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2篇 您的检索式：作者名="Mathijs Baens"

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		题名	作者	年代	出处	被引量
	1	The Product of the t(11;18), an API2 - MLT Fusion, Marks Nearly Half of Gastric MALT Type Lymphomas without Large Cell Proliferation显示文摘	Mathijs Baens Brigitte Maes Anja Steyls Karel Geboes Peter Marynen Christiane De Wolf-Peeters	2000	The American Journal of Pathology2000，，4：	1
	2	T(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas are heterogeneous with respect to the V_H gene mutation status显示文摘AIM: To investigate how t(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas relate to other marginal zone lymphomas with respect to the somatic mutation pattern of the VH genes and the expression of the marker CD27. METHODS: The VH gene of 7 t(11;18)(q21;q21)- positive gastrointestinal MALT lymphomas was amplif iedby PCR using family specif ic VH primers and a consensus JH primer. PCR products were sequenced and mutation analysis of the CDR and the FR regions was performed. All cases were immunostained for CD27. RESULTS: One case showed unmutated VH genes while the others showed mutated VH genes with mutation frequencies ranging from 1.3 to 14.7% and with evidence of antigen selection in 2 cases. These data suggest that the translocation t(11;18)(q21;q21) can target either B-cells at different stages of differentiation or naive B-cells that retain the capacity to differentiate upon antigen stimulation. All cases but one displayed weak to strong CD27 expression which did not correlate with the VH gene mutation status. CONCLUSION: t(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas are heterogeneous with respect to the VH mutation status and CD27 is not a marker of somatically mutated B-cells.	Xavier Sagaert Vera Vanhentenrijk Gert De Hertogh Karel Geboes Thomas Tousseyn Brigitte Maes Mathijs Baens Eric Van Cutsem	2011	World Journal of Gastrointestinal Oncology2011，3，2：	0

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