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| 1 | Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism显示文摘Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domaincontaining 5(FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue(WAT) and uncoupling protein 1(UCP1) expression, leading to an increase in total body energy expenditure by augmented UCP1-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones,including growth plate, trabecular bone, cortical bone, articular cartilage, and bone–tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal(IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-k B ligand(RANKL)-induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice. | Jin Zhang Paloma Valverde Xiaofang Zhu Dana Murray Yuwei Wu Liming Yu Hua Jiang Michel M Dard Jin Huang Zhiwei Xu Qisheng Tu Jake Chen | 2017 | Bone Research2017，5，1： | 23 |
| 2 | Quality improvement and extension of shelf life by 1 -methylcyclopropene in plum as affected by ripening stage at harvest显示文摘 | VALERO D MARTINEZ-ROMERO D VALVERDE J M | 2003 | Innovative Food Science and Emerging Technologies2003，4，： | 1 |
| 3 | Deterruination of photoirradiated high polar benzoylureas in tomato by HPLC with luminol chemiluminescence detection显示文摘 | Martinez Galera M Gil Gareia M D Santiago Valverde R | 2008 | Talanta2008，76，4： | 1 |
| 4 | Determination of solublecarbohydrates in yogurts by high performance liquid chromatography显示文摘 | VALVERDE V C VILLA C M HERRANZ J | 1983 | Journal of Dairy Science1983，67，4： | 1 |
| 5 | Human ClC-3 is not the swelling-activated chloride channel involved in cell volume regulation显示文摘 | Weylandt KH Valverde MA Nobles M | 2001 | J Biol Chem2001，276，17： | 1 |
| 6 | Particle bombardment, a method for gene transfer in marigold 显示文摘 | Vanegas P E Valdez-Morales M Valverde M E | 2006 | Plant Cell Tissue and Organ Culture2006，84，3： | 1 |
| 7 | Quality and antioxidant properties on sweet cherries as affected by preharvest salicylic and acetylsalicylic acids treatments 显示文摘 | Gimenez M J Valverde J M Valero D | 2014 | Food Chem2014，160，： | 1 |
| 8 | Reduction of pomegranate chilling injury during storage after heat treatment: Role of polyamines显示文摘 | MIRDEHGHAN S H RAHEMIC M MARTINEZ-ROMERO D GUILLEN F VALVERDE J M ZAPATA P J SERRANO M VALERO D | 2007 | Postharvest Biology and Technology2007，44，： | 1 |
| 9 | Deactivation of toluene alkylation with methanol over magnesium-modified ZSM-5 : shape selectivity changes induced by coke formation 显示文摘 | Sotelo J L Uguina M A Valverde J L | 1994 | Appl Catal1994，114，2： | 1 |
| 10 | The Arabidopsis E3 ubiquitin ligase HOS1 negatively regulates Constans abundance in the photoperiodic control of flowering显示文摘 | LAZARO A VALVERDE F PIEIRO M | 2012 | The Plant Cell2012，24，3： | 1 |
| 11 | Volume - regulated chloride channels associated with the human multidrug - resistance P - glycoprotein 显示文摘 | Valverde MA Diaz M Sepulveda FV | 1992 | Nature1992，355，6363： | 1 |
| 12 | Deaetivation kineties of toluene alkylation with methanol over magnesium- modified ZSM-5 显示文摘 | Sotelo J L Uguina M A Valverde J L | 1996 | Ind Eng Chem Res1996，35，： | 1 |
| 13 | Enhancing the electrical performance of a solid oxide fuel cell using multiobjective genetic algorithms显示文摘 | JURADO F VALVERDE M | 2005 | Renewable Energy2005，30，： | 1 |
| 14 | Diversity and community structure of culturable arsenic-resistant bacteria across a soil arsenic gradient at an abandoned tungsten-tin mining area显示文摘 | Valverde A Gonzalez-Tirante M Medina-Sierra M Santa-Regina I Garcia-Sanchez A Igual JM | | 0，，1： | 1 |
| 15 | CB1 receptor-deficient mice as a model for depression显示文摘 | Valverde O Torrens M | 2012 | Neuroscience2012，204，： | 1 |
| 16 | Role of crystal structure on CO2 capture by limestone derived CaO subjected to carbonation/recarbon- ation/calcination cycles at Ca-looping conditions显示文摘 | Valverde J M Sanchez-Jimenez P E Perez-Maqueda L A | 2014 | Ap- plied Energy2014，125，： | 1 |
| 17 | Tools to maintain postharvest fruit and vegetable quality through the inhibition of ethylene action: a review显示文摘 | MARTINEZ-ROMERO D BALIEN G SERRANO M GUILLENF VALVERDE J M ZAPATA P CASTILLO S VALERO D | 2007 | Critical Reviews in Food Science and Nutrition2007，47，： | 1 |
| 18 | Combined adsorption and ion exchange equilibrium of phenol on Amberlite IRA-420 显示文摘 | Carmona M De Lucas A Valverde J L | 2006 | Chemical Engineering Journal2006，117，2： | 1 |
| 19 | Human ClC-3 is not the swelling-activated chloride channel involved in cell volume regulation显示文摘 | Weylandt K H Valverde M A Nobles M | 2001 | J Biol Chem2001，276，17： | 1 |
| 20 | Single cell gel electrophoresis assay:methodology and applications 显示文摘 | Rojas E Lopez MC Valverde M | 1999 | Journal of Chromatography B1999，722，： | 1 |
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