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| 1 | Giant cavernous liver hemangiomas: is it the time to change the size categories?显示文摘BACKGROUND: Four different sizes(4, 5, 8 and 10 cm in diameter) can be found in the literature to categorize a liver hemangioma as giant. The present review aims to clarify the appropriateness of the size category 'giant' for liver hemangioma.DATA SOURCES: We reviewed the reports on the categorization of hemangioma published between 1970 and 2014. The number of hemangiomas, size criteria, mean and range of hemangioma sizes, and number of asymptomatic and symptomatic patients were investigated in patients aged over 18 years. Liver hemangiomas were divided into four groups: <5.0 cm, 5.0-9.9 cm, 10.0-14.9 cm and ≥15.0 cm in diameter. Inclusion criteria were noted in 34 articles involving 1972(43.0%) hemangiomas(>4.0 cm).RESULTS: The patients were divided into the following groups: 154 patients(30.0%) with hemangiomas less than 5.0 cm in diameter(small), 182(35.5%) between 5.0 cm and 9.9 cm(large), 75(14.6%) between 10.0 and 14.9 cm(giant), and 102(19.9%) more than 15.0 cm(enormous). There were 786(39.9%) asymptomatic patients and 791(40.1%) symptomatic patients. Indications for surgery related to symptoms were reported in only 75(3.8%) patients. Operations including 137 non-anatomical resection(12.9%) and 469 enucleation(44.1%) were unclearly related to size and symptoms.CONCLUSIONS: The term 'giant' seems to be justified for liver hemangiomas with a diameter of 10 cm. Hemangiomas categorized as 'giant' are not indicated for surgery. Surgery should be performed only when other symptoms are apparent. | isidoro di carlo renol koshy saif al mudares annalisa ardiri gaetano bertino adriana toro | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，1： | 22 |
| 2 | Tensile and Spring-Back Behavior of DP600 Advanced High Strength Steel at Warm Temperatures显示文摘In recent years,the use of advanced high strength steels in automotive industry has been increased remarkably.Among advanced high strength steels,dual phase(DP) steels have gained a great attention owing to a combination of high strength and good formability.However,high strength usually increases the spring-back behavior of the material,which creates problems for the parts during the assembly.Thus,the uniaxial tensile deformation and spring-back behaviors of DP600 advanced high strength steel were investigated in rolling(0°),diagonal(45°),and transverse(90°) directions in the temperature range from room temperature(RT) to 300 ℃.All tests were performed at a deformation speed of 25 mm/min.A V-shaped die(60°) was used for the spring-back measurements.The results indicated that the formability and spring-back of the material were decreased with increasing the temperatures.The material showed complex behaviors in different directions and at different temperatures. | F Ozturk S Toros S Kilic | 2009 | Journal of Iron and Steel Research(International)2009，16，6： | 17 |
| 3 | Relationship between lipoprotein (a) and micro/macro complications in type 2 diabetes mellitus: a forgotten target显示文摘ObjectivesIncreased 脂蛋白(a) 浆液集中似乎是一个心血管的风险因素;这没在 extracoronary 动脉粥样硬化复杂并发症被证实。我们因此希望获得更深的卓见 into 在脂蛋白(a) 的血浆集中和类型 2 糖尿病 mellitus 并且到的微脉管、宏脉管的复杂并发症之间的关系在这 association.MethodsThis 识别可能的差别是描述的观察代表性的研究。二 -- 有类型 2 糖尿病 mellitus 的 117 个老病人从内部药 outclinic 被包括。人体测量的数据,分析数据(象高血压的胰岛素保守,基础、饭后的肽 C, glycosylated 血红素,肾的参数,类脂化合物侧面和临床的数据,肥胖,微 -- 并且 macrovascular 复杂并发症是 collected.ResultsPatients 根据类型被组织进化的 2 糖尿病 mellitus 时间。脂蛋白(a) 的吝啬的血浆集中是 22.2 ±17.3 mg/dL (22.1 ±为男性的 15.9 mg/dL,和 22.1 ±为女性的 18.4 mg/dL ) 。有高血压,冠的心疾病,脑血管的事故, microalbuminuria 和 proteinuria 的病人介绍了脂蛋白(a) 的统计上重要的增加的水平。同样,有 hyperlipoprotein (a) 的病人(≥30 mg/dL ) 脲和全部的胆固醇的介绍显著地增加的层次。在 multivariate 回归模型,脂蛋白(a) 的水平断然与冠的心疾病和糖尿病的 nephropathy 被相关(P <0.01 并且 P <0.005,分别地) 脂蛋白(a) 的血浆层次的 .ConclusionsThe 举起与冠的心疾病和 diabe tic nephropathy 的发展被联系。因此,我们认为脂蛋白(a) 的决心可以是在有类型 2 糖尿病 mellitus 的病人的脉管的复杂并发症的一个预示的标记。 | Rocio Toro Eduardo Segura Jesfis Millan Nunez-Cortes Juan Carlos Pedro-Botet Maribel Quezada-Feijoo Alipio Mangas | 2015 | Journal of Geriatric Cardiology2015，12，2： | 10 |
| 4 | Chronic hepatitis C:This and the new era of treatment显示文摘Over the last years it has started a real revolution in the treatment of chronic hepatitis C. This occurred for the availability of direct-acting antiviral agents that allow to reach sustained virologic response in approximately 90% of cases. In the near future further progress will be achieved with the use of pan-genotypic drugs with high efficacy but without side effects. | Gaetano Bertino Annalisa Ardiri Maria Proiti Giuseppe Rigano Evelise Frazzetto Shirin Demma MariaIrene Ruggeri Laura Scuderi Giulia Malaguarnera Nicoletta Bertino Venerando Rapisarda Isidoro Di Carlo Adriana Toro Federico Salomone Mariano Malaguarnera Emanuele Bertino Michele Malaguarnera | 2016 | World Journal of Hepatology2016，8，2： | 10 |
| 5 | Bone alterations in inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBDs)are characterized by a multifactorial partially unknown etiology that involves genetic,immunological and environmental factors.Up to 50%of IBD patients experience at least one extraintestinal manifestation;among them is the involvement of bone density which is referred to as metabolic bone disease(MBD),including osteopenia and osteoporosis.Bone alterations in IBDs population appear to have a multifactorial etiology:Decreased physical activity,inflammation-related bone resorption,multiple intestinal resections,dietary malabsorption of minerals and vitamin D deficiency,genetic factors,gut-bone immune signaling interaction,steroid treatment,microbiota and pathogenic micro-organisms interaction,and dietary malabsorption of minerals,that,all together or individually,may contribute to the alteration of bone mineral density.This review aims to summarize the prevalence and pathophysiology of metabolic bone alterations in IBD subjects outlining the main risk factors of bone fragility.We also want to underline the role of the screening and prophylaxis of bone alterations in Crohn’s disease and ulcerative colitis patients and the importance of treating appropriately MBD. | Dolores Sgambato Francesca Gimigliano Cristiana De Musis Antimo Moretti Giuseppe Toro Emanuele Ferrante Agnese Miranda Domenico De Mauro Lorenzo Romano Giovanni Iolascon Marco Romano | 2019 | World Journal of Clinical Cases2019，7，15： | 8 |
| 6 | Umbilical cord as a mesenchymal stem cell source for treating joint pathologies显示文摘Articular cartilage disorders and injuries often result in life-long chronic pain and compromised quality of life.Regrettably,the regeneration of articular cartilage is a continuing challenge for biomedical research.One of the most promising therapeutic approaches is cellbased tissue engineering,which provides a healthy population of cells to the injured site but requires differentiated chondrocytes from an uninjured site.The use of healthy chondrocytes has been found to have limitations.A promising alternative cell population is mesenchymal stem cells(MSCs),known to possess excellent proliferation potential and proven capability for differentiation into chondrocytes.The“immunosuppressive”property of human MSCs makes them an important candidate for allogeneic cell therapy.The use of allogeneic MSCs to repair large defects may prove to be an alternative to current autologous and allogeneic tissue-grafting procedures.An allogeneic cell-based approach would enable MSCs to be isolated from any donor,expanded and cryopreserved in allogeneic MSC banks,providing a readily available source of progenitors for cell replacement therapy.These possibilities have spawned the current exponential growth in stem cell research in pharmaceutical and biotechnology communities.Our objective in this review is to summarize the knowledge about MSCs from umbilical cord stroma and focus mainly on their applications for joint pathologies. | María Carmen Arufe Alexandre De la Fuente Isaac Fuentes Francisco Javier De Toro Francisco Javier Blanco | 2011 | World Journal of Orthopedics2011，2，6： | 7 |
| 7 | Could the number of CT angiograms be reduced in emergency department patients suspected of pulmonary embolism?显示文摘BACKGROUND:This study was undertaken to identify the prevalence of pulmonary embolism(PE) in the emergency department(ED) of an urban teaching hospital and also to test a Bayesian model in estimating the number of CT pulmonary angiography(CTA) expected to be performed in an emergency department.METHODS:The data for this study was obtained through a retrospective review of electronic medical records for all ED patients suspected of PE who underwent chest CTA or ventilation perfusion scanning(V/Q) between 2009 and 2010.The data is presented as means and standard deviation for continuous variables and percentages with 95%confidence intervals(95%CI) for proportions.The prevalence of PE was used as pre-test probability in the Bayesian model.Post-test probability was obtained using a Fagan nomogram and likelihood ratios for CTA.RESULTS:A total of 778 patients(560 females) with mean age of 50 years(range 18-98 years)were enrolled(98.3%underwent chest CTA and 1.7%underwent V/Q scan).A total of 69 patients had PE,rendering an overall prevalence of 8.9%(95%CI,7.1%to 11.1%) for PE.We calculated that132 CTA's per year could be avoided in our institution,without compromising safe exclusions of PE(keeping post-test probability of PE below 2%).CONCLUSIONS:Despite differences in our patient populations and /or study designs,the prevalence of PE in our institution is about average compared to other institutions.Our proposed model for calculating redundant chest CTA is simple and can be used by institutions to identify overuse of CTA. | Zehtabchi Shahriar Rinnert Stephan Malhotra Shweta Subramanian Arun Timberger Mathew Patel Brijal Toro David Hassan Khaled Sinert Richard | 2012 | World Journal of Emergency Medicine2012，3，3： | 7 |
| 8 | Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats显示文摘AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU)to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats(median weight,235 g)were used in this study.The rats were fed with standard laboratory food and given tap water ad libitum.The animals were divided into three groups: Group 1:Control group(chemotherapy was not administered),Group 2:Intraperitoneally(IP)administered 5-FU group(chemotherapy was administered IP to animals at a dose of 20 mg/kg daily during the 5 d preceeding surgery),Group 3:Intravenously(IV)administered 5-FU group.Chemotherapy was administered via the penil vein,using the same dosing scheme and duration as the second group.After a 3-d rest to minimize the side effects of chemotherapy,both groups underwent surgery.One centimeter of colon was resected 2 cm proximally from the peritoneal reflection,thensutured intermittently and subsequently end-to-end anastomosed.In each group,half the animals were given anaesthesia on the 3rd postoperative(PO)day and the other half on the 7th PO day,for in vivo analytic procedures.The abdominal incisions in the rats were dissected,all the new and old anastomotic segments were clearly seen and bursting pressures of each anastomotic segment,tissue hydroxyproline levels and DNA content were determined to assess the histologic tissue repair process. RESULTS:When the IV group was compared with the IP group,bursting pressures of the anastomotic segments on the 3rd and 7th PO days,were found to be significantly decreased,hydroxyproline levels at the anastomotic segment on the 7th PO day were significantly decreased(P<0.01). CONCLUSION:In this study,we conclude that early preoperative 5-FU,administered IV,negatively affects wound healing.However,IP administered 5-FU does not negatively affect wound healing. | Leyla Ozel M Sefa Ozel Ahmet Burak Toros Melih Kara Kemal Sirri Ozkan Gurkan Tellioglu Osman Krand Meral Koyuturk Ibrahim Berber | 2009 | World Journal of Gastroenterology2009，15，33： | 7 |
| 9 | Hepatocellular carcinoma and the risk of occupational exposure显示文摘Hepatocellular carcinoma(HCC)is the most common type of liver cancer.The main risk factors for HCC are alcoholism,hepatitis B virus,hepatitis C virus,nonalcoholic steatohepatitis,obesity,type 2 diabetes,cirrhosis,aflatoxin,hemochromatosis,Wilson’s disease and hemophilia.Occupational exposure to chemicals is another risk factor for HCC.Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent.This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem. | Venerando Rapisarda Carla Loreto Michele Malaguarnera Annalisa Ardiri Maria Proiti Giuseppe Rigano Evelise Frazzetto Maria Irene Ruggeri Giulia Malaguarnera Nicoletta Bertino Mariano Malaguarnera Vito Emanuele Catania Isidoro Di Carlo Adriana Toro Emanuele Bertino Dario Mangano Gaetano Bertino | 2016 | World Journal of Hepatology2016，8，13： | 5 |
| 10 | Strain Hardening and Strain Rate Sensitivity Behaviors of Advanced High Strength Steels显示文摘The mechanical properties of commercial dual phase (DP), transformation induced plasticity (TRIP), and high strength low alloy (HSLA-340) steel sheets are investigated and compared at various strain rates ranging from 0.001 7to 0.17 s-1 at ambient temperature.TRIP steel outperforms the other two materials , having comparable ductility and twice as large strength relative to DP steel.TRIP has larger strength and much larger ductility than HSLA-340.The exceuent ductility of TRIP800is due to its high strain hardening capability , which promotes stable plastic deformation.It is observed that the strain hardening rate in TRIP800does not decrease to zero at failure , as common in most materials in which failure is preceded by necking. | F Ozturk A Polat S Toros R C Picu | 2013 | Journal of Iron and Steel Research(International)2013，20，6： | 4 |
| 11 | Systemic therapies in hepatocellular carcinoma: present and future显示文摘 | Gaetano Bertino Isidoro Di Carlo Annalisa Ardiri Giuseppe Stefano Calvagno Shirin Demma Giulia Malaguarnera Nicoletta Bertino Mariano Malaguarnera Adriana Toro Michele Malaguarnera | 2013 | Future Oncol2013，，10： | 3 |
| 12 | Effectiveness of dry needling on reducing pain intensity in patients with myofascial pain syndrome: a Meta-analysis显示文摘OBJECTIVE: To summarize the literature about the effectiveness of dry needling(DN) on relieving pain and increasing range of motion(ROM) in individuals with myofascial pain syndrome(MPS).METHODS: Papers published from January 2000 to January 2013 were identified through an electronic search in the databases MEDLINE, Dialnet, Cochrane Library Plus, Physiotherapy Evidence Database(PEDro) and Spanish Superior Council of Scientific Research(CSIC). The studies included were randomized controlled trials written in English and/or Spanish about the effectiveness of DN on pain and ROM in individuals with MPS.RESULTS: Out of 19 clinical trials that were potentially relevant, a total of 10 were included in the Meta-analysis. Regarding pain intensity reduction when measured before and immediately after the intervention, DN achieved improvement compared with the placebo treatment [d =-0.49; 95% CI(-3.21, 0.42)] and with the control group [d =-9.13;95% CI(- 14.70,- 3.56)]. However, other treatments achieved better results on the same variable compared with DN, considering the measurements for pre-treatment and immediately after [d = 2.54;95% CI(-0.40, 5.48)], as well as the pre-treatment and after 3-4 weeks [d = 4.23; 95% CI(0.78, 7.68)].DN showed a significantly increased ROM when measured before the intervention and immediately after, in comparison with the placebo [d = 2.00;95% CI(1.60, 2.41)]. However, other treatments achieved a significant better result regarding ROM when it was measured before the intervention and immediately after, as compared with DN [d =-1.42;95% CI(-1.84,-0.99)].CONCLUSION: DN was less effective on decreasing pain comparing to the placebo group. Other treatments were more effective than DN on reducing pain after 3-4 weeks. However, on increasing ROM,DN was more effective comparing to that of placebo group, but less than other treatments. | Juan Rodriguez-Mansilla Blanca Gonzalez-Sanchez Alvaro De Toro Garcia Enrique Valera-Donoso Elisa Maria Garrido-Ardila Maria Jimenez-Palomares Maria Victoria Gonzalez Lopez-Arza | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 3 |
| 13 | Precision micro-mechanical components in single crystal diamond by deep reactive ion etching显示文摘The outstanding material properties of single crystal diamond have been at the origin of the long-standing interest in its exploitation for engineering of high-performance micro-and nanosystems.In particular,the extreme mechanical hardness,the highest elastic modulus of any bulk material,low density,and the promise for low friction have spurred interest most notably for micro-mechanical and MEMS applications.While reactive ion etching of diamond has been reported previously,precision structuring of freestanding micro-mechanical components in single crystal diamond by deep reactive ion etching has hitherto remained elusive,related to limitations in the etch processes,such as the need of thick hard masks,micromasking effects,and limited etch rates.In this work,we report on an optimized reactive ion etching process of single crystal diamond overcoming several of these shortcomings at the same time,and present a robust and reliable method to produce fully released micro-mechanical components in single crystal diamond.Using an optimized Al/SiO_(2) hard mask and a high-intensity oxygen plasma etch process,we obtain etch rates exceeding 30μm/h and hard mask selectivity better than 1:50.We demonstrate fully freestanding micro-mechanical components for mechanical watches made of pure single crystal diamond.The components with a thickness of 150μm are defined by lithography and deep reactive ion etching,and exhibit sidewall angles of 82°–93°with surface roughness better than 200 nm rms,demonstrating the potential of this powerful technique for precision microstructuring of single crystal diamond. | Adrien Toros Marcell Kiss Teodoro Graziosi Hamed Sattari Pascal Gallo Niels Quack | 2018 | Microsystems & Nanoengineering2018，4，1： | 2 |
| 14 | Isoscalar-vector interaction and its influence on the hadron-quark phase transition显示文摘The hadron-quark phase transition is studied with the newly constructed Hadron-Poyakov-Nambu- Jona-Lasinio(PNJL) model.Particularly,in the description of quark matter,we include the isoscalar-vector interaction.With the constraints of neutron star observations,our calculation shows the isoscalar-vector interaction between quarks is indispensable if massive hybrids star exist in the universe.Its strength determines the onset density of quark matter,and the mass-radius relations of hybrid stars.Also,as a connection with heavy-ion-collision experiments,we discuss the strength of isoscalar-vector interaction and its effect on the signals of hadron-quark phase transition in heavy-ion collisions,such as NICA at JINR-Dubna and FAIR at GSI-Darmstadt. | SHAO Guoyun COLONNA Maria DI TORO Massimo LIU Yuxin LIU Bo | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 15 | Effect of Computerized Tomography on Classification and Treatment Plan for Patellar Fractures显示文摘 | Lionel E. Lazaro David S. Wellman Nadine C. Pardee Michael J. Gardner Jose B. Toro Neil R. MacIntyre David L. Helfet Dean G. Lorich | 2013 | Journal of Orthopaedic Trauma2013，，6： | 2 |
| 16 | Reversible and resistant components of PCB adsorption-desorption: Isotherms 显示文摘 | Horzempa L M | 1982 | Environ Sci Technol1982，16，9： | 1 |
| 17 | Template-free and seedless growth of Pt nanocolumns:imaging and probing their nanoelectrical properties显示文摘 | NIGRO R L TORO R G MALANDRINO G | 2003 | Adv Mater2003，15，13： | 1 |
| 18 | Decreased transcription,expression and function of low-density lipoprotein receptor in leukocytes from patients with systemic lupus erythematosus显示文摘 | Rivas L Zabaleta M Toro F | 2009 | Autoimmunity2009，42，4： | 1 |
| 19 | Proliferation activety and steroid hormone receptor status in male breast carcinoma显示文摘 | Munoz D E Toro M M Maffini M V | 1998 | J Steroid Biochem Mol Boil1998，67，4： | 1 |
| 20 | Heritahility esti- mates of larval and spat shell height in the Chilean blue mussel (Mytilus chilensis Hupe 1854) produced under controlled laborato ry conditions 显示文摘 | Toro J E Alcapan A C Vergara A M | 2004 | Aquae Res2004，35，： | 1 |
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