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您的检索式：作者名="Kenneth Tichauer"
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| 1 | Is tumor cell specificity distinct from tumor selectivity in vivo?A quantitative NIR molecular imaging analysis of nanoliposome targeting显示文摘The significance and ability for receptor targeted nanoliposomes(tNLs)to bind to their molecular targets in solid tumors in vivo has been questioned,particularly as the efficiency of their tumor accumulation and selectivity is not always predictive of their efficacy or molecular specificity.This study presents,for the first time,in situ near-infrared(NIR)molecular imaging-based quantitation of the in vivo specificity of tNLs for their target receptors,as opposed to tumor selectivity,which includes influences of enhanced tumor permeability and retention.Results show that neither tumor delivery nor selectivity(tumor-to-normal ratio)of cetuximab and IRDye conjugated tNLs correlate with epidermal growth factor receptor(EGFR)expression in U251,U87,and 9L tumors,and in fact underrepresent their imaging-derived molecular specificity by up to 94.2%.Conversely,their in vivo specificity,which we quantify as the concentration of tNL-reported tumor EGFR provided by NIR molecular imaging,correlates positively with EGFR expression levels in vitro and ex vivo(Pearson’s r=0.92 and 0.96,respectively).This study provides a unique opportunity to address the problematic disconnect between tNL synthesis and in vivo specificity.The findings encourage their continued adoption as platforms for precision medicine,and facilitates intelligent synthesis and patient customization in order to improve safety profiles and therapeutic outcomes. | Girgis Obaid Kimberley Samkoe Kenneth Tichauer Shazia Bano Yeonjae Park Zachary Silber Sassan Hodge Susan Callaghan Mina Guirguis Srivalleesha Mallidi Brian Pogue Tayyaba Hasan | 2021 | Nano Research2021，14，5： | 1 |
| 2 | In Vivo Quantification of Tumor Receptor Binding Potential with Dual-Reporter Molecular Imaging显示文摘 | Kenneth Tichauer Kimberley Samkoe Kristian Sexton Shannon Hextrum Harold Yang W. Klubben Jason Gunn Tayyaba Hasan Brian Pogue | 2012 | Molecular Imaging and Biology2012，，5： | 1 |
| 3 | High Vascular Delivery of EGF, but Low Receptor Binding Rate Is Observed in AsPC-1 Tumors as Compared to Normal Pancreas显示文摘 | Kimberley Samkoe Kristian Sexton Kenneth Tichauer Shannon Hextrum Omar Pardesi Scott Davis Julia O’Hara P. Hoopes Tayyaba Hasan Brian Pogue | 2012 | Molecular Imaging and Biology2012，，4： | 1 |
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