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| 1 | Hepatocellular carcinoma: From clinical practice to evidence-based treatment protocols显示文摘Hepatocellular carcinoma(HCC) is one of the major malignant diseases in many healthcare systems. The growing number of new cases diagnosed each year is nearly equal to the number of deaths from this cancer. Worldwide, HCC is a leading cause of cancerrelated deaths, as it is the fifth most common cancer and the third most important cause of cancer related death in men. Among various risk factors the two are prevailing: viral hepatitis, namely chronic hepatitis C virus is a well-established risk factor contributing to the rising incidence of HCC. The epidemic of obesity and the metabolic syndrome, not only in the United States but also in Asia, tend to become the leading cause of the long-term rise in the HCC incidence. Today, the diagnosis of HCC is established within the national surveillance programs in developed countries while the diagnosis of symptomatic, advanced stage disease still remains the characteristic of underdeveloped countries. Although many different staging systems have been developed and evaluated the BarcelonaClinic Liver Cancer staging system has emerged as the most useful to guide HCC treatment. Treatment allocation should be decided by a multidisciplinary board involving hepatologists, pathologists, radiologists, liver surgeons and oncologists guided by personalized-based medicine. This approach is important not only to balance between different oncologic treatments strategies but also due to the complexity of the disease(chronic liver disease and the cancer) and due to the large number of potentially efficient therapies. Careful patient selection and a tailored treatment modality for every patient, either potentially curative(surgical treatment and tumor ablation) or palliative(transarterial therapy, radioembolization and medical treatment, i.e., sorafenib) is mandatory to achieve the best treatment outcome. | Danijel Galun Dragan Basaric Marinko Zuvela Predrag Bulajic Aleksandar Bogdanovic Nemanja Bidzic Miroslav Milicevic | 2015 | World Journal of Hepatology2015，7，20： | 13 |
| 2 | Meta-optics and bound states in the continuum显示文摘We discuss the recent advances in meta-optics and nanophotonics associated with the physics of bound states in the continuum(BICs). Such resonant states appear due to a strong coupling between leaky modes in optical guiding structures being supported by subwavelength high-index dielectric Mieresonant nanoantennas or all-dielectric metasurfaces. First, we review briefly very recent developments in the BIC physics in application to isolated subwavelength particles. We pay a special attention to novel opportunities for nonlinear nanophotonics due to the large field enhancement inside the particle volume creating the resonant states with high-quality(high-Q) factors, the so-called quasi-BIC, that can be supported by the subwavelength particles. Second, we discuss novel applications of the BIC physics to alldielectric optical metasurfaces with broken-symmetry meta-atoms when tuning to the BIC conditions allows to enhance substantially the Q factor of the flat-optics dielectric structures. We also present the original results on nonlinear high-Q metasurfaces and predict that the frequency conversion efficiency can be boosted dramatically by smart engineering of the asymmetry parameter of dielectric metasurfaces in the vicinity of the quasi-BIC regime. | Kirill Koshelev Andrey Bogdanov Yuri Kivshar | 2019 | Science Bulletin2019，64，12： | 11 |
| 3 | Intelligent metaphotonics empowered by machine learning显示文摘In the recent years,a dramatic boost of the research is observed at the junction of photonics,machine learning and artifi-cial intelligence.A new methodology can be applied to the description of a variety of photonic systems including optical waveguides,nanoantennas,and metasurfaces.These novel approaches underpin the fundamental principles of light-matter interaction developed for a smart design of intelligent photonic devices.Artificial intelligence and machine learn-ing penetrate rapidly into the fundamental physics of light,and they provide effective tools for the study of the field of metaphotonics driven by optically induced electric and magnetic resonances.Here we overview the evaluation of meta-photonics induced by artificial intelligence and present a summary of the concepts of machine learning with some specif-ic examples developed and demonstrated for metasystems and metasurfaces. | Sergey Krasikov Aaron Tranter Andrey Bogdanov Yuri Kivshar | 2022 | Opto-Electronic Advances2022，5，3： | 8 |
| 4 | Targeting DNA Double-Strand Breaks with TAL Effector Nucleases显示文摘 | Christian Michelle Cermak Tomas Doyle Erin L Schmidt Clarice Zhang Feng Hummel Aaron Bogdanove Adam J Voytas Daniel F | 2010 | Genetics2010，，2： | 3 |
| 5 | Linear hulls with correlation zero and linear cryptanalysis of block ciphers显示文摘 | Andrey Bogdanov Vincent Rijmen | 2014 | Designs Codes and Cryptography2014，，3： | 2 |
| 6 | Tyrosine phosphatase inhibitors,vanadate and prevanadate, stimulate glucose transport and GLUT translocation in muscle cells by a mechanism independent of phosphatidylinositol B-kinase and protein kinase C显示文摘 | Tsiani E Bogdanovic E Sorisky A | | Diabetes0，1，： | 2 |
| 7 | Fluorescence waveforms and coupled energy levels in Er3+:ZBLAN 显示文摘 | Bogdanov V K Booth D J Gibbs W E K | 2002 | Non-Crystalline Solids2002，311，： | 2 |
| 8 | Modulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes显示文摘AIM:To investigate the role of protein tyrosine phosphorylation in gastric wound formation and repair following ulceration. METHODS:Gastric lesions were induced in rats using restraint cold stress.To investigate the effect of oxidative and nitrosative cell stress on tyrosine phosphorylation during wound repair,total activity of protein tyrosine kinase(PTK),protein tyrosine phosphatase (PTP),antioxidant enzymes,nitric oxide synthase (NOS), 2',5'-oligoadenylate synthetase,hydroxyl radical and zinc levels were assayed in parallel. RESULTS:Ulcer provocation induced an immediate decrease in tyrosine kinase(40% in plasma membranes and 56% in cytosol,(P<0.05) and phosphatase activity (threefold in plasma membranes and 3.3-fold in cytosol),followed by 2.3-2.4-fold decrease (P<0.05) in protein phosphotyrosine content in the gastric mucosa. Ulceration induced no immediate change in superoxide dismutase (SOD) activity,30% increase (P<0.05) in catalase activity,2.3-fold inhibition (P<0.05) of glutathione peroxidase,3.3-fold increase (P<0.05) in hydroxyl radical content,and 2.3-fold decrease (P<0.05) in zinc level in gastric mucosa.NOS activity was three times higher in gastric mucosa cells after cold stress. Following ulceration,PTK activity increased in plasma membranes and reached a maximum on day 4 after stress (twofold increase,P<0.05),but remained inhibited(1.6-3-fold decrease on days 3,4 and 5,P<0.05) in the cytosol.Tyrosine phosphatases remained inhibited both in membranes and cytosol(1.5-2.4-fold,P< 0.05).NOS activity remained increased on days 1,2 and 3(3.8-,2.6-,2.2-fold,respectively,P<0.05).Activity of SOD increased 1.6 times(P<0.05)days 4 and 5 after stress.Catalase activity normalized after day 2. Glutathione peroxidase activity and zinc level decreased (3.3-and 2-fold,respectively,P<0.05)on the last day. Activity of 2',5'-oligoadenylate synthethase increased 2.8-fold (P<0.05) at the beginning,and 1.6-2.3-fold (P<0.05) during ulcer recuperation,and normalized on day 5,consistent with slowing of inflammation processes. CONCLUSION:These studies show diverse changes in total tyrosine kinase activity in gastric mucosa during the recovery process.Oxidative and nitrosative stress during lesion formation might lead to the observed reduction in tyrosine phosphorylation during ulceration. | Olena V Bogdanova Larysa I Kot Kateryna V Lavrova Volodymyr B Bogdanov Erica K Sloan Tetyana V Beregova Ludmyla I Ostapchenko | 2010 | World Journal of Biological Chemistry2010，1，11： | 2 |
| 9 | Mechanisms of retinal neuroprotection of calcium dobesilate:therapeutic implications显示文摘Current treatments for diabetic retinopathy(DR)are based on laser photocoagulation and intravitreal injections of corticosteroids or anti-vascular endothelial growth factor(VEGF)agents.These treatments are applicable only at advanced stages of the disease.In addition,they are expensive,require a vitreoretinal specialist and are associated with significant adverse ef- | Olga Simó-Servat Cristina Solà-Adell Patricia Bogdanov Cristina Hernández Rafael Simó | 2017 | Neural Regeneration Research2017，12，10： | 2 |
| 10 | Appearance of right bundle branch block in electrocardiograms of patients with pulmonary embolism as a marker for obstruction of the main pulmonary trunk显示文摘 | Daniel Bogdanov Petrov | 2001 | Journal of Electrocardiology2001，，3： | 2 |
| 11 | rAL Effectors Drive Transcription Bidirectionally in Plants显示文摘phytopathogenic Xanthomonas 种类交付的 TAL 受动器是主人危险性基因并且有时的 DNA-sequence-specific transcriptional 使活跃之物抵抗基因。由 TAL 受动器的 DNA 识别的模块化为基因指向并且染色体编辑作为工具也使他们重要。本国的 TAL 受动器在植物认出的受动器有约束力的元素(EBE ) 仅仅在目标倡导者的前面的海滨上被识别了。这里,我们证明 TAL 受动器能在任何一个海滨上并且在两个方向从 EBE 驾驶植物抄写。而且,我们显示出那从 Xanthomonas oryzae pv 的一个本国的 TAL 受动器。oryzicola 在每束它的倡导者上与 EBE 驾驶一个目标的表示。由在二记者基因之间插入那个倡导者和衍生物面向面对面,我们证明从在各自的取向的任何一个 EBE 的 TAL 受动器运动表示,和在反向海滨的 EBE 的那项活动也向前加强活动在前面海滨的 EBE 驾驶的抄写。我们的结果为 TAL 受动器揭示行动的新模式,建议在植物疾病重要的还未被认出的目标的可能性,扩展为特定的 TAL 受动器的离开目标的搜索空间,并且加亮为探查植物抄写的基本方面的 TAL 受动器的潜力。 | Li Wang Fabio C. Rinaldi Pallavi Singh Erin L. Doyle Zoe E. Dubrow Tuan Tu Tran Alvaro L. Perez-Quintero Boris Szurek Adam J. Bogdanove | 2017 | Molecular Plant2017，10，2： | 2 |
| 12 | A study of sensing properties of Pt-and Au-loaded In2O3 ceramics 显示文摘 | Romanovskaya V Ivanovskaya M Bogdanov P | 1999 | Sens Actuat B1999，56，： | 2 |
| 13 | Effect of Ni2+ ions on the In2O3-based ceramic sensors 显示文摘 | Ivanovskaya M Bogdanov P | 1998 | Sens Actuat B1998，53，： | 2 |
| 14 | Effect of nickel ions on sensitivity of In2O3 thin film sensors to NO2 显示文摘 | Bogdanov P Ivanovskaya M Comini E | 1999 | Sens Actuat B1999，57，： | 2 |
| 15 | Light metal hydrides and complex hydrides for hydrogen storage显示文摘 | Schuth F Bogdanovic B Felderhoff M | 2004 | Chemical Communications2004，20，： | 1 |
| 16 | Virtual reactor as a new tool for modeling and optimization of SiC bulk crystal growth 显示文摘 | BOGDANOV M V GALYUKOV A O KARPOV S Y | 2001 | Journal of Crystal Growth2001，225，24： | 1 |
| 17 | Spectral holography of pico-and nonosecond optical pulses显示文摘 | Mazurenko Y T Putilin S E Bogdanov V L | 1996 | Optics & Laser Technology1996，28，4： | 1 |
| 18 | Thermodynamic investigation of the magnesium-hydrogen system显示文摘 | Bogdanovíc B Bohmhammel K Christ B | 1999 | J Alloys Compd1999，282，： | 1 |
| 19 | Ti-doped alkali metal aluminium hydrides as potential novel reversible hydrogen storage material 显示文摘 | BOGDANOVIC B SCHWICKARDI M | 1997 | J Alloys Compd1997，253，： | 1 |
| 20 | A simple cipher governs DNA recognition by TAL effectors 显示文摘 | Moscou M J Bogdanove AJ | 2009 | Science2009，326，5959： | 1 |
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