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| 1 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet . 2012 (9859)2012，，9859： | 7 |
| 2 | Drug eluting biliary stents to decrease stent failure rates:Areview of the literature显示文摘Biliary stenting is clinically effective in relieving both malignant and non-malignant obstructions. However, there are high failure rates associated with tumor ingrowth and epithelial overgrowth as well as internally from biofilm development and subsequent clogging. Within the last decade, the use of prophylactic drug eluting stents as a means to reduce stent failure has been investigated. In this review we provide an overview of the current research on drug eluting biliary stents. While there is limited human trial data regarding the clinical benefit of drug eluting biliary stents in preventing stent obstruction, recent research suggests promise regarding their safety and potential efficacy. | Joseph Shatzel Jisoo Kim Kartik Sampath Sharjeel Syed Jennifer Saad Zilla H Hussain Kabir Mody J Marc Pipas Stuart Gordon Timothy Gardner Richard I Rothstein | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 6 |
| 3 | Ischemic post-conditioning to counteract intestinal ischemia/reperfusion injury显示文摘Intestinal ischemia is a severe disorder with a variety of causes.Reperfusion is a common occurrence during treatment of acute intestinal ischemia but the injury resulting from ischemia/reperfusion(IR)may lead toeven more serious complications from intestinal atrophy to multiple organ failure and death.The susceptibility of the intestine to IR-induced injury(IRI)appears from various experimental studies and clinical settings such as cardiac and major vascular surgery and organ transplantation.Where as oxygen free radicals,activation of leukocytes,failure of microvascular perfusion,cellular acidosis and disturbance of intracellular homeo-stasis have been implicated as important factors inthe pathogenesis of intestinal IRI,the mechanisms underlying this disorder are not well known.To date,increasing attention is being paid in animal studies to potential pre-and post-ischemia treatments that protect against intestinal IRI such as drug interference with IR-induced apoptosis and inflammation processes and ischemic pre-conditioning.However,better insight is needed into the molecular and cellular events associated with reperfusion-induced damage to develop effective clinical protection protocols to combat this disorder.In this respect,the use of ischemic post-conditioning in combination with experimentally prolonged acidosis blocking deleterious reperfusion actions may turn out to have particular clinical relevance. | Timothy A Pritts Marshall H Montrose | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，4： | 6 |
| 4 | 超声心动图对左心发育不良综合征术前诊断及术后评价的意义显示文摘目的 总结 1998年在美国贝勒医学院工作期间 ,左心发育不良综合征 (HLHS)患者改良NorwoodⅢ期心脏重建手术前后超声心动图诊断的资料和经验 ,评价其价值并为国内同行借鉴。方法 HLHS患者 18例 ,NorwoodⅠ期手术 10例 ,Ⅱ期手术 6例 ,Ⅲ期手术 2例。术前超声心动图结果与术中外科诊断比较 ,分诊断符合、诊断不符和轻微差别。结果 NorwoodⅠ期手术 10例患者均无术前心导管检查 ,超声心动图术前诊断与术中外科诊断达到 10 0 %的诊断符合。Ⅱ期手术患者 6例 ,超声心动图对Ⅰ期手术术后评价的诊断符合率为10 0 % ,分支肺动脉的评价 33 .3 %诊断符合 ,6 6 .7%有轻微差别。Ⅲ期手术的 2例病患者超声心动图与术中诊断均相符。结论 单靠超声心动图能够确立HLHS的诊断并为NorwooⅠ期手术提供足够的信息 ,对NorwoodⅡ期和Ⅲ期术前及术后诊断超声心动图能够提供大量正确的信息 。 | 吴进 Ricardo H Pignatelli Louis I Bezold J Timothy Bricker | 2001 | 中华超声影像学杂志2001，10，9： | 6 |
| 5 | Reelin induces EphB activation显示文摘进功能的 neuronal 网络的新生的神经原的集成在 neuronal 进程和与另外的神经原的 synaptic 接触的形成的发展中的大脑,生长和树枝状要求房间的移植到他们的最后的位置。在协调区别事件的这个复杂序列的信号之中的一个中央播放器是分泌 glycoprotein Reelin,它也调制 synaptic 粘性,学习并且在成年大脑的记忆形成。到 ApoER2 和 VLDL 受体的 Reelin 有约束力, LDL 受体家庭的二个成员,开始包含细胞内部的细胞质的适配器蛋白质 Disabled-1 的酷氨酸 phosphorylation 的发信号的串联,它指向 neuronal 细胞骨架并且最终控制在整个发展中的大脑放神经原。然而, Reelin 信号与另外的调停受体的发信号串联交往调整大脑开发和粘性的不同方面,是可能的。EphB 酷氨酸 kinases 经由通过 ephrin B transmembrane 蛋白质的双向发信号调整房间粘附和排斥依赖者过程。这里,我们证明 Reelin 绑在 EphB transmembrane 蛋白质的细胞外的领域,导致受体聚类和向前在神经原发信号的 EphB 的激活,独立于“古典”的 Reelin 受体, ApoER2 和 VLDLR。因此,鼠标缺乏 EphB1 和 EphB2 显示 CA3 海马趾的金字塔形的神经原的一个放的缺点,类似于那在 Reelin 缺乏的鼠标,和这房间迁居,缺点取决于 EphB 蛋白质的 kinase 活动。一起,我们的数据为在向前发信号的 Reelin 和 EphB 之间的信号集成提供生物化学、功能的证据。 | Elisabeth Bouche Mario I Romero-Ortega Mark Henkemeyer Timothy Catchpole Jost Leemhuis Michael Frotscher Petra May Joachim Herz Hans H Bock | 2013 | Cell Research2013，23，4： | 5 |
| 6 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet2012，，9859： | 5 |
| 7 | Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana显示文摘Gastroduodenal disease(GDD)was initially thought to be uncommon in Africa.Amongst others,lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the world.Following the increasing availability of flexible upper gastro-intestinal endoscopy,it has now become apparent that GDD,especially peptic ulcer disease(PUD),is prevalent across the continent of Africa.Recognised risk factors for gastric cancer(GCA)include Helicobater pylori(H.pylori),diet,Epstein-Barr virus infection and industrial chemical exposure,while those for PUD are H.pylori,non-steroidal antiinflammatory drug(NSAID)-use,smoking and alcohol consumption.Of these,H.pylori is generally accepted to be causally related to the development of atrophic gastritis(AG),intestinal metaplasia(IM),PUD and distal GCA.Here,we perform a systematic review of the patterns of GDD across Africa obtained with endoscopy,and complement the analysis with new data obtained on premalignant gastric his-topathological lesions in Accra,Ghana which was compared with previous data from Maputo,Mozambique.As there is a general lack of structured cohort studies in Africa,we also considered endoscopy-based hospital or tertiary centre studies of symptomatic individuals.In Africa,there is considerable heterogeneity in the prevalence of PUD with no clear geographical patterns.Furthermore,there are differences in PUD within-country despite universally endemic H.pylori infection.PUD is not uncommon in Africa.Most of the African tertiary-centre studies had higher prevalence of PUD when compared with similar studies in western countries.An additional intriguing observation is a recent,ongoing decline in PUD in some African countries where H.pylori infection is still high.One possible reason for the high,sustained prevalence of PUD may be the significant use of NSAIDs in local or over-the-counter preparations.The prevalence of AG and IM,were similar or modestly higher over rates in western countries but lower than those seen in Asia..In our new data,sampling of 136 patients in Accra detected evidence of pre-malignant lesions(AG and/or IM)in 20 individuals(14.7%).Likewise,the prevalence of pre-malignant lesions,in a sample of 109 patients from Maputo,were 8.3%AG and 8.3%IM.While H.pylori is endemic in Africa,the observed prevalence for GCA is rather low.However,cancer data is drawn from country cancer registries that are not comprehensive due to considerable variation in the availability of efficient local cancer reporting systems,diagnostic health facilities and expertise.Validation of cases and their source as well as specificity of outcome definitions are not explicit in most studies further contributing to uncertainty about the precise incidence rates of GCA on the continent.We conclude that evidence is still lacking to support(or not)the African enigma theory due to inconsistencies in the data that indicate a particularly low incidence of GDD in African countries. | Timothy N Archampong Richard H Asmah Cathy J Richards Vicki J Martin Christopher D Bayliss Edília Botao Leonor David Sandra Beleza Carla Carrilho | 2019 | World Journal of Gastroenterology2019，25，26： | 3 |
| 8 | 丁醇同分异构体/汽油混合燃料的燃烧和非常规污染物特性的试验研究(英文)显示文摘本文研究了丁醇同分异构体与汽油混合燃料在进气道喷射的火花点火发动机中的燃烧和排放特性。试验在发动机转速为1200 r/min、发动机负荷为3 bar BMEP 和5 bar BMEP 以及不同混合气空燃比条件下(φ=0.83~1.25)进行,使用了70%体积比的纯汽油和30%体积比的丁醇同分异构体混合燃料(N30,S30,I30 和T30)。结果表明,相比于纯汽油,所有的丁醇同分异构体/汽油混合燃料表现出更高的缸内压力,其中N30 有最高的缸内压力峰值和最早的缸内压力峰值相位;T30 表现出较高的brake燃油消耗率(BSFC)和较低的制动热效率(BTE);相比于其他燃料,N30 的UHC 排放较低而I30 的CO排放较高。在非常规排放物特性方面,相比于纯汽油,丁醇同分异构体/汽油混合燃料有较高的乙醛排放;相比于其他混合燃料,N30 的1,3-丁二烯排放较高。使用丁醇同分异构体/汽油混合燃料可以有效地抑制单环芳烃类质(BTEX)的排放。 | 李元绪 宁智 闫峻豪 Timothy H LEE Chia-fon F LEE | 2019 | Journal of Central South University2019，26，8： | 3 |
| 9 | Serious infections in patients with inflammatory bowel disease receiving anti‐tumor‐necrosis‐factor‐alpha therapy: An Australian and New Zealand experience显示文摘 | Ian CLawrance Graham LRadford‐Smith Peter ABampton Jane MAndrews Pok‐KernTan AnthonyCroft Richard BGearry Timothy H JFlorin | 2010 | Journal of Gastroenterology and Hepatology2010，，11： | 2 |
| 10 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | 2012 (9859)2012，，9859： | 2 |
| 11 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 12 | Adaptive Responses of the Endothelium to Stress显示文摘 | Timothy H Pohlman John MH | 2000 | J Surg Res2000，89，： | 1 |
| 13 | Arsenic removal from drinking water by flocculation and microfiltration显示文摘 | BINBING H TIMOTHY R JULIO Z | 2002 | Desalination2002，，145： | 1 |
| 14 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 15 | Epididymitis andOrchitis:An Overview American Family Physician显示文摘 | HOMAS H TROJIAN TIMOTHY S | 2009 | American Fam ly Phys c anm2009，79，7： | 1 |
| 16 | Development and potential role of type-2 sodium-glucose transporter inhibitors for management of type 2 diabetes 显示文摘 | Timothy C H Simon W D | 2011 | Diabetes Ther2011，2，3： | 1 |
| 17 | The determinants of technology a- doption : The case of the banking firm显示文摘 | TIMOTHY H JOHN M | 1984 | The Rand Journal of Economics1984，，15： | 1 |
| 18 | A Universal Noise Removal Algorithm with an Impulse Detector 显示文摘 | ROMAN G TIMOTHY H CHARLES C WENJIE H | 2005 | IEEE Transactions on Neural Networks2005，14，： | 1 |
| 19 | Conjugated polymer / lanthanide complex based blends as near-IR light emitting diodes 显示文摘 | Mohamed B Benjamin S H Timothy J F | 2002 | Polymer Preprints2002，43，1： | 1 |
| 20 | Polarization insensitive wavelength conversion by FWM of multiformat DWDM signals using birefringent PCF显示文摘 | John P M Timothy U H William A | 2012 | IEEE Journal of selected topics in quantum electronics2012，18，2： | 1 |
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