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| 1 | Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer screening:A meta-analysis显示文摘AIM:To present a critical discussion of the efficacy of the faecal pyruvate kinase isoenzyme type M2(faecal M2-PK) test for colorectal cancer(CRC) screening based on the currently available studies.METHODS:A literature search in PubMed and Embase was conducted using the following search terms:fecal Tumor M2-PK,faecal Tumour M2-PK,fecal M2-PK,faecal M2-PK,fecal pyruvate kinase,faecal pyruvate kinase,pyruvate kinase stool and M2-PK stool.RESULTS:Stool samples from 704 patients with CRC and from 11 412 healthy subjects have been investigated for faecal M2-PK concentrations in seventeen independent studies.The mean faecal M2-PK sensitivity was 80.3%;the specificity was 95.2%.Four studies compared faecal M2-PK head-to-head with guaiacbased faecal occult blood test(gFOBT).Faecal M2PK demonstrated a sensitivity of 81.1%,whereas the gFOBT detected only 36.9% of the CRCs.Eight independent studies investigated the sensitivity of faecal M2-PK for adenoma(n = 554),with the following sensitivities:adenoma < 1 cm in diameter:25%;adenoma > 1 cm:44%;adenoma of unspecified diameter:51%.In a direct comparison with gFOBT of adenoma > 1 cm in diameter,47% tested positive with the faecal M2-PK test,whereas the gFOBT detected only 27%.CONCLUSION:We recommend faecal M2-PK as a routine test for CRC screening.Faecal M2-PK closes a gap in clinical practice because it detects bleeding and nonbleeding tumors and adenoma with high sensitivity and specificity. | Carolin Tonus Markus Sellinger Konrad Koss Gero Neupert | 2012 | World Journal of Gastroenterology2012，18，30： | 17 |
| 2 | Colorectal cancer screening by non-invasive metabolic biomarker fecal tumor M2-PK显示文摘AIM: To evaluate the utility of the innovative fecal tumor M2-Pyruvate kinase (M2-PK) test in our daily clinical routine, as a marker for the pre-selection of patients who should subsequently undergo colonoscopy for the diagnosis or exclusion of colorectal cancer. METHODS: Fecal tumor M2-PK was measured in stool samples of 96 study participants (33 patients with colorectal cancer, 21 patients with rectal carcinoma and 42 controls) who all underwent total colonoscopy. RESULTS: In 39 of 42 individuals in the control group, fecal tumor M2-PK was below 4.0 kU/L (93% specificity). Colorectal tumors were accompanied by a highly significant increase (P < 0.001) in fecal tumor M2- PK levels (median: colon carcinoma, 23.1 kU/L; rectal carcinoma, 6.9 kU/L; colorectal carcinoma, 14.7 kU/L), which correlated with Duke’s staging and T-classification. The overall sensitivity was 78% for colorectal cancer, increasing from 60% for stage T1 to 100% for stage T4 and from 60% for Duke’s A to 90% for Duke’s D tumors. CONCLUSION: Fecal tumor M2-PK is an appropriately sensitive tool to pre-select those patients requiring colonoscopy for the further diagnostic confirmation or exclusion of colorectal cancer. | Carolin Tonus Gero Neupert Markus Sellinger | 2006 | World Journal of Gastroenterology2006，12，43： | 14 |
| 3 | Biogenesis of mitochondrial c-type cytochromes显示文摘 | Gonzales D H Neupert W | 2000 | Bioenerg Biomembr2000，22，： | 1 |
| 4 | Active Control for an Offshore Crane Using Prediction of the Vessel' s Motion 显示文摘 | Kuchler S Mahl T & Neupert J | 2011 | IEEE/ASME Transactions on Mechatronics2011，16，2： | 1 |
| 5 | Yeast mitochondrial Fl F0-ATP synthase exists as a dimer: iden- tification of three dimer-specific subunits 显示文摘 | ARNOLD I PFEIFFER K NEUPERT W | 1998 | The EM- BO Journal1998，17，24： | 1 |
| 6 | The Oxa2 protein of Neurospora crassa plays a critical role in the biogenesis of cytochrome oxidase and defines a ubiquitous subbranch of the Oxal/YidC/Alb3 protein family显示文摘 | Funes S Nargang FE Neupert W | 2004 | Molecular Biology of the Cell2004，15，4： | 1 |
| 7 | Unique accumulation of neuropeptides in an insect: FMRFamide-related peptides in the cockroach, Periplaneta americana显示文摘 | Predel R Neupert S Wicher D | 2004 | Eur J Neurosci2004，20，6： | 1 |
| 8 | Evaluation of dexamethasone for reduction of postsurgical sequelae of third molar removal显示文摘 | Neupert EA 3rd Lee JW Philput CB | 1992 | J Oral Maxillofac Surg1992，50，11： | 1 |
| 9 | Heterotopes Pankreasgewebe in der Gallenblase显示文摘 | G. Neupert P. Appel S. Braun C. Tonus | 2007 | Der Chirurg2007，，3： | 1 |
| 10 | Mass spectrometric analysis of single identified neurons of an insect显示文摘 | Neupert S Predel R | 2005 | Biochem Biophys Res Commun2005，327，3： | 1 |
| 11 | Mass spectrometric analysis of FMRFamide-like immunoreactive neurons in the prothoracic and subesophageal ganglion of Periplaneta americana显示文摘 | Neupert S Gundel M | 2007 | Peptides2007，28，1： | 1 |
| 12 | Biogenesis of Tom40, core component of the TOM complex of mitochondria显示文摘 | Rapaport D Neupert W | 1999 | The Jour- nal of Ceil Biology1999，146，2： | 1 |
| 13 | Knowledge acquisition from foreign parents in interna-tional joint ventures:an empirical study in Vietnam显示文摘 | Anh P T T Baughn C C Hang N T M Neupert K E | 2006 | International Business Review2006，15，5： | 1 |
| 14 | Evaluation of dexamethasone for reduction of postsurgical sequelae of third molar removal显示文摘 | Neupert EA 3rd Lee JW Philput CB | 1992 | J Oral Maxillofac Surg1992，50，11： | 1 |
| 15 | Prohibitins regulate membrane protein degradation by the m-AAA protease in mitochondria 显示文摘 | Steglich G Neupert W Langer T | 1999 | Mol Biol Cell1999，19，5： | 1 |
| 16 | Mdj2p,a novel DnaJ homolog in the mitochondrial inner membrane of the yeast Saccharomyces cerevisiae显示文摘 | Westermann B Neupert W | 1997 | J Mol Biol1997，272，4： | 1 |
| 17 | Hsp70 in mitochondrial biogenesis: from chaperoning nascent polypeptide chain to facilitation of protein degradation显示文摘 | Stuart RA Cyr DM Neupert W | 1994 | Experientia1994，50，： | 1 |
| 18 | Toward a singlecell-based analysis of neuropeptide expression in periplaneta Americana antennal lobe neurons显示文摘 | Neupert S Fusca D Schachtner J | 2012 | J Comp Neurol2012，520，： | 1 |
| 19 | Translocation of proteins into mi-toehondria显示文摘 | Neupert W Herrman JM | 2007 | Annu Rev Biochem2007，76，： | 1 |
| 20 | Corazonin in insects显示文摘 | Predel Reinhard Neupert Susanne Russell ec.al | | 0，，01： | 1 |
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