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| 1 | Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery. | Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen | 2008 | World Journal of Gastroenterology2008，14，45： | 4 |
| 2 | Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial显示文摘 | Edward J Gane Stuart K Roberts Catherine AM Stedman Peter W Angus Brett Ritchie Rob Elston David Ipe Peter N Morcos Linda Baher Isabel Najera Tom Chu Uri Lopatin M Michelle Berrey William Bradford Mark Laughlin Nancy S Shulman Patrick F Smith | 2010 | The Lancet2010，，9751： | 1 |
| 3 | Rapid income growth adversely affects diet quality in China--particularly for the poor 显示文摘 | Shufa D Tom AM Fengying Z | 2004 | Social Science & Medicine2004，59，7： | 1 |
| 4 | E- valuating Prothrom botic state in lung cancer using molecular m ark- ers显示文摘 | Esteban C Cabazza O sam u Taguchi Tom oya Y am akam i | 1993 | Chest1993，103，1： | 1 |
| 5 | Transjugular intrahepatic portosystemic shunt-placement increases arginine/asymmetric dimethylarginine ratio in cirrhotic patients显示文摘AIM:To analyze the change of dimethylarginine plasma levels in cirrhotic patients receiving transjugular intrahepatic portosystemic shunt(TIPS).METHODS:To determine arginine,asymmetric dimethylarginine(ADMA),symmetric dimethylarginine(SDMA),and nitric oxide(NO) plasma levels,blood samples were collected from the superior cava,hepatic,and portal vein just before,directly after,and 3 mo after TIPS-placement.RESULTS:A significant increase in the arginine/ADMA ratio after TIPS placement was shown.Moreover,TIPS placement enhanced renal function and thereby decreased systemic SDMA levels.In patients with renal dysfunction before TIPS placement,both the arginine/ADMA ratio and creatinine clearance rate increased significantly,while this was not the case in patients with normal renal function before TIPS placement.Hepatic function did not change significantly after TIPS placement and no significant decline in ADMA plasma levels was measured.CONCLUSION:The increase of the arginine/ADMA ratio after TIPS placement suggests an increase in intracellular NO bioavailability.In addition,this study suggests that TIPS placement does not alter dimethylarginine dimethylaminohydrolase(DDAH) activity and confirms the major role of the liver as an ADMA clearing organ. | Michiel PC Siroen Reiner Wiest Milan C Richir Tom Teerlink Jan A Rauwerda Friedrich T Drescher Niels Zorger Paul AM van Leeuwen | 2008 | World Journal of Gastroenterology2008，14，47： | 1 |
| 6 | The evaluation of the introduction of a quality management system: a process-oriented case study in a large rehabilitation hospital显示文摘 | Willem H Tom F Olat AM | 2002 | Health Policy2002，60，： | 1 |
| 7 | A hybrid system for combustion turbine inlet air cooling at a cogeneration plant in Pasadena,Texas显示文摘 | PUNWANI DHAR AM V PIERSON TOM BAGLEY JAMES | 2001 | ASHRAE Transactions2001，107，1： | 1 |
| 8 | Genetic influence on cytokine production and fatal meningococcal disease显示文摘 | Rudi GJ Westendorp Jan AM Langermans Tom WJ Huizinga Abdul H Elouali Cornelis L Verweij Dorret I Boomsma Jan P Vandenbrouke | 1997 | The Lancet1997，，9046： | 1 |
| 9 | Permissive hypercapnia during mechanical ventilation of neonates 显示文摘 | Toms R Am balavanan N | 2004 | Indian Pediatr2004，41，8： | 1 |
| 10 | Rapid income growth adversely affects diet quality in China particularly for the poor显示文摘 | Shufa D Tom AM Fengying Z | 2004 | Soc Sci Med2004，59，： | 1 |
| 11 | Prevention of theonset and progression of collagen-induced arthritis in rats by the potentp38mitogen activated protein kinase inhibitor FR167653 显示文摘 | Nish Ikaw AM Myou IA Tom Ita T | 2003 | ArthritisRheum2003，48，9： | 1 |
| 12 | Expression of signal-induced proliferation- associated gene 1 ( SIPAI ), a RapGTPase-activating protein, is in- creased in colorectal cancer and has diverse effects on functions of colorectal cancer cells显示文摘 | Ji K Ye L Toms AM | 2012 | Cancer Genomics Proteomics2012，9，5： | 1 |
| 13 | Changes in tumorigenesis-and angiogenesis-related gene transcript abundance profiles in ovarian cancer detected by tailored high density cDNA arrays显示文摘 | Martoglio AM Tom BD Starkey M | | 0，，9： | 1 |
| 14 | Changes in tu-morigenesis and angiogenesis-related gene transcript abun-dance profiles in ovarian cancer detected by tailored high density cDNA arrays显示文摘 | Martoglio AM Tom BD Starkey M | | 0，，09： | 1 |
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