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| 1 | STIM1 and Orai1:novel targets for vascular diseases?显示文摘The past five years have witnessed the discovery of the endoplasmic reticulum calcium(Ca2+) sensor STIM1 and the plasma membrane Ca2+channel Orai1 as the bona fide molecular components of the store-operated Ca2+ entry(SOCE) and the Ca2+ release-activated Ca2+current(I CRAC) .It has been known for two decades that SOCE and ICRAC are required for lymphocyte activation as evidenced by severe immunodeficient phenotypes in patients lacking ICRAC.In recent years however,studies have uncovered expression of STIM1 and Orai1 proteins in various tissues and described additional roles for these proteins in physiological functions and pathophysiological conditions.Here,we will summarize novel findings pertaining to the role of STIM1 and Orai1 in the vascular system and discuss their potential use as targets in the therapy of vascular disease. | Mohamed TREBAK | 2011 | Science China(Life Sciences)2011，54，8： | 6 |
| 2 | Interplay between calcium and reactive oxygen/nitrogen species: an essential paradigm for vascularsmooth muscle signaling显示文摘 | Trebak M Ginnan R Singer HA | 2010 | Antioxid Redox Signal2010，12，5： | 1 |
| 3 | The TRPC3/6/7 subfamily of cation channels显示文摘 | Trebak M Vazquez G Bird GS | | 0，，： | 1 |
| 4 | New developments in the signaling mechanisms of the store-operated calcium entry pathway显示文摘 | Marie Potier Mohamed Trebak | 2008 | Pflügers Archiv - European Journal of Physiology2008，，2： | 1 |
| 5 | The non-excitable smooth muscle: Calcium signaling and phenotypic switching during vascular disease显示文摘 | Suzanne J. House Marie Potier Jonathan Bisaillon Harold A. Singer Mohamed Trebak | 2008 | Pflügers Archiv - European Journal of Physiology2008，，5： | 1 |
| 6 | The TRPC36/7 subfamily of cation channels显示文摘 | Trebak M Vazquez G Bird GS | 2003 | Cell Calcum2003，33，56： | 1 |
| 7 | Complex regulation of the TRPC3,6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol- 4, 5 - bisphosphate显示文摘 | Lemonnier L Trebak M Putney JW Jr | 2008 | Cell Calcium2008，43，5： | 1 |
| 8 | Signalling mechanisms for TRPC3 channels显示文摘 | PUTNEY J W TREBAK M VAZQUEZ G | 2004 | Novartis Found Symp2004，258，： | 1 |
| 9 | Phos-pholipase C-coupled receptors and activation of TR-PC channels显示文摘 | Trebak M Lemonnier L Smyth JT | 2007 | Handb Exp Pharmacol2007，179，1： | 1 |
| 10 | Signaling mechanism for receptor-activated canonical transient receptor potential 3 (TRPC3) channels显示文摘 | Trebak M St JBG McKay RR | 2003 | J Biol Chem2003，278，16： | 1 |
| 11 | Interleukin-10 Released by CD4+CD25+ Natural Regulatory T Cells Improves Microvascular Endothelial Function Through Inhibition of NADPH Oxidase Activity in Hypertensive Mice显示文摘 | Modar Kassan Maria Galan Megan Partyka Mohamed Trebak Khalid Matrougui | 2011 | Arteriosclerosis, Thrombosis, and Vascular Biology2011，，： | 1 |
| 12 | Complex regulation of the TRPC3,6 and 7 channel subfamily by diacylglycerol and phosphati-dylinositol-4,5-bisphosphate显示文摘 | Lemonnier L Trebak M Putney JW Jr | 2008 | Cell Calcium2008，43，： | 1 |
| 13 | Expression level of the canonical transient receptor potential 3 (TRPC3) channel determines its mechanism of activation显示文摘 | Vazquez G Wedel BJ Trebak M | 2003 | J Biol Chem2003，278，21： | 1 |
| 14 | The puzzling role of TRPC3 channels in motor coor- dination 显示文摘 | TREBAK M | 2010 | Pflugers Arch2010，459，3： | 1 |
| 15 | The TRPC3/6/ 7 subfamily of cation channels 显示文摘 | Trebak M Vazquez G Bird GS | 2003 | Cell Calcium2003，33，56： | 1 |
| 16 | TRPC channels in smoothmuscle cells 显示文摘 | GONZALEZ-COBOS JC TREBAK M | 2010 | Front Biosci2010，15，7： | 1 |
| 17 | Expressionlevel of the canonical transient receptor potential 3 (TRPC3)channel determines its mechanism of activation 显示文摘 | VAZQUEZ G WEDEL BJ TREBAK M | 2003 | J BiolChem2003，278，21： | 1 |
| 18 | Efficient laboratory-scale production of monoclonal antibodies using membrane-based high-density cell culture technology显示文摘 | Trebak M Chong J M Herlyn D | 1999 | Journal of Immunological Methods1999，230，： | 1 |
| 19 | TRPC channels in smoothmuscle cells 显示文摘 | GONZALEZ-COBOS JC TREBAK M | 2010 | Front Biosci2010，15，7： | 1 |
| 20 | Complex regulation of the TRPC3,6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate 显示文摘 | Lemonnier L Trebak M Putney J W Jr | 2008 | Cell Calcium2008，43，： | 1 |
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