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| 1 | Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights显示文摘AIM To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157. METHODS Medication [BPC 157,L-NAME,L-arginine(alone/combined),saline] was bath at the blood deprived colon segment. During reperfusion,medication was BPC 157 or saline. We recorded(USB microscope camera) vessel presentation through next 15 min of ischemic colitis(ICrats) or reperfusion(removed ligations)(IC + RL-rats);oxidative stress as MDA(increased(IC-and IC + RLrats)) and NO levels(decreased(IC-rats);increased(IC + RL-rats)) in colon tissue. IC + OB-rats [IC-rats had additional colon obstruction(OB)] for 3 d(IC + OBrats),then received BPC 157 bath. RESULTS Commonly,in colon segment(25 mm,2 ligations on left colic artery and vein,3 arcade vessels within ligated segment),in IC-,IC + RL-,IC + OB-rats,BPC 157(10 μg/kg) bath(1 m L/rat) increased vessel presentation,inside/outside arcade interconnections quickly reappeared,mucosal folds were preserved and the pale areas were small and markedly reduced. BPC 157 counteracted worsening effects induced by L-NAME(5 mg) and L-arginine(100 mg). MDA-and NO-levels were normal in BPC 157 treated IC-rats and IC + RLrats. In addition,on day 10,BPC 157-treated IC + OBrats presented almost completely spared mucosa with very small pale areas and no gross mucosal defects;the treated colon segment was of normal diameter,and only small adhesions were present.CONCLUSION BPC 157 is a fundamental treatment that quickly restores blood supply to the ischemically injured area and rapidly activates collaterals. This effect involves the NO system. | Antonija Duzel Josipa Vlainic Marko Antunovic Dominik Malekinusic Borna Vrdoljak Mariam Samara Slaven Gojkovic Ivan Krezic Tinka Vidovic Zdenko Bilic Mario Knezevic Marko Sever Nermin Lojo Antonio Kokot Marijan Kolovrat Domagoj Drmic Jaksa Vukojevic Tamara Kralj Katarina Kasnik Marko Siroglavic Sven Seiwerth Predrag Sikiric | 2017 | World Journal of Gastroenterology2017，23，48： | 2 |
| 2 | A Theoretical Model Applying Fuzzy Logic Theory for Evaluating Personnel in Project Management显示文摘 | Darko Galinec Slavko Vidovic | 2006 | Journal of Behavioral and Applied Management2006，，： | 1 |
| 3 | Laparoscopic totally extraperitoneal hernia repair versus open Lichtenstein hernia repair:results and complications显示文摘 | Vidovic D Kirac I Glavan E | 2007 | J Laparoen- dosc Adv Surg Tech A2007，17，5： | 1 |
| 4 | Analysis of EphB receptors and their ligands in the developing retinocollicular system of the wallaby reveals dynanic patterns of expression in the retina显示文摘 | Vidovic M Marotte LR | 2003 | Eur J Neurosci2003，8，6： | 1 |
| 5 | Heat acclimation and the role of RpoS in prolonged heat shock of Escherichia coli O157显示文摘 | Vidovic S Mangalappalli i Anil K | 2012 | Food Microbiology2012，30，2： | 1 |
| 6 | Influence of liposomes on the stability of vitamin A incorporated in polyacrylate hydrogel显示文摘 | Arsic I Vidovic S Vuleta G | 1999 | Int J Cosmet Sci1999，21，4： | 1 |
| 7 | Renal arterial resistance index in pregnant and nonpregnant women; evaluation with color and pulse doppler ultrasound显示文摘 | Kurjak A Vidovic MI Velemir D | 1992 | J Perinat Med1992，20，： | 1 |
| 8 | The 'head-to-head' comparison of etanercept and infliximab in treating children with juvenile idiopathic arthritis 显示文摘 | Lamot L Bukovac LT Vidovic M | 2011 | Clin Exp Rheumatol2011，29，1： | 1 |
| 9 | Comparison of fetal outcome in premature vaginal or cesarean breech delivery at24-37gestational weeks显示文摘 | Vidovics M Jacobs VR Fischer T | 2014 | Arch Gynecol Obstet2014，290，2： | 1 |
| 10 | Prolonged cold stress response of Escherichia coli O157 and the role of rpos显示文摘 | vidovic s MANGALAPPALLI-IIIATHU A K KORBER D R | 2011 | International Journal of Food Microbiology2011，146，2： | 1 |
| 11 | 显示文摘 | VIDOVIC D ALDRIDGE S | 2009 | Angew Chem2009，121，： | 1 |
| 12 | Alpha-adrenergic,neurokinin and muscarinic receptors in rat mesenteric artery; an mRNA study during postnatal development显示文摘 | Phillips JK Vidovic M Hill CE | 1996 | Mech Ageing Dev1996，92，： | 1 |
| 13 | Surface modification of Alumina powder for LPIM 显示文摘 | NOVAK S VIDOVIC K SAJKO M | 1997 | Journal of the European Ceramic Society1997，17，23： | 1 |
| 14 | Simultaneous determination of some water-soluble vitamins and preservatives in multivitamin syrup by validated stability-indicating high-performance liquid chromatography method显示文摘 | VIDOVIC S STOJANOVIC B VELJKOVIC J | 2008 | J Chromatogr A2008，1202，2： | 1 |
| 15 | Incidenceand types of speech disorders in stroke patients显示文摘 | Vidovic M Sinanovic O Sabaskic L | 2011 | Acta Clin Croat2011，50，： | 1 |
| 16 | Application of genetic algorithms for sequencing of AS/RS with a triple- shuttle module in class-based storage显示文摘 | POPOVIC D VIDOVIC M BJELIC N | 2014 | Flexible Services and Manufacturing Journal2014，26，3： | 1 |
| 17 | DPPⅣ-Serum Activity and Expression on Lymphocytes in Different Hematological Malignancies显示文摘 | Matic1 M Djordjevic A Vidovic J | 2012 | Eur J Cancer2012，48，5： | 1 |
| 18 | External Chemical trees显示文摘 | Fischermann M Gutman I Haffman A Rautenbach D Vidovic' D and Volkman L | 2002 | Z Naturforsch2002，57，： | 1 |
| 19 | Is there a “gold” standard treatment for patients with isolated myeloid sarcoma?显示文摘 | Darko Antic Ivo Elezovic Natasa Milic Nada Suvajdzic Ana Vidovic Maja Perunicic Irena Djunic Mirjana Mitrovic Dragica Tomin | 2012 | Biomedicine & Pharmacotherapy2012，，： | 1 |
| 20 | Prevalence and prevention of dental injuries in young taekwondo athletes in Croatia显示文摘 | Vidovic D Bursae D Skrinjaric T | 2015 | European Journal of Paediatric Dentistry2015，16，2： | 1 |
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