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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers显示文摘AIM:To investigate the polymorphic simple sequencerepeat in intron 1 of the epidermal growth factor receptorgene(EGFR)(CA-SSRⅠ),which is known to affect theefficiency of gene transcription as a putative target of themismatch repair(MMR)machinery in colorectal tumors.METHODS:The CA-SSRⅠgenotype was analyzed ina total of 86 primary colorectal tumors,selected upontheir microsatellite instability(MSI)status[42 with highfrequency MSI(MSI-H)and 44 microsatellite stable(MSS)]and their respective normal tissue.The effect of the CA-SSRⅠgenotype on the expression of the EGFR gene wasevaluated in 18 specimens using quantitative real-timereverse transcription PCR and immunohistochemistry.RESULTS:Mutations in CA-SSRⅠwere detected in 86%(36 of 42)of MSI-H colorectal tumors and 0%(0 of 44)ofMSS tumors,indicating the EGFR gene as a novel putativespecific target of the defective MMR system(P<0.001).Impaired expression of EGFR was detected in most ofthe colorectal tumors analyzed[6/12(50%)at the mRNAlevel and 15/18(83%)at the peptide level].However,noassociation was apparent between EGFR expression andCA-SSRⅠstatus in tumors or normal tissues.CONCLUSION:Our results suggest that CA-SSRⅠsequence does not contribute to the regulation of EGFRtranscription in colon,and should thus not be consideredas a promising predictive marker for response to EGFRinhibitors in patients with colorectal cancer. | Marie-Pierre Buisine Agnès Wacrenier Christophe Mariette Emmanuelle Leteurtre Fabienne Escande Sana Aissi Amandine Ketele Annette Leclercq Nicole Porchet Thécla Lesuffleur | 2008 | World Journal of Gastroenterology2008，14，7： | 3 |
| 3 | Developmental aspects of parathyroid hormone-related protein biology显示文摘 | Escande B Lindner V Massfelder T | 2001 | Semin Perinatol2001，25，2： | 1 |
| 4 | Molecular identification of new varieties of Nierembergia linariaefolia(Graham),a native Argentinean ornamental plant显示文摘 | Escandón A.S Zelener N de la Torre M.P Soto S | | 0，，02： | 1 |
| 5 | Structural organization and classification of the human mucin genes显示文摘 | Moniaux N Escande F Porchet N | 2001 | Front Biosci2001，6，： | 1 |
| 6 | Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice显示文摘 | ESCANDE C CHINI C C NIN V | 2010 | J Clin Invest2010，120，2： | 1 |
| 7 | Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins 显示文摘 | Moniaux N Escande F Batra SK | 2000 | Eur J Biothem2000，267，： | 1 |
| 8 | Structural organization and classification of the human mucin genes显示文摘 | Moniaux N Escande F Porchet N | 2001 | Front Biosci2001，6，： | 1 |
| 9 | Structural organization and classification of the human mucin genes显示文摘 | MONIAUX N ESCANDE F PORCHET N | 2001 | Front Biosci2001，6，： | 1 |
| 10 | Renormalization method for computing the threshold of the large-scale stochastic instability in two degrees of freedom Hamiltonian systems 显示文摘 | Escande D F Dovekl F | 1981 | J Stat Phys1981，26，： | 1 |
| 11 | Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts显示文摘 | Nathalie Gaborit Andras Varro Sabrina Le Bouter Viktoria Szuts Denis Escande Stanley Nattel Sophie Demolombe | 2010 | Journal of Molecular and Cellular Cardiology2010，，： | 1 |
| 12 | Binding of estrogenic compounds to recombinant estrogen receptoR-alpha: application to environmental analysis 显示文摘 | Pillon A Boussioux A M Escande A | 2005 | Environ Health Perspeet2005，113，3： | 1 |
| 13 | Structural organization and classification of the human mucin genes显示文摘 | Moniaux N Escande F Porchet N | 2001 | Front Biosci2001，10，10： | 1 |
| 14 | Estrogen-like and dioxin-like or- ganic contaminants in reclaimed wastewater: transfer to irrigated soil and groundwater显示文摘 | Mahjoub O Escande A Rosain D | 2011 | Water Sci Technol2011，63，： | 1 |
| 15 | 显示文摘 | Wilde AA Escand D | 2001 | Proc Natl Acad Sci U S A2001，98，： | 1 |
| 16 | Human mucin gene MUC5AC:organization of its 5′-region and central repetivive region显示文摘 | Escande F aubert JP Porchet N | 2001 | Biochen J2001，358，3： | 1 |
| 17 | Myoclonic absence epilepsy with photosensitivity and a gain of function mutation in glutamate dehydrogenase显示文摘 | Nadia Bahi-Buisson Sandra El Sabbagh Christine Soufflet Fabienne Escande Nathalie Boddaert Vassili Valayannopoulos Christine Bellané-Chantelot Karine Lascelles Olivier Dulac Perrine Plouin Pascale de Lonlay | 2008 | Seizure: European Journal of Epilepsy2008，，7： | 1 |
| 18 | Role of deleted in breast cancer 1(DBC1)protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase显示文摘 | Nin V Escande C Chini CC | 2012 | J Biol Chem2012，287，23： | 1 |
| 19 | Profiling of benzophenone derivatives using fish and human estrogen receptor-specific in vitro bioassays 显示文摘 | Molina-Molina J Escande A Pillon A | 2008 | Toxicology and Applied Pharmacology2008，232，： | 1 |
| 20 | Structural organization and classification of the human mucin genes显示文摘 | Moniaux N Escande F Porchet N | 2001 | Front Biosci2001，6，： | 1 |
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