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| 1 | Genetic determination of irritable bowel syndrome显示文摘急躁的肠症候群(IBS ) 是普通功能的胃肠的混乱。根据罗马 III 标准, IBS 在下列症状的与二联系的以前的 3 瞬间或更多期间每月为至少 3 d 被定义为周期性的腹的疼痛或不快:有澄清,在凳子的频率与一个变化联系的发作或与一个变化联系处于良好的竟技状态的发作或凳子的外观的改进。在 IBS 关于基因贡献正在种证据,然而, IBS 的精确病原学仍然是未知的。基因影响的评估基于成双的研究,家庭聚集和基因流行病学调查。大多数研究比在 dizygotic 为在单合子显著地更大的 IBS 显示出一个词语索引。研究的多数证明了家庭聚集可以代表暴露到基因因素的类似的环境,以及影响。而没有特定的基因与 IBS 联合被识别了,最近的研究在血清素的倡导者区域注意了多型性的重要性再入伍拿 transporter 基因,G蛋白质贝它 3 子单元基因( C825T ),缩胆囊素受体( CCKAR 基因 779T >C ),并且高制片人的肿瘤坏死因素遗传型。进一步的研究是必要的决定基因因素怎么在 IBS 病人影响临床的表明和 therapeutical 反应。 | Cristina Hotoleanu Radu Popp Adrian Pavel Trifa Laurentiu Nedelcu Dan L Dumitrascu | 2008 | World Journal of Gastroenterology2008，14，43： | 4 |
| 2 | Comprehensive review of autoantibodies in patients with hyper-IgM syndrome显示文摘Hyper-immunoglobulin M syndrome is an X-linked primary immunodeficiency disease caused by mutations in the CD40 ligand gene.The CD40 ligand has been recently highlighted as playing a key role in the pathogenesis of primary biliary cholangitis.In the present study,we assessed an extensive set of serum autoantibodies in a series of well-defined patients with hyper-immunoglobulin M syndrome.Serum,liver-related and liver-not-related autoantibodies IgG,IgM and IgA were tested by ELISA and standard indirect immunofluorescence in HEp-2 cells in 13 Tunisian patients(8 males and 5 females,aged 1–12 years)with hyper-immunoglobulin M syndrome during 1995–2012 and,as controls,21 age-and gender-matched blood donors.The level of IgM antibody against MIT3 was significantly higher in patients than in controls(35.8 vs 10.7,P=0.002).Half of the hyperimmunoglobulin M syndrome patients were found to be anti-MIT3 IgM positive vs none of the controls(Po0.0001).Twenty-three percent of patients were found to be anti-sp100 antibody positive vs only 0.05%of controls.By immunofluorescence,92.3%of patients were MIT3 IgM positive vs none of the controls.In conclusion,the IgM class of anti-MIT3 antibodies was shown to be present by both ELISA and immunofluorescence in most of the patients with hyper-immunoglobulin M syndrome.The presence of the hallmark of primary biliary cholangitis,a disease where the CD40 ligand is a key player,in an immunodeficiency disease caused by mutations in the CD40 ligand gene is very intriguing and opens new scenarios in understanding the immune pathogenesis of primary biliary cholangitis. | Mohamed-Ridha Barbouche Qubo Chen Marco Carbone Imen Ben-Mustapha Zakera Shums Mehdi Trifa Federica Malinverno Francesca Bernuzzi Haiyan Zhang Nourhen Agrebi Gary L Norman Christopher Chang M Eric Gershwin Pietro Invernizzi | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 3 | Aberrantmethylation of RASSF1A is associated with poor survival inTunisian breast cancer patients显示文摘 | Karray-Chouayekh S Trifa F Khabir A | 2010 | J Cancer Res Clin Oncol2010，136，2： | 1 |
| 4 | Design of 2000kW switched reluctance machine system显示文摘 | Chen Hao Trifa V | 2009 | Procedia Earth and Planetary Science2009，1，1： | 1 |
| 5 | DNA content in embryo and endosperm of Maize kernel (Zea mays L):impact on GMO quantification显示文摘 | Trifa Y Zhang D | 2004 | Agric Food Chem2004，52，： | 1 |
| 6 | Interacting with the SOA-based Internet of things:discovery,query,selection,and on-demand provisioning of Web services显示文摘 | GUINARD D TRIFA V KAMOUSKOS S | 2010 | IEEE Transactions on Services Computing2010，3，3： | 1 |
| 7 | Contrast enhancement of medical images using muhiscale decomposition 显示文摘 | Trifas Monica A Tyler John M Pianykh Oleg S | 2006 | Proceedings of SPIE2006，6057，： | 1 |
| 8 | Integracting with the SOA- based intemet of things: discovery, query, selection, and on-de- mand provisioning of Web services 显示文摘 | Guinard D Trifa V Karnouskos S | 2010 | IEEE Transactions on Services Computing2010，3，3： | 1 |
| 9 | Interacting with the SOA-based intemet of things:Discovery,query,selection,and on-demand provisioning of web services显示文摘 | D Guinard S Karnouskos V Trifa B Dober P Spiess D Savio | | 0，，03： | 1 |
| 10 | From the Intemet of Things to the Web of Things : Resource-oriented Architecture and Best Practice- sSpringer Journal on Architecting the Internet of Things 显示文摘 | D Guinard V Trifa F Mattern | 2011 | Springer Journal on Architeeting the Internet of Things2011，，： | 1 |
| 11 | Integracting with the SOA-based internet of things:discovery,query,selection,and on-demand provisioning of web services显示文摘 | GUINARD D TRIFA V KARNOUSKOS S | 2010 | IEEE Transactions on Services Computing2010，3，3： | 1 |
| 12 | From the in-ternet of things to the web of things: resource-oriented ar-chitecture and best practices显示文摘 | GUINARD D’TRIFA V’MATTERN F’ | 2011 | Springer Journal of Archi-tecting the Internet of Things2011，，6： | 1 |
| 13 | Clonidine does not improve quality of ropivacaine axillary brachial plexus block in children显示文摘 | Trifa M Ben Khalifa S Jendoubi A | 2012 | Pediatric Anesth2012，22，5： | 1 |
| 14 | Aberrant methylation of RASSFIA is associated with poor survival in Tunisian breast cancer patients显示文摘 | Korray Chouayekh S Trifa F Khabir A | 2010 | J Cancer Res CAin Oncol2010，136，2： | 1 |
| 15 | Analysis of CYP2C9 * 2, CYP2C9 * 3 and VKORCI - 1639 G > A polymorphisms in a population from South - Eastern Europe显示文摘 | Buzoianu AD Trifa AP Muresanu DF | 2012 | J Cell Mol Med2012，16，： | 1 |
| 16 | NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid显示文摘 | Zhou J Trifa Y Silva H Pontier D Lam E Shah J Klessig DF | 2000 | Mol Plant Microbe In2000，13，2： | 1 |
| 17 | Negative/low HER2 expression alone or combined with E-cadherin positivity is predictive of better prognosis in patients with breast carcinoma 显示文摘 | Karray-Chouayekh S Trifa F Khabir A | 2012 | Histol Histopathol2012，27，3： | 1 |
| 18 | NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid显示文摘 | Zhou J M Trifa Y Silva H | 2000 | MolecularPlant-microbeInteractions2000，13，2： | 1 |
| 19 | Interacting with the SOA-based Internet of Things:Discovery,query,selection,and on demand provisioning of Web services显示文摘 | Guinard D Trifa V Karnouskos S | | 0，，3： | 1 |
| 20 | The relationship between factor V Leiden, prothrombin G20210A, and MTHFR mutations and the first major thrombotic episode in polycythemia vera and essential thrombocythemia显示文摘 | Adrian P. Trifa Andrei Cucuianu Radu A. Popp Camelia A. Coad? Roxana M. Costache Mariela S. Militaru ?tefan C. Vesa Ioan V. Pop | 2014 | Annals of Hematology2014，，： | 1 |
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