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| 1 | BCLC策略:预后预测和治疗推荐2022版更新显示文摘2018版BCLC预后和治疗推荐策略发布后,肝细胞癌(简称HCC)的研究又取得了重大进展。本次更新基于肝癌各领域的研究进展结果。重点关注影响策略的重要研究进展。虽然近年的研究结果成绩斐然,但将其引入为临床医生和研究者提供行动依据的循证模型指南来说证据效力依然不够确切。本文对该问题进行分析,阐述了为HCC患者制定个体化治疗临床决策所需的批判性思维和专业知识。 | Reig M Forner A Rimola J Ferrer-Fabrega J Burrel M Garcia-Criado A Kelley RK Galle PR Mazzaferro V Salem R Sangro B Singal AG Vogel A Fuster J Ayuso C Bruix J 刘永凡(摘译) 崔笑(摘译) 耿小平(审校) | 2022 | 肝胆外科杂志2022，30，5： | 80 |
| 2 | 数据驱动的电子健康服务管理研究:挑战与展望显示文摘电子健康的产生和发展为解决现阶段医疗资源的紧缺和分配不均、医患关系紧张等问题提供了新的途径,同时也带来了新的问题和挑战,而当前关于该方向的基础理论和方法尚不完善,亟待研究者和实践者的关注和探索。结合国内外研究现状,对电子健康服务包含的4个主要方向(即健康大数据分析、基于数据的健康评估和疾病预警、服务管理和价值创造、服务管理实践)进行回顾和梳理,并对中国的研究和实践现状进行详细分析。基于数据驱动的电子健康服务管理的实践和研究现状,对当前研究中存在的问题进行分析和总结,主要包括由于健康数据的多源性导致的信息管理问题、多参与方导致的服务管理问题和管理实践问题。在此基础上提出健康大数据分析方法、数据驱动的健康评估和疾病预警、基于大数据的电子健康服务过程和管理机制研究、基于大数据的电子健康可持续性价值创造机理研究和管理实践研究5个未来研究方向,健康大数据分析方法包括有偏样本数据检验和矫正方法、纵向研究中健康大数据分析方法、中文医疗信息处理,数据驱动的健康评估和疾病预警包括基于电子病历和移动医疗的个人健康评估和疾病预警、基于电子病历和社交媒体的群体疾病监测和预警,基于大数据的电子健康服务过程和管理机制研究包括用户决策、服务传递和服务管理,基于大数据的电子健康可持续性价值创造机理研究包括用户持续使用、反馈有效性,为今后的电子健康相关研究提供理论和实践指导。 | 郭熙铜 张晓飞 刘笑笑 Doug Vogel | 2017 | 管理科学2017，30，1： | 43 |
| 3 | Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients显示文摘AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy subjects.CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology. | Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel Jan Knol Kaouther Ben-Amor Louis MA Akkermans | 2009 | World Journal of Gastroenterology2009，15，23： | 33 |
| 4 | Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology显示文摘AIM: To evaluate ATP-binding cassette(ABC) transporters in colonic pathophysiology as they had recently been related to colorectal cancer(CRC) development. METHODS: Literature search was conducted on Pub Med using combinations of the following terms: ABC transporters, ATP binding cassette transporter proteins, inflammatory bowel disease, ulcerative, colitis, Crohns disease, colorectal cancer, colitis, intestinal inflammation, intestinal carcinogenesis, ABCB1/P-glycoprotein(P-gp/CD243/MDR1), ABCC2/multidrug resistance protein 2(MRP2) and ABCG2/breast cancer resistance protein(BCRP), Abcb1/Mdr1 a, abcc2/Mrp2, abcg2/Bcrp, knock-out mice, tight junction, membrane lipid function. RESULTS: Recently, human studies reported thatchanges in the levels of ABC transporters were early events in the adenoma-carcinoma sequence leading to CRC. A link between ABCB1, high fat diet and gut microbes in relation to colitis was suggested by the animal studies. The finding that colitis was preceded by altered gut bacterial composition suggests that deletion of Abcb1 leads to fundamental changes of hostmicrobiota interaction. Also, high fat diet increases the frequency and severity of colitis in specific pathogenfree Abcb1 KO mice. The Abcb1 KO mice might thus serve as a model in which diet/environmental factors and microbes may be controlled and investigated in relation to intestinal inflammation. Potential molecular mechanisms include defective transport of inflammatory mediators and/or phospholipid translocation from one side to the other of the cell membrane lipid bilayer by ABC transporters affecting inflammatory response and/or function of tight junctions, phagocytosis and vesicle trafficking. Also, diet and microbes give rise to molecules which are potential substrates for the ABC transporters and which may additionally affect ABC transporter function through nuclear receptors and transcriptional regulation. Another critical role of ABCB1 was suggested by the finding that ABCB1 expression identifies a subpopulation of pro-inflammatory Th17 cells which were resistant to treatment with glucocorticoids. The evidence for the involvement of ABCC2 and ABCG2 in colonic pathophysiology was weak. CONCLUSION: ABCB1, diet, and gut microbes mutually interact in colonic inflammation, a well-known risk factor for CRC. Further insight may be translated into preventive and treatment strategies. | Vibeke Andersen Katrine Svenningsen Lina Almind Knudsen Axel Kornerup Hansen Uffe Holmskov Allan Stensballe Ulla Vogel | 2015 | World Journal of Gastroenterology2015，21，41： | 10 |
| 5 | Small bowel adenocarcinoma in Crohn's disease:A case report and review of literature显示文摘小肠腺癌为他们的稀有,困难的诊断和差的预后是显著的。这里,我们报导小肠的渗透性的腺癌在 Crohn 的疾病的 10 年的历史以后在被诊断的一个 33 岁的病人的一个不平常的案例。在最以前报导的案例中, Crohn 的疾病的察觉对小肠的癌的随后或包含的病人有疾病的甚至更长的历史。我们的文学评论建议小肠腺癌的风险比在全面人口在有 Crohn 的疾病的病人是更高的。我们传染病学以及这个稀罕疾病实体的临床、诊断的方面上的现在的细节。 | Irmgard E Kronberger Ivo W Graziadei Wolfgang Vogel | 2006 | World Journal of Gastroenterology2006，12，8： | 8 |
| 6 | Transjugular intrahepatic portosystemic shunt in liver transplant recipients显示文摘AIM:To evaluate the efficacy of transjugular intrahepatic portosystemic shunts (TIPSs) after liver transplantation (LT). METHODS: Between November 1996 and December 2005, 10 patients with severe recurrent hepatitis C virus infection (n=4), ductopenic rejection (n=5) or portal vein thrombosis (n=1) were included in this analysis. Eleven TIPSs (one patient underwent two TIPS procedures) were placed for management of therapy-refractory ascites (n=7), hydrothorax (n=2) or bleeding from colonic varices (n=1). The median time interval between LT and TIPS placement was 15 (4-158) mo. RESULTS: TIPS placement was successful in all patients. The mean portosystemic pressure gradient was reduced from 12.5 to 8.7 mmHg. Complete and partial remission could be achieved in 43% and 29% of patients with ascites. Both patients with hydrothorax did not respond to TIPS. No recurrent bleeding was seen in the patient with colonic varices. Nine of 10 patients died during the study period. Only one of two patients, who underwent retransplantation after the TIPS procedure, survived. The median survival period after TIPS placement was 3.3 (range 0.4-20) mo. The majority of patients died from sepsis with multiorgan failure.CONCLUSION: Indications for TIPS and technical performance in LT patients correspond to those in non-transplanted patients. At least partial control of therapy-refractory ascites and variceal bleeding could be achieved in most patients. Nevertheless, survival rates were disappointing, most probably because of the advanced stages of liver disease at the time of TIPS placement and the high risk of sepsis as a consequence of immunosuppression. | Armin Finkenstedt Ivo W Graziadei Karin Nachbaur Werner Jaschke Walter Mark Raimund Margreiter Wolfgang Vogel | 2009 | World Journal of Gastroenterology2009，15，16： | 8 |
| 7 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 8 | Effects of Soil Fertility and Atmospheric CO_2 Enrichment on Leaf, Stem and Root Dark Respiration of Populus tremuloides显示文摘An open-top chamber experiment was conducted at the University of Michigan Biological Station near Pellston, Michigan, USA, to study the effects of soil fertility and CO2 on leaf, stem and root dark respiration (Rd) of Populus tremuloides. Overall, area-based day-time leaf Rd (Rda) was significantly greater at elevated than at ambient CO2 in high-fertility soil, but not in low-fertility soil. Mass-based leaf Rd (Rdm) was overall greater for high- than for low-fertility soil grown trees at elected, but not at ambient CO2. Nighttime leaf Rd. and Rdm were unthected by soil fertility or CO2, nor was stem Rda, which ranged from 1.0 to 1.4 μmol m-2 s-1 in the spring and 3.5 to 4.5 μmol m-2 s-1 in the summer. Root Rda. was significantly higher in high- than in low-fertility soil, but was unaffected by CO2. Since biomass production of P. tremuloides will be significantly greater at elevated CO2 while specific Rd will either increase or remain unchanged, we predict that carbon loss to the atmosphere through respiration from this ecologically important species would increase at higher CO2. Soil fertility would also interact with elevated CO2 in affecting the carbon flow in the plant-soil-air system. | X. Z. WANG P. S. CURTIS and C. S. VOGEL Columbia University, Palisades, New York 10964-8000 (USA) The Ohio State University, Columbus, Ohio 43210-1293 (USA) University of Michigan Biological Station, Pellston, Michigan 49769 (USA) | 2001 | Pedosphere2001，11，3： | 6 |
| 9 | New tight junction protein 2 variant causing progressive familial intrahepatic cholestasis type 4 in adults: A case report显示文摘BACKGROUND Progressive familial intrahepatic cholestasis(PFIC)encompasses a group of autosomal recessive disorders with high morbidity and mortality.Variants in the gene encoding tight junction protein-2(TJP2)have been linked to PFIC type 4(PFIC4),which predominantly presents in childhood.However,there are only limited data from adults with TJP2-related PFIC4.We report a family with an autosomal recessive disorder with a novel variant in the TJP2 gene in adults with very variable expression of PFIC4.CASE SUMMARY The index patient presented at 19 years old with liver cirrhosis and variceal bleeding and was treated with endoscopic banding and beta-blockers.In 2018,he developed primary liver cancer that was treated with radiofrequency ablation followed by liver transplantation in 2019.Genetic testing revealed a novel homozygous TJP2 variant causing PFIC4(TJP2([NM_004817.3]:c.[3334C>T];[3334C>T])).The consanguineous family consists of the father and mother(both heterozygous)and their 12 children,of which five carry the variant in a homozygous state;however,these five siblings have highly variable expression of PFIC4.Two homozygous brothers had cirrhosis and portal hypertension at diagnosis at the ages of 19 and 36.Two other homozygous brothers,age 23 and 19,and the homozygous sister,age 21,have elevated liver enzymes but presently no cirrhosis,which may suggest an age-dependent penetrance.In addition,five sisters had severe and mild intrahepatic cholestasis of pregnancy and carry the TJP2 variant in a homozygous and heterozygous state,respectively.CONCLUSION This novel TJP2 variant is associated with PFIC4 causing severe liver disease with cirrhosis and primary liver cancer in adolescents/adults. | Chun-Shan Wei Naja Becher Jenny Blechingberg Friis Peter Ott Ida Vogel Henning Grønbæk | 2020 | World Journal of Gastroenterology2020，26，5： | 6 |
| 10 | Bone marrow-derived mesenchymal stem cells migrate to healthy and damaged salivary glands following stem cell infusion显示文摘Xerostomia is a severe side effect of radiation therapy in head and neck cancer patients. To date, no satisfactory treatment option has been established. Because mesenchymal stem cells(MSCs) have been identified as a potential treatment modality, we aimed to evaluate stem cell distribution following intravenous and intraglandular injections using a surgical model of salivary gland damage and to analyse the effects of MSC injections on the recruitment of immune cells. The submandibular gland ducts of rats were surgically ligated. Syngeneic adult MSCs were isolated, immortalised by simian virus 40(SV40) large T antigen and characterized by flow cytometry. MSCs were injected intravenously and intraglandularly. After 1, 3 and 7 days, the organs of interest were analysed for stem cell recruitment. Inflammation was analysed by immunohistochemical staining. We were able to demonstrate that, after intravenous injection, MSCs were recruited to normal and damaged submandibular glands on days 1, 3 and 7. Unexpectedly, stem cells were recruited to ligated and non-ligated glands in a comparable manner. After intraglandular injection of MSCs into ligated glands, the presence of MSCs, leucocytes and macrophages was enhanced, compared to intravenous injection of stem cells. Our data suggest that injected MSCs were retained within the inflamed glands, could become activated and subsequently recruited leucocytes to the sites of tissue damage. | Silke Schwarz Ralf Huss Michaela Schulz-Siegmund Breda Vogel Sven Brandau Stephan Lang Nicole Rotter | 2014 | International Journal of Oral Science2014，6，3： | 5 |
| 11 | Contribution to the taxonomy of the genus Lycodon H.Boie in Fitzinger,1827(Reptilia:Squamata:Colubridae)in China,with description of two new species and resurrection and elevation of Dinodon septentrionale chapaense Angel,Bourret,1933显示文摘While considerable progress has been made in the taxonomic studies of the genus Lycodon in Asia,questions remain to be clarified regarding the taxonomy of certain groups,particularly those containing species in China.Not only do many regions in China remain overlooked by herpetologists,resulting in the possibility of undiscovered new species,but the surveyed areas also have suspicious records of recognized congeners that require taxonomic confirmations.Combining both morphological and genetic data,we tackle these outstanding issues in the taxonomy of Lycodon in China.In particular,we discover two new species of Lycodon:one from the previously neglected hot-dry valley in the northern Hengduan Mountain Region close to Tibet,and another recluse and cryptic species from the L.fasciatus complex in the downtown park of a major city in southern Sichuan Province.Additionally,we clarify the distribution of L.septentrionalis in China and resurrect and elevate its junior synonym subspecies,Dinodon septentrionale chapaense,as a full,valid species,and we synonymize the recently described L.namdongensis to the resurrected L.chapaensis comb.nov..Lycodon chapaensis comb.nov.thus represents a new national record of reptilian fauna of China.Lastly,based on literature review,we also correct some of the erroneous records of L.fasciatus and L.ruhstrati in China,point out remaining taxonomic issues of the genus for future research,and update the dichotomous key and distribution of the 20 species of Lycodon currently recorded from China. | Kai Wang Zhong-Bin Yu Gernot Vogel Jing Che | 2021 | Zoological Research2021，42，1： | 5 |
| 12 | The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation显示文摘MRE11/RAD50/NBS1 建筑群是很快招募到 DNA 双海滨裂缝(DSB ) 的主要传感器。MRE11 被知道是由在它的 glycine-arginine-rich (长嘴硬鳞鱼) 以内的 PRMT1 的精氨酸 methylated 主题。在这研究,我们报导在 GAR 主题与离氨酸代替精氨酸并且产生 MRE11 缺乏 methylated 精氨酸的 RK 蛋白质。Mre11 RK/RK 老鼠对 γ 过分敏感;照耀(红外) 和从这些老鼠的房间显示了房间周期检查点缺点和染色体不稳定性。而且, Mre11 RK/RK MEF 展出了在 RPA 和 RAD51 的招募表明缺点和缺陷到损坏地点的 ATR/CHK1。M RK 形成的 RN 建筑群并且对 DNA 损坏并且通常的地点局部性响应红外激活 ATM 小径。M RK RN 建筑群在为响应红外在 vivo 观察的损害 DNA 结束切除术和 ATR 激活负责的 vitro 展出了 exonuclease 和 DNA 有约束力的缺点。我们的调查结果在 DSB 修理为 MRE11 长嘴硬鳞鱼主题的关键角色提供基因证据,并且在 MRE11 长嘴硬鳞鱼表明在 translational 以后修正之间的一个机械学的连接主题并且 DSB 处理,以及发信号的 ATR/CHK1 检查点。 | Zhenbao Yu Gillian Vogel Yan Coulombe Danielle Dubeau Elizabeth Spehalski Josee Hebert David O Ferguson Jean Yves Masson Stephane Richard | 2012 | Cell Research2012，22，2： | 5 |
| 13 | 蛇类研究简讯三则显示文摘1福清白环蛇恢复为有效种兼记黑背白环蛇大陆亚种
2009年底,Vogel等合作在《Tropical Zoology》上发表黑背白环蛇新亚种——大陆亚种Lycodon ruhstrati abditus和新种——食蛇白环蛇Lycodon ophiophagus; | 罗键 Gernol Vogel Sergei A Ryabov | 2011 | 重庆师范大学学报(自然科学版)2011，28，3： | 4 |
| 14 | Evolutionary ecology of microsporidia associated with the invasive ladybird Harmonia axyridis显示文摘侵略种类被他们的人口的快速的生长和传播在在新产地建立一个立脚点以后描绘,并且现在有否定地影响它是的生物多样性和经济的如此的种类的许多例子不清楚某种类为什么能成为成功的侵略者,而大多数(就算仔细联系了)我们以前建议了的遗体 noninvasive 如果他们向侵略者是无害的,寄生虫与入侵种联系了的一个假设能支持他们的侵略成功但是对他们在我们讨论的这里的最新开拓殖民地于的产地的竞争者或食肉动物有害最近被发现了在里面的 microsporidia 侵略瓢虫 Harmonia axyridis 贡献它我们显示出的侵略成功在整个世界从多样的收集地点采购的所有H. axyridis 甲壳虫带这建议的丰富的 microsporidia 本国、侵略的H. axyridis 人口与这些被联系,这容忍了寄生虫,它是可能的在扩大前在本国的人口存在而非在最新开拓殖民地于的区域被获得我们在H. axyridis 的不同发展阶段期间描述 microsporidia 的致病,我们探讨它由竞争本国的瓢虫种类的感染的鸡蛋和幼虫的 predation 可以导致的可能性他们的感染并且最终到他们的衰落最后,我们讨论我们的起始的假设:被一只侵略向量昆虫容忍的 microsporidia 能对易受影响的本国的竞争者或食肉动物种类是活跃的。 | Andreas Vilcinskas Henrike Schmidtberg Arnaud Estoup Ashraf Tayeh Benoit Facon Heiko Vogel | 2015 | Insect Science2015，22，3： | 4 |
| 15 | Global variance reduction method for global Monte Carlo particle transport simulations of CFETR显示文摘It can be difficult to calculate some under-sampled regions in global Monte Carlo radiation transport calculations. The global variance reduction(GVR) method is a useful solution to the problem of variance reduction everywhere in a phase space. In this research, a GVR procedure was developed and applied to the Chinese Fusion Engineering Testing Reactor(CFETR). A cylindrical CFETR model was utilized for comparing various implementations of the GVR method to find the optimum.It was found that the flux-based GVR method could ensure more reliable statistical results, achieving an efficiency being 7.43 times that of the analog case. A mesh tally of the scalar neutron flux was chosen for the GVR method to simulate global neutron transport in the CFETR model.Particles distributed uniformly in the system were sampled adequately through ten iterations of GVR weight window.All voxels were scored, and the average relative error was 2.4% in the ultimate step of the GVR iteration. | Xing-Chen Nie Jia Li Song-Lin Liu Xiao-Kang Zhang Ping-Hui Zhao Min-You Ye German Vogel Xiao Yang Qing-Jun Zhu | 2017 | Nuclear Science and Techniques2017，28，8： | 4 |
| 16 | Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma: Detection by oligonucleotide microarray and real-time PCR analysis显示文摘AIM: To investigate the molecular pathways involved in human cholangiocarcinogenesis by gene expression profiling. METHODS: Oligonucleotide arrays (Affymetrix U133A) were used to establish a specific gene expression profile of intrahepatic CCC in comparison to corresponding non- malignant liver tissue. To validate the expression values of the most overexpressed genes, RT-PCR experiments were performed. RESULTS: Five hundred and fifty-two statistically differentially expressed genes/ESTs (221 probes significantly up-regulated, 331 probes down-regulated; P < 0.05; fold change > 2; ≥ 70%) were identified. Using these data and two-dimensional cluster analysis,a specific gene expression profile was obtained allowing fast and reproducible differentiation of CCC, which was confirmed by supervised neuronal network modelling. The most consistently overexpressed gene (median fold change 33.5, significantly overexpressed in 100%) encoded osteopontin. Furthermore, an association of various genes with the histopathological grading could be demonstrated. CONCLUSION: A highly specific gene expression profile for intrahepatic CCC was identified, allowing for its fast and reproducible discrimination against non- malignant liver tissue and other liver masses. The most overexpressed gene in intrahepatic CCC was the gene encoding osteopontin. These data may lead to a better understanding of human cholangiocarcinogenesis. | Holger G Hass Oliver Nehls Juergen Jobst Andrea Frilling Ulrich Vogel Stephan Kaiser | 2008 | World Journal of Gastroenterology2008，14，16： | 4 |
| 17 | Exploring the utility of three nuclear regions to reconstruct reticulate evolution in the fern genus Asplenium显示文摘三个原子区域原子 ribosomal 内部抄录分隔符(nrITS ) 和二原子低拷贝的 genesgapCp 的 intron 区域,和 pgiC,在有一个叶绿体染色体的联合,区域被采用在蕨纲植物类 Asplenium 探索 reticulate 进化的模式。这是用在蕨纲植物的多重原子标记的 DNA 序列的第一研究中的一个。与 PCR 和几个拷贝放大很好的所有三个原子标记被克隆 PCR 产品恢复。所有三个原子区域由作为双 A 的混血儿恢复 neo-allotetraploid Asplenium adulterinum 显示出适合的结果。trichomanes 和双 A。viride。冲突结果为几个节点被获得。首先, gapCp 没在 A 之间区别。aethiopicum 和 A。praegracile 而另外的标记作为不同恢复了这二 taxa。在基因树之中的冲突在尊重被发现到 A。monanthes,叶绿体和 pgiC 建议了 A 的一种姐妹关系。monanthes 和 A。trichomanes 但是 gapCp 和 nrITS 嵌套 A。在 A 以内的 monanthes。normale。我们的结果证实:(i) 几个原子区域,特别地 gapCp 和 pgiC 的实用性,解开在蕨纲植物的 reticulate 进化和种类区别并且(ii ) 加亮需要采用超过一个原子区域在排序的 reticulate 事件对不完全的系上获得可靠假设。特别,如果一个人假设网状事件可能发生在更远的过去。就在蕨纲植物的 reticulate 进化的期望的高频率而言,柔韧、增进知识的原子 genomic 标记的建立是批评的在我们阐明的努力获得进一步的进步蕨纲植物进化。 | Harald SCHNEIDER Adriana NAVARRO-GOMEZ Stephen J. RUSSELL Stephen ANSELL Michal GRUNDMANN Johannes VOGEL | 2013 | Journal of Systematics and Evolution2013，51，2： | 4 |
| 18 | Polymorphisms in NF-κB,PXR,LXR,PPARγ and risk of inflammatory bowel disease显示文摘AIM:To investigate the contribution of polymorphisms in nuclear receptors to risk of inflammatory bowel disease(IBD) . METHODS:Genotypes of nuclear factor(NF) -κB(NFKB1) NFκB-94ins/del(rs28362491) ;peroxisome proliferatoractivated receptor(PPAR) -γ(PPARγ) PPARγPro12Ala(rs1801282) and C1431T(rs 3856806) ;pregnane X receptor(PXR) (NR1I2) PXR A-24381C(rs1523127) ,C8055T(2276707) ,and A7635G(rs 6785049) ;and liver X receptor(LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients,495 ulcerative colitis(UC) patients,and 779 healthy controls.Odds ratio(OR) and 95%CI were estimated by logistic regression models. RESULTS:The PXR A7635G variant,the PPARγPro12Ala and LXR T-rs2695121-C homozygous variant genotypes were associated with risk of UC(OR:1.31,95% CI:1.03-1.66,P=0.03,OR:2.30,95%CI:1.04-5.08,P=0.04,and OR:1.41,95%CI:1.00-1.98,P=0.05,respectively) compared to the corresponding homozygous wild-type genotypes.Among never smokers,PXR A7635G and the LXR T-rs1405655-C and T-rs2695121-C variant genotypes were associated with risk of IBD(OR:1.41,95%CI:1.05-1.91,P=0.02,OR:1.63,95%CI:1.21-2.20,P=0.001,and OR:2.02,95%CI:1.36-2.99,P=0.0005,respectively) compared to the respective homozygous variant genotypes.PXR A7635G(rs6785049) variant genotype was associated with a higher risk of UC diagnosis before the age of 40 years and with a higher risk of extensive disease(OR:1.34,95%CI:1.03-1.75 and OR:2.49,95%CI:1.24-5.03,respectively) . CONCLUSION:Common PXR and LXR polymorphisms may contribute to risk of IBD,especially among never smokers. | Vibeke Andersen Jane Christensen Anja Ernst Bent A Jacobsen Anne Tjφnneland Henrik B Krarup Ulla Vogel | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 19 | Multilocus Phylogeny of Lycodon and the Taxonomic Revision of Oligodon multizonatum显示文摘Classification of the Asian snake genera Lycodon and Oligodon has proven challenging. We conducted a molecular phylogenetic analysis to estimate the phylogenetic relationships in the genus of Lycodon and clarify the taxonomic status of Oligodon multizonatum using mitochondrial(cyt b, ND4) and nuclear(c-mos) genes. Phylogenetic trees estimated using Maximum Likelihood and Bayesian Inference indicated that O. multizonatum is actually a species of Lycodon. Comparing morphological data from O. multizonatum and its closest relatives also supported this conclusion. Our results imply that a thorough review of the evolutionary relationships in the genus of Lycodon is strong suggested. | Juan LEI Xiaoyu SUN Ke JIANG Gernot VOGEL David T.BOOTH Li DING | 2014 | Asian Herpetological Research2014，5，1： | 3 |
| 20 | 吐鲁番阿斯塔那古墓群三六一号墓葬出土皮鞋保护修复报告显示文摘2015年3月,在皮制品修复保护专家Regine Vogel教授的全程指导下,以陈展与保护为主要目标,首次圆满完成了阿斯塔那古墓群出土的66TAM361∶6皮制品的修复保护工作。修复过程中,通过扫描电镜检测分析,鉴别出本次修复的皮革为山羊皮;与同种款式的文物比较分析,推断本件文物可能为唐时遗物。 | 陈玉珍 徐东良 赵阳 玛尔亚木.依不拉音木 李媛 王丽梅 Regine Vogel 魏骏骁 邓永红 古丽努尔.汉木都 | 2015 | 吐鲁番学研究2015，，1： | 3 |
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