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| 1 | Neoadjuvant treatment of esophageal cancer显示文摘The management of esophageal cancer has been evolving over the past 30 years. In the United States, multimodality treatment combining chemotherapy and radiotherapy (RT) prior to surgical resection has come to be accepted by many as the standard of care, although debate about its overall effect on survival still exists, and rightfully so. Despite recent improvements in detection and treatment, the overall survival of patients with esophageal cancer remains lower than most solid tumors, which highlights why further advances are so desperately needed. The aim of this article is to provide a complete review of the history of esophageal cancer treatment with the addition of chemotherapy, RT, and more recently, targeted agents to the surgical management of resectable disease. | Nicholas P Campbell Victoria M Villaflor | 2010 | World Journal of Gastroenterology2010，16，30： | 16 |
| 2 | Treatment of functional dyspepsia with sertraline:A double-blind randomized placebo-controlled pilot study显示文摘AIM:To evaluate sertraline,a selective serotonin reuptake inhibitor in the treatment of patients with functional dyspepsia.METHODS:Consecutive tertiary hospital patients with a clinical diagnosis of functional dyspepsia(FD) according to the Rome Ⅱ criteria with a Hong Kong dyspepsia index(HKDI) of greater than 16 were recruited.Patients commenced enrolment prior to the inception of the Rome Ⅲ criteria for functional dyspepsia.All patients were ethnic Chinese,had a normal upper endoscopy and were Helicobacter pylori negative prior to enrolment.Study patients were randomized to receive sertraline 50 mg or placebo daily for 8 wk.HKDI symptom scores,quality of life,hospital anxiety and depression(HAD) scale and global symptom relief were evaluated before,during and after treatment.Adverse effects were monitored during and after treatment.RESULTS:A total of 193 patients were randomized in the intention to treat(ITT),and 150 patients were included in the per protocol(PP) analysis.In both the ITT and PP,there was no difference in the primary outcome of global dyspepsia symptoms between the sertraline and placebo groups at week 8.In the ITT analysis,98 and 95 patients were randomized to the sertraline and placebo groups respectively.A total of 43 patients withdrew from the study(22.3%) by week 8,with 23 of the 24 drop-outs in the sertraline group occurring prior to week 4(95.8%).In contrast,in the placebo arm,11 of 19 patients dropped out by week 4(57.9%).Utilizing the last response carried forward to account for the drop-outs,there were no differences between the sertraline and placebo groups at baseline in terms of the HKDI,HKDI 26.08 ± 6.19 vs 26.70 ± 5.89,P = 0.433;and at week 8,HKDI 22.41 ± 6.36 vs 23.25 ± 7.30,P = 0.352 respectively.In the PP analysis,74 and 76 patients were randomized to the sertraline and placebo groups respectively.At baseline,there were no statistically significant differences between the sertraline and placebo groups,HKDI 25.83 ± 6.313 vs 27.19 ± 5.929 respectively,P = 0.233;however by week 8,patients in the sertraline group demonstrated a statistically significant difference in their Hong Kong Dyspepsia Index compared to placebo,HKDI 20.53 ± 6.917 vs 23.34 ± 7.199,P = 0.02,respectively).There was also no statistically significant difference in overall quality of life measures or the HAD scale related to treatment in either the ITT or PP analysis at week 8.CONCLUSION:This pilot study,the first to examine sertraline,a selective serotonin reuptake inhibitor,for the management of FD,did not find that it was superior to placebo. | Victoria PY Tan Tin K Cheung Wai M Wong Roberta Pang Benjamin CY Wong | 2012 | World Journal of Gastroenterology2012，18，42： | 14 |
| 3 | Multidisciplinary approach for patients with esophageal cancer显示文摘Patients with esophageal cancer have a poor prognosis because they often have no symptoms until their disease is advanced. There are no screening recommendations for patients unless they have Barrett's esophagitis or a significant family history of this disease. Often, esophageal cancer is not diagnosed until patients present with dysphagia, odynophagia, anemia or weight loss. When symptoms occur, the stage is often stage Ⅲ or greater. Treatment of patients with very early stage disease is fairly straight forward using only local treatment with surgical resection or endoscopic mucosal resection. The treatment of patients who have locally advanced esophageal cancer is more complex and controversial. Despite multiple trials, treatment recommendations are still unclear due to conflicting data. Sadly, much of our data is difficult to interpret due to many of the trials done have included very heterogeneous groups of patients both histologically as well as anatomically. Additionally, studies have been underpowered or stopped early due to poor accrual. In the United States, concurrent chemoradiotherapy prior to surgical resection has been accepted by many as standard of care in the locally advanced patient. Patients who have metastatic disease are treated palliatively. The aim of this article is to describe the multidisciplinary approach used by an established team at a single high volume center for esophageal cancer, and to review the literature which guides our treatment recommendations. | Victoria M Villaflor Marco E Allaix Bruce Minsky Fernando A Herbella Marco G Patti | 2012 | World Journal of Gastroenterology2012，18，46： | 9 |
| 4 | Validation of a new scoring system: Rapid assessment faecal incontinence score显示文摘AIM: To implement a quick and simple test- rapid assessment faecal incontinence score(RAFIS) and show its reliability and validity.METHODS: From March 2008 through March 2010, we evaluated a total of 261 consecutive patients, including 53 patients with faecal incontinence. Demographic and comorbidity information was collected. In a single visit, patients were administered the RAFIS. The results obtained with the new score were compared with those of both Wexner score and faecal incontinence quality of life scale(FIQL) questionnaire. The patient withoutinfluence of the surgeon completed the test. The role of surgeon was explaining the meaning of each section and how he had to fill. Reliability of the RAFIS score was measured using intra-observer agreement and Cronbach's alpha(internal consistency) coefficient. Multivariate analysis of the main components within the different scores was performed in order to determine whether all the scores measured the same factor and to conclude whether the information could be encompassed in a single factor. A sample size of 50 patients with faecal incontinence was estimated to be enough to detect a correlation of 0.55 or better at 5% level of significance with 80% power.RESULTS: We analysed the results obtained by 53 consecutive patients with faecal incontinence(median age 61.55 ± 12.49 years) in the three scoring systems. A total of 208 healthy volunteers(median age 58.41 ± 18.41 years) without faecal incontinence were included in the study as negative controls. Pearson's correlation coefficient between 'state' and 'leaks' was excellent(r = 0.92, P < 0.005). Internal consistency in the comparison of 'state' and 'leaks' yielded also excellent correlation(Cronbach's α = 0.93). Results in each score were compared using regression analysis and a correlation value of r = 0.98 was obtained with Wexner score. As regards FIQL questionnaire, the values of 'r ' for the different subscales of the questionnaire were: 'lifestyle' r =-0.87, 'coping/behaviour' r =-0.91, 'depression' r =-0.36 and 'embarrassment' r =-0.90,(P < 0.01). A multivariate analysis showed that all the scoring systems measured the same factor. A single factor may explain 80.84% of the variability of FI, so all the scoring systems measure the same factor. Patient's continence improves when RAFIS and Jorge-Wexner scores show low values and when the values obtained in the FIQL questionnaire are high.CONCLUSION: RAFIS is a valid and reliable tool to assess Faecal Incontinence. | Fernando de la Portilla Arantxa Calero-Lillo Rosa M Jiménez-Rodríguez Maria L Reyes Manuela Segovia-González María Victoria Maestre Ana M García-Cabrera | 2015 | World Journal of Gastrointestinal Surgery2015，7，9： | 5 |
| 5 | BCL-XL regulates TNF-α-mediated cell death independently of NF-κB, FLIP and IAPs显示文摘 | Raffaella Gozzelino Carme Sole Nuria Llecha Miguel F Segura Rana S Moubarak Victoria Iglesias-Guimarais M Jose Perez-Garcia Stephanie Reix Jisheng Zhang Nahuai Badiola Daniel Sanchis Jose Rodriguez-Alvarez Ramon Trullas Victor J Yuste Joan X Comella | 2008 | Cell Research2008，18，10： | 4 |
| 6 | Early experience in human hybrid transgastric and transvaginal endoscopic cholecystectomy显示文摘 | Gustavo Salinas Lil Saavedra Hellen Agurto Rosa Quispe Edwin Ramírez José Grande Juan Tamayo Victoria Sánchez Daniel Málaga Jeffrey M. Marks | 2010 | Surgical Endoscopy2010，，5： | 2 |
| 7 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 8 | Parturition and urinary incontinence in primiparas 1 1 Statistical analysis was done by Pantelis Andreou.显示文摘 | Scott A Farrell Victoria M Allen Thomas F Baskett | 2001 | Obstetrics & Gynecology2001，，3： | 2 |
| 9 | Effect of aspirin and sodium salicylate on cataract development in diabetic rats 显示文摘 | Shastri GV Thomas M Victoria AJ | 1998 | Indian J Exp Biol1998，36，7： | 1 |
| 10 | Complex genitourinary abnormalities on fetal MRI: imaging findings and approach to diagnosis 显示文摘 | Chauvin NA Epelman M Victoria T | 2012 | A JR Am J Roentgenol2012，199，2： | 1 |
| 11 | CO2-delayed crystallization of isotactic polypropylene:A kinetic study显示文摘 | Zhang Z Day M Victoria Nawaby A | 2003 | Journal of Polymer Science (Part B):Polymer Physics2003，41，13： | 1 |
| 12 | Evaluation of an ad- sorption - elution method for detection of astrovirus and norovirus in environmental waters 显示文摘 | Victoria M Guimaraes F Fumian T | 2009 | J Virol Methods2009，156，12： | 1 |
| 13 | Positive psychology group intervention for breast cancer patients: a ran- domised trial显示文摘 | Victoria Cerezo M Ortiz-Tallo M Cardenal V | 2014 | Psychol Rep2014，115，1： | 1 |
| 14 | Singing teaching as a therapy for chronic respiratory disease-a randomised controlled trial and qualitative evaluation显示文摘 | Victoria M Phoene Cave Victoria J | 2010 | BMC Pulmonary Medicine2010，10，： | 1 |
| 15 | Surveillance of norovirus infections in the state of Rio De Janeiro,Brazil 2005-2008显示文摘 | Ferreira M S Victoria M Carvalho-Costa F A | 2010 | J Med Virol2010，82，8： | 1 |
| 16 | Development and e- valuation of a new lateral flow immunoassay for serodiagnosis of human fciolosis显示文摘 | Victoria MS Laura M Maria JP | 2011 | PLoS Negl Trop Dis2011，5，11： | 1 |
| 17 | Adepuate thyroid-stimulating hormone levels after levothyroxine discontinuation in the follow-up of patients with well-differentiated thyroid carcinoma显示文摘 | Reyna S Ana LE Victorias M | 2002 | Arch of Med Res2002，33，： | 1 |
| 18 | Diagnosis and management of chronic exertional compartment syndrome ( CECS ) in the United Kingdom 显示文摘 | Victoria T Nicola M Nat P | 2006 | Clin J Sport Med2006，16，： | 1 |
| 19 | Reference potential calibration and vohammetry atmacrodisk electrodes of metallocene derivatives in the ionic liquid 显示文摘 | Victoria M H Andrew W A M Alan M B | 2002 | Anal Chem2002，74，： | 1 |
| 20 | Spread of metals through an invertebrate food chain as influenced by a plant that hyperaccumulates nickel显示文摘 | Lynsey R Peterson Victoria Trivett Alan J M Baker | 2003 | Chemoecology2003，，13： | 1 |
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