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| 1 | Comprehensive review of autoantibodies in patients with hyper-IgM syndrome显示文摘Hyper-immunoglobulin M syndrome is an X-linked primary immunodeficiency disease caused by mutations in the CD40 ligand gene.The CD40 ligand has been recently highlighted as playing a key role in the pathogenesis of primary biliary cholangitis.In the present study,we assessed an extensive set of serum autoantibodies in a series of well-defined patients with hyper-immunoglobulin M syndrome.Serum,liver-related and liver-not-related autoantibodies IgG,IgM and IgA were tested by ELISA and standard indirect immunofluorescence in HEp-2 cells in 13 Tunisian patients(8 males and 5 females,aged 1–12 years)with hyper-immunoglobulin M syndrome during 1995–2012 and,as controls,21 age-and gender-matched blood donors.The level of IgM antibody against MIT3 was significantly higher in patients than in controls(35.8 vs 10.7,P=0.002).Half of the hyperimmunoglobulin M syndrome patients were found to be anti-MIT3 IgM positive vs none of the controls(Po0.0001).Twenty-three percent of patients were found to be anti-sp100 antibody positive vs only 0.05%of controls.By immunofluorescence,92.3%of patients were MIT3 IgM positive vs none of the controls.In conclusion,the IgM class of anti-MIT3 antibodies was shown to be present by both ELISA and immunofluorescence in most of the patients with hyper-immunoglobulin M syndrome.The presence of the hallmark of primary biliary cholangitis,a disease where the CD40 ligand is a key player,in an immunodeficiency disease caused by mutations in the CD40 ligand gene is very intriguing and opens new scenarios in understanding the immune pathogenesis of primary biliary cholangitis. | Mohamed-Ridha Barbouche Qubo Chen Marco Carbone Imen Ben-Mustapha Zakera Shums Mehdi Trifa Federica Malinverno Francesca Bernuzzi Haiyan Zhang Nourhen Agrebi Gary L Norman Christopher Chang M Eric Gershwin Pietro Invernizzi | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 2 | Contrast enhancement of medical images using muhiscale decomposition 显示文摘 | Trifas Monica A Tyler John M Pianykh Oleg S | 2006 | Proceedings of SPIE2006，6057，： | 1 |
| 3 | Clonidine does not improve quality of ropivacaine axillary brachial plexus block in children显示文摘 | Trifa M Ben Khalifa S Jendoubi A | 2012 | Pediatric Anesth2012，22，5： | 1 |
| 4 | NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid显示文摘 | Zhou J M Trifa Y Silva H | 2000 | MolecularPlant-microbeInteractions2000，13，2： | 1 |
| 5 | NPRI differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid 显示文摘 | Zhou J M Trifa Y Silva H | 2000 | Molecular plant-microbe interactions : MPMI2000，13，2： | 1 |
| 6 | NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid显示文摘 | Zhou J M Trifa Y Silva H | 2000 | MPMI2000，13，： | 1 |
| 7 | Clonidine does not improve quality of ropivacaine axillary brachial plexus block in children显示文摘 | Trifa M Ben Khalifa S Jendoubi A | 2012 | Pediatric Anesthesia2012，22，5： | 1 |
| 8 | Nitric oxide and salicylic acid signaling in plant defense显示文摘 | Klessig D F Durner J Noad R Navarre D A Wendehenne D Kumar D Zhou J M Shah J Zhang S Kachroo P Trifa Y Pontier D Lam E Silva H | 2000 | Proceedings of the National Academy of Sciences2000，97，16： | 1 |
| 9 | Premedication for tracheal intuba- tion:aprospective suiveyin 75neonatal andpediatricin2 tensivecareunits 显示文摘 | Simon L Trifa M Mokhtari M | 2004 | Crie Care Med2004，32，： | 1 |
| 10 | NPR 1 differentially interacts with members of the TGA/PBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid显示文摘 | Zhou J M Trifa Y Silva H | 2000 | Molecular Plant-Microbe Interacts2000，13，： | 1 |
| 11 | NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid显示文摘 | Zhou J M Trifa Y Silva H | 2000 | MPMI2000，13，： | 1 |
| 12 | NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid显示文摘 | Trifa Y Silva H Pontier D Lam E Shah J Klessig D F | 2000 | Mol Plant Microbe Interact2000，13，2： | 1 |
| 13 | NPR1 diffrentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid显示文摘 | Zhou J M Trifa Y Silva H | 2000 | Mol Plant Microbe Interact2000，13，2： | 1 |
| 14 | NPR1 differentially interacts with members of the TGA/OBF family of transcription faelors that bind an element of lhe PR-1 gene required for induction by salicylic acid显示文摘 | ZHOU J M TRIFA Y SILVA H | 2000 | Molecular Plant-Microbe Interactions2000，13，： | 1 |
| 15 | Deep venous thrombo- sis associated with acute hematogenous osteomyelitis in children 显示文摘 | Bouehoucha S Benghachame F Trifa M | 2010 | Orthop Traumatol Surg Res2010，96，： | 1 |
| 16 | Aerobic bacteria associated with a- cute appendicitis in children 显示文摘 | Trifa M Douiri H Skhiri A | 2009 | Ann Fr Anesth Reanim2009，28，1： | 1 |
| 17 | NPR1 differentially Interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR 1 gene required for induction by salicylic acid显示文摘 | Zhou J M Trifa Y silva H | 2000 | Mol Plant Microb interact2000，13，2： | 1 |
| 18 | NPRI differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of PR-1 gene requied for induction by salicylic acid显示文摘 | ZHOU J M TRIFA Y SILVA H | 2000 | MPMI2000，13，： | 1 |
| 19 | NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid显示文摘 | Zhou J M Trifa Y Silva H | 2000 | Molecular Plant-Microbe Interactions2000，13，： | 1 |
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