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| 1 | Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study显示文摘AIM To evaluate the prognostic value of the tumor-stroma ratio(TSR) in rectal cancer.METHODS TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assessreproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage(CP) ≥ 70%], TSR-intermediate(CP 40%, 50% and 60%) and TSR-low(CP ≤ 30%). The relation between categorized TSR and survival was analyzed using Cox proportional hazards model.RESULTS Thirty-six(23.4%) patients were scored as TSR-low, 70(45.4%) as TSR-intermediate and 48(31.2%) as TSRhigh. TSR had a good interobserver agreement(κ = 0.724, concordance 82.5%). Overall survival(OS) and disease free survival(DFS) were significantly better for patients with a high TSR(P = 0.01 and P = 0.02, respectively). A similar association existed for disease specific survival(P = 0.06). In multivariate analysis, patients without lymph node metastasis and an intermediate TSR had a higher risk of dying from rectal cancer(HR = 5.27, 95%CI: 1.54-18.10), compared to lymph node metastasis negative patients with a high TSR. This group also had a worse DFS(HR = 6.41, 95%CI: 1.84-22.28). An identical association was seen for OS. These relations were not seen in lymph node metastasis positive patients. CONCLUSION The TSR has potential as a prognostic factor for survival in surgically treated rectal cancer patients, especially in lymph node negative cases. | René Scheer Alexi Baidoshvili Shorena Zoidze Marloes AG Elferink Annefleur EM Berkel Joost M Klaase Paul J van Diest | 2017 | World Journal of Gastrointestinal Oncology2017，9，12： | 3 |
| 2 | 老龄小鼠模型内皮细胞衰老导致射血分数保留的心力衰竭显示文摘由于全球老龄化,射血分数保留的心力衰竭(heart failure with preserved ejection fraction,HFpEF)发生率持续上升。虽然HFpEF的病理生理机制仍然不完全清楚,但通常认为内皮炎症发挥了核心作用。细胞衰老是一种与老化和炎症有关的细胞生长停滞过程。Gevaert等使用加速老化的小鼠(senescence-accelerated mice,SAM)模型探究细胞衰老在HFpEF发生发展中的作用。 | 刘莉 叶鹏 Gevaert AB Shakeri H Leloup AJ Van Hove CE De Meyer GRY Vrints CJ Lemmens K Van Craenenbroeck EM | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Broad-spectrum antimicrobial activity of human intestinal defensin 5显示文摘 | Porter EM van Dam E Valre EV | 1997 | J Immunol1997，65，6： | 2 |
| 4 | 跟骨关节内移位骨折的功能疗效和患者满意度——切开复位、经皮手术和非手术治疗对比研究显示文摘对于跟骨关节内移位骨折,约60%的工薪阶层患者会选择切开复位内固定术(openreductionandinternalfixation,ORIF)治疗,术后恢复工作通常需要5~10个月,相当一部分患者1年内无法恢复工作;而对于保守治疗患者,骨折症状通常会持续1~2年,高达16%的患者需行关节内固定手术。本研究的主要目的是比较3种跟骨关节内移位骨折治疗方案——ORIF、经皮手术和非手术治疗的疗效差异。 | De Boer AS Van Lieshout EM Den Hartog D 叶翔凌 夏远军 | 2016 | 中国骨科临床与基础研究杂志2016，8，6： | 2 |
| 5 | The preparation of dextran microspheres in an all-aqueous system: effect of the formulation parameters on particle characteristics 显示文摘 | Stenekes RJ Franssen O van Bommel EM | 1998 | Pharm Res1998，15，： | 1 |
| 6 | Diagnosis of turberculosis based on the two specific antigens ESAT-6 and CFP10显示文摘 | van Pinxteren LAH Ravn P Agger EM | 2000 | Clin Diagn Lab Immunol2000，7，2： | 1 |
| 7 | Inflammatory response in the acute phase of deep vein thrombosis显示文摘 | Roumen-Klappe EM den Heijer M van Uum SH | 2002 | J Vasc Surg2002，35，4： | 1 |
| 8 | CD47-signal regula?tory protein-alpha (SIRPalpha) interactions form a barrier for anti?body-mediated tumor cell destruction显示文摘 | Zhao XW van Beek EM Schornagel K | 2011 | Proc Natl Acad Sci V S A2011，108，18： | 1 |
| 9 | Signal regulatory proteins in the immune system显示文摘 | van Beek EM Cochrane F Barclay AN | 2005 | J Immu- nol2005，175，12： | 1 |
| 10 | Current perspective of pathophysiological and interventional effects on endothelial progenitor cell biology:Focus on Pi3K/AKT/eNOS pathway显示文摘 | Everaert BR Van Craenenbroeck EM Hoymans VY | | 0，，03： | 1 |
| 11 | Unlicensed and off-label drug use in a paediatric ward of a general hospital in the Netherlands显示文摘 | 't Jong GW van der Linden PD Bakker EM | | 0，，04： | 1 |
| 12 | Epicardial cells of human adults can undergo an epithelial-to-mesenchymal transition and obtain characteristics of smooth muscle cells in vitro显示文摘 | van Tuyn J Atsma DE Winter EM | 2007 | Stem Cells2007，25，2： | 1 |
| 13 | Multistage electrodialysis for large-scale separation of raeemie mixtures显示文摘 | Van der Ent EM Van Hee P Keurentjes JTF | 2002 | J Membr Sei2002，204，12： | 1 |
| 14 | Inflammatory response in the acute phase of deep veinthrombosis显示文摘 | Roumen-Klappe EM den Heijer M van Uum SH | 2002 | J VascSurg2002，35，4： | 1 |
| 15 | Online MRI guidance for healthy tissue sparing in patients with cervical cancer: an IMRT planning study 显示文摘 | Kerkhof EM Raaymakers BW van der Heide UA | 2008 | Radiother Oncol2008，88，2： | 1 |
| 16 | A comparison offrontal radiographs obtained from cone beam CT scans and conven-tional frontal radiographs of human skulls显示文摘 | Van Vlijmen OJ BergéSJ Bronkhorst EM | 2009 | Int J Oral Maxillo-fac Surg2009，38，7： | 1 |
| 17 | The lectin-like domain of thrombomedulin confels by suppressing adhesin activa-ted protein kinase pathways显示文摘 | Conway EM Van de Wouwer M Polhfeyt S | 2002 | J Exp Med2002，196，5： | 1 |
| 18 | Perinatal outcome after selective feticide in monochorionic twin pregnancies 显示文摘 | van den Bos EM van Klink JM Middeldorp JM | 2013 | Ultrasound Obstet Gynecol2013，41，： | 1 |
| 19 | MicroRNAs in ovarian cancer biology and therapy resistance显示文摘 | van Jaarsveld MT Helleman J Berns EM Wiemer EA | | 0，，： | 1 |
| 20 | Complications in maxillary distraction using the RED Ⅱ device:a retrospective analysis of 21 patients显示文摘 | Nout E Wolvius EB van Adrichem LN Ongkosuwito EM van der Wal KG | | 0，，： | 1 |
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