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| 1 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 2 | Root-Specific Transcript Profiling of Contrasting Rice Genotypes in Response to Salinity Stress显示文摘提高的咸度强加渗透并且离子毒性在生活上强调房间并且要求大量的回答以便启用植物幸存。在在米饭( Oryza sativa )介绍抄本层次的更早的工作上造 FL478 射击,盐容忍的 indica recombinant 生来的线,和 IR29 ,盐敏感的栽培变种,抄本层次在这二就职的根以及在二另外的盐容忍的 indica 遗传型的根被比较, landrace Pokkali 和 recombinant 生来的线 IR63731 。这研究的目的是比较抄本在敏感并且容忍的线以便多半识别基因涉及工厂咸度忍耐,而非响应咸度本身。有到咸度忍耐的已知的连接的几个基因家庭的抄本侧面被描述(例如 HKT, NHX ) 。通过他们的盐应答,抄本层次,或 chromosomal 地点识别的一套基因的通常认为的功能(即在为咸度忍耐的 QTL 下面) 也被讨论。最后,在 FL478 的 Saltol 区域的父母起源进一步被调查。总的来说,介绍的数据集看起来柔韧,这个系统能为涉及咸度忍耐的新奇基因的发现提供可靠策略,似乎可能。 | Olivier Cotsaftis Darren Plett Alexander A.T. Johnson Harkamal Walia Clyde Wilson Abdelbagi M. Ismail Timothy J. Close Mark Tester Ute Baumann | 2011 | Molecular Plant2011，4，1： | 14 |
| 3 | 白蛋白刺激肾小管上皮细胞表达基质金属蛋白酶2和9显示文摘目的探讨白蛋白对近端肾小管上皮细胞表达基质金属蛋白酶2(MMP-2)和MMP-9的影响。方法大鼠近端肾小管细胞株NRK52E培养至70%或100%融合时,分别给予不同浓度(0.1~1.0g/L)去脂和非去脂牛血清白蛋白(dBSA和BSA)刺激,于24、48、72h收集培养液,用明胶酶谱和Western印迹方法检测培养液MMP-2和MMP-9活性和蛋白水平。结果与空白对照组比较,1.0g/LBSA刺激未完全融合NRK52E72h后,MMP-2和MMP-9活性分别上调276%、176%(P〈0.05)。与刺激24h比较,1.0g/LBSA刺激72h,在未完全融合NRK52E的MMP-2和MMP-9活性分别上调536%、148%;在完全融合NRK52E分别上调212%、184%(P〈0.05)。与完全融合NRK52E比较,1.0g/LBSA刺激未完全融合NRK52E 72h,MMP-2活性上调增加了274%,MMP-9活性上调减少了45.1%(P〈0.05)。dBSA刺激结果与BSA类似。结论白蛋白刺激呈剂量和时间依赖性上调近端肾小管细胞表达MMP-2和MMP-9。细胞完全融合可抑制MMP-2表达,促进MMP-9表达。 | 孙良忠 Ibrini Juma Parker Emma 陈述枚 Johnson Timothy S. El Nahas A. Meguid | 2007 | 中华肾脏病杂志2007，23，8： | 9 |
| 4 | Radial artery access site complications during cardiac procedures,clinical implications and potential solutions: The role of nitric oxide显示文摘Percutaneous coronary intervention for the treatment of coronary artery disease is most commonly performed in the UK through the radial artery,as this is considered to be safer than the femoral approach.However,despite improvements in technology and techniques,complications can occur.The most common complication,arterial spasm,can cause intense pain and,in some cases,procedural failure.The incidence of spasm is dependent on several variables,including operator experience,artery size,and equipment used.An antispasmolytic cocktail can be applied to reduce spasm,which usually includes an exogenous nitric oxide(NO)donor(glyceryl trinitrate).NO is an endogenous local vasodilator and therefore is a potential target for anti-spasm intervention.However,systemic administration can result in unwanted side-effects,such as hypotension.A method that adopts local delivery of NO might be advantageous.This review article describes the mechanisms involved in radial artery spasm,discusses the advantages and disadvantages of current strategies to reduce spasm,and highlight the potential of NO-loaded nanoporous materials for use in this setting. | Emma M Coghill Timothy Johnson Russell E Morris Ian L Megson Stephen J Leslie | 2020 | World Journal of Cardiology2020，12，1： | 4 |
| 5 | Development and optimization of thermal contrast amplification lateral flow immunoassays for ultrasensitive HIV p24 protein detection显示文摘Detection of human immunodeficiency virus(HIV)p24 protein at a single pg/ml concentration in point-of-care(POC)settings is important because it can facilitate acute HIV infection diagnosis with a detection sensitivity approaching that of laboratory-based assays.However,the limit of detection(LOD)of lateral flow immunoassays(LFAs),the most prominent POC diagnostic platform,falls short of that of laboratory protein detection methods such as enzyme-linked immunosorbent assay(ELISA).Here,we report the development and optimization of a thermal contrast amplification(TCA)LFA that will allow ultrasensitive detection of 8 pg/ml p24 protein spiked into human serum at POC,approaching the LOD of a laboratory test.To achieve this aim,we pursued several innovations as follows:(a)defining a new quantitative figure of merit for LFA design based on the specific to nonspecific binding ratio(BR);(b)using different sizes and shapes of gold nanoparticles(GNPs)in the systematic optimization of TCA LFA designs;and(c)exploring new laser wavelengths and power regimes for TCA LFA designs.First,we optimized the blocking buffer for the membrane and running buffer by quantitatively measuring the BR using a TCA reader.The TCA reader interprets the thermal signal(i.e.,temperature)of GNPs within the membrane when irradiated by a laser at the plasmon resonance wavelength of the particle.This process results in higher detection and quantitation of GNPs than in traditional visual detection(i.e.,color intensity).Further,we investigated the effect of laser power(30,100,200 mW),GNP size and shape(30 and 100 nm gold spheres,150 nm gold-silica shells),and laser wavelength(532,800 nm).Applying these innovations to a new TCA LFA design,we demonstrated that 100nm spheres with a 100 mW 532 nm laser provided the best performance(i.e.,LOD=8pg/ml).This LOD is significantly better than that of the current colorimetric LFA and is in the range of the laboratory-based p24 ELISA.In summary,this TCA LFA for p24 protein shows promise for detecting acute HIV infection in POC settings. | Li Zhan Timothy Granade Yilin Liu Xierong Wei Ae Youngpairoj Vickie Sullivan Jeff Johnson John Bischof | 2020 | Microsystems & Nanoengineering2020，6，1： | 3 |
| 6 | Worsening renal function in heart failure: The need for a consensus definition显示文摘 | Noella J. Sheerin Phillip J. Newton Peter S. Macdonald Dominic Y.C. Leung David Sibbritt Stephen Timothy Spicer Kay Johnson Henry Krum Patricia M. Davidson | 2014 | International Journal of Cardiology2014，，： | 2 |
| 7 | Asymbiotic and symbiotic seed germination of Eulophia alta (Orchidaceae)—preliminary evidence for the symbiotic culture advantage显示文摘 | Timothy R. Johnson Scott L. Stewart Daniela Dutra Michael E. Kane Larry Richardson | 2007 | Plant Cell, Tissue and Organ Culture2007，，3： | 1 |
| 8 | An introduction to date envelopment analysis: An efficiency evaluation of prisons显示文摘 | Johnson Wesley Timothy W Butler | 1997 | Criminal Justice Review1997，22，： | 1 |
| 9 | The pap operon of avian pathogenic Escherichia coli strain O1:K1 is located on a novel pathogenicity island显示文摘 | Timothy J Johnson Lisa K Nolan | 2006 | Infection and Immunity2006，74，1： | 1 |
| 10 | Aflatoxin and PAH exposure biomarkers in a U.S. population with a high incidence of hepatocellular carcinoma显示文摘 | Natalie M. Johnson Guoqing Qian Li Xu Danielle Tietze Alicia Marroquin-Cardona Abraham Robinson Melanie Rodriguez Linda Kaufman Kyle Cunningham James Wittmer Fernando Guerra Kirby C. Donnelly Jonathan H. Williams Jia-Sheng Wang Timothy D. Phillips | 2010 | Science of the Total Environment2010，，23： | 1 |
| 11 | Biology of Hepatocellular Carcinoma显示文摘 | Roberta W. C. Pang PhD Jae Won Joh MD Philip J. Johnson MD Morito Monden MD Timothy M. Pawlik MD MPH Ronnie T. P. Poon MS PhD | 2008 | Annals of Surgical Oncology2008，，4： | 1 |
| 12 | The management of multiple pregnancy:pre natal carpart I 显示文摘 | Johnson AA Timothy RB | 2005 | Obstetrical & Gynecological Survey2005，60，8： | 1 |
| 13 | Diesel emission control in review 显示文摘 | Timothy V Johnson | 2009 | SAE Paper2009，，： | 1 |
| 14 | Organizationand regulation of mitogenactivated proteinkinase signaling pathways显示文摘 | Timothy PG Johnson GL | 1999 | Current Opinionin Cell Bioligy1999，1，： | 1 |
| 15 | Optimal Control-Surface Locations for Flexible Aircraft 显示文摘 | Timothy L Johnson Michael Athans Grant B Skelton | 1971 | IEEE Transactions on Automatic Control (S0018-9286)1971，16，4： | 1 |
| 16 | Nanostructured Thermoelectric Materials and High-Efficiency Power-Generation Modules显示文摘 | Timothy P. Hogan Adam Downey Jarrod Short Jonathan D’Angelo Chun-I Wu Eric Quarez John Androulakis Pierre F.P. Poudeu Joseph R. Sootsman Duck-Young Chung Mercouri G. Kanatzidis S.D. Mahanti Edward J. Timm Harold Schock Fei Ren Jason Johnson Eldon D. Case | 2007 | Journal of Electronic Materials2007，，7： | 1 |
| 17 | Phenotypic Heterogeneity among Tumorigenic Melanoma Cells from Patients that Is Reversible and Not Hierarchically Organized显示文摘 | Elsa Quintana Mark Shackleton Hannah R. Foster Douglas R. Fullen Michael S. Sabel Timothy M. Johnson Sean J. Morrison | 2010 | Cancer Cell2010，，5： | 1 |
| 18 | Diverse and abundant antibiotic resistance genes in Chinese swine farms显示文摘 | Yong Guan Zhu Timothy A Johnson Jian Qiang Su | 2013 | Pans2013，110，9： | 1 |
| 19 | The retirement consumption conundrum: Evidence from a consumption survey显示文摘 | Jonathan D. Fisher David S. Johnson Joseph Marchand Timothy M. Smeeding Barbara Boyle Torrey | 2007 | Economics Letters2007，，3： | 1 |
| 20 | The pap operon of avian pathogenic Escherichia coli strain O1 : K1 is located on a novel pathogenicity island 显示文摘 | Kariyawasam subhashinie Johnson timothy J Nolan lisa K | 2006 | Inf Imm2006，74，1： | 1 |
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