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| 1 | Triggers of histologically suspected drug-induced colitis显示文摘BACKGROUND Drug toxicity is a common and even serious problem in the gastrointestinal tract that is thought to be caused by a broad spectrum of agents.Although withdrawal of the causative agent would cure the disease knowledge is scarce and mostly derives from case reports and series.AIM To investigate potential triggers of drug-induced colitis(DiC).METHODS We conducted a retrospective,observational case control study.Patients were assigned to DiC or one of two age-and gender-matched control groups(noninflammatory controls and inflammatory colitis of another cause)based on histopathological findings.Histopathology was reassessed in a subset of patients(28 DiC with atherosclerosis,DiC without atherosclerosis and ischaemic colitis each)for validation purposes.Medical history was collected from the electronic database and patient records.Statistical analysis included chi-squared test,t-test,logistic and multivariate regression models.RESULTS Drug-induced colitis was detected in 211 endoscopically sampled biopsy specimens of the colon mucosa(7%of all screened colonoscopic biopsy samples);a total of 633 patients were included equally matched throughout the three groups(291 males,mean age:62.1±16.1 years).In the univariate analysis,DiC was associated with diuretics,dihydropyridines,glycosides,ASS,platelet aggregation inhibitors,nonsteroidal anti-inflammatory drugs(NSAIDs),statins and fibrates,and with atherosclerosis,particularly coronary heart disease,and hyperlipoproteinaemia.Echocardiographic parameters did not show substantial differences.In the multivariate analysis only fibrates[odds ratio(OR)=9.1],NSAIDs(OR=6.7)and atherosclerosis(OR=2.1)proved to be associated with DiC.Both DiC reassessment groups presented milder inflammation than ischaemic colitis.The DiC patients with atherosclerosis exhibited histological features from both DiC without atherosclerosis and ischaemic colitis.CONCLUSION Several drugs indicated for the treatment of cardiovascular and related diseases are associated with DiC.Atherosclerosis and microcirculatory disturbances seem to play an important pathogenetic role. | Thorsten Brechmann Katharina Günther Matthias Neid Wolff Schmiegel Andrea Tannapfel | 2019 | World Journal of Gastroenterology2019，25，8： | 3 |
| 2 | Management of severe perioperative bleeding: Guidelines from the European Society of Anaesthesiology显示文摘 | Sibylle A. Kozek-Langenecker Arash Afshari Pierre Albaladejo Cesar Aldecoa Alvarez Santullano Edoardo De Robertis Daniela C. Filipescu Dietmar Fries Klaus G?rlinger Thorsten Haas Georgina Imberger Matthias Jacob Marcus Lancé Juan Llau Sue Mallett Jens Mei | 2013 | European Journal of Anaesthesiology2013，，6： | 3 |
| 3 | Cholangiocarcinoma, gone without the Wnt?显示文摘Cholangiocarcinoma(CCA) is a relatively rare malignancy of the intra- or extra-hepatic bile ducts that is classified according to its anatomical localization as intrahepatic, perihilar or distal. Overall, CCA has a dismal prognosis due to typical presentation at an advanced irresectable stage, lack of effective non-surgical treatments, and a high rate of disease recurrence. CCA frequently arises on a background of chronic liver inflammation and cholestasis. Chronic inflammation is accompanied by enhanced cell turnover with generation of additional inflammatory stimuli, and a microenvironment rich in pro-inflammatory mediators and proliferative factors that enable accumulation of mutations, transformation and expansion of mutated cells. A recent study by Boulter et al implicates the Wnt signaling cascade in cholangiocarcinogenesis. Wnt ligands Wnt7 B and Wnt10 A were found to be highly overexpressed in human CCA tissue. Wnt7 B protein was present throughout the tumor stroma, and often co-localized with a subset of CD68+ macrophages. To address in a direct manner whether Wnt signaling is engaged in development of CCA, Boulter et al explored the Wnt signaling pathway in an experimental model that recapitulates the multi-stage progression of human CCA.Wnt ligands found to be elevated in human CCA were also upregulated during the course of CCA development following thioacetamide treatment. Wnt10 a increased during the(pre-cancerous) regenerative phase, while Wnt7 b induction paralleled tumor growth. Along with upregulation of target genes, the findings demonstrate that the canonical Wnt pathway is progressively activated during cholangio-carcinogenesis. Macrophage depletion,eliminating a major source of Wnt7 b, prevented activation of the canonical Wnt cascade, and resulted in reduced number and volume of tumors in this model. Moreover,specific inhibitors of the canonical Wnt pathway(ICG-001 and C-59) caused reduction of tumor area and number,in xenograft and thioacetamide models of CCA. The aggregated findings show that experimental, and presumably human CCA, is a Wnt-driven tumor. Modulation of Wnt signaling, alone or in combination with surgicalor chemotherapy approaches, holds promise in the management of this fatal malignancy. | Anne T R Noll Thorsten Cramer Steven W M Olde Damink Frank G Schaap | 2016 | World Journal of Hepatology2016，8，26： | 3 |
| 4 | Are all smiles created equal? How emotional contagion and emotional labor affect service relationships 显示文摘 | Thorsten H Markus G Michael P | 2006 | Journal of Marketing2006，，70： | 1 |
| 5 | Transient global amnesia: functional anatomy and clinical implications显示文摘 | Thorsten Bartsch Günther Deuschl | 2010 | Lancet Neurology2010，，2： | 1 |
| 6 | Structural Bonding Tape: An innovation in adhesive bonding显示文摘 | GREGG B JURGEN K PAUL L G THORSTEN N | 1996 | Adhesives Age1996，，9： | 1 |
| 7 | The cold spray process and its industrial applications 显示文摘 | Frank G Thorsten S Tobias S | 2006 | Journal of Thermal Spray Technology2006，15，2： | 1 |
| 8 | Color image segmentation in HSI space for automotive applications显示文摘 | Calin R Thorsten G Jianwei Z | 2008 | Journal of Real-time Image Processing2008，3，4： | 1 |
| 9 | Electronic Word-of-mouth via Consumer-opinion Platforms: What Motivates Consumers to Articulate Themselves on the Internet显示文摘 | THORSTEN H T GWINNER K P WALSH G | 2004 | Journal of Interactive Marketing2004，18，1： | 1 |
| 10 | Understandg Relinationship Marketing Outcomes: An Integration of Relational Benefits and Relationship Quality 显示文摘 | Thorsten H T Kevin P G Dwayne D G | 2002 | Journal of Service Research2002，，14： | 1 |
| 11 | Transoral thyroid and parathyroid surgery-development of a new transoral technique显示文摘 | Elias K Thorsten S Andreas G | 2011 | Surgery2011，14，1： | 1 |
| 12 | Transoral thyroid and parathyroid surgery显示文摘 | Elias K Thorsten S Andreas G | 2010 | Surgical Endoscopy2010，21，6： | 1 |
| 13 | Electrical properties of (Ba, Sr)TiO3 thin films with Pt and ITO electrodes:dielectric and rectifying behavior显示文摘 | Li S Y Cosmina G Thorsten J M B | 2011 | Journal of Physics2011，23，33： | 1 |
| 14 | Survival and growth of Francisella tularensis in Acanthamoeba castellanii显示文摘 | Hadi A Thorsten J lgor G | 2003 | Appl Environ Microbiol2003，1，： | 1 |
| 15 | Electronic Word-of-Mouth via Consumer-Opinion Platforms: What Motivates Consumers to Articulate Themselves on the Internet 显示文摘 | Thorsten Hennig-Thurau F Gwinner K Walsh G Gremler D | 2004 | Journal of Interactive Marketing2004，，11： | 1 |
| 16 | Electronic Word-ofMouth Via Consumer-Opinion Platforms:What Motivates Consumers to Articulate Themselves on the Internet?显示文摘 | Thorsten H F Gwinner K P Walsh G | 2004 | Journal of Interactive Marketing2004，18，1： | 1 |
| 17 | Electro- nic Word- of-mouth Via consumer-Opinion platf-orms what motivates consumers to articulate themselves on the internet 显示文摘 | Thorsten H T Gwinner K P Walsh G | 2004 | Journal of In- teract Market2004，18，1： | 1 |
| 18 | Molecular characterization of dissolved organic matter in a north Brazilian mangrove porewater and mangrove-fringed estuaries by ultrahigh resolution fourier transform ion cyclotron resonance mass spectrometry and excitation/emission spectroscopy显示文摘 | Thorsten D Alan G M | 2007 | Marin Chemistry2007，105，： | 1 |
| 19 | Penicillin-binding proteins 2b and 2x of Streptococcus pneurnoniae are primary resistance determinants for dif- ferent class of β-Lactam antibiotics显示文摘 | THORSTEN G HAKENBECK R | 2003 | Antimierob Agents Chemother2003，40，4： | 1 |
| 20 | The cold spray process and its potential for industrial applications显示文摘 | Frank G?rtner Thorsten Stoltenhoff Tobias Schmidt Heinrich Kreye | 2006 | Journal of Thermal Spray Technology2006，，2： | 1 |
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