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| 1 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 2 | Maternal and perinatal morbidity of caesarean delivery at full cervical dilatation compared with caesarean delivery in the first stage of labour 显示文摘 | Victoria MA Colleen MO Connell TF | 2005 | B JOG2005，112，： | 1 |
| 3 | A qualitative study of perspectives on access to tuberculosis health services in Xigaze, China显示文摘Background:Tuberculosis(TB)is a major global health threat and the leading infectious disease cause of death worldwide.Access to and retention in TB care remains a challenge for patients,particularly those living in rural and remote settings.This qualitative study explored barriers and facilitators to accessing and maintaining contact with TB care services in communities in Xigaze(Shigatse)prefecture,Xizang Autonomous Region(Tibet Autonomous Region),China from the perspective of persons impacted by TB.Methods:We conduced in-depth interviews with 23 participants impacted by TB in four rural districts in Xigaze prefecture,Xizang Autonomous Region,China between April 2019 and November 2020.Interviews were conducted in Tibetan and Mandarin,transcribed in Mandarin and translated into English.Transcripts were checked against recordings by native Tibetan and Mandarin speakers.QSR NVivo12 software was used for framework analysis guided by an access to care conceptual framework by Levesque et al.Results:Overall patients reported low awareness of and an indiferent attitude towards TB,although all reported understanding the need to adhere to treatment.Participants reported complex pathways to care,often requiring visits to multiple healthcare facilities.Some participants reported visiting traditional Tibetan medicine(TTM)providers.Participants reported various barriers to accessing care including challenges physically reaching care,out-of-pocket payments for tests,diagnostics and transport.Barriers to maintaining care included medication side efects and worry about treatment efectiveness.Enablers to accessing care identifed included knowledge or past experience with TB,integrated models of TTM and western care,supportive village doctors who conducted home visits,free TB treatment and other subsidies,as well as having family support with care and social support as barriers and facilitators to maintaining treatment.Conclusions:We identifed barriers and facilitators to accessing services in rural communities in Xigaze from the perspective of persons impacted by TB.Challenges include complex pathways to care,travel distances,wait times and low awareness.Tuberculosis care in the region could be strengthened by ongoing culturally tailored educational campaigns to increase awareness,partnerships with TTM providers,providing comprehensive treatment subsidies and strengthening the role of family members in comprehensive TB care. | Victoria Haldane Zhitong Zhang Qi Ma Tingting Yin Bei Zhang Yinlong Li Qiuyu Pan Katie N.Dainty Elizabeth Rea Pande Pasang Xiaolin Wei Jun Hu | 2021 | Infectious Diseases of Poverty2021，10，5： | 1 |
| 4 | Phacoemulsifica- tion cataract surgery in vitrectomized eyes 显示文摘 | Victoria DL Francisco JOG Nerea MA | 1998 | J Cataract Refr Surg1998，24，6： | 1 |
| 5 | Maternal and perinatal morbidity of caesarean delivery at full cervical dilatation compared with caesarean delivery in the first stage of labour显示文摘 | Victoria MA Colleen MO Connell TF | 2005 | BJOG2005，112，7： | 1 |
| 6 | Extended-Field-of-View Three-Dimensional Transesophageal Echocardiography Using Image-Based X-Ray Probe Tracking显示文摘 | R. James Housden YingLiang Ma Aruna Arujuna Niels Nijhof Pascal Cathier Geert Gijsbers Roland Bullens Jaswinder Gill C. Aldo Rinaldi Victoria Parish Kawal S. Rhode | 2013 | Ultrasound in Medicine & Biology2013，，6： | 1 |
| 7 | Maternal and perinatal morbidity of caesarean delivery at full cervical dilatation compared with caesarean delivery in the first stage of labor显示文摘 | Victoria MA Colleen MO Connell TF | 2005 | BJOG2005，112，： | 1 |
| 8 | Role of vascular endothelial growth factor on erythropoietin-related endothelial cell proliferation 显示文摘 | Victoria M Arroyo A Castilla MA | 1998 | J Am Soc Nephrol1998，9，11： | 1 |
| 9 | Impact of genetic and acquired alteration in cytochrome P450 system on pharmacologic and clinical response to clopidogrel显示文摘 | Terry K.W. Ma Yat-Yin Lam Victoria P. Tan Thomas J. Kiernan Bryan P. Yan | 2009 | Pharmacology and Therapeutics2009，，2： | 1 |
| 10 | Maternal and perinatal morbidity of caesarean delivery at full cervical dilatation compared with caesarean delivery in the first stage of labour显示文摘 | Victoria MA Colleen MO Connell TF | 2005 | BJOG2005，112，： | 1 |
| 11 | Impact of time to reperfusion after acute myocardial infarctionon myocardial damage assessed by left ventricular longitudinal strain 显示文摘 | Matteo Bertini Sjoerd Molle MA Victoria Delgado | 2009 | Am J Cardiol2009，104，4： | 1 |
| 12 | Maternal and perina- tal morbidity of caesarean delivery at full cervical dilatation com- pared with caesarean delivery in the first stage of labour 显示文摘 | Victoria MA Colleen MO Connell TF | 2005 | BJOG2005，112，： | 1 |
| 13 | Maternal and perinatal morbidity of caesarean delivery at full cervical dilatation compared with caesarean delivery in the first stage of labour显示文摘 | Victoria MA Colleen MO connell TF | 2005 | BJOG2005，112，： | 1 |
| 14 | Maternal and perinatal morbidity of caesarean delivery at full cervical dilatation compared with caesarean delivery in the first stage-of labor显示文摘 | Victoria MA Connell TF | 2005 | BJOG2005，112，： | 1 |
| 15 | Non-small cell lung cancer and silent brain metastasis显示文摘 | Julio Sánchez de Cos M. Agustín Sojo González Ma Victoria Montero Ma Cristina Pérez Calvo Ma Jesús Martín Vicente Manuel Hernández Valle | 2008 | Lung Cancer2008，，1： | 1 |
| 16 | Popular Use of Traditional Chinese Medicine in HIV Patients in the HAART era显示文摘 | Kurtland Ma Shui-Shan Lee Elsie K. Y. Chu Dennise K. P. Tam Victoria S. C. Kwong Choi-Fung Ho Kathy Cheng Ka-Hing Wong | 2008 | AIDS and Behavior2008，，4： | 1 |
| 17 | Study of the preparation and mechanism of formation of hollow monodis- perse polystyrene microspheres by SPG (Shirasu Porous Glass) emulsification technique显示文摘 | Guang-Hui Ma Shinzo Omi Victoria L | 2002 | Journal of Applied Pol- ymer Science2002，85，7： | 1 |
| 18 | Cancer immunotherapy with envelopedself-amplifying mRNA CARG-2020 thatmodulates IL-12,IL-17 and PD-L1 pathways toprevent tumor recurrence显示文摘Targeting multiple immune mechanisms may overcome therapy resistance and further improve cancer immunotherapy for humans.Here,we describe the application of virus-like vesicles(VLV)for delivery of three immunomodulators alone and in combination,as a promising approach for cancer immunotherapy.VLV vectors were designed to deliver single chain interleukin(IL)-12,shorthairpin RNA(shRNA)targeting programmed death ligand 1(PD-L1),and a dominant-negative form of IL-17 receptor A(dn-IL17RA)as a single payload or as a combination payload.Intralesional delivery of the VLV vector expressing IL-12 alone,as well as the trivalent vector(designated CARG-2020)eradicated large established tumors.However,only CARG-2020 prevented tumor recurrence and provided long-term survival benefit to the tumor-bearing mice,indicating a benefit of the combined immunomodulation.The abscopal effects of CARG-2020 on the non-injected contralateral tumors,as well as protection from the tumor cell re-challenge,suggest immune-mediated mechanism of protection and establishment of immunological memory.Mechanistically,CARG-2020 potently activates Th1 immune mechanisms and inhibits expression of genes related to T cell exhaustion and cancer-promoting inflammation.The ability of CARG-2020 to prevent tumor recurrence and to provide survival benefit makes it a promising candidate for its development for human cancer immunotherapy. | Ju Chen Bhaskara Reddy Madina Elham Ahmadi Timur Olegovich Yarovinsky Marie Marthe Krady Eileen Victoria Meehan Isabella China Wang Xiaoyang Ye Elise Pitmon Xian-Yong Ma Bijan Almassian Valerian Nakaar Kepeng Wang | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
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