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| 1 | Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer screening:A meta-analysis显示文摘AIM:To present a critical discussion of the efficacy of the faecal pyruvate kinase isoenzyme type M2(faecal M2-PK) test for colorectal cancer(CRC) screening based on the currently available studies.METHODS:A literature search in PubMed and Embase was conducted using the following search terms:fecal Tumor M2-PK,faecal Tumour M2-PK,fecal M2-PK,faecal M2-PK,fecal pyruvate kinase,faecal pyruvate kinase,pyruvate kinase stool and M2-PK stool.RESULTS:Stool samples from 704 patients with CRC and from 11 412 healthy subjects have been investigated for faecal M2-PK concentrations in seventeen independent studies.The mean faecal M2-PK sensitivity was 80.3%;the specificity was 95.2%.Four studies compared faecal M2-PK head-to-head with guaiacbased faecal occult blood test(gFOBT).Faecal M2PK demonstrated a sensitivity of 81.1%,whereas the gFOBT detected only 36.9% of the CRCs.Eight independent studies investigated the sensitivity of faecal M2-PK for adenoma(n = 554),with the following sensitivities:adenoma < 1 cm in diameter:25%;adenoma > 1 cm:44%;adenoma of unspecified diameter:51%.In a direct comparison with gFOBT of adenoma > 1 cm in diameter,47% tested positive with the faecal M2-PK test,whereas the gFOBT detected only 27%.CONCLUSION:We recommend faecal M2-PK as a routine test for CRC screening.Faecal M2-PK closes a gap in clinical practice because it detects bleeding and nonbleeding tumors and adenoma with high sensitivity and specificity. | Carolin Tonus Markus Sellinger Konrad Koss Gero Neupert | 2012 | World Journal of Gastroenterology2012，18，30： | 17 |
| 2 | Colorectal cancer screening by non-invasive metabolic biomarker fecal tumor M2-PK显示文摘AIM: To evaluate the utility of the innovative fecal tumor M2-Pyruvate kinase (M2-PK) test in our daily clinical routine, as a marker for the pre-selection of patients who should subsequently undergo colonoscopy for the diagnosis or exclusion of colorectal cancer. METHODS: Fecal tumor M2-PK was measured in stool samples of 96 study participants (33 patients with colorectal cancer, 21 patients with rectal carcinoma and 42 controls) who all underwent total colonoscopy. RESULTS: In 39 of 42 individuals in the control group, fecal tumor M2-PK was below 4.0 kU/L (93% specificity). Colorectal tumors were accompanied by a highly significant increase (P < 0.001) in fecal tumor M2- PK levels (median: colon carcinoma, 23.1 kU/L; rectal carcinoma, 6.9 kU/L; colorectal carcinoma, 14.7 kU/L), which correlated with Duke’s staging and T-classification. The overall sensitivity was 78% for colorectal cancer, increasing from 60% for stage T1 to 100% for stage T4 and from 60% for Duke’s A to 90% for Duke’s D tumors. CONCLUSION: Fecal tumor M2-PK is an appropriately sensitive tool to pre-select those patients requiring colonoscopy for the further diagnostic confirmation or exclusion of colorectal cancer. | Carolin Tonus Gero Neupert Markus Sellinger | 2006 | World Journal of Gastroenterology2006，12，43： | 14 |
| 3 | Long-term results of endoscopic balloon dilatation of lower gastrointestinal tract strictures in Crohn's disease:A prospective study显示文摘AIM:To examine the long-term results of endoscopic treatment in a prospective study conducted over a period of 10 years,1997 to January 2007.METHODS:A total of 25 patients(20 female and five male:aged 18-75 years),with at least one symptom of stricture not passable with the standard colonoscope and with a confirmed scarred Crohn's stricture of the lower gastrointestinal tract,were included in the study.The main symptom was abdominal pain.The endoscopic balloon dilatation was performed with an 18 mm balloon under endoscopic and radiological control.RESULTS:Eleven strictures were located in the colon,13 at the anastomosis after ileocecal resection,three at the Bauhin valve and four in the ileum.Four patients had two strictures and one patient had three strictures.Of the 31 strictures,in 30 was balloon dilatation successful in a single endoscopic session,so that eventually the strictures could be passed easily with the standard colonoscope.In one patient with a long stricture of the ileum involving the Bauhin valve and an additional stricture of the ileum which were 15 cm apart,sufficient dilatation was not possible.This patient therefore required surgery.Improvement of abdominal symptoms was achieved in all cases which had technically successful balloon dilatation,althoughin one case perforation occurred after dilatation of a recurrent stricture.Available follow-up was in the range of 54-118 mo(mean of 81 mo).The relapse rate over this period was 46%,but 64% of relapsing strictures could be successfully dilated again.Only in four patients was surgery required during this follow-up period.CONCLUSION:We conclude from these initial results that endoscopic balloon dilatation,especially for short strictures in Crohn's disease,can be performed with reliable success.Perforation is a rare complication.It is our opinion that in the long-term,the relapse rate is probably higher than after surgery,but usually a second endoscopic treatment can be performed successfully,leading to a considerable success rate of the endoscopic procedure. | Klaus Stienecker Daniel Gleichmann Ulrike Neumayer H Joachim Glaser Carolin Tonus | 2009 | World Journal of Gastroenterology2009，15，21： | 9 |
| 4 | Size effect of lead-free halide double perovskite on luminescence property显示文摘Lead-free halide double perovskites have gathered wide scientific interest since they are environmentally friendly and stable.However,compared to the lead perovskites,their optoelectronic properties are compromised.Herein we report a series of bulk lead-free mixed Bi-In halide double perovskites:Cs2AgBi1-xInxCl6(0 | Peigeng Han Xue Zhang Xin Mao Bin Yang Songqiu Yang Zha Zhochi Feng Donghui Wei Weiqiao Deng Tonu Pullerits Keli Han | 2019 | Science China Chemistry2019，62，10： | 4 |
| 5 | On the change of periodicities in the Hicksian multiplier-accelerator model with a consumption floor显示文摘 | Tonu Puu Laura Gardini Iryna Sushko | 2006 | Chaos Solitons & Fractals2006，29，3： | 1 |
| 6 | Hotelling’s“Ice Cream Dealers”with Elastic Demand显示文摘 | Tonu P | 2002 | The Annals of Regional Science2002，36，1： | 1 |
| 7 | Heterotopes Pankreasgewebe in der Gallenblase显示文摘 | G. Neupert P. Appel S. Braun C. Tonus | 2007 | Der Chirurg2007，，3： | 1 |
| 8 | Purification of resveratrol from vine stems 显示文摘 | AAVO A MATI H TONU P | 2003 | Proc Estonian Acad Sci Chem2003，52，4： | 1 |
| 9 | Nutrient cycline and biomass growth at a north American hardwood site in relation to climate change: FORSVA assessments 显示文摘 | Tonu Oja Paul Aarp | 1996 | Climatic Change1996，34，： | 1 |
| 10 | Hotelling's 'Ice cream dealers' with elastic demand显示文摘 | Tonu P | 2002 | Region Science2002，36，1： | 1 |
| 11 | Inhibition of lipid oxidation and dynamics of polyphenol content in mechanically deboned meat supplement with sea buckthorn (Hippophae rhamnoides) berry residues显示文摘 | TONU P REGINA P PIRET R | 2008 | Food Chemistry2008，107，： | 1 |
| 12 | CsPbBr_(3)纳米晶微观形貌非依赖的线性吸收截面显示文摘胶体钙钛矿纳米晶的形貌变化赋予其不同的光学和电子特性,其中,线性吸收截面是决定材料本征光物理特性及其应用潜力的主要参数.本文研究了三种不同形貌的全无机钙钛矿CsPbBr3纳米晶(纳米立方体、纳米片和纳米线),通过飞秒瞬态吸收光谱分析了它们的线性吸收截面值σ.在高于带隙的能量激发下,单个CsPbBr_(3)纳米晶的吸收截面值与形貌无关,且随着粒子的体积(VNC)呈σ400=9.45×10^(4)cm^(−1)×VNC(cm^(2))趋势变化.密度泛函理论证实了形貌对光学选择规则基本没有影响,同时,根据吸收截面值也计算得到了定义本征辐射复合率的爱因斯坦自发辐射系数.然而,当激发能接近带隙(460 nm)时,吸收截面值对纳米晶尺寸的依赖关系变弱,取值满足σ460=2.82×10^(8)cm0.65×(VNC)0.45(cm^(2)),这主要归因于钙钛矿纳米晶的离散能级及靠近带边的较低的态密度.本文的研究结果为洞悉钙钛矿纳米晶的光学特性提供了深入的见解. | 张凤英 刘禹辰 卫诗倩 陈俊生 周莹 何荣幸 Tonu Pullerits 郑凯波 | 2021 | Science China Materials2021，64，6： | 1 |
| 13 | Inhibition of lipid oxidation and dynamics of polyphenol content in mechanically deboned meat supplemented with sea buckthom (Hippophae rhanmoides) berry residues显示文摘 | Tonu P Regina P Piret R | 2008 | Food Chemistry2008，107，： | 1 |
| 14 | On the change of periodicities in the Hicksian multiplier-accelerator model with a consumption floor显示文摘 | Tonu Puu Laura Gardini and Iryna Sushko | 2006 | Chaos Solitons & Fractals2006，29，3： | 1 |
| 15 | A Hieksian multiplier-accelerator model with floor determined by capital stock显示文摘 | Tonu Puu Laura Gardini and Irina Sushko | 2005 | Journal of Economic Behavior & Organization2005，56，3： | 1 |
| 16 | Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin显示文摘 | C. A. Curat V. Wegner C. Sengenès A. Miranville C. Tonus R. Busse A. Bouloumié | 2006 | Diabetologia2006，，4： | 1 |
| 17 | Colorec- tal cancer screening by non-invasive metabolic biomarker fecal tumor M2-PK显示文摘 | Carolin Tonus Gero Neupert Markus Sellinge | 2007 | World J Gastroenterol2007，13，19： | 1 |
| 18 | Bacteriochlorophyll in electric field显示文摘 | KJEELLBERG P ZHI H TONU P | 2003 | J Phys Chem B2003，107，13： | 1 |
| 19 | On Bertrand du- opoly game with differentiated goods 显示文摘 | Ahmed E Elsadany A A Puu Tonu | 2015 | Applied Mathematics and Computation2015，251，1： | 1 |
| 20 | Hotelling's 'Ice cream dealers' with elastic demand显示文摘 | Tonu Puu | 2002 | The Annals of Regional Science2002，36，： | 1 |
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