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| 1 | The molecular machinery of regulated cell death显示文摘Cells may die from accidental cell death(ACD)or regulated cell death(RCD).ACD is a biologically uncontrolled process,whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms.A growing number of novel nonapoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies.Here,we critically review the current state of the art regarding non-apoptotic types of RCD,including necroptosis,pyroptosis,ferroptosis,entotic cell death,netotic cell death,parthanatos,lysosome-dependent cell death,autophagy-dependent cell death,alkaliptosis and oxeiptosis.The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidanee of pathogenic cell loss. | Daolin Tang Rui Kang Tom Vanden Berghe Peter Vandenabeele Guido Kroemer | 2019 | Cell Research2019，29，5： | 143 |
| 2 | Autophagy: for better or for worse显示文摘Autophagy 是降级的降级小径损坏了的 lysosomal 或过剩房间部件进基本 biomolecules,它然后回来被再循环进 cytosol。在这个方面, autophagy 在一个连续降级新生周期驾驶 biomolecules 的流动。Autophagy 通常被认为在应力或差的滋养的条件下面保护房间的支持幸存的机制。当前的研究清楚地证明 autophagy 在重要生物过程完成众多的功能。它在开发被含有,区别,天生、适应的免疫,变老并且房间死亡。另外,积累证据表明在 autophagy 和几人的疾病和肿瘤开发之间的有趣的连接。因此, autophagy 似乎是在细胞和有机体的生活和死亡的一个重要播放器。尽管有 autophagy 的增长知识, autophagic 机械通过调整这些多样的过程的机制完全没被理解。在这评论,我们给表明小径的 autophagic 的全面概述,它的角色一般来说细胞的过程和它的连接到房间死亡。另外,我们在场发信号到疾病的有缺点的 autophagic 的可能的贡献的简短概述。 | Ellen Wirawan Tom Vanden Berghe Saskia Lippens Patrizia Agostinis Peter Vandenabeele | 2012 | Cell Research2012，22，1： | 70 |
| 3 | Neutrophil extracellular trap cell death requires both autophagy and superoxide generation显示文摘嗜中性的细胞外的陷井(网) 是能套住并且降级的细胞外的染色质结构微生物。他们从激活称为网络房间死亡,或 NETosis 的一个房间死亡程序的 neutrophils 产生。NETosis 的激活被显示了包含 NADPH oxidase 活动,原子信封的崩溃和大多数小粒膜,网的原子染色质和形成的 decondensation。我们报导在 phorbol,十四酸盐醋酸盐(PMA ) 刺激了 neutrophils,细胞内部的染色质 decondensation 和网形成跟随 autophagy 和 superoxide 生产,哪个被要求调停导致 PMA 的 NETosis 并且独立于对方发生。从有长期的 granulomatous 疾病的病人的 Neutrophils,缺乏 NADPH oxidase 活动,仍然展出导致 PMA 的 autophagy。相反地,导致 PMA 的 NADPH oxidase 活动没被 autophagy 的药理学抑制影响。有趣地,任何一个 autophagy 的抑制或 NADPH oxidase 阻止细胞内部的染色质 decondensation,它为 NETosis 和网形成是必要的,并且导致 apoptosis 的特点描绘的房间死亡。当 autophagy 或 NADPH oxidase 活动被阻止时,这些结果显示 apoptosis 可能为 NETosis 作为一个备份节目工作。 | Quinten Remij sen Tom Vanden Berghe Ellen Wirawan Bob Asselbergh Eef Parthoens Riet De Rycke Sam Noppen Michel Delforge Jean Wlllems Peter Vandenabeele | 2011 | Cell Research2011，21，2： | 46 |
| 4 | A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling显示文摘The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells,which are profoundly moulded by cancer cells.An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs.Here,we profile 233,591 single cells from patients with lung,colorectal,ovary and breast cancer(n=36)and construct a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies.We identify 68 stromal cell populations,of which 46 are shared between cancer types and 22 are unique.We also characterise each population phenotypically by highlighting its marker genes,transcription factors,metabolic activities and tissue-specific expression differences.Resident cell types are characterised by substantial tissue specificity,while tumor-infiltrating cell types are largely shared across cancer types.Finally,by applying the blueprint to melanoma tumors treated with checkpoint immunotherapy and identifying a naive CD4+T-cell phenotype predictive of response to checkpoint immunotherapy,we illustrate how it can serve as a guide to interpret scRNA-seq data.In conclusion,by providing a comprehensive blueprint through an interactive web server,we generate the first panoramic view on the shared complexity of stromal cells in different cancers. | Junbin Qian Siel Olbrecht Bram Boeckx Hanne Vos Damya Laoui Emre Etlioglu Els Wauters Valentina Pomella Sara Verbandt Pieter Busschaert Ayse Bassez Amelie Franken Marlies Vanden Bempt Jieyi Xiong Birgit Weynand Yannick van Herck Asier Antoranz Francesca Maria Bosisio Bernard Thienpont Giuseppe Floris Ignace Vergote Ann Smeets Sabine Tejpar Diether Lambrechts | 2020 | Cell Research2020，30，9： | 11 |
| 5 | 纳米药物的风险及控制显示文摘纳米技术在药学领域的应用表现为药物的靶向传递和纳米级粒子药物。纳米药物的风险表现为对人健康的风险和对环境损害的风险。应对纳米药物带来的风险和伦理问题,需要创建风险评估标准;维护人的知情权和自主权;遵守自然规律,严格规范生产设计;强化政策导向、监督管理和法律保障。 | 赵迎欢 Jeroen Vanden Hoven | 2010 | 医学与哲学(A)2010，31，7： | 10 |
| 6 | 呼吸前反馈调节、情景想象和过度通气显示文摘 | Ilse Van Diest 韩江娜 Karel P.Vande Woestijne Stephan Devriese Winnie Winters Omer Vanden Bergh | 2002 | 中华结核和呼吸杂志2002，25，5： | 4 |
| 7 | 地理空间约束的业务流程建模方法显示文摘明晰了受地理空间约束的业务流程的两个基本概念:地理位置与地理空间信息.首先,提出了地理空间约束思想,分析了地理空间约束的内涵,并在工作流元模型的知识基础上构建了地理空间约束的UML语义框架;其次,以形式化的方式提出了地理空间约束的业务流程建模方法(LAWF-net),并描述了LAWF-net模型转化为CPN可执行模型的规则,探讨了地理空间约束对流程建模的影响;最后,通过案例结合GIS系统来扩展CPN Tools,不仅验证了LAWF-net建模方法的可行性,而且实现了地理空间约束的业务流程的可视化. | 朱鑫伟 朱国宾 Seppe VANDEN BROUCKE | 2015 | 软件学报2015，26，3： | 3 |
| 8 | Modulation of PPAR activity via phosphorylation显示文摘 | Katherine A. Burns John P. Vanden Heuvel | 2007 | BBA - Molecular and Cell Biology of Lipids2007，，8： | 2 |
| 9 | Apoptosis and necrosis: Detection, discrimination and phagocytosis显示文摘 | Dmitri V. Krysko Tom Vanden Berghe Katharina D'Herde Peter Vandenabeele | 2008 | Methods2008，，3： | 2 |
| 10 | Non-parametric efficiency, progress and regress measures for panel data: Methodological aspects显示文摘 | Henry Tulkens Philippe Vanden Eeckaut | 1995 | European Journal of Operational Research1995，，3： | 2 |
| 11 | Acute infectious bursal disease in poultry:immunological and molecular basis of antigenicity of a highly virulent strain显示文摘 | Vanden Berg T P Gonze M Morales D | 1991 | Avian Pathology1991，25，： | 2 |
| 12 | Adverse skin reactions to anti-TNF-alpha monoclonal antibody therapy 显示文摘 | DEVOS S A VANDEN B N DEVOS M | 2003 | Dermatology2003，206，4： | 2 |
| 13 | Ultra-high performance liquid chromatography–tandem mass spectrometry in high-throughput confirmation and quantification of 34 anabolic steroids in bovine muscle显示文摘 | Lynn Vanhaecke Julie Vanden Bussche Klaas Wille Karen Bekaert Hubert F. De Brabander | 2010 | Analytica Chimica Acta2010，，1： | 2 |
| 14 | Anti-infective potential of natural products: How to develop a stronger in vitro ‘proof-of-concept’显示文摘 | Paul Cos Arnold J. Vlietinck Dirk Vanden Berghe Louis Maes | 2006 | Journal of Ethnopharmacology2006，，3： | 2 |
| 15 | Hepatoma ceils adapted to proliferate under normally lethal hyperthermic stress conditions show rapid decay of thermoresistance and heat shock protein synthesis when returned to 37 degrees C 显示文摘 | Van Rijn J Vanden Berg J Souren JE | 1995 | Int J Hyperthermia1995，11，5： | 1 |
| 16 | Coronary side-effect potential of current and prospective antimigraine drugs 显示文摘 | Reekers M Bax WA Ferrari MD | 1998 | Circulation1998，98，1： | 1 |
| 17 | Efficiency estimation from Cobb-Douglas production functions with composed error 显示文摘 | Meeusenm W and Vanden Broeck | 1977 | International Economic Reviews1977，18，43： | 1 |
| 18 | Development of a eombline new mechanical and enzymatic method for the isolationof intact preantral follicles from fetal, calf and adult bovine ovaries 显示文摘 | Figueiredo J R Hulshof S J Vanden R | 1993 | Theriogenology1993，40，： | 1 |
| 19 | A paradigm for gene regulation: inflammation,NF-kappaB and PPAR显示文摘 | Vanden BW Vermeulen L Delerive P | 2003 | Adv Exp Med Biol2003，544，： | 1 |
| 20 | Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells显示文摘 | Lyman SD James L Vanden Bos T | 1993 | Cell1993，75，6： | 1 |
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