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| 1 | Endoscopic papillary large balloon dilatation with sphincterotomy is safe and effective for biliary stone removal independent of timing and size of sphincterotomy显示文摘AIM To describe the efficacy and safety of endoscopic papillary large balloon dilatation(EPLBD) in the management of bile duct stones in a Western population. METHODS Data was collected from the endoscopic retrograde cholangiopancreatography(ERCP) and Radiology electronic database along with a review of case notes over a period of six years from 1 st August 2009 to 31 st July 2015 and incorporated into Microsoft excel. Statistical analyses were performed using Med Calc for Windows,version 12.5(Med Calc Software,Ostend,Belgium). Simple statistical applications were applied in order to determine whether significant differences exist in comparison groups. We initially used simple proportions to describe the study populations. Furthermore,we used chi-square test to compare proportions and categorical variables. Non-parametric Mann-Whitney U-test was applied in order to compare continuous variables. All comparisons were deemed to be statistically significant if P values were less than 0.05.RESULTS EPLBD was performed in 229 patients(46 females) with mean age of 68 ± 14.3 years. 115/229(50%) patients had failed duct clearance at previous ERCP referred from elsewhere with standard techniques. Duct clearance at the Index* ERCP(1 st ERCP at our centre) was 72.5%. Final duct clearance rate was 98%. EPLBD after fresh sphincterotomy was performed in 81(35.4%). Median balloon size was 13.5 mm(10-18). In addition to EPLBD,per-oral cholangioscopy(POC) and electrohydraulic lithotripsy(EHL) was performed in 35(15%) patients at index* ERCP. 63(27.5%) required repeat ERCP for stone clearance. 28(44.5%) required POC and EHL and 11(17.4%) had repeat EPLBD for complete duct clearance. Larger stone size(12.4 mm vs 17.4 mm,P < 0.000001),multiple stones(2,range(1-13) vs 3,range(1-12),P < 0.006) and dilated common bile duct(CBD)(12.4 mm vs 18.3 mm,P < 0.001) were significant predictors of failed duct clearance at index ERCP. 47 patients(20%) had ampullary or peri-ampullary diverticula. Procedure related adverse events included 2 cases of bleeding and pancreatitis(0.87%) each.CONCLUSION EPLBD is a safe and effective technique for CBDS removal. There is no difference in outcomes whether it is performed at the time of sphincterotomy or at a later procedure or whether there is a full or limited sphincterotomy. | Usman Iqbal Aujla Nimzing Ladep Laura Dwyer Stephen Hood Nicholas Stern Richard Sturgess | 2017 | World Journal of Gastroenterology2017，23，48： | 8 |
| 2 | Cotton yield and water use efficiency at various levels of water and N through drip irrigation under two methods of planting显示文摘 | Aujla M S Thind H S Buttar G S | 2005 | Agricultural Water Management2005，71，1： | 1 |
| 3 | Pathogenesis of adolescent idiopathic scoliosis in girls-a double neuroosseous theory involving disharmony between two nervous systems,somatic and autonomic expressed in the spine and trunk:possible dependency on sympathetic nervous system and hormones with implications for medical therapy显示文摘 | Burwell RG Aujla RK Grevitt MP | 2009 | Scoliosis2009，4，： | 1 |
| 4 | Cotton yield and water use efficiency at various levels of water and N through drip irrigation under two methods of planting显示文摘 | M S Aujla H S Thind G S Buttar | 2005 | Agricultural Water Manage ment2005，71，： | 1 |
| 5 | IL-22: A critical mediator in mucosal host defense显示文摘 | S. J. Aujla J. K. Kolls | 2009 | Journal of Molecular Medicine2009，，5： | 1 |
| 6 | The management of thoracolumbar burst fractures:a prospective study between conservative management,traditional open spinal surgery and minimally interventional spinal surgery显示文摘 | Kumar A Aujla R Lee C | 2015 | Springerplus2015，4，： | 1 |
| 7 | Th17 cells and mucosal host defense显示文摘 | Aujla SJ Dubin PJ Kolls JK | 2007 | Semin Immunol2007，19，6： | 1 |
| 8 | Cotton yield and water use efficiency at various levels of water and N through drip irrigation under two methods of planting显示文摘 | M.S. Aujla H.S. Thind G.S. Buttar | 2004 | Agricultural Water Management2004，，： | 1 |
| 9 | Response of cotton to various levels of nitrogen and water applied to normal and paired sown cotton under drip irrigation in relation to check-basin显示文摘 | H.S. Thind M.S. Aujla G.S. Buttar | 2007 | Agricultural Water Management2007，，： | 1 |
| 10 | IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia显示文摘 | Aujla S J Chan Y R Zheng M | 2008 | Nat Med2008，14，3： | 1 |
| 11 | IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia显示文摘 | Aujla SJ Chan YR Zheng M | 2008 | Nature Medicine2008，14，3： | 1 |
| 12 | Methods of planting and irrigation at various levels of nitrogen affect the seed yield and water use efficiency in transplanted oilseed rape ( Brassica napus L.)显示文摘 | G.S. Buttar H.S. Thind M.S. Aujla | 2006 | Agricultural Water Management2006，，3： | 1 |
| 13 | IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia 显示文摘 | Aujla SJ Chan YR Zheng M | 2008 | Nat Med2008，14，3： | 1 |
| 14 | Notch/Rbpjκ signalingregulates progenitor maintenance and differentiation ofhypothalamic arcuate neurons显示文摘 | Aujla PK Naratadam GT Xu L | 2013 | Development2013，140，17： | 1 |
| 15 | IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia 显示文摘 | Aujla SJ Chan YR Zheng M | 2008 | Nat Med2008，14，3： | 1 |
| 16 | Cotton yield and water use efficiency at various levels of water and N through drip irrigation under two methods of planting显示文摘 | Aujla M S Thind H S Buttar G S | 2005 | Agriculture Water Management2005，71，2： | 1 |
| 17 | Thl7 cells and mucosal host defense显示文摘 | Aujla SJ Dubin PJ Kolls JK | | 0，，06： | 1 |
| 18 | Persistent expression of activated notch in the developing hypothalamus affects survival of pituitary progenitors and alters pituitary structure显示文摘 | Paven K. Aujla Vedran Bogdanovic George T. Naratadam Lori T. Raetzman | 2015 | Dev. Dyn2015，，： | 1 |
| 19 | Incidence of hypotony and sympathetic ophthalmia following trans-scleral cyclophotocoagulation for glaucoma and a report of risk factors显示文摘 | Aujla JS Lee GA Vincent SJ | 2013 | Clin Exper Ophthalmol2013，41，： | 1 |
| 20 | IL-22 mediates mucosal hostdefense against Gram-negative bacterial pneumonia显示文摘 | Aujla SJ Chan YR Zheng M | 2008 | Nat Med2008，14，3： | 1 |
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