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| 1 | Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats显示文摘AIM: To investigate the preventive effect of kefir on colitis induced with dextran sulfate sodium(DSS) in rats.METHODS: Twenty-four male Wistar-albino rats were randomized into four groups: normal control,kefircontrol,colitis,and kefir-colitis groups. Rats in the normal and kefir-control groups were administered tap water as drinking water for 14 d. Rats in the colitis and kefir-colitis groups were administered a 3% DSS solution as drinking water for 8-14 d to induce colitis. Rats in the kefir-control and kefir-colitis groups were administered 5 m L kefir once a day for 14 d while rats in the normal control and colitis group were administered an identical volume of the placebo(skim milk) using an orogastric feeding tube. Clinical colitis was evaluated with reference to the disease activity index(DAI),based on daily weight loss,stool consistency,and presence of bleeding in feces. Rats were sacrificed on the 15 th day,blood specimens were collected,and colon tissues were rapidly removed. Levels of myeloperoxidase(MPO),tumor necrosisfactor(TNF)-α,interleukin(IL)-10,malondialdehyde,and inducible nitric oxide synthase(i NOS) were measured in colon tissue.RESULTS: The DAI was lower in the kefir-colitis group than in the colitis group(on the 3rd and 5th days of colitis induction; P < 0.01). The DAI was also significantly higher in the colitis group between days 2 and 6 of colitis induction when compared to the normal control and kefir-control groups. The DAI was statistically higher only on the 6th day in the kefircolitis group when compared to that in the normal control groups. Increased colon weight and decreased colon length were observed in colitis-induced rats. Mean colon length in the colitis group was significantly shorter than that of the kefir-control group. Kefir treatment significantly decreased histologic colitis scores(P < 0.05). MPO activity in the colitis group was significantly higher than in the kefir-control group(P < 0.05). Kefir treatment significantly reduced the DSS colitis-induced TNF-α increase(P < 0.01). No statistically significant differences were observed among groups for IL-10 and MDA levels. Colon tissue i NOS levels in the colitis group were significantly higher than those in the control and kefir-colitis groups(P < 0.05).CONCLUSION: Kefir reduces the clinical DAI and histologic colitis scores in a DSS-induced colitis model,possibly via reduction of MPO,TNF-α,and i NOS levels. | Altug Senol Mehmet Isler Recep Sutcu Mete Akin Ebru Cakir Betul M Ceyhan M Cem Kockar | 2015 | World Journal of Gastroenterology2015，21，46： | 3 |
| 2 | An algorithm for the capacitated, multi-commodity multi-period facility location problem显示文摘 | Canel Cem Khumawala Basheer M | 2001 | Computers & Operations Research2001，，28： | 1 |
| 3 | Endoscopic submucosal dissection in gastric lesions: the 100 cases experience from a tertiary reference center in West显示文摘 | Fatih Aslan Emrah Alper Cem Cek&imath c Derya Arslan Yurtlu Nese Ek&imath nc&imath Mahmut Arabul Belkis Unsal Yoshimasa M&imath ura Hironori Yamamoto | 2014 | Scandinavian Journal of Gastroenterology2014，，3： | 1 |
| 4 | The effect of nitrogen fertilization on tocopherols in rapeseed genotypes显示文摘 | Cem (O)mer Egesel M Kemal Gül Fatih Kahr man | | 0，，03： | 1 |
| 5 | Ge- netic and environmental contributions to self-report obsessive-compulsive symptoms in dutch adolescents at ages 12, 14 and 16显示文摘 | Van Grootheest DS Bartels M Van Beijsterveldt CEM et aI | 2008 | I Am Acad Child Adolesc Psychiatry2008，47，： | 1 |
| 6 | Immunolo- calization of peroxisome proliferators - activated receptors and retinoid X receptors in the adult rat CNS 显示文摘 | Moreno S Farioli - Vecchioli S Cem M P | 2004 | Neu- roscience2004，123，1： | 1 |
| 7 | Continuous glucose monitoring in medical intensive careunit 显示文摘 | de Block CEM M anuely Keenoy B van Gaal LF | 2005 | Continuous Glucose Monitoring2005，37，： | 1 |
| 8 | Expression of CK-19 and CEA mRNA in peripheral blood of gastric cancer patients 显示文摘 | Kutun S Celik A Cem Kockar M | 2010 | Exp Oncol2010，32，4： | 1 |
| 9 | Short term spatial and temporal variation of phytoplankton in a shallow tropical oligotrophic reservoir, southeast Brazil 显示文摘 | Lopes MRM Bicudo CEM Ferragut M C | 2005 | Hydrobiologia2005，542，： | 1 |
| 10 | The effect of steroids in combina- tion with optic nerve decompression surgery in traumatic optic neuropathy显示文摘 | Thorsten R Bernhard S Cem M | 2013 | Laryngoscope2013，123，5： | 1 |
| 11 | Acute phase proteins and other systemic responses to inflammation显示文摘 | Cem G M D Irving K M D | 1999 | Mechanisms of Disease1999，340，： | 1 |
| 12 | An algorithm for the capacitated multi-commodity multi-period facility location problem显示文摘 | Cem C Basheer M Khumawala Japhett L Anthony L | 2001 | Computers Operations research2001，28，： | 1 |
| 13 | Adjuvant treatment modalities to control macular edema in diabetic patients undergoing cataract surgery显示文摘 | Ebru Nevin Cetin Cem Y?ld?r?m | 2013 | International Ophthalmology2013，，5： | 1 |
| 14 | Allopurinol Ameliorates Thioacetamide-Induced Acute Liver Failure by Regulating Cellular Redox-Sensitive Transcription Factors in Rats显示文摘 | Ulvi Demirel Mehmet Yaln?z Cem Aygün Cemal Orhan Mehmet Tuzcu Kaz?m Sahin ?brahim Hanifi ?zercan ?brahim Halil Bah?ecio?lu | 2012 | Inflammation2012，，4： | 1 |
| 15 | Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with COPD显示文摘 | Aydin M Altintas N Cem ML | 2015 | Clin Respir J2015，48，4： | 1 |
| 16 | Effect of artificial tears on automated visual field testing in patients with glaucoma and dry eye 显示文摘 | Kocabeyoglu S Cem Mocan M Bozkurt B | 2013 | Canadian Journal of Ophthalmology2013，48，2： | 1 |
| 17 | Hysteroscopic findings in women with recurrent IVF failures and the effect of correction of hysteroscopic findings on subsequent pregnancy rates显示文摘 | Pinar Cenksoy Cem Ficicioglu Gazi Y?ld?r?m Mert Yesiladali | 2013 | Archives of Gynecology and Obstetrics2013，，2： | 1 |
| 18 | Association of an HLA class II allele with clearance of hepatitis B virus infection in the Gambia显示文摘 | Kwiatkowski D Allsopp CEM | 1995 | N Engl J Med1995，332，： | 1 |
| 19 | Conversion of leather wastes to useful products 显示文摘 | YILMAZ O CEM KANTARLI I YUKSEL M | 2007 | Resources Conservation and Recycling2007，49，4： | 1 |
| 20 | Simulation Based ABS Algorithm Development 显示文摘 | Cem H Amer M | 1999 | SAE1999，，： | 1 |
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