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| 1 | Role of angiogenesis and angiogenic factors in acute and chronic wound healing显示文摘Angiogenesis plays a crucial role in wound healing by forming new blood vessels from preexisting vessels by invading the wound clot and organizing into a microvascular network throughout the granulation tissue.This dynamic process is highly regulated by signals from both serum and the surrounding extracellular matrix environment.Vascular endothelial growth factor,angiopoietin,fibroblast growth factor and transforming growth factor-beta are among the potent angiogenic cytokines in wound angiogenesis.Specific endothelial cell ECM receptors are critical for morphogenetic changes in blood vessels during wound repair.In particular integrin(αvβ3)receptors for fibrin and fibronectin,appear to be required for wound angiogenesis:αvβ3 is focally expressed at the tips of angiogenic capillary sprouts invading the wound clot,and any functional inhibitors ofαvβ3 such as monoclonal antibodies,cyclic RGD peptide antagonists,and peptidomimetics rapidly inhibit granulation tissue formation.In spite of clear knowledge about influence of many angiogenic factors on wound healing,little progress has been made in defining the source of these factors,the regulatory events involved in wound angiogenesis and in the clinical use of angiogenic stimulants to promote repair. | Thittamaranahalli Muguregowda Honnegowda Pramod Kumar Echalasara Govindarama Padmanabha Udupa Sudesh Kumar Udaya Kumar Pragna Rao | 2015 | Plastic and Aesthetic Research2015，2，1： | 3 |
| 2 | Potential of biochar and organic amendments for reclamation of coastal acidic-salt affected soil显示文摘Salinity and acidity have affected several hundred million hectares of land throughout the globe which poses a major threat to global food security and biodiversity.Application of organic amendments for salt-affected soils has been identified as one of the most effective ways to mitigate salinity-induced problems and considered as a green technique offering twin benefits of waste load reduction and land reclamation.However,studies on reclaiming acidic-salt affected soils are limited.Therefore,this study aimed to determine the reclamation potential of biochars and organic amendments involving Gliricidia sepium biochar produced at 300℃,500℃,and 700℃,green waste compost,and municipal sewage sludge at three different amend-ment ratios,1.0%,2.5%and 5.0%.The incubation experiment was conducted for a 4-month period with different amendment ratios applied to the coastal acidic-salt affected soil.Subsamples were extracted from incubation pots after 1 and 4 months and analyzed for soil chemical parameters(pH,EC,NO_(3)^(−),PO_(4)^(3−,total organic carbon,cation exchange capacity,sodium adsorption ratio,exchangeable sodium percentage)and microbial enzyme activity(catalase activity,and acid-and alkaline phosphatase activity).All organic amendments demonstrated enhancement of the soil properties in a significant manner.However,increasing incubation time and amendment ratio increase the changes of soil parameters by a great percentage.Therefore,the maximum amendment ratio of 5.0%and 4 months of incubation period rendered a significant improvement in the reclamation of acidic-salt affected soil.However,the biochar produced at 500℃ contributed the maximum towards the improved physicochemical and biochemical profile of acidic-salt affected soil,making it the most promising organic amend-ment for the reclamation of acidic-salt affected soil.The overall reclamation efficiency of organic amendments registered the following order of variation:700 BC | Viraj Gunarathne Athula Senadeera Udaya Gunarathne Jayanta Kumar Biswas Yaser A.Almaroai Meththika Vithanage | 2020 | Biochar2020，2，1： | 2 |
| 3 | CD133-Targeted Paclitaxel Delivery Inhibits Local Tumor Recurrence in a Mouse Model of Breast Cancer显示文摘 | Suresh Kumar Swaminathan Emilie Roger Udaya Toti Lin Niu John R. Ohlfest Jayanth Panyam | 2013 | Journal of Controlled Release2013，，： | 2 |
| 4 | UVA and UVB in sunlight:Optimal utilization of UV rays in sunlight for phototherapy 显示文摘 | Balasaraswathy P Udaya Kumar Srinivas C R | 2002 | Indian Journal of Dermatology Venereology and Leprology2002，68，4： | 1 |
| 5 | Detection of l'obacco mosaic virus and Tomato mosaic virus in pepper and tomato by multiplex RT-PCR显示文摘 | KUMAR S UDAYA SHANKAR AC NAYAKA SC | 2011 | Lett Appl Microbio12011，53，3： | 1 |
| 6 | Genetic variability in recovery growth and stress proteins in response to polyethylene glycol and salt stress in finger millet 显示文摘 | UMA S T PRASAD G UDAYA M KUMAR | 1995 | Annals of Botany1995，76，： | 1 |
| 7 | Learning curve in human laparoscopic surgery显示文摘 | Udaya Kumar MS FRCS (Urol) Inderbir S. Gill MD MCh | 2006 | Current Urology Reports2006，，2： | 1 |
| 8 | Mean platelet volume in Type 2 diabetes meliitus显示文摘 | Thomas Alex Kodiatte Udaya Kumar Manikyam Suraksha Bellur Rao | 2012 | J Lab Physicians2012，4，1： | 1 |
| 9 | Ureteroslopic Holmium laser lithotripsy in patients with renal impairment显示文摘 | AHMED SS NABILK BISSADA UDAYA KUMAR | 2008 | Int Urol Nephrol2008，40，： | 1 |
| 10 | Detection of tobacco mosaic virus and tomato mosaic virus in pepper and tomato by multiplex RT-PCR显示文摘 | Kumar S Udaya Shankar A C Nayaka S C Lund O S Prakash H S | 2011 | Letters in Applied Microbiology2011，53，3： | 1 |
| 11 | Virtual instrumentation with graphical programming for enhanced detection & amp; monitoring of partial discharges显示文摘 | Wahidabanu R S D Panneer Selvam M A Udaya Kumar K | 1997 | IEEE Piscataway NJ USA Rosemont IL USA1997，1997，： | 1 |
| 12 | A serendipitous discover显示文摘 | Arava Veera Reddyl Siripalli Udaya Bhaskara Rao Dubey Pramod Kumar Efficient cyclopropanation of active methylene compounds | 2005 | Tetrahedron Letters 20052005，，： | 1 |
| 13 | Failure Analysis o{ Internal Combustion Engine Valve by U- sing Ansys显示文摘 | Goli Udaya Kumar Venkata Ramesh Mamilla | 2014 | American International Journal of Re- search in Science Technology Engineering Mathe- matics2014，183，14： | 1 |
| 14 | Studies on characteristics of lightning generated currents in an interconnected lightning protection system显示文摘 | Vishwanath Hegde Udaya Kumar | 2009 | Journal of Electrostatics2009，67，4： | 1 |
| 15 | Histopathological study of chronic wounds modulated by intermittent negative pressure therapy under limited access dressing显示文摘Aim:Negative pressure wound therapy(NPWT)has achieved widespread success in the treatment of chronic wounds.However,its effects have been only partially explored,and investigations have generally concentrated on the wound-dressing interface;a detailed histopathological description of the evolution of wounds under NPWT is still lacking.The present study was performed to investigate the effect of a limited access dressing(LAD)which exerts intermittent NPWT in a moist environment on chronic wounds.Methods:A total of 140 patients were randomized into 2 groups:LAD group(n=64)and conventional dressing group(n=76).By histopathological analysis of the granulation tissue,the amount of inflammatory infiltrate,necrotic tissue,angiogenesis,and extracellular matrix(ECM)deposition was studied and compared to determine healing between the 2 groups.Results:After 10 days of treatment,histopathological analysis showed a significant decrease in necrotic tissue with LAD compared to the conventional dressing group(mean±standard error,11.5±0.48 vs.10.1±0.30,P=0.007),the number of inflammatory cells(12.6±0.60 vs.8.63±0.35,P=0.018),a significant increase in new blood vessels(12.8±0.58 vs.9.3±0.29,P=0.005)and ECM deposit(13.3±0.50 vs.9.6±0.24,P=0.001).Conclusion:LAD exerts its beneficial effects on chronic wound healing by decreasing the amount of necrotic tissue and inflammatory cells while increasing the amount of ECM deposition and angiogenesis. | Thittamaranahalli Muguregowda Honnegowda Pramod Kumar Rekha Singh Swarna Shivakumar Pragna Rao Hemanth K.Prasad Sudesh Kumar Udaya Kumar Echalasara Govindarama Padmanabha Udupa | 2015 | Plastic and Aesthetic Research2015，2，1： | 0 |
| 16 | Co-immunolocalization of Disc1 and Gas7 protein in adult mice brain显示文摘Objective: The aim of the present study was to check the potential interaction of two neurodevelopmental proteins, Disc1 and Gas7, in the adult mice brain. Methods: Twenty-four male Swiss albino mice were used for the study. The mice were 12 weeks old in the beginning of the experiment. Immunohistochemistry and co-immunofluorescence were performed on the coronal sections of mice brain and immunoblotting and co-immunoprecipitation were done on the whole brain lysate. Results: Data from immunohistochemistry and co-immunofluorescence indicate the occurrence and co-localization of Disc1 and Gas7 proteins in soma and projections of the brain cells. Immunostaining was observed in cerebral cortex, hypothalamus, midbrain, pons, medulla oblongata and CA3 of hippocampus of the brain. The data from Immunoblotting and co-immunoprecipitation validates the presence and interaction of Disc1 and Gas7 protein in whole brain lysate. Conclusion: Data indicates the potential interaction of Disc1 and Gas7 protein in adult brain. The study highlights the need for further research on Disc1-Gas7 protein interaction in brain development and neuro-disorders. | Udaya Kumar | 2022 | Brain Science Advances2022，8，1： | 0 |
| 17 | Elegant procedure to estimate series capacitance of a uniform transformer winding from its measured FRA:implementable on existing FRA instruments显示文摘A simple procedure to estimate series capacitance of a uniform transformer winding from its measured frequency response analysis(FRA)and shunt capacitance is presented.Unlike previously published approaches,this method does not involve any cumbersome and time-consuming curve-fitting nor running optimisation/search algorithms,and neither does it require data of winding geometry.The procedure relies on a property that is observable in the impedance function of a lossless winding,viz.,the ratio of the product of squares of open circuit natural frequencies to the product of squares of short circuit natural frequencies bears a special relation to impedance function coefficients.Its feasibility was initially verified by simulation,and then by experiments on small-sized continuous-disk and interleaved-disc windings,followed by a large-sized 33 kV,3.5 MVA continuous-disc winding,and finally on a 315 kVA 11/13.8 kV transformer.After measuring FRA,the process involves just finding roots of a polynomial,from which the initial impulse voltage distribution constant and series capacitance can directly be determined.Given these attractive features,authors believe that this method is implementable on existing FRA instruments,so that,along with routinely measured FRA,these two important constants of a winding can be displayed. | Ashiq Muhammed Lakshminarayana Satish Udaya Kumar | 2020 | High Voltage2020，5，4： | 0 |
| 18 | High amplitude high frequency oscillations during posttraumatic epileptogenesis显示文摘Background: The aim of the present study was to investigate if high amplitude high frequency oscillations(haHFOs) could be a biomarker of posttraumatic epileptogenesis. Methods: After an initial craniotomy of rats and inducement of traumatic brain injury(TBI) through a fluid percussion, recording microelectrodes were implanted bilaterally in different brain areas.Wideband brain electrical activity was recorded intermittently from Day 1 of TBI and continued till week 21. HaHFO analysis was performed during the first 4 weeks to investigate whether the occurrence of this brain activity predicted development of epilepsy or not. Results: Of the 21 rats which received the TBI, 9 became epileptic(E+) and 12 did not(E-). HaH FOs were observed in the prefrontal and perilesional cortices, hippocampus, and striatum in both E+ and E-group. In comparison to the rats in E-, the E+ group showed a significant increase in the rate of haHFO from weeks 1 to 4 after TBI.Conclusion: The results indicate that an increase in the rate of haHFOs after TBI could be an electroencephalographic biomarker of posttraumatic epileptogenesis. | Jagannathan Rangarajan Udaya Kumar | 2023 | Brain Science Advances2023，9，4： | 0 |
| 19 | 中老年尿毒症患者肾移植术前后左室结构和功能的对比分析显示文摘目的分析20例中老年尿毒症患者肾移植前、后左室结构和功能的改变。方法二维、M型及多普勒超声心动图测量20例正常人、20例中老年尿毒症患者肾移植前、肾成功移植后1个月及三个月以后的左室结构及功能。结果病例组肾移植后一个月扩张的左房内径、左室舒末径均较术前减小,增厚的左室壁厚度开始变薄,三个月后增厚的左室壁厚度、收缩功能及舒张功能较移植术前明显改善(P<0.01),左房内径及左室壁厚度仍高于对照组(P<0.05),左室舒末径与正常无差异。结论中老年尿毒症患者在成功进行肾移植术后,左室的结构及功能逐渐得以改善,术后3个月变化明显。 | 陈丽萍 | 2009 | 中国老年学杂志2009，29，18： | 0 |
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