|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Noncoherent sequential acquisition of PN sequence for DS/SS communications with/without dhannel fading显示文摘 | TANTARTANS S LAN A W VINCENT P J | 1995 | IEEE Trans on COM1995，43，2： | 2 |
| 3 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 4 | Analysis of sliding behaviour for fretting loading: determination of transition criteria 显示文摘 | Fouvry S Kapsa P Vincent L | 1995 | Wear1995，185，12： | 2 |
| 5 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 6 | Laser in situ keratomileusis for myopia and astigmatism: safety and efficacy显示文摘 | Alan Sugar Christopher J Rapuano William W Culbertson David Huang Gary A Varley Peter J Agapitos Vincent P de Luise Douglas D Koch | 2002 | Ophthalmology2002，，1： | 2 |
| 7 | Preparation and Swelling Properties of Poly ( NIPAM ) Minigel Particles Prepared by Inverse Suspension Polymerization 显示文摘 | Dowding P J Vincent B Williams E | 2000 | J Colloid and Interface Sei2000，221，26： | 1 |
| 8 | Photodynamic action of red light for treatment of erythrasma: preliminary Results显示文摘 | Darras-Vercambre S Carpentier O Vincent P | 2006 | Photodermatol Photoimmunol Photomed2006，22，3： | 1 |
| 9 | Dendritic cells harbor infectious porcine circovirus type 2 in the absence of apparent cell modulation or replication of the virus显示文摘 | Vincent I E Carrasco C P Herrmann B | 2003 | J Virol2003，77，13： | 1 |
| 10 | Watersheds in digital spaces: an efficient algorithm based on immersion simulations 显示文摘 | VINCENT L SOILLE P | 1991 | IEEE Transactions on Pattern Analysis and Machine Intelligence1991，13，6： | 1 |
| 11 | Activation of the alpha-secretase processing of AbetaPP as a therapeutic approach in Alzheimer's disease显示文摘 | Vincent B Govitrapong P | 2011 | J Alzheimers Dis2011，24，2： | 1 |
| 12 | The me-chanical design of nacre显示文摘 | Jackson A P Vincent J F V Turner R M | | 0，，： | 1 |
| 13 | Optimization of Resilient Wheels for Rolling Noise Control 显示文摘 | BOUVET P VINCENT N COBLENTZ A | 2000 | Journal of Sound and Vibration2000，231，3： | 1 |
| 14 | Neuropathic pain depends upon d - serine co - activation of spinal NMDA eceptors in rats显示文摘 | Lefevre Y Amadio A Vincent P | 2015 | Neurosci Lett2015，603，： | 1 |
| 15 | Stacked Denoising Autoencoders:Learning Useful Representations in a Deep Network with a Local Denoising Criterion显示文摘 | Vincent P Larochelle H Lajoie I | 2010 | Journal of Machine Learning Research2010，11，6： | 1 |
| 16 | Composite hopanoid biosynthesis in Zymomonas mobilis: N-acetyl-D-glucosamine as precursor for the cyclopentane ring linked to bacteriohopanetetrol 显示文摘 | Vincent S P Sinay P RohmerM | 2003 | Chemical Communications2003，6，： | 1 |
| 17 | Immunisation with a combination of two complementary feline calicivirus strains induces a broad cross-protection against heterologous challenges 显示文摘 | Herve P Sylvie B Vincent L | 2005 | Vet Microbiol2005，106，： | 1 |
| 18 | Anti-aquaporin-4 auto-antibodies orchestrate the pathogenesis in neuromyelitis optica显示文摘 | Saikali P Cayrol R Vincent T | 2009 | Autoimmun Rev2009，92，2： | 1 |
| 19 | Watersheds in digital spaces: An efficient algorithm based on immersion simulations显示文摘 | L Vincent P Soille | 1991 | IEEE Trans PAMI1991，13，6： | 1 |
| 20 | Iterative (Turbo) Soft Interference Cancollation and Decoding for Coded CDMA 显示文摘 | Wang Xiaodong Vincent P V | 1999 | IEEE Trans Commu1999，47，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员