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| 1 | -449 C>G polymorphism of NFKB1 gene,coding nuclear factor-kappa-B,is associated with the susceptibility to ulcerative colitis显示文摘AIM:To clarify the association between a polymorphism-449 C>G(rs72696119) in 5'-UTR of NFKB1 with ulcerative colitis(UC).METHODS:The studied population comprised 639 subjects,including patients with UC(UC cases,n = 174) and subjects without UC(controls,n = 465).We employed polymerase chain reaction-single strand conformation polymorphism to detect the gene polymorphism.RESULTS:The rs72696119 G allele frequencies in controls and UC cases were 33.4% and 38.5%,respectively(P = 0.10).Genotype frequency of the GG homozygote in UC cases was significantly higher than that in controls(P = 0.017),and the GG homozygote was significantly associated with susceptibility to UC [odds ratio(OR),1.88;95%CI,1.13-3.14].In male subjects,the GG homozygote was associated with an increased risk for UC(OR,3.10;95%CI,1.47-6.54;P = 0.0053),whereas this association was not found in female subjects.In addition,the GG homozygote was significantly associated with the risk of non-continuous disease(OR,2.06;95%CI,1.12-3.79;P = 0.029),not having total colitis(OR,2.40;95%CI,1.09-3.80,P = 0.040),disease which developed before 20 years of age(OR,2.80;95%CI,1.07-7.32,P = 0.041),no hospitalization(OR,2.28;95%CI,1.29-4.05;P = 0.0090) and with a maximum of 8 or less on the UCDAI score(OR,2.45;95%CI,1.23-4.93;P = 0.022).CONCLUSION:Our results provide evidence that NFKB1 polymorphism rs72696119 was significantly associated with the development of UC.This polymorphism influences the susceptibility to and pathophysiological features of UC. | Ranji Hayashi Tomomitsu Tahara Tsukasa Yamaaki Takashi Saito Kazuhiro Matsunaga Nobuhiko Hayashi Atsushi Fukumura Kazuaki Ozaki Masakatsu Nakamura Hisakazu Shiroeda Mikihiro Tsutsumi Tomoyuki Shibata Tomiyasu Arisawa | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 2 | The biology and demographic parameters of Aedes albopictus in northern peninsular Malaysia显示文摘Objective:To generate life table characteristics for the dengue vector Aedes albopictus(A. albopictus) under uncontrolled conditions,incorporating both the aquatic and the adult stages. Methods:Ten females derived from wild pupae were allowed to fully blood-feed on restrained mice.774 eggs were hatched in seasoned water.F1 larvae were followed for development until their F2 counterparts emerged as adults.Some population parameters were monitored(Fl) or estimated(F2).Results:A.albopictus exhibited increased fecundity and egg hatch success. Immature development was quick.Immature survival was high,with lowest rate in the pupal stage.Adult emergence was about 81%and sex ratio was close to 1:1.Generational mortality(K) was about 28%.A high proportion of females completed a reproductive cycle and the obtained parity rate was predicted to lead to higher fecundity in the next generation.Conclusios:It can be concluded that natural A.albopictus populations in Penang seem largely determined by quick development in combination with low immature loss and increased oviposition. | H Nur Aida Hamady Dieng Abu Hassan Ahmad Tomomitsu Satho AT Nurita MR Che Salmah Fumio Miake B Norasmah | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 2 |
| 3 | Insecticide susceptibility of the dengue vector Aedes aegypti (Diptera: culicidae) in Makkah City, Saudi Arabia显示文摘 | Al Thbiani Aziz Hamady Dieng Ahmad Abu Hassan Tomomitsu Satho Fumio Miake Md Rawi Che Salmah Sazaly AbuBakar | 2011 | Asian Pacific Journal of Tropical Disease2011，，2： | 2 |
| 4 | Synthesis of super-high-molecular-weight poly-γ-glutamic acid by Bacillus subtilis subsp. chungkookjang显示文摘 | Chung Park Jae-Chul Choi Yoon-Ho Choi Hisaaki Nakamura Kazuya Shimanouchi Terumi Horiuchi Haruo Misono Tomomitsu Sewaki Kenji Soda Makoto Ashiuchi Moon-Hee Sung | 2005 | Journal of Molecular Catalysis B Enzymatic2005，，4： | 1 |
| 5 | Quantitative analysis of MMP-2 and -9,and their tissue inhibitor -1,-2 in human placenta throughout gestation显示文摘 | Rong Niu Tomomitsu Okamoto Katsutoshi Iwase | 2000 | Life Sciences2000，66，12： | 1 |
| 6 | Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations显示文摘 | Emiko Noguchi Hiromi Sakamoto Tomomitsu Hirota | 2011 | PLoS Genetics2011，7，7： | 1 |
| 7 | Low-intensity pulsed ultrasound stimulates cell proliferation and proteoglycan production in rabbit intervertebral disc cells cultured in alginate显示文摘 | Toru Iwashina Joji Mochida Takeshi Miyazaki Takuya Watanabe Sadahiro Iwabuchi Kiyoshi Ando Tomomitsu Hotta Daisuke Sakai | 2005 | Biomaterials2005，，3： | 1 |
| 8 | Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3′-UTR, influence susceptibility to gastric cancer显示文摘 | Tomiyasu Arisawa Tomomitsu Tahara Hisakazu Shiroeda Yasuhito Matsue Takahiro Minato Tomoe Nomura Hideto Yamada Ranji Hayashi Takashi Saito Kazuhiro Matsunaga Tomoki Fukuyama Nobuhiko Hayashi Toshimi Otsuka Atsushi Fukumura Masakatsu Nakamura Tomoyuki Shib | 2012 | Human Immunology2012，，7： | 1 |
| 9 | Level of placenta growth factor in gestational trophoblastic diseases显示文摘 | Tomomitsu Okamoto MD Rong Niu MD Shigehiko Mizutani MD | 2003 | Am J Obstet Gynecol2003，188，： | 1 |
| 10 | Gastric mucosal pattern by using magnifying narrow-band imaging endoscopy clearly distinguishes histological and serological severity of chronic gastritis显示文摘 | TOMOMITSU T TOMOYKUI S | 2009 | Gastrointestinal Endoscopy2009，70，2： | 1 |
| 11 | Biochemical markers for the detection of bone metastasis in patients with prostate cancer:diagnostic efficacy and the effect of hormonal therapy显示文摘 | Tamada T Sone T Tomomitsu T | 2001 | J Bone Miner Metab2001，19，1： | 1 |
| 12 | Biochemical markers for the detection of hone metastasis in patients with prostate cancer: diagnostic efficacy and the effect of hormonal therapy显示文摘 | Tarnada T Sone T Tomomitsu T | 2001 | J Bone Miner Metab2001，19，1： | 1 |
| 13 | Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura显示文摘 | Nomura S K azuo D Tomomitsu H | 2002 | Blood2002，100，3： | 1 |
| 14 | Quantitative analysis of matrix metalloproteinase-2 and-9, and their tissue inhibitors-1and - 2 in human placenta throughout gestation显示文摘 | Rong Niu Tomomitsu Okamoto Katsutoshi Iwase | 2000 | Life Science2000，66，12： | 1 |
| 15 | Pain relief of oral ulcer by dibucaine-film显示文摘 | KEIKO Y TOSHIHISA Y TOMOMITSU O | 1999 | Pain1999，83，： | 1 |
| 16 | Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with id-iopathic thrombocytopenie purpura显示文摘 | Nomura S Kazuo D Tomomitsu H | 2002 | Blood2002，100，3： | 1 |
| 17 | Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population显示文摘 | Tomomitsu H Atsushi T Michiaki K | 2012 | Nat Genet2012，44，11： | 1 |
| 18 | The usefulness of magnifying endoscopy with narrow-band imaging to distinguish carcinoma in flat elevated lesions in the stomach diagnosed as adenoma by using biopsy samples显示文摘 | Masakatsu Nakamura Tomoyuki Shibata Tomomitsu Tahara Daisuke Yoshioka Masaaki Okubo Yoshikazu Mizoguchi Makoto Kuroda Tomiyasu Arisawa Ichiro Hirata | 2010 | Gastrointestinal Endoscopy2010，，6： | 1 |
| 19 | Homozygous 825T Allele of the GNB3 Protein Influences the Susceptibility of Japanese to Dyspepsia显示文摘 | Tomomitsu Tahara Tomiyasu Arisawa Tomoyuki Shibata Fangyu Wang Masakatsu Nakamura Mikijyu Sakata Ichiro Hirata Hiroshi Nakano | 2008 | Digestive Diseases and Sciences2008，，3： | 1 |
| 20 | Seasonal Changes in Mayfly Communities and Abundance in Relation to Water Physicochemistry in Two Rivers at Different Elevations in Northern Peninsular Malaysia显示文摘A field study was performed at rivers in Gunung Jerai forest reserve(Kedah,Malaysia) to assess seasonal changes in mayfly community structure and abundance in relation to altitude and water physicochemistry.Rivers at lower(Batu Hampar River) and higher(Teroi River) elevations were visited through dry and wet seasons in September 2007 to August 2008.Monthly visits were made to 20 sites on each river,and water and aquatic insects were sampled using D-pond aquatic nets.Water was warmer,more acid,and more turbid in Teroi River during wet season.Ammonia was the only nutrient exhibiting significant seasonal variations(greater during wet season).Chemical oxygen demand content was higher in Teroi River where biochemical oxygen demand content was low during wet season.Species richness was higher in Batu Hampar River,but displayed seasonal variations only in Teroi River.Among the eight families encountered,Baetidae was the commonest.Baetid abundance was usually high during wet season,and those belonging to the dominant genus(Baetis) were more abundant in Teroi River.Heptageniidae was the second commonest family;its predominant genus,Thalerospyrus was more abundant in Teroi River during dry season.Caenidae,Leptophlebiidae and Oligoneuriidae were only found in Batu Hampar River where their abundances peaked during dry season,i.e.,Habrophlebiodes sp.and Isonychia sp.Ephemerellidae and Teloganodidae occurred only in Teroi River,with the first found only during dry season.Mayflies were recorded under very distinct physicochemical conditions,illustrating their potential usefulness for assessing water quality.Caenids,leptophlebids,oligoneurids ephemerellids and teloganodids seem to be particularly sensitive to temperature,acidity,turbidity,chemical oxygen demand and biochemical oxygen demand,parameters that varied with river altitude. | Suhaila Abdul Hamid Mohd Ravi Che Salmah Hamady Dieng Abu Hassan Ahmad Tomomitsu Satho Fumio Miake | 2011 | 湿地科学2011，9，3： | 1 |
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