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| 1 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 2 | Does physical therapy and rehabilitation improve outcomes for diabetic foot ulcers?显示文摘One of the most common and serious complications of diabetes mellitus is ulceration of the foot. Among persons with diabetes, 12%-25% will present to a healthcare institution for a foot disorder during their lifespan. Despite currently available medical and surgical treatments, these are still the most common diabetes-related cause of hospitalization and of lower extremity amputations. Thus, many adjunctive and complementary treatments have been developed in an attempt to improve outcomes. We herein review the available literature on the effectiveness of several treatments, including superficial and deep heaters, electro-therapy procedures, prophylactic methods, exercise and shoe modifications, on diabetic foot wounds. Overall, although physical therapy modalities seem to be useful in the treatment of diabetic foot wounds, further randomized clinical studies are required. | Yasemin Turan Bulent M Ertugrul Benjamin A Lipsky Kevser Bayraktar | 2015 | World Journal of Experimental Medicine2015，5，2： | 7 |
| 3 | 老年男性勃起功能及迟发性性腺功能减退症状与下尿路症状严重性的关系显示文摘本文旨在研究土耳其爱琴海地区的老年男性下尿路症状(LUTSs)、勃起功能障碍(ED)和有症状的迟发性性腺功能减退症(SLOH)三者间的关系。符合以下标准的500名男性患者被纳入该研究:40周岁以上;过去6个月内有稳定的性关系;在六个泌尿外科诊所之一进行过就诊登记。每位患者均行血清PSA、睾酮水平及尿流率的检测,并填写国际前列腺症状评分和生活质量评分(IPSS-QoL)量表、国际勃起功能指数(IIEF)问卷和老年男性症状(AMS)量表。在所有的研究对象中,23.9%的患者有轻度LUTSs,53.3%有中度LUTSS,22.8%有重度LUTSS。每组间总睾酮水平无明显差异。除此之外,69.6%的病人患有ED,且ED的发生率与LUTS严重性呈正相关。71.2%的患者出现SLOH(AMS〉27),且IPSS评分越高,严重的性腺功能减退症状的发生率也越高。相关性分析显示以上三种问卷分数之间有显著关联。总之,LUTS严重性是ED和SLOH的非年龄依赖性危险因素,LUTS严重性和SLOH症状之间似乎有显著的相关性,但还需要从病因学和生物学角度进行深入阐明。 | Ozan Bozkurt Deniz Bolat Omer Demir Oktay Ucer Ali Sahin Burak Ozcift Abdulkadir Pekta Tahir Turan Bilal H Gümü Ertan Cans Ahmet Bolukbasi Haluk Erol Adil Esenx | 2013 | Asian Journal of Andrology2013，15，6： | 4 |
| 4 | Methylation of the human papillomavirus-18 L1 gene:a biomarker of neoplastic progression?显示文摘 | Turan T Kalantari M Calleja-Macias IE | 2006 | Virology2006，349，1： | 1 |
| 5 | Comparison of the adsorption characteristics of azo-reaetive dyes on mezoporous minerals显示文摘 | Ozdemir O Armagan B Turan M | 2004 | Dyes Pigments2004，62，1： | 1 |
| 6 | Vulvar syvingoma exacerbated during pregnancy显示文摘 | Turan C Ugur M Kutluay L | 1996 | Eur J Obstet Gynecol Reprod Biol1996，64，1： | 1 |
| 7 | Remifentanil for general anaesthesia : a system-atic review 显示文摘 | Komatsu R Turan AM Orhan-Sungur M | 2007 | Anaesthesia2007，62，： | 1 |
| 8 | Sunitinib-and sorafenib-inducednephrotic syndrome in a patient with gastrointestinaf stromal tumor显示文摘 | Turan N Benekli M Ozturk SC | 2012 | Ann Pharmacother2012，46，10： | 1 |
| 9 | Relationship be- tween blood pressure and stroke recurrence in patients with intracranial arterial stenosis 显示文摘 | Turan TN Cotsonis G Lynn M J | 2007 | Circulation2007，115，23： | 1 |
| 10 | Factors affecting fever follow-ing percutaneous nephrolithotomy:a prospective clinical study显示文摘 | Gonen M Turan H Ozturk B | 2008 | JEndourol2008，22，9： | 1 |
| 11 | Role of soil enzymes produced by PGPR strains in wheat growth and nutrient uptake parameters in the filed conditions显示文摘 | Turan M Gulluce M Karadayi M | | 0，，1： | 1 |
| 12 | Characterization and adsorption properties of chemlcally modified sepiolite显示文摘 | Turban Y Turan P Dogan M | 2008 | Industrial & Engineering Chemistry Research2008，47，6： | 1 |
| 13 | Application of low pressure NF membme for the recovery and reuse of dairy in- dustry effluents显示文摘 | Koyuncu I Turan M Topacik D | 2000 | Water Sci Techn2000，41，1： | 1 |
| 14 | Remifentanil for general anaesthesia: a systematic review 显示文摘 | Komatsu R Turan AM Orhan-Sungur M | 2007 | Anaesthesia2007，62，12： | 1 |
| 15 | Treatment of sanitary landfill leachate using a combined anaerobic fluidized bed reactor and Fenton's oxidation显示文摘 | Gulsen H Turan M | 2004 | Environment Engineer Science2004，21，5： | 1 |
| 16 | Do vascular endothelial growth factor and basic fibroblast growth factor promote phenytoin's wound healing effect in rat? An immunohistochemical and histopathologic study显示文摘 | Turan M Saraydyn SU Bulut HE | | 0，，10： | 1 |
| 17 | Theeffects of G-CSF and naproxen sodium on the serum TGF-betal level and fracture healing in rat tibias显示文摘 | KAYGUSUZ M A TURAN C C AYDIN N E | 2006 | Life Sci2006，80，1： | 1 |
| 18 | Factors affecting fever following percutaneous nephrolithotomy: a prospective clinical study显示文摘 | Gonen M Turan H Ozturk B | 2008 | J Endourol2008，22，9： | 1 |
| 19 | DNA methylation and gene expression differences in children conceived in vitro or in vivo 显示文摘 | Katari S Turan N Bibikova M | 2009 | HumMolGenet2009，18，20： | 1 |
| 20 | Hematological presentation in systemic lupus erythematosus and its relationship with disease activity 显示文摘 | Bevan E Bevan C Turan M | 2007 | Hematology2007，12，3： | 1 |
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