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| 1 | Neoadjuvant treatment of esophageal cancer显示文摘The management of esophageal cancer has been evolving over the past 30 years. In the United States, multimodality treatment combining chemotherapy and radiotherapy (RT) prior to surgical resection has come to be accepted by many as the standard of care, although debate about its overall effect on survival still exists, and rightfully so. Despite recent improvements in detection and treatment, the overall survival of patients with esophageal cancer remains lower than most solid tumors, which highlights why further advances are so desperately needed. The aim of this article is to provide a complete review of the history of esophageal cancer treatment with the addition of chemotherapy, RT, and more recently, targeted agents to the surgical management of resectable disease. | Nicholas P Campbell Victoria M Villaflor | 2010 | World Journal of Gastroenterology2010，16，30： | 16 |
| 2 | Venous and arterial disease in inflammatory bowel disease显示文摘 | Victoria P Tan Alvin Chung Bryan P Yan Peter R Gibson | 2013 | J Gastroenterol Hepatol2013，，7： | 3 |
| 3 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 4 | Translation and validation of the Greek chronic liver disease questionnaire显示文摘AIM:To translate into Greek and validate the chronic liver disease questionnaire (CLDQ).METHODS:Two hundred and six consecutive adult patients with the diagnosis of a chronic liver disease from 2 general hospitals in Athens were enrolled in the study from May to September 2008.In order to assess their quality of life (QOL) the CLDQ was applied.The instrument was translated from English,back translated and reviewed in focus groups within the framework of a large multicenter study.The measurements that were performed included:2 independent sample t tests,oneway analysis of variance,reliability coefficients,explanatory factor analysis using a varimax rotation and the principal components method.RESULTS:One hundred and twenty five (61%) patients were men,half were aged 40-59 years and > 33% were > 60 years old.Among the patients,48 (23%) were hospitalized and 97 (47%) were cirrhotic according to the Child-Pugh score.The internal consistency of the Greek CLDQ version using Cronbach's alpha coefficient was found to be 0.93.Exploratory factor analysis identified 7 domains accounting for 65% of the variance of CLDQ items and only partially overlapping with those found in the original version.The area under the receiver operating characteristics curve was calculated at 0.813 and the logistic estimate for the threshold score of 167.50 provided a sensitivity of 74.3% and a specificity of 71.6% for the model.CONCLUSION:Our data confirmed the validity of the Greek version of the CLDQ in identifying the QOL among patients with chronic liver disease. | Zoi Kollia Evridiki Patelarou Victoria Vivilaki Eleni Kollia Florentia Kefou Ioannis Elefsiniotis Spyros P Dourakis Hero Brokalaki | 2010 | World Journal of Gastroenterology2010，16，46： | 2 |
| 5 | The actiflo method显示文摘 | Victoria P Claus P D Leif B | | 0，，01： | 1 |
| 6 | Neural network and regression spline value function ap- proximations for stochastic dynamic programming 显示文摘 | Cristiano Cervellera Aihong Wen Victoria C P Chen | 2007 | Computer & Operations Research2007，34，1： | 1 |
| 7 | The use of stable isotopes in studies of nutrient cycling:Carbon isotope composition of Amazon varzea sediments显示文摘 | VICTORIA R L MARTINELLI L A TRIVELIN P C | 1992 | Biotropica1992，24，： | 1 |
| 8 | Association Between Corticos- teroids and Infection, Sepsis, and Infectious Death in Pediatric A- cute Myeloid Leukemia (AML): Results From theCanadian Infec- tions in AML Research Group 显示文摘 | David D Sonia C Victoria P | 2012 | Clin Infect Dis2012，55，12： | 1 |
| 9 | Cooperative ecosystem management across the Canada–US border: approaches and experiences of transboundary programs in the Gulf of Maine, Great Lakes and Georgia Basin/Puget Sound显示文摘 | Lawrence P Hildebrand Victoria Pebbles David A Fraser | 2002 | Ocean and Coastal Management2002，，6： | 1 |
| 10 | Dicaffeoyltartaric acid analogues inhibit human immunodeficiency virus type 1 ( HIV - 1 ) inte-grase and HIV - 1 replication at nontoxic concentrations 显示文摘 | REINKE R A KING P J VICTORIA J G | 2002 | J Med Chem2002，45，： | 1 |
| 11 | Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators 显示文摘 | KATY B VICTORIA P RICK D | 2004 | Diabetes2004，53，3： | 1 |
| 12 | Diagnosis and management of chronic exertional compartment syndrome ( CECS ) in the United Kingdom 显示文摘 | Victoria T Nicola M Nat P | 2006 | Clin J Sport Med2006，16，： | 1 |
| 13 | Real-time detection of Mycoplasma pneumorrtiae in respiratory samples with an internal processing control 显示文摘 | David P Victoria JC Carmen S | 2006 | J Med Microbio12006，55，2： | 1 |
| 14 | Geographical distribution of four sugarcane yellow leaf virus genotypes 显示文摘 | Ahmad Y A Royer M Daugrois J H Costet L Lett J M Victoria J I Girard J C Rott P | 2006 | Plant Disease2006，90，9： | 1 |
| 15 | Exercise accelerates cutaneous wound healing and decreases wound inflammation in aged mice 显示文摘 | Keylock P Victoria J Matthew A | 2008 | Am J Physiol Regul Integr Comp Physio2008，1294，： | 1 |
| 16 | The timecourse of induction of brain - drived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise 显示文摘 | Paul A A Victoria M P Christie E C | 2004 | Neurosci2004，363，1： | 1 |
| 17 | 查看详情显示文摘 | Andrew R P Victoria L W Dominique D | | 0，，： | 1 |
| 18 | The ACTIFLO method显示文摘 | Victoria P Claus P D | 1998 | Water Sci Technol1998，37，1： | 1 |
| 19 | Pemphigus: A treatment update 显示文摘 | Dick Sarah E Werth Victoria P | 2006 | Autoimmunity2006，39，7： | 1 |
| 20 | Deformation behaviour and microstructure of nanocrystalline electrodeposited and high pressure torsioned nickel显示文摘 | DALLA T F SPATIG P SCHAUBLIN R VICTORIA M | 2005 | Acta Materialia2005，53，： | 1 |
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