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| 1 | Clinical outcome and predictors of survival after TIPS insertion in patients with liver cirrhosis显示文摘AIM:To determine the clinical outcome and predictors of survival after transjugular intrahepatic portosystemic stent shunt (TIPS) implantation in cirrhotic patients. METHODS:Eighty-one patients with liver cirrhosis and consequential portal hypertension had TIPS implantation (bare metal) for either refractory ascites (RA) (n= 27) or variceal bleeding (VB) (n = 54). Endpoints for the study were:technical success, stent occlusion and stent stenosis, rebleeding, RA and mortality. Clinical records of patients were collected and analysed. Baseline characteristics [e.g., age, sex, CHILD score and the model for end-stage liver disease score (MELD score), underlying disease] were retrieved. The Kaplan-Meier method was employed to calculate survival from the time of TIPS implantation and comparisons were made by log rank test. A multivariate analysis of factors influencing survival was carried out using the Cox proportional hazards regression model. Results were expressed as medians and ranges. Comparisons between groups were performed by using the Mann-Whitney Utest and the χ 2 test as appropriate. RESULTS:No difference could be seen in terms of age, sex, underlying disease or degree of portal pressure gradient (PPG) reduction between the ascites and the bleeding group. The PPG significantly decreased from 23.4 ± 5.3 mmHg (VB) vs 22.1 ± 5.5 mmHg (RA) before TIPS to 11.8 ± 4.0 vs 11.7 ± 4.2 after TIPS implantation (P = 0.001 within each group). There was a tendency towards more patients with stage CHILD A in the bleeding group compared to the ascites group (24 vs 6, P = 0.052). The median survival for the ascites group was 29 mo compared to > 60 mo for the bleeding group (P = 0.009). The number of radiological controls for stent patency was 6.3 for bleeders and 3.8 for ascites patients (P = 0.029). Kaplan-Meier calculation indicated that stent occlusion at first control (P = 0.027), ascites prior to TIPS implantation (P = 0.009), CHILD stage (P = 0.013), MELD score (P = 0.001) and those patients not having undergone liver transplantation (P = 0.024) were significant predictors of survival. In the Cox regression model, stent occlusion (P = 0.022), RA (P = 0.043), CHILD stage (P = 0.015) and MELD score (P = 0.004) turned out to be independent prognostic factors of survival. The anticoagulation management (P = 0.097), the porto-systemic pressure gradient (P= 0.460) and rebleeding episodes (P = 0.765) had no significant effect on the overall survival. CONCLUSION:RA, stent occlusion, initial CHILD stage and MELD score are independent predictors of survival in patients with TIPS, speaking for a close follow-up in these circumstances. | Hauke S Heinzow Philipp Lenz Michael Khler Frank Reinecke Hansjrg Ullerich Wolfram Domschke Dirk Domagk Tobias Meister | 2012 | World Journal of Gastroenterology2012，18，37： | 17 |
| 2 | Prospective observational multicenter study to define a diagnostic algorithm for biliary candidiasis显示文摘AIM:To develop an algorithm to improve the diagnosis and treatment of patients with biliary candidiasis.METHODS:We performed a prospective study of 127patients who underwent endoscopic retrograde cholangiopancreatography,for various biliary disorders,at 3 tertiary referral centers in Germany from July 2011through July 2012(ClinicalTrials.gov:NCT01109550).Bile,buccal,and stool samples were collected.When indicated,endoscopic transpapillary bile duct biopsies were performed to clarify the etiology of bile duct strictures and to prove invasive fungal infections.RESULTS:Candida species were detected in 38 of the 127 bile samples(29.9%).By multivariate analysis patients’age and previous endoscopic sphincterotomy were independent risk factors for biliary candidiasis(P<0.05).Patients with immunosuppression(P=0.058)and recent long-term antibiotic therapy(>7 d)(P=0.089)tend to be at risk for biliary candidiasis.One patient was negative in mycological culture of bile fluid but invasive biliary candidiasis was diagnosed histologically.Of Candida subspecies detected,36.7%were azole-resistant,such as C glabrata.Eight patients received anti-mycotic therapy,based on our algorithm.Of these,3 had cancer with biliary tract involvement,2had secondary sclerosing cholangitis,1 had retroperitoneal fibrosis,and 5 had septicemia.In all patients contamination was ruled out by smears of the endoscope channel.CONCLUSION:Gastroenterologists should be aware of frequent candida colonization in patients with cholangitis and biliary disorders.Our suggested algorithm facilitates the further clinical management. | Philipp Lenz Franziska Eckelskemper Thomas Erichsen Tim Lankisch Alexander Dechêne Gabriele Lubritz Frank Lenze Torsten Beyna Hansjorg Ullerich Andre Schmedt Dirk Domagk | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 3 | Single- vs. double-balloon enteroscopy in small-bowel diagnostics: a randomized multicenter trial显示文摘 | D. Domagk P. Mensink H. Aktas P. Lenz T. Meister A. Luegering H. Ullerich L. Aabakken A. Heinecke W. Domschke E. Kuipers M. Bretthauer | 2011 | Endoscopy2011，，06： | 1 |
| 4 | Theory and measurement of hydrate dissociation 显示文摘 | Ullerich J W Selim M S Sloan E D | 1987 | AIChE J1987，33，5： | 1 |
| 5 | Theory during the dissociation of hydrate dissociation 显示文摘 | Ullerich J W Sehm M S Sloan E D | 1987 | AIChE J1987，33，5： | 1 |
| 6 | Systemic granulomatous disease after intravesical BCG instillation显示文摘 | Mooren FC Lerch MM Ullerich H | 2000 | BMJ2000，320，7229： | 1 |
| 7 | MARS (molecular adsorbent recycling system)as a novel hepatic detoxfication procedure until orthotopic liver transplantation显示文摘 | Ullerich H Avenhaus W Menzel J | | 0，，： | 1 |
| 8 | Theory and Measurement of Hydrate Dissociation显示文摘 | Selim M S Sloan E D | 1987 | AIChE1987，33，： | 1 |
| 9 | Idetification' of the genetic sex chromosomes in the monogenic blowfly Chrysomya rufifacies (Calliphoridae, Diptera) 显示文摘 | Ullerich F H | 1975 | Chromosoma1975，50，： | 1 |
| 10 | Damage to the esophagus after atrial fibrillation ablation: Just the tip of the iceberg? High prevalence of mediastinal changes diagnosed by endosonography 显示文摘 | Zellerhoff S Ullerich H Lenze F | 2010 | Circ Arrhythm Electrophysiol2010，3，2： | 1 |
| 11 | Theory and measurement of hydrate dissociation显示文摘 | Ullerich J W Selim M S Sloan E D | 1987 | AIChE1987，33，： | 1 |
| 12 | Theory and measurement of hydrate dissociation 显示文摘 | Ullerich J W Selim M S Sloan E D | 1987 | AIChE Journal1987，33，： | 1 |
| 13 | Ileal gallstone obstruction:Single-balloon enteroscopic removal显示文摘Gallstone-induced ileus is a rare complication of cholelithiasis.Since localization of gallstones impacted in the small bowel,especially in the ileum,prevents access by conventional endoscopy in most cases,the mainstay of treatment remains surgical.Recent invention of double-and single-balloon enteroscopy has added much to the ability of imaging the small bowel and enables endoscopically directed therapy.Herein,for the first time,we report a successful endoscopic calculus removal via peroral single-balloon enteroscopy in an 81-year-old woman suffering from gallstone ileus of the ileum. | Hauke Sebastian Heinzow Tobias Meister Johannes Wessling Wolfram Domschke Hansjoerg Ullerich | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，9： | 1 |
| 14 | Digital single-operator video cholangioscopy improves endoscopic management in patients with primary sclerosing cholangitis-a retrospective observational study显示文摘BACKGROUND Patients with primary sclerosing cholangitis(PSC)are at a high risk of developing cholestatic liver disease and biliary cancer,and endoscopy is crucial for the complex management of these patients.AIM To clarify the utility of recently introduced digital single-operator video cholangioscopy(SOVC)for the endoscopic management of PSC patients.METHODS In this observational study,all patients with a history of PSC and in whom digital SOVC(using the SpyGlass DS System)was performed between 2015 and 2019 were included and retrospectively analysed.Examinations were performed at a tertiary referral centre in Germany.In total,46 SOVCs performed in 38 patients with a history of PSC were identified.The primary endpoint was the evaluation of dominant biliary strictures using digital SOVC,and the secondary endpoints were the performance of selective guidewire passage across biliary strictures and the diagnosis and treatment of biliary stone disease in PSC patients.RESULTS The 22 of 38 patients had a dominant biliary stricture(57.9%).In 4 of these 22 patients,a cholangiocellular carcinoma was diagnosed within the stricture(18.2%).Diagnostic evaluation of dominant biliary strictures using optical signs showed a sensitivity of 75%and a specificity of 94.4%to detect malignant strictures,whereas SOVC-guided biopsies to gain tissue for histopathological analysis showed a sensitivity of 50%and a specificity of 100%.In 13%of examinations,SOVC was helpful for guidewire passage across biliary strictures that could not be passed by conventional methods(technical success rate 100%).Biliary stone disease was observed in 17.4%of examinations;of these,in 37.5%of examinations,biliary stones could only be visualized by SOVC and not by standard fluoroscopy.Biliary stone treatment was successful in all cases(100%);25%required SOVC-assisted electrohydraulic lithotripsy.Complications,such as postinterventional cholangitis and pancreatitis,occurred in 13%of examinations;however,no procedure-associated mortality occurred.CONCLUSION Digital SOVC is effective and safe for the endoscopic management of PSC patients and may be regularly considered an additive tool for the complex endoscopic management of these patients. | Arne Bokemeyer Frank Lenze Viorelia Stoica Timur Selcuk Sensoy Iyad Kabar Hartmut Schmidt Hansjoerg Ullerich | 2022 | World Journal of Gastroenterology2022，28，20： | 1 |
| 15 | Endocuff-assisted colonoscopy: a new accessory to improve adenoma detection rate? Technical aspects and first clinical experiences显示文摘 | Frank Lenze Torsten Beyna Philipp Lenz Hauke Heinzow Karin Hengst Hansjoerg Ullerich | 2014 | Endoscopy2014，，： | 1 |
| 16 | Department of Chemical Engineering and Petroleum Refining Colorado School of Mines 显示文摘 | Ullerich J W Selim M S Sloan E D | 1987 | AIChE Journal1987，，33： | 1 |
| 17 | Theory and measurement of hydrate dissociation显示文摘 | Ullerich J W Selim M S Sloan E D | 1987 | AICHE J1987，33，： | 1 |
| 18 | Carbon dioxide insufflation improves intubation depth in double-balloon enteroscopy: a randomized, controlled, double-blind trial显示文摘 | D. Domagk M. Bretthauer P. Lenz L. Aabakken H. Ullerich C. Maaser W. Domschke T. Kucharzik | 2007 | Endoscopy2007，，12： | 1 |
| 19 | Single- vs. double-balloon enteroscopy in small-bowel diagnostics: a randomized multicenter trial显示文摘 | D. Domagk P. Mensink H. Aktas P. Lenz T. Meister A. Luegering H. Ullerich L. Aabakken A. Heinecke W. Domschke E. Kuipers M. Bretthauer | 2011 | Endoscopy2011，，06： | 1 |
| 20 | Theory and measurement of hydrate dissociation 显示文摘 | ULLERICH J W SELIM M S SLOAN E D | 1987 | AIChE J1987，33，5： | 1 |
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