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| 1 | Placental accommodations for transport and metabolism during intra-uterine crowding in pigs显示文摘Litter size and birth weights are limited by uterine capacity, defined as the ability of the uterus to maintain the appropriate development of some number of conceptuses. Uterine capacity is the result of the combined effects of uterine, placental and embryo/fetal function. The number of living conceptuses that the uterus is capable of supporting is greater during early gestation compared to later gestation. Plots of log fetal weight versus log placental weight also indicate that fetal weights are less sensitive to reduced placental weight(and therefore reduced intrauterine space) in early gestation compared to late gestation. However, even in late gestation,mechanisms still exist that maintain fetal growth when the size of the placenta is reduced. One such mechanism is likely to be improved development of the folded placental-epithelial/maternal-epithelial bilayer. Fold depth, and therefore the maternal fetal interactive surface, increases as gestation advances and is greater in placenta from small fetuses. On the fetal side of the placenta, the epithelial bilayer is embedded in stromal tissue. Glycosaminoglycans are major components of stroma, including hyaluronan and heparan sulfate. Hyaluronidases and heparanases are present within placental tissues, and likely play roles in modification of stromal components to facilitate fold development. Glycosaminoglycans are polymers of forms of glucose(glucosamine, glucuronic acid, iduronic acid)suggesting that glycosaminoglycan synthesis may compete with the glucose needs of the developing fetus.Pig conceptuses are fructogenic, such that a substantial portion of glucose transferred from mother to fetus is converted to fructose. Fructose is an intermediate product in the synthesis of glucosamine from glucose, and glucosamine is linked to regulation of trophoblast cell proliferation through regulation of m TOR. These findings suggest a link between glucose, fructose, glucosamine synthesis, GAG production, and placental morphogenesis,but the details of these interactions remain unclear. In addition, recent placental epithelial transcriptome analysis identified several glucose, amino acid, lipid, vitamin, mineral and hormone transporter mechanisms within the placenta. Further elucidation of mechanisms of placental morphogenesis and solute transport could provide clues to improving nutrient transport to the pig fetus, potentially increasing litter size and piglet birth weights. | Jeffrey L Vallet Anthony K Mc Neel Jeremy R Miles Bradley A Freking | 2015 | Journal of Animal Science and Biotechnology2015，6，2： | 5 |
| 2 | Postconditioning in focal cerebral ischemia: Role of the mitochondrial ATP-dependent potassium channel显示文摘 | Emmanuel Robin Malika Simerabet Sidi Mohammed Hassoun Sebastien Adamczyk Benoit Tavernier Benoit Vallet Régis Bordet Gilles Lebuffe | 2010 | Brain Research2010，，： | 2 |
| 3 | Hydroxyapatite, tricalcium phosophate and biphasic matericals prepared by a liquid mix tech-nique 显示文摘 | PENA J VALLET R M | 2003 | Journal of the European Ceramic Society2003，，23： | 1 |
| 4 | The effect of breed and intrauterine crow-ding on fetal erythropoiesis on day35of gestation in swine显示文摘 | VALLET J L KLEMCKE H G CHRISTENSON R K | 2003 | J Anim Sci2003，81，9： | 1 |
| 5 | Uterine function in Meishan pigs显示文摘 | CHRISTENSON R K VALLET J L LEYMASTER K A | 1993 | J Reprod Fertil1993，，： | 1 |
| 6 | The effect of breed and intrauterine crowding on fetal erythropoiesis on day 35 of gestation in swine 显示文摘 | Vallet J L Klemcke H G Christenson R K | 2003 | J Anita Sei2003，81，： | 1 |
| 7 | Interleaver de- sign for serial concatenated convol-utional cedes 显示文摘 | JUNGPIL Y BOUCHERET M VALLET R | 2004 | IEEE Com- munications Letters2004，8，8： | 1 |
| 8 | Beneficial effect of glycoprotein IIb/IIIa inhibitor (AZ-1) on endothelium in Escherichia coli endotoxin-induced shock显示文摘 | Qian Pu Eric Wiel Delphine Corseaux Régis Bordet Michael A. Azrin Michael D. Ezekowitz Niels Lund Brigitte Jude Beno?t Vallet | 2001 | Critical Care Medicine2001，，6： | 1 |
| 9 | Effect of progesterone, mifepristone and estrogen treatment durtin early pregnancy on conceptus development and uterine capacity in swine 显示文摘 | VALLET J L CHRISTENSON R K | 2004 | B iol Reprod2004，70，98： | 1 |
| 10 | 显示文摘 | del Real R Wolke J Vallet - Regi M | 2002 | Biomaterials2002，23，： | 1 |
| 11 | The effect of breed and intrauterine crowding on fetal erythropoiesis on day 35 of gestation in swine 显示文摘 | Vallet J L Klemcke H G Christenson R K | 2003 | J AnimSci2003，81，： | 1 |
| 12 | Fraction spaced multi-carrier modulation显示文摘 | Vallet R Taieb K H | 1995 | Wireless Personal Commun1995，2，： | 1 |
| 13 | Dobutamine improves gastrointestinal mucosal blood flow in a porcine model of endotoxin shock显示文摘 | Neviere R Chagnon J L Vallet B | 1997 | Crit Care Med1997，25，： | 1 |
| 14 | A radioimmunoassay for porcine intrauterine folate binding protein 显示文摘 | Vallet J L Christenson R K Klemcke H G | 1999 | Journal of Animal Science1999，77，： | 1 |
| 15 | A new method to produce macrospores in calcium phosphate cements显示文摘 | DEL REAL R P WOLKE J G C VALLET R M | 2002 | Biomaterials2002，23，： | 1 |
| 16 | Fraction spaced multi-carrier modulation 显示文摘 | Vallet R Taieb K H | 1995 | Wirwlwess Personal Communications1995，，2： | 1 |
| 17 | Purification and characterization of intrauterine folate-binding proteins from swine显示文摘 | Vallet J L Christenson R K Klemcke H G | 1998 | Biol Reprod1998，59，： | 1 |
| 18 | In vitro bioactivity of sili- con-substituted hydroxyapatites 显示文摘 | BALAS F PEREZ P J VALLET R M | 2003 | J Biomed Mater Res2003，67，36： | 1 |
| 19 | Conceptus, progesterone, and breed effects on uterine protein secretion in swine显示文摘 | Vallet J L Christenson R K Trout W E | 1998 | J Anim Sci1998，76，： | 1 |
| 20 | Silicon incorporation in hydroxyapatite obtained by controlled crystallization 显示文摘 | ARCOS D RODRIGUEZ C J VALLET R M | 2004 | Chem Mater2004，16，6： | 1 |
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