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| 1 | Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas. | Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang | 2022 | Protein & Cell2022，13，7： | 2 |
| 2 | On brain activity mapping: Insights and lessons from Brain Decoding Project to map memory patterns in the hippocampus显示文摘The BRAIN project recently announced by the president Obama is the reflection of unrelenting human quest for cracking the brain code, the patterns of neuronal activity that define who we are and what we are. While the Brain Activity Mapping proposal has rightly emphasized on the need to develop new technologies for measuring every spike from every neuron, it might be helpful to consider both the theoretical and experimental aspects that would accelerate our search for the organizing principles of the brain code. Here we share several insights and lessons from the similar proposal, namely, Brain Decoding Project that we initiated since 2007. We provide a specific example in our initial mapping of real-time memory traces from one part of the memory circuit, namely, the CA1 region of the mouse hippocampus. We show how innovative behavioral tasks and appropriate mathematical analyses of large datasets can play equally, if not more, important roles in uncovering the specific-to-general feature-coding cell assembly mechanism by which episodic memory, semantic knowledge, and imagination are generated and organized. Our own experiences suggest that the bottleneck of the Brain Project is not only at merely developing additional new technologies, but also the lack of efficient avenues to disseminate cutting edge platforms and decoding expertise to neuroscience community. Therefore, we propose that in order to harness unique insights and extensive knowledge from various investigators working in diverse neuroscience subfields, ranging from perception and emotion to memory and social behaviors, the BRAIN project should create a set of International and National Brain Decoding Centers at which cutting-edge recording technologies and expertise on analyzing large datasets analyses can be made readily available to the entire community of neuroscientists who can apply and schedule to perform cutting-edge research. | TSIEN Joe Z. LI Meng OSAN Remus CHEN GuiFen LIN LongNian WANG Phillip Lei FREY Sabine FREY Julietta ZHU DaJiang LIU TianMing ZHAO Fang KUANG Hui | 2013 | Science China(Life Sciences)2013，56，9： | 1 |
| 3 | New norlignan enantiomers from the fruit of Crataegus pinnatifida with neuroprotective activities显示文摘(±)-Crataegusnorin A(la/1b) and B(2a/2b),two pairs of rare 8,9’-epoxy-type norlignan enantiomers featuring a y-butyrolactone ring,were isolated from the fruit of Crataegus pinnatifida.Their structures were determined via extensive spectroscopic analyses.Gauge-independent atomic orbital(GIAO) NMR chemical shift calculations,combined with the advanced statistical method DP4+were employed to establish the relative configurations of four compounds.Next,chiral separation was accomplished by chiral chromatographic column and the absolute configurations of the four compounds were unambiguously assigned by comparison between their experimental electronic circular dichroism curves with the quantum-mechanically calculated curves based on time-dependent density functional theory(TDDFT).All the isolates were evaluated fo r their neuroprotective activities against H2O2-induced cell injury in human neuroblastoma SH-SY5Y cells.The results showed that two pairs of enantiomers 1a/1b and 2a/2b displayed diff;erent effect on neuroprotective activity.Among them,compound 2a displayed the most potent neuroprotective effect Further flow cytometry analysis indicated that 2a could protect SH-SY5Y cells from oxidative damage through inhibiting cell apoptosis. | Rui Guo Tianming Lv Fengying Han Zilin Hou Guodong Yao Bin Lin Xiaobo Wang Xiaoxiao Huang Shaojiang Song | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
| 4 | Prediction of cognitive scores by joint use of movie-watching fMRI connectivity and eye tracking via Attention-CensNet显示文摘Background:Brain functional connectivity under the naturalistic paradigm has been shown to be better at predicting individual behaviors than other brain states,such as rest and doing tasks.Nevertheless,the state-of-the-art methods have found it difcult to achieve desirable results from movie watching paradigm functional magnetic resonance imaging(mfMRI)-induced brain functional connectivity,especially when there are fewer datasets.Incorporating other physical measurements into the prediction method may enhance accuracy.Eye tracking,becoming popular due to its portability and lower expense,can provide abundant behavioral features related to the output of human's cognition,and thus might supplement the mfMRI in observing participants'subconscious behaviors.However,there are very few studies on how to effectively integrate the multimodal information to strengthen the performance by a unified framework.objective:A fusion approach with mfMRI and eye tracking,based on convolution with edge-node switching in graph neural networks(CensNet),is proposed in this article.Methods:In this graph model,participants are designated as nodes,mfMRI derived functional connectivity as node features,and different eye-tracking features are used to compute similarity between participants to construct heterogeneous graph edges.By taking multiple graphs as different channels,we introduce squeeze-and-excitation attention module to CensNet(A-CensNet)to integrate graph embeddings from multiple channels into one.Results:The proposed model outperforms those using a single modality and single channel,and state-of-the-art methods.Conclusions:The results indicate that brain functional activities and eye behaviors might complement each other in interpreting trait-like phenotypes. | Jiaxing Gao Lin Zhao Tianyang Zhong Changhe Li Zhibin He Yaonei Wei Shu Zhang Lei Guo Tianming Liu Junwei Han Xi Jiang Tuo Zhang | 2023 | Psychoradiology2023，3，1： | 0 |
| 5 | High-efficiency removal of NOx by a novel integrated chemical absorption and two-stage bioreduction process using magnetically stabilized fluidized bed reactors显示文摘To enhance the bioregeneration of Fe(II)EDTA and to avoid the inhibition of the components in nitrogen oxides(NOx) scrubbing solution, a novel integrated process of metal chelate absorption and two-stage bioreduction was developed. In this process, magnetically stabilized fluidized beds(MSFB) were used as the bioreactors, and the phase diagram for the MSFB operation was determined. Factors including inlet NO, O2 and SO2 concentrations, magnetic field intensity, gas flow rate and liquid circulation rate, were studied experimentally to investigate their effects on NO removal. In addition, a mathematical model for NO removal in this integrated system was developed. The results revealed that the integrated system could be steadily operated with a high NO removal efficiency and elimination capacity, even under the condition of high NO and O2 shock-loading. The established model showed that NO removal efficiency was related to the spray column property and the active Fe(II)EDTA concentration, while the latter depends on the bioregeneration of the disabled absorbent in the MSFB. | Zuoming Zhou Tianming Lin Guohua Jing Bihong Lv Yixuan Liu | 2015 | Science China Chemistry2015，58，10： | 0 |
| 6 | Single-cell transcriptome analysis uncovers underlying mechanisms of acute liver injury induced by tripterygium glycosides tablet in mice显示文摘Tripterygium glycosides tablet(TGT),the classical commercial drug of Tripterygium wilfordii Hook.F.has been effectively used in the treatment of rheumatoid arthritis,nephrotic syndrome,leprosy,Behcet's syndrome,leprosy reaction and autoimmune hepatitis.However,due to its narrow and limited treatment window,TGT-induced organ toxicity(among which liver injury accounts for about 40%of clinical reports)has gained increasing attention.The present study aimed to clarify the cellular and molecular events underlying TGT-induced acute liver injury using single-cell RNA sequencing(scRNA-seq)technology.The TGT-induced acute liver injury mouse model was constructed through short-term TGT exposure and further verified by hematoxylin-eosin staining and liver function-related serum indicators,including alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase and total bilirubin.Using the mouse model,we identified 15 specific subtypes of cells in the liver tissue,including endothelial cells,hepatocytes,cholangiocytes,and hepatic stellate cells.Further analysis indicated that TGT caused a significant inflammatory response in liver endothelial cells at different spatial locations;led to marked inflammatory response,apoptosis and fatty acid metabolism dysfunction in hepatocytes;activated hepatic stellate cells;brought about the activation,inflammation,and phagocytosis of liver capsular macrophages cells;resulted in immune dysfunction of liver lymphocytes;disturbed the intercellular crosstalk in liver microenvironment by regulating various signaling pathways.Thus,these findings elaborate the mechanism underlying TGT-induced acute liver injury,provide new insights into the safe and rational applications in the clinic,and complement the identification of new biomarkers and therapeutic targets for liver protection. | Qiuyan Guo Jiangpeng Wu Qixin Wang Yuwen Huang Lin Chen Jie Gong Maobo Du Guangqing Cheng Tianming Lu Minghong Zhao Yuan Zhao Chong Qiu Fei Xia Junzhe Zhang Jiayun Chen Feng Qiu Jigang Wang | 2023 | Journal of Pharmaceutical Analysis2023，13，8： | 0 |
| 7 | Platycodin D inhibits angiogenic vascular mimicry in NSCLC by regulating the eIF4E-mediated RNA methylome显示文摘The treatment of non-small cell lung cancer(NSCLC)remains a challenge due to tumor evolution during anti-angiogenesis therapies,in which the mechanism of vascular mimicry(VM)is believed to result in ineffective treatment[1].To conquer this challenge,substantial effort has recently been devoted to seeking out natural compounds on account of their multitarget actions.As a traditional herbal medicine,platycodin D(PD)is the major bioactive monomer derived from Platycodon grandiflorum(P.grandiflorum)and is used as an expectorant for pulmonary disease in Asia[2]. | Shuyu Zheng Yanlin Xin Jiamin Lin Zejuan Xie Keyu Cheng Shanshan Wang Wenli Lu Hao Yang Tianming Lu Jun Li Ruogu Qi Yuanyuan Guo | 2024 | Journal of Pharmaceutical Analysis2024，14，1： | 0 |
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