Rovcanin Ivan Ivanovski Olivera Djuric Dimitrije Nikolic Jelena Petrovic Petar Ivanovski | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 5 | Subfractions and Subpopulations of HDL: An Update显示文摘 | M. Rizzo J. Otvos D. Nikolic G. Montalto P.P. Toth M. Banach | 2014 | Current Medicinal Chemistry2014，，25： | 2 |
| 6 | The DNA-binding factor Ctcf critically controls gene expression in macrophages显示文摘巨噬细胞在免疫和动态平衡起一个重要作用。在经由特定的受体的病原体识别之上,他们很快导致煽动性的回答。这个过程紧在 transcriptional 水平被控制。DNA 有约束力的锌手指蛋白质 CCCTC 有约束力的因素(Ctcf ) 是远程的染色质相互作用的一个关键管理者并且协调在抄写因素和基因表达式进程之间的特定的通讯。在这研究, Ctcf 基因被使用转基因的 Cre-LoxP 系统明确地在 myeloid 房间删除。在 myeloid 房间的 Ctcf 基因的有条件的删除在 vivo 导致了温和显型。显著地展出的 Ctcf 缺乏的老鼠减少了主要 histocompatibility 的表示在肝的建筑群(MHC ) 班 II。Ctcf 缺乏的巨噬细胞表明了正常表面显型和吞噬作用能力。在像使用费的受体(TLR ) 之上刺激,他们生产了支持 inflammatory cytokines IL-12 和 IL-6 的正常层次,但是表明了一个强烈损害的能力生产肿瘤坏死因素(TNF ) 和 IL-10,以及表示 IL-10 家庭成员 IL-19, IL-20 和 IL-24。一起拿,我们的数据表明涉及巨噬细胞功能调整的 Ctcf 的一个角色。 | Tatjana Nikolic Dowty Movita Margaretha EH Lambers Claudia Ribeiro de Almeida] Paula Biesta Kim Kreefft Marjolein JW de Bruijn Ingrid Bergen Niels Galjart Andre Boonstra Rudi Hendriks | 2014 | Cellular & Molecular Immunology2014，11，1： | 2 |
| 7 | 不同电解条件下制备铜粉的形貌及结晶学比较分析(英文)显示文摘研究不同析氢条件下恒电位电解法制备铜粉的过程。采用扫描电镜(SEM)、X射线衍射(XRD)、粒度分布(PSD)和比表面积测定(SSA)对铜粉进行表征。根据电解过程析氢量的大小,形成树枝状和菜花状两种类型的颗粒。当析氢量大到足以对近电极层中的流体动力学条件产生强烈影响时,形成菜花状颗粒,否则形成树枝状颗粒。虽然颗粒的宏观结构差异很大,但他们的微观结构却相似,也就是说,这两种颗粒在微观层面上都是由近似球形的Cu颗粒小团聚体组成;球状形貌的存在是造成两种颗粒中Cu晶粒随机取向的原因。菜花样颗粒的比表面积是树枝状颗粒的3倍以上,其粒径则比树枝状颗粒的小很多。由此可见,强析氢条件对于铜粉制备是有益的。 | Nebojsa D. NIKOLIC Ljiljana AVRAMOVIC Evica R. IVANOVIC Vesna M. MAKSIMOVIC Zvezdana BASCAREVIC Nenad IGNJATOVIC | 2019 | Transactions of Nonferrous Metals Society of China2019，29，6： | 2 |
| 8 | IRRITABLE BOWEL SYNDROME, ANXIETY, DEPRESSION AND PERSONALITY CHARACTERISTICS显示文摘 | Suzana Tosic-Golubovic Srbobran Miljkovic Aleksandar Nagorni Dusan Lazarevic Gordana Nikolic | 2010 | Psychiatria Danubina2010，，3： | 2 |
| 9 | 骨髓动员对骨髓造血干细胞在心肌梗死后心脏中定植及分化的影响显示文摘目的观察小鼠心肌梗死后骨髓造血干细胞在心脏内的分化及细胞因子的影响。方法C57/BL6小鼠60只分为骨髓动员组和对照组,先后行脾切除、骨髓移植(骨髓供体为增强绿色荧光蛋白转基因小鼠)、骨髓动员及建立心肌梗死模型。心肌梗死后3周将小鼠心脏取出并切片行组织学及激光共聚焦显微镜免疫荧光检查。结果骨髓动员可以增加EGFP阳性细胞在心脏中梗死区和边缘区的定植,但绝大多数EGFP阳性细胞都同时表达CD45。仅发现有极少数骨髓来源的心肌细胞、成纤维细胞及血管内皮细胞,且与骨髓动员无相关性。结论骨髓动员能够明显促进骨髓来源细胞定植入小鼠心脏的梗死区;极少数骨髓造血干细胞可以分化为心肌细胞,其数量远不足以修复梗死心肌及改善心功能;骨髓造血干细胞不参与梗死区疤痕形成的病理过程。 | 田文 曾定尹 Michael Kuhl mann Sigrid Nikol | 2009 | 中国组织化学与细胞化学杂志2009，18，3： | 2 |
| 10 | Expression of cytokeratins in Helicobacter pylori-associated chronic gastritis of adult patients infected with cagA+strains:An immunohistochemical study显示文摘瞄准:为了与长期的胃炎在成年病人的胃的上皮调查不同 cytokeratins (CK ) 的表示,与 Helicobacter pylori (H pylori ) 感染了 cagA+ 紧张。方法:CK 7 的表示, 8, 18, 19 和 20 在 84 个病人的窦的胃的活体检视组织化学地是学习免疫。所有 CK 是在 cagA+H pylori 胃炎(57 个案例) 染色的免疫, non-H pylori 胃炎(17 个案例) 和正常胃粘膜(10 个案例) 。结果:在 cagA+ H pylori 胃炎, CK8 从表面上皮可比较地被表示到正常的窦粘膜到深腺。CK18 和 CK 19 的分发是未改变的,即表示的 transmucosal,而是紧张在与正常相比的小凹的区域是不同的胃粘膜。Cytokeratin 18 免疫反应在与 H pylori 否定的胃炎和控制相比的 H pylori 积极的胃炎的小凹的上皮是显著地更高的。相反,在 CK19 免疫反应的减少发生在 H pylori 积极的胃炎的小凹的上皮。在没有 H pylori 感染的正常、煽动的窦粘膜, CK20 在表面上皮和上面的小凹的区域强烈 / 中等并且同类地被表示,但是在 H, pylori 导致了胃炎在小凹的区域的表示的重要减少被注意。通常,在正常窦的粘膜和 H pylori 否定的胃炎,, CK7 的表示没被观察在关于半 cagA+ , H 感染 pylori 的病人,节制颈的焦点的 CK7 免疫反应,卷的腺区域被登记,特别在区域与更严重煽动性渗入。结论:在 CK 7 的表示的改变, 18, 19 和 20 在感染 cagA+ 紧张的成年病人和 CK8 的正常表示发生在 H 联系 pylori 的长期的胃炎的窦粘膜。在不同 cytokeratins 表示力量的改变贡献在 H 感染 pylori 的胃粘膜观察的上皮的紧密的连接变弱。 | Vera Todorovic Neda Drndarevic Olivera Mitrovic Institutefor MedicalResearch Aleksandra Sokic-Milutinovic Tomica Milosavljevic Marjan Micev Ivan Nikolic Thomas Wex Peter Malfertheiner | 2006 | World Journal of Gastroenterology2006，12，12： | 2 |
| 11 | Chronic pancreatitis and the heart disease:Still terra incognita?显示文摘BACKGROUND It has been suggested that chronic pancreatitis(CP)may be an independent risk factor for development of cardiovascular disease(CVD).At the same time,it seems that congestive heart failure(CHF)and CP share the responsibility for the development of important clinical conditions such as sarcopenia,cachexia and malnutrition due to development of cardiac cachexia and pancreatic exocrine insufficiency(PEI),respectively.AIM To explore the evidence regarding the association of CP and heart disease,more specifically CVD and CHF.METHODS A systematic search of MEDLINE,Web of Science and Google Scholar was performed by two independent investigators to identify eligible studies where the connection between CP and CVD was investigated.The search was limited to articles in the English language.The last search was run on the 1st of May 2019.The primary outcomes were:(1)Incidence of cardiovascular event[acute coronary syndrome(ACS),chronic coronary disease,peripheral arterial lesions]in patients with established CP;and(2)Incidence of PEI in patients with CHF.RESULTS Out of 1166 studies,only 8 were eligible for this review.Studies regarding PEI and CHF showed an important incidence of PEI as well as associated malabsorption of nutritional markers(vitamin D,selenium,phosphorus,zinc,folic acid,and prealbumin)in patients with CHF.However,after substitution of pancreatic enzymes,it seems that,at least,loss of appetite was attenuated.On the other side,studies investigating cardiovascular events in patients with CP showed that,in CP cohort,there was a 2.5-fold higher incidence of ACS.In another study,patients with alcohol–induced CP with concomitant type 3c diabetes had statistically significant higher incidence of carotid atherosclerotic plaques in comparison to patients with diabetes mellitus of other etiologies.Earlier studies demonstrated a marked correlation between the clinical symptoms in CP and chronic coronary insufficiency.Also,statistically significant higher incidence of arterial lesions was found in patients with CP compared to the control group with the same risk factors for atherosclerosis(hypertension,smoking,dyslipidemia).Moreover,one recent study showed that PEI is significantly associated with the risk of cardiovascular events in patients with CP.CONCLUSION Current evidence implicates a possible association between PEI and malnutrition in patients with CHF.Chronic pancreatic tissue hypoxic injury driven by prolonged splanchnic hypoperfusion is likely to contribute to malnutrition and cachexia in patients with CHF.On the other hand,CP and PEI seem to be an independent risk factor associated with an increased risk of cardiovascular events. | Sara Nikolic Ana Dugic Corinna Steiner Apostolos V Tsolakis Ida Marie Haugen Lofman J-Matthias Lohr Miroslav Vujasinovic | 2019 | World Journal of Gastroenterology2019，25，44： | 2 |
| 12 | Sudden cardiac death caused by complicated atherosclerosis of the anterior intraventricular branch of the left coronary artery with a myocardial muscle bridge显示文摘 | Micic I Nikolic S Savic S | 2003 | Srp Arh Celok Lek2003，131，34： | 1 |
| 13 | Uterine artery embolization:reduced radiation with refined technique显示文摘 | Spies J B Campbell L | 2001 | J Vasc Interv Radiol2001，12，1： | 1 |
| 14 | The microglial 'activation' continuum:from innate to adaptive responses显示文摘 | Town T Nikolic V Tan J | 2005 | J Neuroinflam2005，2，24： | 1 |
| 15 | Responses of hybrid poplar to cadmium stress:photosynthetic characteristics,cadmium and proline accumulation, and antioxidant enzyme aetivity显示文摘 | NIKOLIC N KOJIC D PILIPOVIC A | 2008 | Acta Biologiea Cracoviensia Series Botantea2008，50，2： | 1 |
| 16 | Ovarian artery supply of uterine fibroids as a cause of treatment failure after uterine artery embolization:a case report显示文摘 | Nikolic B Spies JB Abbara S | 1999 | J Vasc Interv Radiol1999，10，9： | 1 |
| 17 | Evaluation of a glassy carbon electrode modified by a bilayer lipid membrane with incorporated DNA 显示文摘 | SIONTOROU C G OLIVEIRA - BREETT A M NIKOLELIS D P | 1996 | Talanta1996，43，： | 1 |
| 18 | Uterine artery embolization:reduced radiation with refined technique显示文摘 | Nikolic B Spies JB Campbell L | 2001 | J Vasc Interv Radiol2001，12，1： | 1 |
| 19 | Needle injection catheter delivery of gene of antibacterial agent inhibits neoiatimal formation显示文摘 | Nikol S Huehas TY krausze | 1999 | Genc ther1999，6，： | 1 |
| 20 | Preparation of Y203 Eu3+ Nanopowders Via Polymer Complex Solution Method and Luminescence Properties of the Sintered Ceramics显示文摘 | Krsmanovic R M Antic Z Nikolic M G | 2011 | Ceram&s International2011，37，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员