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| 1 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | Selective sphincteroplasty of the papilla in cases at risk due to atypical anatomy显示文摘AIM: To analyze the indications, effi cacy and safety of sphincteroplasty in our centre. METHODS: A retrospective study of sphincteroplasty in 53 cases of papilla at high risk was performed in 2004-2006. The procedure consisted of duodenoscopy with Olympus TJF 145 Videoduodenoscope, approach to the biliary tract using a catheter with a guidewire, and dilatation of the papilla with a dilatation balloon catheter using a syringe with a manometer for control of the fi lling pressure. RESULTS: The indications included intradiverticular papilla in 26 patients (49/), stenosis of a previous sphincterotomy in 19 patients (35.8/), small size of the papilla in 4 patients (7.5/), Billroth Ⅱ gastrectomy in 3 patients (5.6/), and coagulopathy in one patient (1.9/). The efficacy was 97.8/, with all the calculi extracted from the common bile duct in 84.4/ of the patients, even though 21 of the patients (39.6/) had calculi with a diameter equal to or greater than 10 mm. Seven patients (13.2/) presented complications: haemorrhage in 1 patient (1.9/) and mild pancreatitis in 6 patients (11.3/). The mean hospital stay in case of complications was of 3 ± 0.63 d. CONCLUSION: Sphincteroplasty is highly effective, with a complication rate similar to that of sphincterotomy, furthermore, the complications are of low clinical importance. The use of the 10 mm balloon makes it possible to extract calculi with a diameter of over 15 mm and to extract more than 3 calculi without increasing the rate of complications and reduces the need to resort tolithotripsy or rescue sphincterotomy. | F Mugica G Urdapilleta A Castiella A Berbiela F Alzate E Zapata L Zubiaurre P Lopez JI Arenas | 2007 | World Journal of Gastroenterology2007，13，22： | 5 |
| 3 | Reduction of pomegranate chilling injury during storage after heat treatment: Role of polyamines显示文摘 | MIRDEHGHAN S H RAHEMIC M MARTINEZ-ROMERO D GUILLEN F VALVERDE J M ZAPATA P J SERRANO M VALERO D | 2007 | Postharvest Biology and Technology2007，44，： | 1 |
| 4 | Efficacy of 1-MCP Treatment in Tomato Fruit显示文摘 | GUILLEN F CASTILLO S ZAPATA P J | 2007 | Postharvest Biology and Technology2007，43，： | 1 |
| 5 | Polyamines and ethylene changes during germina- tion of different plant species under salinity显示文摘 | Zapata P J Serrano M A Pretel M T | 2004 | Plant Science2004，167，4： | 1 |
| 6 | Energy Consumption of As- phalt and ReinforcedConcrete Pavement Materials and Construction显示文摘 | Zapata P Gambatese J A | 2005 | Journal of Infrastructure Systems2005，11，1： | 1 |
| 7 | Synthetic layered and tube-like silica nanopartieles as novel supports for metal- locene catalysts in ethylene polymerization显示文摘 | Zapata P A Quijada R Lieberwirth I | 2011 | Appl Catal A: Gen2011，407，1： | 1 |
| 8 | Co(ll)-(IlI) hydrotalcite-like compounds 显示文摘 | ZaPata B Bosch P Fetter G | 2001 | Inter JoflnorganicMater2001，3，： | 1 |
| 9 | Trust in Typical and High - reliability Contexts : Building and Reacting to Trust an'long Firefighters 显示文摘 | Colquitt J A Lepine J A Zapata C P | 2011 | Academy of Management Journal2011，54，5： | 1 |
| 10 | Neu tralizing monoclonal antibody to the E1 glycoprotein epitope of rubella virus mediates virus arrest in VERO cells显示文摘 | Cordoba P Grutadauria S Cuffini C Zapata M | 2000 | Viral Immunol2000，13，1： | 1 |
| 11 | Tools to maintain postharvest fruit and vegetable quality through the inhibition of ethylene action: a review显示文摘 | MARTINEZ-ROMERO D BALIEN G SERRANO M GUILLENF VALVERDE J M ZAPATA P CASTILLO S VALERO D | 2007 | Critical Reviews in Food Science and Nutrition2007，47，： | 1 |
| 12 | Carbon isotope discrimination,leaf ash content andgrain yield in bread wheat and durum wheat grown under irrigated conditions显示文摘 | MONNEVEUX P REYNOLDS M P TRETHOWAN R PENNA J ZAPATA F | 2004 | Agronomy & Crop Science2004，190，： | 1 |
| 13 | Lead-lag Rela- tionships between Trading Volume and Price Varia- bility: New Evidence显示文摘 | Carcia P R M Leuthold H Zapata | 1986 | Journal of Futures Mar- kets1986，6110，： | 1 |
| 14 | The effects of essential oils carvacrol and thymol on growth of Penicillium digitatum and P. italicum involved in lemon decay显示文摘 | C.O. Pérez-Alfonso D. Martínez-Romero P.J. Zapata M. Serrano D. Valero S. Castillo | 2012 | International Journal of Food Microbiology2012，，2： | 1 |
| 15 | Polyamines induced by hot water treatments reduce chilling injury and decay in pepper fruit显示文摘 | GONZALEZ-AGUILAR G A GAYOSSO L CRUZ R GUILLEN F VALVERDE J M ZAPATA P J SERRANO M VALERO D | 2000 | Postharvest Biology and Technology2000，18，： | 1 |
| 16 | Experimental aller- gic encephalomyelitis in pituitary-grafted Lewis rats显示文摘 | Esquifino AI Cano P Zapata A | 2006 | J Neuroinflammation2006，3，： | 1 |
| 17 | High level secretion of a humanized bispecific cliabody from Escherichla coli 显示文摘 | Zhu Z P Zapata G Shalaby R | 1996 | Bio Technology1996，14，： | 1 |
| 18 | Reduction of pomegranate chilling injury during storage after heat treatment: Role of polyamines显示文摘 | MIRDEHGHAN S H RAHEMIC M MARTINEZ-ROMERO D GUILLEN F VALVERDE J M ZAPATA P J SERRANO M VALERO D | 2007 | Postharvest Biology and Technology2007，44，： | 1 |
| 19 | Carbon isotope discrimination, leaf ash content and grain yield in bread wheat and durum wheat gown under full irrigated conditions 显示文摘 | Monneveux P Reynolds M P Trethowan R Penna J Zapata F | 2004 | Agronomy & Crop Science2004，190，： | 1 |
| 20 | Experimental allergic encephalomyelitis in pituitary- grafted Lewis rats显示文摘 | Esquifino AI Cano P Zapata A | 2006 | J Neuroinflammation2006，3，： | 1 |
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