|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Functional dyspepsia:Are psychosocial factors of relevance?显示文摘机能性消化不良(FD ) 的致病仍然保持不清楚,显得多样并且是不充分地理解的 thus。与另外的功能的胃肠的混乱类似,研究表明了在这普通诊断和精神分析聚会因素和精神病学的病态之间的一个协会。Conceptualising 在 FD 的症候群以内的这些因素的关联要求疾病的 biopsychosocial 模型的申请。用这个范例,在大脑和内脏之间的相互的通讯的 dysregulation 对症状产生,解释和恶化中央。对各种各样的心理状态的 neurobiological 相互关联的欣赏和理解也是相关的。精神分析聚会因素施加的看法他们在 FD 的影响也主要通过寻求的护理的动机坚持。这显得太一个维考虑到可得到的证据的断言支持一个更内在的病因论的连接。病原的机制的演变理解和症候群的异构的性质将便于有效管理。公司疾病的精神病学的病与常规治疗保证处理。在 FD,其度服从于变化,承认精神分析聚会变量的关联为评价和管理有含意。可得到的证据建议心理治疗可以特别地有益于 FD 病人那些与长期的症状。为在 FD 的治疗精神病的药的使用的基本原理是明显的,但是支持抗抑郁剂药物疗法的使用的证据底是标明日期有限的。 | Sandra Barry Timothy G Dinan | 2006 | World Journal of Gastroenterology2006，12，17： | 50 |
| 2 | 加拿大和英国医学院校的课程地图显示文摘本文对英国和加拿大医学院校课程地图(CM)的建设现状、特征、挑战和成功的方面进行了调查研究。结果显示,已有20%的学校完成了CM的构建,而大多数院校正在着力构建中;在CM的构建中,使用了各种不同的软件;当前主要的挑战是对人力的需求、医学本体论的应用、教师发展和接口设计。 | Timothy G Willett 梅人朗 | 2010 | 复旦教育论坛2010，8，3： | 30 |
| 3 | Irritable bowel syndrome: A microbiome-gut-brain axis disorder?显示文摘Irritable bowel syndrome(IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions. | Paul J Kennedy John F Cryan Timothy G Dinan Gerard Clarke | 2014 | World Journal of Gastroenterology2014，20，39： | 20 |
| 4 | The paternal epigenome and embryogenesis: poising mechanisms for development显示文摘父亲的贡献的范围长在早胚胎的开发期间被认为有限。在在整个精子发生的染色质结构的戏剧的变化被认为在 DNA 蓝图上 epigenetic 规定的复杂的层让精子空,因此把那条规定的平衡留给卵母细胞。然而, epigenetics 和男因素不孕的地里的最近的工作放了这长抓住、现在争论的教义,在一盏新灯。在发展中的精子房间调查染色质和 epigenetic 修正的漂亮研究提供了可以在发展中的胚胎为父亲的 epigenome 建立一个更关键的角色的新卓见。进染色质的 DNA methylation, histone 尾巴修正,指向的 histone 保留和鱼精朊加入在发展中的精子房间有大影响。在任何这些 epigenetic 标记的建立或维护的不安被表明了影响富饶地位,在严厉从变化对温和灾难。精子要求染色质的这个无数的结构的变化不仅在整个精子发生和未来交货起一个保护的作用到 DNA 到卵,而且,它出现,贡献未来胚胎的发展节目。这评论将集中于我们精子的 epigenetics 的当前的理解。我们将讨论导致对开发必要的基因在胚胎的开发,其混乱可以导致减少的肥沃早为激活被平衡的精子特定的染色质修正。 | Timothy G Jenkins Douglas T Carrell | 2011 | Asian Journal of Andrology2011，13，1： | 14 |
| 5 | 人肿瘤细胞核苷酸切除修复蛋白表达与抗癌药耐药的相关性(英文)显示文摘背景与目的:核苷酸切除修复(Nucleotideexcisionrepair,NER)是真核细胞中的DNA修复多酶系统,它可能与人肿瘤细胞对抗癌药的耐药有关。本实验将探讨NER蛋白(XPA,XPB,XPD和ERCC1)的表达与人肿瘤细胞耐药的关系。方法:采用westernblot检测美国国家癌症研究所(NationalCancerInstitute,NCI)用于抗癌药筛选的60株人肿瘤细胞的ERCC1,XPA,XPBXPD表达,并与170种抗癌药物的细胞毒试验结果进行相关性分析。结果:ERCC1,XPB和XPD的蛋白表达与抗癌药物敏感性呈负相关,在170种抗癌药物中分别有13,17和32种的耐药性与上述蛋白水平相关性显著或非常显著(P<0.05)。而XPA的表达与药物敏感性无明显正/负相关。根据已确定的6种药物作用机理分析,肿瘤细胞XPD表达与其对烷化剂类抗癌药耐药相关性显著。结论:本实验结果肿瘤细胞的XPD蛋白表达与烷化剂类抗癌药的耐药相关,提示XPD在肿瘤细胞耐药过程中起重要作用。 | 陈忠平 Areti MALAPETSA Anne MONKS Timothy G. MYERS Gérard MOHR Eaward A. SAUSVILLE Dominic A. SCUDIERO Lawrence C. PANASCI | 2002 | 癌症2002，21，3： | 12 |
| 6 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet . 2012 (9859)2012，，9859： | 7 |
| 7 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet2012，，9859： | 5 |
| 8 | The Genetic Architecture of Multiple Myeloma显示文摘 | Steven M. Prideaux Emma Conway O’Brien Timothy J. Chevassut G?sta Gahrton | 2014 | Advances in Hematology2014，，： | 2 |
| 9 | Near stoichiometric silicon carbide from an economical polysilane precursor显示文摘 | SEYFERTH D TIMOTHY G HENRY J | 1992 | J Am Ceram Soc1992，75，5： | 2 |
| 10 | The temporal price relationship between S&P 500 futures prices and the S&P 500 index显示文摘 | Kawaller Ira G Paul D Koch Timothy W Koch | 1987 | Journal of Finance1987，5，： | 2 |
| 11 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 12 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | 2012 (9859)2012，，9859： | 2 |
| 13 | Structural and magnetic properties of nanoscale iron oxide particles synthesized in the presence of dextran or polyvinyl alcohol显示文摘 | Heath P Wanida C Timothy G | 2001 | J Magn Magn Mater2001，225，1： | 1 |
| 14 | Effect of fluid thermal properties on the heat transfer characteristics in a double-pipe helical heat exchanger显示文摘 | Timothy J Rennie Vijaya G S Raghavan | 2006 | International Journal of Thermal Sciences2006，45，： | 1 |
| 15 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 16 | Finding drug targets in microbial genomes 显示文摘 | Timothy D R Steven R G Herve T | 2001 | Res Focus2001，6，17： | 1 |
| 17 | Effect of organic amendments and slow-release nitrogen fertilizer on willow biomass production and soil chemical characteristics 显示文摘 | Hector G A Russell D B Timothy A V | 2003 | Biomass Bioenerg2003，25，： | 1 |
| 18 | A Universal Noise Removal Algorithm with an Impulse Detector 显示文摘 | ROMAN G TIMOTHY H CHARLES C WENJIE H | 2005 | IEEE Transactions on Neural Networks2005，14，： | 1 |
| 19 | Experimental studies of a double-pipe helical heat exchanger显示文摘 | Timothy J Rennie Vijaya G S Raghavan | 2005 | Experimental Thermal and Fluid Science2005，29，： | 1 |
| 20 | CODEHOP (COnsensus-DEgenerate Hybrid Oligonucleotide Primer ) PCR primer design 显示文摘 | Timothy M Rose Jorja G Henikoff Steven Henikoff | 2003 | Nucleic Acids Research2003，31，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员