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| 1 | Nearinfrared spectroscopy measurements of cerebral blood flow and oxygen consumption following hypoxia-ischemla in newborn piglets 显示文摘 | Tichauer KM Brown DW Hadway J Lee TY Lawrence KS | 2006 | J Appl Physio2006，100，3： | 1 |
| 2 | Quantitative in vivo cell-surface receptor imaging in oncology: kinetic modeling and paired-agent principles from nuclear medicine and optical imaging 显示文摘 | Tichauer KM Wang Y Pogue BW | 2015 | Phys Med Biol2015，60，： | 1 |
| 3 | Early traumatic life events, parental attitudes, family history and birth risk factors in patients with panic disorder显示文摘 | Bandelow B Spath C Tichauer GA | 2002 | Compr Psychiatry2002，43，4： | 1 |
| 4 | Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders显示文摘 | von Bernhardi R Tichauer JE Eugenin J | 2010 | J Neuro Chem2010，112，5： | 1 |
| 5 | The emergency medicine approach to the evaluation and treatment of pulmonary embolism显示文摘 | Church A Tichauer M | 2012 | Emerg Med Pract2012，14，12： | 1 |
| 6 | Separation anxiety and actual separation experiences during childhood in patients with panic disorder显示文摘 | Alvarez Tichauer G Spath C | 2001 | Can J Psychiatry2001，46，10： | 1 |
| 7 | Separation anxiety and actual separation experiences during childhood in patients with panic disqrder显示文摘 | Alvarez Tichauer G Spath C | 2001 | Can J Psychiatry2001，46，10： | 1 |
| 8 | Aging-de- pendent changes of microglial cells and their relevance for neurodegenerative disorders显示文摘 | Von Bernhardi R Tichauer J E Eugenin J | 2010 | Journal of Neurochemis-try2010，112，： | 1 |
| 9 | Xenobioticinducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element显示文摘 | Filling RS Bensimon A Tichauer Y | 1990 | Proc Nail Acad Sci USA1990，87，16： | 1 |
| 10 | Is tumor cell specificity distinct from tumor selectivity in vivo?A quantitative NIR molecular imaging analysis of nanoliposome targeting显示文摘The significance and ability for receptor targeted nanoliposomes(tNLs)to bind to their molecular targets in solid tumors in vivo has been questioned,particularly as the efficiency of their tumor accumulation and selectivity is not always predictive of their efficacy or molecular specificity.This study presents,for the first time,in situ near-infrared(NIR)molecular imaging-based quantitation of the in vivo specificity of tNLs for their target receptors,as opposed to tumor selectivity,which includes influences of enhanced tumor permeability and retention.Results show that neither tumor delivery nor selectivity(tumor-to-normal ratio)of cetuximab and IRDye conjugated tNLs correlate with epidermal growth factor receptor(EGFR)expression in U251,U87,and 9L tumors,and in fact underrepresent their imaging-derived molecular specificity by up to 94.2%.Conversely,their in vivo specificity,which we quantify as the concentration of tNL-reported tumor EGFR provided by NIR molecular imaging,correlates positively with EGFR expression levels in vitro and ex vivo(Pearson’s r=0.92 and 0.96,respectively).This study provides a unique opportunity to address the problematic disconnect between tNL synthesis and in vivo specificity.The findings encourage their continued adoption as platforms for precision medicine,and facilitates intelligent synthesis and patient customization in order to improve safety profiles and therapeutic outcomes. | Girgis Obaid Kimberley Samkoe Kenneth Tichauer Shazia Bano Yeonjae Park Zachary Silber Sassan Hodge Susan Callaghan Mina Guirguis Srivalleesha Mallidi Brian Pogue Tayyaba Hasan | 2021 | Nano Research2021，14，5： | 1 |
| 11 | Separation anxiety and actual separation experiences during childhood in patients with panic disonder显示文摘 | Bandelow B Alvarez Tichauer G Spath C | 2001 | Can J Psychiatry2001，46，10： | 1 |
| 12 | Modulation by astrocytes of microglial cell-mediated neuroinflammation:effect on the activation of microglial signaling pathways显示文摘 | Tichauer J Saud K Von Bernhardi R | 2006 | Neuroimmunomodulation2006，14，34： | 1 |
| 13 | Near-infrared spectroscopy measurements of cerebral blood flow and oxygen consumption following hypoxia-ischemia in newborn piglets 显示文摘 | Tichauer KM Brown DW Hadway J | 2006 | JAppl Physiol2006，100，3： | 1 |
| 14 | Separation anxiety and actual separation experiences during childhood in patients with panic disorder 显示文摘 | Bandelow B Alvarez Tichauer G Spath C | 2001 | Can J Psychiatry2001，46，10： | 1 |
| 15 | Near-infrared spec- troscopy measurements of cerebral blood flow and oxygen con- sumption following hypoxia isehemia in newborn piglets显示文摘 | Tichauer KM Brown DW Hadway J | 2006 | Jour- nal of Applied Physiology2006，100，3： | 1 |
| 16 | Separation anxiety and ac- tual separation experiences during childhood in patients with panic disor- der 显示文摘 | Bandelow B Alvarez - Tichauer G Spath C | 2001 | Can J Psychiatry2001，46，10： | 1 |
| 17 | In Vivo Quantification of Tumor Receptor Binding Potential with Dual-Reporter Molecular Imaging显示文摘 | Kenneth Tichauer Kimberley Samkoe Kristian Sexton Shannon Hextrum Harold Yang W. Klubben Jason Gunn Tayyaba Hasan Brian Pogue | 2012 | Molecular Imaging and Biology2012，，5： | 1 |
| 18 | High Vascular Delivery of EGF, but Low Receptor Binding Rate Is Observed in AsPC-1 Tumors as Compared to Normal Pancreas显示文摘 | Kimberley Samkoe Kristian Sexton Kenneth Tichauer Shannon Hextrum Omar Pardesi Scott Davis Julia O’Hara P. Hoopes Tayyaba Hasan Brian Pogue | 2012 | Molecular Imaging and Biology2012，，4： | 1 |
| 19 | Separation anxiety and actual seperiences during childhood in patients with panic disorder显示文摘 | Bandelow B Alvarez Tichauer G Spath C | 2001 | Can J Psychiatry2001，46，10： | 1 |
| 20 | Overexpression of the cholesterol-binding protein MLN64 induces liver damage in the mouse显示文摘AIM: To examine the in vivo phenotype associated with hepatic metastatic lymph node 64 (MLN64) over-expression. METHODS: Recombinant-adenovirus-mediated MLN64 gene transfer was used to overexpress MLN64 in the livers of C57BL/6 mice. We measured the effects of MLN64 overexpression on hepatic cholesterol content, bile flow, biliary lipid secretion and apoptosis markers. For in vitro studies cultured CHO cells with transient MLN64 overexpression were utilized and apoptosis by TUNEL assay was measured. RESULTS: Livers from Ad.MLN64-infected mice exhibited early onset of liver damage and apoptosis. This response correlated with increases in liver cholesterol content and biliary bile acid concentration, and impaired bile flow. We investigated whether liver MLN64 expression could be modulated in a murine model of hepatic injury. We found increased hepatic MLN64 mRNA and protein levels in mice with chenodeoxycholic acid-induced liver damage. In addition, cultured CHO cells with transient MLN64 overexpression showed increased apoptosis. CONCLUSION: In summary, hepatic MLN64 over- expression induced damage and apoptosis in murinelivers and altered cholesterol metabolism. Further studies are required to elucidate the relevance of these fi ndings under physiologic and disease conditions. | Juan Enrique Tichauer María Gabriela Morales Ludwig Amigo Leopoldo Galdames Andrés Klein Verónica Quiones Carla Ferrada Alejandra Alvarez R Marie-Christine Rio Juan Francisco Miquel Attilio Rigotti Silvana Zanlungo | 2007 | World Journal of Gastroenterology2007，13，22： | 0 |
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