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18篇 您的检索式:作者名="Tim L G"
    题名 作者 年代 出处 被引量
1Ritual-enema-induced colitis显示文摘Segal I Tim L O Hamilton D G 1979Dis Colon Rectum1979,22,3:1
2Organic compounds trapped in aqueous fluid inclusions 显示文摘Tim E R Simon C G Mark L Robinson A Q 1998Organic Geochemistry1998,29,13:1
3Rheological properties of cellulose/ionic liquid solutions:from dilute to concentrated states 显示文摘Martin G Kerstin S Tim L 2009Biomacromolecules2009,,10:1
4Removal of Cr(IV) from aqueous solution using activated carbon modified with nitric acid显示文摘Huang G L Shi Jeffrey X Langrish Tim A G 2009Chemical Engineering Journal2009,152,:1
5Autotrophic nitrogen removal from low strength waste water at low temperature显示文摘Tim L G Hendrickx Wang Yang 2012Water Research2012,46,7:1
6Co-digestion to support low temperature anaerobic pretreatment of municipal sewage in a UASB-digester显示文摘Lei Zhang Tim L G Hendrickx C K 2013Bioresource Technology2013,148,:1
7Functional rice centromeres are marked by satellite repeat and centromere-special retrotransposon 显示文摘Cheng Z K Feng G D Tim L D 2002The Plant Cell2002,14,:1
8A small plant-specific protein family of ABI five binding protein (AFPs) regulates stress response in germinating Arabidopsis seeds and seeding显示文摘MARY E G Tim L Julian P 2008Plant Mol Biol2008,67,:1
9Removal of Cr( \显示文摘Huang G L Shi J X Langrish Tim A G 2009Chemical Engineering Journal2009,152,23:1
10Developmental expression and stress induction of glutathione S -transferase in the spruce budworm, Choristoneura fumiferana显示文摘Qi-Li Feng Kenneth G Davey Anthony S.D. Pang Tim R Ladd Arthur Retnakaran Bill L Tomkins Sichun Zheng Subba R Palli 2000Journal of Insect Physiology2000,,1:1
11S a tellite S A R geocod in g w ith refined R P C m odel显示文摘Z H A N G L u Tim o B a lz L IA O M in gsh en g 2012IS P R S Journal of Photogrammetryand Remote Sen sin g2012,69,3:1
12A Small plant-specific protein family of ABI five binding proteins (AFPS) regulates stress response in germinating Arabidopsis seeds and seedings显示文摘Mary E G Tim L Julian P 2008Plant Molecular Biology2008,67,:1
13The processing of lF4GI by human rhinovirus type 2Apro:Relationship to self-cleavage and role of zinc显示文摘WALTER G L ANDREA T F TIM S K 2003Virol2003,77,:1
14A new approach to defining diseasestatus in ankylosing spondylitis: The bath ankylosing spondylitis disesse activity index显示文摘SARAH G TIM J L GAILK 1994The Journal of Rheumatology1994,21,12:1
15A new approach to defining diseas- estatus in ankylosing spondylitis: The bath ankylosing spondylitis disease activity index 显示文摘Sarah G Tim J L Gailk 1994The Journal of Rheumato~ogy1994,21,12:1
16Characterization of a spruce budworm chitin deacetylase gene: Stageand tissue-specific expression, and inhibition using RNA interference显示文摘Quan G Tim L Duan J 2013Insect Biochemistry and Molecular Biology2013,43,:1
17CFD simulation of precession in sudden pipe expansion flows with low inlet swirl显示文摘Guo B Y Tim A G L David F F 2002Applied Mathematical Modeling2002,26,1:1
18Layer-by-layer heparinization of decellularized liver matrices to reduce thrombogenicity of tissue engineered grafts显示文摘Background: Tissue-engineered liver grafts may offer a viable alternative to orthotopic liver transplantation and help overcome the donor organ shortage. Decellularized liver matrices (DLM) have a preserved vasculature and sustain hepatocellular function in culture, but graft survival after transplantation remains limited due to thrombogenicity of the matrix. Aim: To evaluate the effect of heparin immobilization on DLM thrombogenicity. Methods: Heparin was immobilized on DLMs by means of layer-by-layer deposition. Grafts with 4 or 8 bilayers and 2 or 4 g/L of heparin were recellularized with primary rat hepatocytes and maintained in culture for 5 days. Hemocompatibility of the graft was assessed by ex vivo diluted whole-blood perfusion and heterotopic transplantation. Results: Heparin was deposited throughout the matrix and the heparin content in the graft was higher with increasing number of bilayers and concentration of heparin. Recellularization and in vitro albumin and urea production were unaffected by heparinization. Resistance to blood flow during ex vivo perfusion was lower with increased heparinization and, macroscopically, no clots were visible in grafts with 8 bilayers. Following transplantation, flow through the graft was limited in all groups. Histological evidence of thrombosis was lower in heparinized DLMs, but transplantation of DLM grafts was not improved. Conclusions: Layer-by-layer deposition of heparin on a DLM is an effective method of immobilizing heparin throughout the graft and does not impede recellularization or hepatocellular function in vitro. Thrombogenicity during ex vivo blood perfusion was reduced in heparinized grafts and optimal with 8 bilayers, but transplantation remained unsuccessful with this method. Relevance for patients: Tissue engineered liver grafts may offer a viable solution to dramatic shortages in donor organs.Bote G Bruinsma Yeonhee Kim Tim A Berendsen Sinan Ozer Martin L Yarmush Basak E Uygun 2015Journal of Clinical & Translational Research2015,1,1:0
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