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| 1 | K-ras^G12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis显示文摘增加的氧气的 glycolysis 和氧化应力是癌症房间新陈代谢的重要特征,但是内在的生物化学、分子的机制留下逃犯。用四圜素可诱导的模型,我们显示出 K 地岬 G12V 原因 mitochondrial 机能障碍,导致反应的氧的减少的呼吸,提高的 glycolysis,和增加的产生种类。K 地岬蛋白质与线粒体被联系,并且导致呼吸的链建筑群的快速的抑制 -- 我和在由影响 cyclosporin 敏感的渗透的 mitochondrial transmembrane 潜力的减少转移毛孔。而且, K 地岬 在 vitro 的 G12V 表示提高转变房间的能力允许新陈代谢的改编到高 glycolytic 新陈代谢在 vivo 形成肿瘤。我们的学习建议 mitochondrial 机能障碍的那正式就职是由 K 地岬 G12V 在癌症房间引起新陈代谢的变化和 ROS 应力,并且支持肿瘤开发。 | Yumin Hu Weiqin Lu Gang Chen Peng Wang Zhao Chen Yan Zhou Marcia Ogasawara Dunyaporn Trachootham Li Feng Helene Pelicano Paul J Chiao Michael J Keating Guillermo Garcia-Manero Peng Huang | 2012 | Cell Research2012，22，2： | 6 |
| 2 | Disrupting redox stabilizer:a novel therapeutic strategy for colorectal cancer显示文摘Altered stress response and metabolic reprogramming have been recently proposed as emerging hallmarks of cancer cells[1].These tumorigenic properties pro-vide survival and proliferative advantages under various stressed-conditions[2].Several lines of evidences suggest that cancer cells exhibited increased reactive oxygen spe-cies(ROS)and are under oxidative stress[3].To counter-balance the stress and survive,cancer cells are depend-ent on ROS scavenging systems,especially glutathione.Inhibiting such ROS scavenging system had proven effec-tive in shifting the redox balance toward an increase in oxidative stress,leading to selective killing of cancer cells[3]. | Dunyaporn Trachootham Watcharapol Khoonin | 2019 | Cancer Communications2019，39，1： | 2 |
| 3 | Redox regulation of cell survival显示文摘 | Trachootham D Lu W OgasawaramA | 2008 | 10(8):1343-13742008，10，8： | 1 |
| 4 | Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate显示文摘 | Dunyaporn Trachootham Yan Zhou Hui Zhang Yusuke Demizu Zhao Chen Helene Pelicano Paul J. Chiao Geetha Achanta Ralph B. Arlinghaus Jinsong Liu Peng Huang | 2006 | Cancer Cell2006，，3： | 1 |
| 5 | Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism显示文摘 | TRACHOOTHAM D ZIqANG H ZHANG W | 2008 | Blood2008，112，5： | 1 |
| 6 | Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate 显示文摘 | Trachootham D Zhou Y Zhang H | 2006 | Cancer Cell2006，10，3： | 1 |
| 7 | Targeting cancer cells by ROS-mediated mechanisms:a radical therapeutic approach显示文摘 | Trachootham D Alexandre J Huang P | 2009 | Nat Rev Drug Discov2009，8，7： | 1 |
| 8 | Alterations of cellular redox state during NNK-induced malignant transformation and resistance to radiation显示文摘 | Demizu Y Sasaki R Trachootham D | 2008 | Antioxid Redox Signal2008，10，5： | 1 |
| 9 | Redox regulation of cell survival 显示文摘 | Trachootham D Lu W Ogasawara MA | 2008 | Antioxid Redox Signal2008，10，8： | 1 |
| 10 | Selective killing of oncogenically transformed ceils through a ROS-mediated mechanism by beta-phenylethyl isothio-cyanate显示文摘 | Trachootham D Zhou Y Zhang H | 2006 | Cancer Cell2006，10，3： | 1 |
| 11 | Selective killing of oncogen- ically transformed cells through a ROS-mediated mechanism by beta- phenylethyl isothiocyanate 显示文摘 | Trachootham D Zhou Y Zhang H | 2006 | Cancer Cell2006，10，3： | 1 |
| 12 | Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism 显示文摘 | Trachootham D Zhang H Zhang W | 2008 | Blood2008，112，5： | 1 |
| 13 | Redox regu- lation of cell survival 显示文摘 | Trachootham D Lu W Ogasawara MA | 2008 | Antioxid Redox Signa2008，10，8： | 1 |
| 14 | Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-media- ted mechanism 显示文摘 | Trachootham D Zhang H Zhang W | 2008 | Blood2008，112，5： | 1 |
| 15 | Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? 显示文摘 | Trachootham D Alexandre J Huang P | 2009 | Nat Rev Drug Discov2009，8，7： | 1 |
| 16 | Stromal controlof cystine metabolismpromotes cancercell survival in chroniclymphocytic leukaemia 显示文摘 | ZHANG W TRACHOOTHAM D LIU J | 2012 | Nat Cell Biol2012，14，3： | 1 |
| 17 | Redox regula-tion of cell survival显示文摘 | Trachootham D Lu W Ogasawara MA | 2008 | Antioxid Redox Signal2008，10，8： | 1 |
| 18 | Redox regulation of cell survival 显示文摘 | Trachootham D Lu W Ogasawara MA | 2008 | Antioxid Redox Signal2008，10，8： | 1 |
| 19 | Redox regulation of cell survival显示文摘 | Trachootham D Lu W Ogasawara MA | 2008 | Antioxid Redox Signal2008，10，8： | 1 |
| 20 | Targeting Cancer cells by ROS-mediated mechanisms:a radical therapeutic approach?显示文摘 | Trachootham D Alexandre J Huang P | 2009 | Nature Reviews Drug Discovery2009，8，7： | 1 |
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