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| 1 | 氮肥对稻株含水量和伤流液的影响及其与对褐飞虱为害耐性的关系显示文摘在实验室测定了不同含氮量稻株的含水量和叶鞘伤流液以及被褐飞虱为害后稻株相对含水量的变化 ,在温室监测和评价了不同氮肥施用量条件下稻株对褐飞虱的耐性。结果表明 ,随着稻株含氮量的增加 ,稻株的含水量和相对含水量均显著增加 ,但叶鞘伤流液总量却明显减少。被高密度的褐飞虱若虫为害后 ,高氮肥施用量稻株的相对含水量显著低于低氮肥施用量稻株的相对含水量。 | 吕仲贤 Sylvia VILLAREAL 俞晓平 HEONG Kongluen 胡萃 | 2004 | 中国水稻科学2004，18，2： | 16 |
| 2 | An update on iron physiology显示文摘Iron is an essential micronutrient, as it is required for adequate erythropoietic function, oxidative metabolism and cellular immune responses. Although the absorption of dietary iron (1-2 mg/d) is regulated tightly, it is just balanced with losses. Therefore, internal turnover of iron is essential to meet the requirements for erythropoiesis (20-30 mg/d). Increased iron requirements, limited external supply, and increased blood loss may lead to iron deficiency (ID) and iron-deficiency anemia. Hepcidin, which is made primarily in hepatocytes in response to liver iron levels, inflammation, hypoxia and anemia, is the main iron regulatory hormone. Once secreted into the circulation, hepcidin binds ferroportin on enterocytes and macrophages, which triggers its internalization and lysosomal degradation. Thus, in chronic inflammation, the excess of hepcidin decreases iron absorption and prevents iron recycling, which results in hypoferremia and iron-restricted erythropoiesis, despite normal iron stores (functional ID), and anemia of chronic disease (ACD), which can evolve to ACD plus true ID (ACD + ID). In contrast, low hepcidin expression may lead to iron overload, and vice versa. Laboratory tests provide evidence of iron depletion in the body, or reflect iron-deficient red cell production. The appropriate combination of these laboratory tests help to establish a correct diagnosis of ID status and anemia. | Manuel Muoz Isabel Villar José Antonio García-Erce | 2009 | World Journal of Gastroenterology2009，15，37： | 12 |
| 3 | COPPER AMINE OXIDASE1 (CuAO1) of Arabidopsis thaliana Contributes to Abscisic Acid- and Polyamine-lnduced Nitric Oxide Biosynthesis and Abscisic Acid Signal Transduction显示文摘Polyamines (PA ) , polyamine oxidases,铜胺 oxidases,和氮的氧化物(没有) 在植物在生理学和压力回答起重要作用。由于由 polyamine oxidases 和铜胺 oxidases 的 PA 的分解代谢的生合成都可以不解释部分地调停 PA 的回答。铜胺 oxidase 基因的参与,铜胺 OXIDASE1 (CuAO1 ) ,用大美人 cuao1-1 和 cuao1-2 在压力回答为它的角色 Arabidopsis 被测试。导致 PA 、导致骆驼毛的织物萤光计和荧光显微镜学调查的生产都没证明 cuao1-1 和 cuao1-2 在没有生产被损害,在 PA 建议 CuAO1 的功能并且调停骆驼毛的织物没有生产。而且,我们在蛋白质 S-nitrosylation 发现了 PA 依赖的增加。PA 和骆驼毛的织物的增加也导致了 H2O2 增加。cuao1-1 和 cuao1-2 作为与相比在萌芽,幼苗建立,和根生长抑制期间显示出更少的敏感到外长的骆驼毛的织物补充野类型。响应骆驼毛的织物处理,压力应答的基因 RD29A 和 ADH1 的表示层次在大美人是显著地更低的。这些观察作为骆驼毛的织物感觉迟钝的异种描绘 cuao1-1 和 cuao1-2。一起拿,我们的调查结果扩大 ABA 信号 transduction 网络作为一个潜在的贡献者包括 CuAO1 到没由骆驼毛的织物提高生产。 | Rinukshi Wimalasekera Corina Villar Tahmina Begum Giinther F. E. Scherer | 2011 | Molecular Plant2011，4，4： | 12 |
| 4 | Association between vitamin D and hepatitis C virus infection: A meta-analysis显示文摘AIM:To evaluate the association between 25-hydroxyvitamin D[25(OH)D]and sustained virological response(SVR)in hepatitis C virus(HCV)infected individuals.METHODS:Relevant studies were identified by systematically searching MEDLINE databases up to March2012 and abstracts of the European and American Congress of Hepatology conducted in 2011.Studies must provide information on SVR and the levels of 25(OH)D3and/or 25(OH)D2[henceforth referred to as 25(OH)D]in sera samples from HCV infected individuals.The inclusion criteria were:clinical studies that included HCV infected patients aged older than 18 years regardless of HCV genotype or ethnic group;provided information on SVR rates;and were reported in the English languageas full papers.Due to the heterogeneity of studies in categorizing serum vitamin D levels,a cut-off value of30 ng/mL of serum 25(OH)D was used.Heterogeneity was assessed using I2statistics.The summary odds ratios with their corresponding 95%CI were calculated based on a random-effects model.RESULTS:Overall,11 studies(8 observational and 3interventional)involving 1575 individuals were included and 1117 HCV infected individuals(71%)showed low vitamin D levels.Most of the studies included monoinfected HCV individuals with the mean age ranging from 38 to 56 years.Four studies were conducted in human immunodeficiency virus/HCV infected individuals.Regarding vitamin D measurement,most of the studies employed radioimmunoassays(n=5)followed by chemiluminescence(n=4)and just one study employed high performance/pressure liquid chromatography(HPLC).Basal vitamin D levels varied from 17 to43 ng/mL in the studies selected,and most of the HCV infected individuals had genotype 1(1068/1575)with mean viral load varying from log 4.5-5.9 UI/mL.With regard to HCV treatment,most of the studies(n=8)included HCV individuals without previous treatment,where the pooled SVR rate was 46.4%.High rates of SVR were observed in HCV individuals with vitamin D levels above 30 ng/mL(OR=1.57;95%CI:1.12-2.2)and those supplemented with vitamin D(OR=4.59;95%CI:1.67-12.63)regardless of genotype.CONCLUSION:Our results demonstrated high prevalence of vitamin D deficiency and high SVR in individuals with higher serum vitamin D levels or receiving vitamin D supplementation. | Livia Melo Villar José Antonio Del Campo Isidora Ranchal Elisabeth Lampe Manuel Romero-Gomez | 2013 | World Journal of Gastroenterology2013，19，35： | 9 |
| 5 | Update on hepatitis B and C virus diagnosis显示文摘Viral hepatitis B and C virus(HBV and HCV) are responsible for the most of chronic liver disease worldwide and are transmitted by parenteral route, sexual and vertical transmission. One important measure to reduce the burden of these infections is the diagnosis of acute and chronic cases of HBV and HCV. In order to provide an effective diagnosis and monitoring of antiviral treatment, it is important to choose sensitive, rapid, inexpensive, and robust analytical methods. Primary diagnosis of HBV and HCV infection is made by using serological tests for detecting antigens and antibodies against these viruses. In order to confirm primary diagnosis, to quantify viral load, to determine genotypes and resistance mutants for antiviral treatment, qualitative and quantitative molecular tests are used. In this manuscript, we review the current serological and molecular methods for the diagnosis of hepatitis B and C. | Livia Melo Villar Helena Medina Cruz Jakeline Ribeiro Barbosa Cristianne Sousa Bezerra Moyra Machado Portilho Letícia de Paula Scalioni | 2015 | World Journal of Virology2015，4，4： | 9 |
| 6 | 在人工接种和自然感虫情况下美洲黑杨后代对桑天牛抗性的研究显示文摘Two Populus deltoides clones ( P.deltoides Bartr.cl.‘55/65’ and P.deltoides Bartr.cl.‘2KEN8’)with high resistance to Anoplophora glabripennis (Resistant rate are 96.16%,97.37%,respectively) were used as parents and crossed by artificial controlled pollination,37 among of which F 1 progenies were planted in Shuyang,Jiangsu province and tested for insect resistance with the borer Apriona germari Hope.Under artificial inoculation and natural infestation with Apriona germari Hope,significant variations of oviposition and larval development were observed between progenies.Both artificial inoculation and natural infestation alow the characterization of plant resistance to insect,although insect behavioral responses sometimes differ between free choice (natural infestation) and no choice experiment (inoculation). | 胡建军 韩一凡 尹伟伦 Sylvie Augustin Marc Villar | 2002 | 林业科学2002，38，1： | 8 |
| 7 | 髋关节圆韧带损伤的关节镜诊断与治疗显示文摘目的探讨髋关节圆韧带损伤的关节镜下分型并观察其手术疗效。方法68例患者均为1990年2月~1999年12月经关节镜确诊的髋关节圆韧带损伤患者,共73髋。按镜下所见分为髋关节圆韧带完全离断28例28髋、部分离断28例32髋和退行性变12例13髋三组,分别施以关节镜下残端切除术、韧带修整术和关节清理术,平均随访42个月。结果具备完整随访资料者32例34髋,髋关节圆韧带完全离断组随访9例9髋,部分离断组随访13例15髋,退行性变组随访10例髋。三组患者术后髋关节改良Harris评分均较术前显著提高,差异有显著性意义P<0.05或P0.01。结论髋关节镜技术是诊断、治疗髋关节圆韧带损伤的有效手段。 | 周一新 Richard N Villar 周乙雄 张洪 | 2001 | 中华骨科杂志2001，21，7： | 7 |
| 8 | 产前保健有效预防孕产妇死亡和严重疾病的证据概述显示文摘 | Guillermo Carroli Cleonr Rooney Jose Villar | 2005 | 生殖与避孕2005，25，4： | 7 |
| 9 | 一种缓冲回填材料的筛选及其特性:西班牙实例(英文)显示文摘介绍了西班牙在高放废物深地质处置中用于缓冲回填材料的泥岩的筛选及其特性的研究成果,这项研究在西班牙核废料管理委员会资助下进行,始于 20 世纪 80 年代,且在开始阶段主要是开展泥岩沉积层及黏土供应商的筛选工作。黏土这些特性与标准已被国际社会广泛接受,但进一步的研究主要涉及到泥岩的矿物纯度、持水特性、可塑性、低渗透性、较高的膨胀压力和热导性。经初步研究,确定两种膨润土沉积层被选中,并在实验室中对其特性进行了研究,主要包括:热–水–力特性的确定、预加热和温度的影响以及石英添加剂的作用。由于膨润土具有较高的膨胀性以及低渗透性,因而必须对传统的试验技术进行改进,并设计出新的试验设备。最终确定Cortijo de Archidona(Almería)选为西班牙膨润土的供应区,其开采的膨润土已在近期结束的数个研究课题中得到了应用。无论是从矿物学、热学、水力学、力学和地质化学,还是从可变性等方面看来,该区膨润土的特性都是最好的;另外,处置库中膨润土的变化特征在实验室以及现场都已经作了相应的研究。 | Villar María Victoria Astudillo Julio Huertas Fernando | 2006 | 岩石力学与工程学报2006，25，4： | 6 |
| 10 | Control of PHERES1 Imprinting in Arabidopsis by Direct Tandem Repeats显示文摘印的 Genomic 是引起依赖于 parent-of-origin 的特定的基因的 monoallelic 表示的 epigenetic 现象。Arabidopsis 基因 PHERES1 印要求 FERTILIZATION 独立种子(FIS ) Polycomb 组建筑群以及包含一个双人脚踏车三元组重复序列的一个远侧地定位的 methylated 区域的功能。在这研究,我们调查了靠近的 PHERES1 相当或相同的事物 PHERES2 的规定。我们发现 PHERES2 也是 FIS Polycomb 组建筑群的直接目标基因,,但是,与 PHERES1 相对照, PHERES2 同等地从母亲、父亲的等位基因被表示。因此, PHERES2 没被印的 genomic 调整,与在 PHERES2 的双人脚踏车重复的缺乏相关。从 PHERES1 地点消除双人脚踏车重复废除印的 PHERES1,证明双人脚踏车重复为印的 PHERES1 是必要的。一起拿这些结果,我们最近复制的基因 PHERES1 和 PHERES2 两个都是 FIS Polycomb 的目标基因的学习表演组织建筑群但是仅仅 PHERES1 被印的 genomic 调整,它是可能的在 PHERES1 地点的最近由重复序列的存在引起了。 | Corina Belle R. Villar Aleksandra Erilova Grigory Makarevich Raphael Trosch Claudia Kohler | 2009 | Molecular Plant2009，2，4： | 6 |
| 11 | Gallbladder tuberculosis: False-positive PET diagnosis of gallbladder cancer显示文摘Gallbladder tuberculosis (GT) is an extremely rare disease, and very few cases have been reported in the literature. The first case of GT was described in 1870 by Gaucher. A correct preoperative diagnosis of GT is unusual, and it is frequently confused with various gallbladder diseases. We present a new case of a patient who underwent surgery with the preoperative diagnosis of gallbladder cancer after a false positive positron emission tomography scan in the diagnostic work-up. | JM Ramia K Muffak A Fernández J Villar D Garrote JA Ferron | 2006 | World Journal of Gastroenterology2006，12，40： | 5 |
| 12 | Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy. | Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，44： | 5 |
| 13 | 氮肥影响节肢动物天敌对褐飞虱种群的自然控制作用显示文摘氮肥在增加粮食产量的同时也可能对整个农田生态系统产生负面影响。稻田过量施用氮肥后,会提高水稻对害虫的敏感性、改变害虫与天敌之间的关系,最终影响到天敌对害虫的自然控制功能,导致害虫大发生。为了合理、公正地评价施用氮肥对稻田节肢动物天敌对害虫自然控制能力的影响,探索性地应用笼罩的方法在菲律宾国际水稻研究所试验农场稻田中研究了害虫天敌在不同氮肥施用水平(0,100 kg N/hm^2和200 kg N/hm^2)稻田中对褐飞虱的捕食能力及自然控制作用。试验结果表明,旱季田间的捕食性天敌对褐飞虱若虫的捕食能力和主要天敌对褐飞虱种群的自然控制能力均随稻田氮肥施用量的增加而减弱。在雨季,虽然天敌对褐飞虱种群的自然控制能力也随稻田氮肥施用量的增加而减弱,但捕食性天敌对褐飞虱若虫捕食能力的差异不明显。本研究表明,天敌对褐飞虱自然控制能力的减弱是稻田过量施用氮肥后褐飞虱种群猖獗的主要原因之一。 | 朱平阳 Heong Kongluen Sylvia VILLAREAL 吕仲贤 | 2017 | 生态学报2017，37，16： | 4 |
| 14 | Novel nutraceutic therapies for the treatment of metabolic syndrome显示文摘Nutraceutic therapies such as berberine, bitter melon,Gymnema sylvestre, Irvingia gabonensis, resveratrol and ursolic acid have been shown to help control metabolic syndrome(MetS). The effect of berberine on glucose and lipid metabolism, hypertension, obesity and MetS has been evaluated in animal models and humans. Most clinical trials involving bitter melon have been conducted to evaluate its effect on glucose metabolism; nevertheless, some studies have reported favorable effects on lipids and blood pressure although there is little information about its effect on body weight. Gymnema sylvestre helps to decrease body weight and blood sugar levels; however, there is limited information on dyslipidemia and hypertension. Clinical trials of Irvingia gabonensis have shown important effects decreasing glucose and cholesterol concentrations as well decreasing body weight. Resveratrol acts through different mechanisms to decrease blood pressure, lipids, glucose and weight, showing its effects on the population with Met S. Finally, there is evidence of positive effects with ursolic acid in in vitro and in vivo studies on glucose and lipid metabolism and on body weight and visceral fat. Therefore, a review of the beneficial effects and limitations of the above-mentioned nutraceutic therapies is presented. | Esperanza Martínez-Abundis Miriam Mendez-del Villar Karina G Pérez-Rubio Laura Y Zuniga Marisol Cortez-Navarrete Alejandra Ramírez-Rodriguez Manuel González-Ortiz | 2016 | World Journal of Diabetes2016，7，7： | 3 |
| 15 | Biodiversity and Dynamics of Planthoppers and Their Natural Enemies in Rice Fields with Different Nitrogen Regimes显示文摘A field experiment was conducted to study the effect of different nitrogen fertilizer rates i.e. 200, 100 and 0 kg N/ha in paddy fields at International Rice Research Institute, Manila, Philippines. Biodiversity of arthropods sampled by Blower-Vac, and dynamics of planthoppers, egg parasitoids of Homoptera trapped by rice plants with eggs of brown planthoppers (BPH) Nilaparvata lugens (St?l), and web spiders on rice canopy collected by sweeping net, were analyzed at different rice growth stages. The most abundant arthropods were sampled at the milking stage of rice, totalling 116 species identified into 14 insect orders and 15 species of spider in all samples. Meanwhile the number of arthropod species significantly increased with rice growth and the diversity indices increased with the increase of nitrogen rate at the booting stage. On the other hand, in the dominant predators, Pardosa pseudoannulata, Callitrichi formosana, Micraspis sp., Cyrtorhinus lividipennis, Veliidae sp. and Mesoveliidae sp., only C. lividipennis and Micraspis sp. were increased significantly in abundance following the application of nitrogen at the milking stage of rice. The egg parasitoids of plant-hoppers were predominated by Anagrus flaveolus and Oligosita sp. and their densities in the field without nitrogen fertilizer were markedly higher than those in fields with 100 and 200 kg N/ha at both booting and milking stages of rice. The number and web area of dominant residential spiders Tetragnatha sp. and Araneus sp. in rice canopy significantly reduced with the increase of nitrogen fertilizer. The population density of planthoppers, included BPH and the white-backed planthoppers (WBPH) Sogatella furcifera Horváth, peaked during the booting stage, however, the number of BPH in rice field with 200 kg N/ha was considerably higher than those in other two rice fields with 100 kg N/ha and 0 kg N/ha at the booting as well as the milking stage. These results indicated that the rapid growth in populations of planthopper due to excessive nitrogen might be attributed to the combination of reduction in control capacity of natural enemies and strong simulation of nitrogen to planthoppers. | Lu Zhong-xian S. VILLAREAL Yu Xiao-ping K. L. HEONG HU Cui | 2006 | Rice science2006，13，3： | 3 |
| 16 | Biosafety and biobanking: Current understanding and knowledge gaps显示文摘Infectious disease outbreaks,such as'Coronavirus disease 20190(COVID-19),can constitute major global health threats with far-reaching consequences.As outbreaks develop,the international scientific community must provide high-quality scientific research-ready biological samples to solve the existing clinical and epidemiological questions to better combat the pandemic.Such examples are provided by dedicated biobank facilities,the latter collecting increasingly high volumes of biological samples.However,the more significant concentrations of infectious or potentially infectious biological materials can create a safety risk.The current short report describes the first attempt to identify the published scientific works on biobanking and safety.Three broad thematic areas have been identified:the physical security relevant to staff and sample integrity,the data safety aspects,and the governance parameters relating to the previous two.While the current publications reflect a broad alignment with existing standards and best practices in the biobanking field,they also demonstrate an opportunity for further in-depth work on this field in the post-COVID-19 era. | Julie Roux Maissa Zeghidi Stephanie Villar Zisis Kozlakidis | 2021 | Biosafety and Health2021，3，5： | 2 |
| 17 | The pharmacokinetics of the prostaglandin E1 analogue misoprostol in plasma and colostrum after postpartum oral administration显示文摘 | Hany Abdel-Aleem José Villar A Metin Gülmezoglu Sayed A Mostafa Alaa A Youssef Mahmoud Shokry Bernhard Watzer | 2002 | European Journal of Obstetrics and Gynecology2002，，1： | 2 |
| 18 | 船厂1862显示文摘我们将建造于1972年的造船厂改造为由剧院、多功能厅、商业店铺三个功能组成的综合设施。造船厂是为了制作巨大尺度的货轮而建,因此它和通常的建筑尺寸不同,拥有独特的尺度感。建筑长200m、高30m,中间没有隔断,净高几乎保持在26m,是一个巨大的通透空间。改建时,首先想到的是如何保留这种尺度感。为此,我们设置了穿过建筑纵向的孔(中庭),同时这个孔也贯穿着建筑的垂直方向,因此当人们进入到这个孔时,瞬间就可以感受到建筑的大小。 | Javier Villar Ruiz 寺崎丰 秋天 Rita Topa 陈威志 胡秀芝 洪人杰 陶鈊潆 涌田纯树 加纳永一 Kengo Kuma | 2019 | 建筑实践2019，2，7： | 2 |
| 19 | Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal显示文摘Primary neoplasms arising in the anal canal are relatively unusual.In particular, adenomas and adenocarcinomas are distinctly rare entities in this region.We describe an infiltrating, well-differentiated adenocarcinoma arising in a villous adenoma from the distal anal canal, in an otherwise healthy patient at low risk for gastrointestinal malignancy.This is the case of an octogenarian man with a several year history of hemorrhoids and intermittent rectal bleeding, more recently complaining of continuous hematochezia.Examination revealed a blood-covered pedunculated mass with a long stalk protruding from the anus.The lesion was amputated at the bedside.Microscopic evaluation revealed an infiltrating well-differentiated adenocarcinoma, arising from a villous adenoma.This was further evaluated under anesthesia and complete excision of distal anal tissue was performed.Our report is the f irst describing the possible malignant degeneration of a villous adenoma in the anal canal. | Marni Colvin Aris Delis Erika Bracamonte Hugo Villar Luis R Leon Jr | 2009 | World Journal of Gastroenterology2009，15，28： | 2 |
| 20 | The Efficiency of the Regional Management Centres of the Tax Administration in Spain显示文摘 | Pedro Enrique Barrilao Gonzalez Elena Villar Rubio | 2013 | Journal of US-China Public Administration2013，10，1： | 2 |
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