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| 1 | An iterative algorithm for solving ill-conditioned linear least squares problems显示文摘Linear Least Squares(LLS) problems are particularly difficult to solve because they are frequently ill-conditioned, and involve large quantities of data. Ill-conditioned LLS problems are commonly seen in mathematics and geosciences, where regularization algorithms are employed to seek optimal solutions. For many problems, even with the use of regularization algorithms it may be impossible to obtain an accurate solution. Riley and Golub suggested an iterative scheme for solving LLS problems. For the early iteration algorithm, it is difficult to improve the well-conditioned perturbed matrix and accelerate the convergence at the same time. Aiming at this problem, self-adaptive iteration algorithm(SAIA) is proposed in this paper for solving severe ill-conditioned LLS problems. The algorithm is different from other popular algorithms proposed in recent references. It avoids matrix inverse by using Cholesky decomposition, and tunes the perturbation parameter according to the rate of residual error decline in the iterative process. Example shows that the algorithm can greatly reduce iteration times, accelerate the convergence,and also greatly enhance the computation accuracy. | Deng Xingsheng Yin Liangbo Peng Sichun Ding Meiqing | 2015 | Geodesy and Geodynamics2015，6，6： | 8 |
| 2 | Phenformin alone or combined with gefitinib inhibits bladder cancer via AMPK and EGFR pathways显示文摘Background:In previous studies,we have shown that the combination of metformin and gefitinib inhibits the growth of bladder cancer cells.Here we examined whether the metformin analogue phenformin,either used alone or in combination with gefitinib,could inhibit growth of bladder cancer cells.Methods:The growth-inhibitory effects of phenformin and gefitinib were tested in one murine and two human bladder cancer cell lines using MTT and clonogenic assays.Effects on cell migration were assessed in a wound healing assay.Synergistic action between the two drugs was assessed using CompuSyn software.The potential involvement of AMPK and EGFR pathways in the effects of phenformin and gefitinib was explored using Western blotting.Results:In MTT and clonogenic assays,phenformin was>10-fold more potent than metformin in inhibiting bladder cancer cell growth.Phenformin also potently inhibited cell migration in wound healing assays,and promoted apop-tosis.AMPK signaling was activated;EGFR signaling was inhibited.Phenformin was synergistic with gefitinib,with the combination of drugs showing much stronger anticancer activity and apoptotic activation than phenformin alone.Conclusions:Phenformin shows potential as an effective drug against bladder cancer,either alone or in combination with gefitinib. | Yanjun Huang Sichun Zhou Caimei He Jun Deng Ting Tao Qiongli Su Kwame Oteng Darko Mei Peng Xiaoping Yang | 2018 | Cancer Communications2018，38，1： | 5 |
| 3 | Metformin targets Clusterin to control lipogenesis and inhibit the growth of bladder cancer cells through SREBP-lc/FASN axis显示文摘Dear Editor,Metformin,a widely prescribed drug for treating typeⅡdiabetes,has shown an important anti-cancer property.1 However,new launched clinical trials did not achieve such desirable results.2 One explanation could be that metformin’s anti-cancer mechan-isms and precise therapeutic targets remain unclear.To identify potential therapeutic targets of metformin in bladder cancer,we screened differential proteins with metformin treatment in T24 cells by high-throughput protein chip. | Jun Deng Mei Peng Sichun Zhou Di Xiao Xin Hu Simeng Xu Jingtao Wu Xiaoping Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 4 | 苯乙双胍单药或联合吉非替尼通过AMPK和EGFR通路抑制膀胱癌显示文摘背景与目的在前期研究中,我们发现二甲双胍和吉非替尼联合使用可抑制膀胱癌细胞生长。本文旨在研究二甲双胍类似物——苯乙双胍单药或联合吉非替尼能否抑制膀胱癌细胞生长。方法在1种鼠源和2种人源膀胱癌细胞系中,采用MTT和克隆形成实验检测苯乙双胍和吉非替尼对细胞生长的抑制作用。采用伤口愈合实验检测细胞迁移情况。使用CompuSyn软件评估2种药物之间的协同作用。采用蛋白免疫印迹实验分析苯乙双胍和吉非替尼对AMPK和EGFR通路的潜在作用。结果 MTT和克隆形成实验结果显示,苯乙双胍抑制膀胱癌细胞生长的作用是二甲双胍的10倍以上。伤口愈合实验结果显示,苯乙双胍可有效抑制细胞迁移,并促进凋亡。AMPK信号被激活,EGFR信号被抑制。苯乙双胍与吉非替尼可协同作用,二者联合使用比苯乙双胍单药表现出更强的抑癌活性和促凋亡活性。结论苯乙双胍单药或联合吉非替尼均可能成为治疗膀胱癌的有效药物。 | Yanjun Huang Sichun Zhou Caimei He Jun Deng Ting Tao Qiongli Su Kwame Oteng Darko Mei Peng Xiaoping Yang | 2019 | 癌症2019，38，5： | 1 |
| 5 | Blind Identification of an Autoregressive System Using a Nonlinear Dynamical Approach 显示文摘 | LEUNG H WANG SICHUN CHAN ALBERT M | 2000 | IEEE Trans Sig Proc2000，48，11： | 1 |
| 6 | Growth and optical properties of wurtzite-type CdS nanocrystals 显示文摘 | CAO Huaqiang WANG Guozhi ZHANG Sichun | 2006 | Inorg Chem2006，45，： | 1 |
| 7 | Recent developments and applications of chemiluminescence sensors 显示文摘 | Zhang Zhenyu Zhang Sichun Zhang Xinrong | 2005 | Analytical Chimistry Acta2005，541，12： | 1 |
| 8 | Prediction of noisy chaotic time series using an optimal radial basis function neural network显示文摘 | LEUNG H LO T WANG Sichun | 1999 | IEEE Trans on Computers1999，，8： | 1 |
| 9 | Prediction of noisy chaotic time series using an optimal radial basis func- tion neural network显示文摘 | Henry L Titus L Wang Sichun | 2001 | IEEE Transaction on Neural Network2001，12，5： | 1 |
| 10 | Prediction of Noisy Chaotic Time Series Using an Optimal Radial Basis Function Neural Network 显示文摘 | Henry Leung Titus Lo Sichun Wang | 2001 | IEEE Transactions on Neural Networks2001，12，5： | 1 |
| 11 | A novel near-infrared fluorescent probe for selectively sensing nitroreductase(NTR) in an aqueous medium显示文摘 | Youmin Shi Sichun Zhang Xinrong Zhang | 2013 | Analyst2013，138，： | 1 |
| 12 | Development of a Dielectric Barrier Discharge Ion Source for Ambient Mass Spectrometry显示文摘 | Na Na Mengxia Zhao Sichun Zhang Chengdui Yang Xinrong Zhang | 2007 | Journal of the American Society for Mass Spectrometry2007，，： | 1 |
| 13 | Developmental expression and stress induction of glutathione S -transferase in the spruce budworm, Choristoneura fumiferana显示文摘 | Qi-Li Feng Kenneth G Davey Anthony S.D. Pang Tim R Ladd Arthur Retnakaran Bill L Tomkins Sichun Zheng Subba R Palli | 2000 | Journal of Insect Physiology2000，，1： | 1 |
| 14 | 显示文摘 | WANG Wenjun ZHANG Sichun LIU Chenghui LU Lingzhao WANG Shidong ZHANG Xinrong | 2009 | Electrophoresis2009，30，17： | 1 |
| 15 | Low selenium status affects arsenic metabolites in an arsenic exposed population with skin lesions显示文摘 | Zhi Huang Qiuling Pei Guifan Sun Sichun Zhang Jiang Liang Yi Gao Xinrong Zhang | 2007 | Clinica Chimica Acta2007，，1： | 1 |
| 16 | The synthesis and photocatalytic activity of ZnSe microspheres 显示文摘 | Cao Huaqiang Xiao Yujiang Zhang Sichun | 2011 | Nanotechnology2011，22，1： | 1 |
| 17 | 显示文摘 | Wu Qingzhi Cao Huaqiang Zhang Sichun | 2006 | Inorg Chem2006，45，18： | 1 |
| 18 | Detection of Multiple Proteins on One Spot by Laser Ablation Inductively Coupled Plasma Mass Spectrometry and Application to Immuno-Microar- ray with Element-Tagged Antibodies 显示文摘 | Shenghong Hu Sichun Zhang Zhaochu Hu | 2007 | Analytical Chemistry2007，79，： | 1 |
| 19 | Determination of Se, Pb, and Sb by atomic fluorescence spectrometry using a new flameless, dielectric barrier discharge atomizer显示文摘 | ZHU Zhenli LIU Jixin ZHANG Sichun | 2008 | Spectrochimica Acta Part B: Atomic Spectroscopy2008，63，3： | 1 |
| 20 | Determination of Se,Pb,and Sb by atomic fluorescence spectrometry using a new flameless,dielectric barrier discharge atomizer显示文摘 | ZHU Zhenli LIU Jixin ZHANG Sichun | 2008 | Spectrochimica Acta Part B:Atomic Spectroscopy2008，63，3： | 1 |
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