|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Effectiveness and time-course adaptation of resistance training vs. plyometric training in prepubertal soccer players显示文摘Purpose:This study aimed to assess the effectiveness and time course for improvements in explosive actions through resistance training(RT)vs.plyometric training(PT)in prepubertal soccer players.Methods:Thirty-four male subjects were assigned to:a control group(n=11);an RT group(5 regular soccer training sessions per week,n=12);a PT group(3 soccer training sessions and 2 RT sessions per week,n=11).The outcome measures included tests for the assessment of muscle strength(e.g.,1 repetition maximum half-squat test),jump ability(e.g.,countermovement jump,squat jump,standing long jump,and multiple 5 bounds test),linear speed(e.g.,20m sprint test),and change of direction(e.g.,Illinois change of direction test).Results:The RTG showed an improvement in the half-squat(△=13.2%;d=1.3,p<0.001)and countermovement jump(△=9.4%;d=2.4,p<0.001)at Week 4,whereas improvements in the 20-m sprint(△=4.2%;d=1.1,p<0.01);change of direction(CoD)(△=3.8%;d=2.1,p<0.01);multiple 5 bounds(△=5.1%;d=1.5,p<0.05);standing long jump(△=7.2%;d=1.2,p<0.01);squat jump(△=19.6%;d=1.5,p<0.01);were evident at Week 8.The PTG showed improvements in CoD(△=2.1%;d=1.3,p<0.05);standing long jump(△=9.3%;d=1.1,p<0.01);countermovement jump(△=16.1%;d=1.2,p<0.01);and squat jump(△=16.7%;d=1.4,p<0.01);at Week 8 whereas improvements in the 20-m sprint(△=4.1%;d=1.3,p<0.01);and multiple 5 bounds(△=7.4%;d=2.4,p<0.001);were evident only after Week.The RT and PT groups showed improvements in all sprint,CoD,and jump tests(p<0.05)and in half-squat performance,for which improvement was only shown within the RTG(p<0.001).Conclusion:RT and PT conducted in combination with regular soccer training are safe and feasible interventions for prepubertal soccer players.In addition,these interventions were shown to be effective training tools to improve explosive actions with different time courses of improvements,which manifested earlier in the RTG than in the PTG.These outcomes may help coaches and fitness trainers set out clear and concise goals of training according to the specific time course of improvement difference between RT and PT on proxies of athletic performance of prepubertal soccer players. | Yassine Negra Helmi Chaabene Thomas Stöggl Mehréz Hammami Mohamed Souhaiel Chelly Younés Hachana | 2020 | Journal of Sport and Health Science2020，9，6： | 3 |
| 3 | MAX – MIN Ant System显示文摘 | Thomas Stützle Holger H. Hoos | 2000 | Future Generation Computer Systems2000，，8： | 2 |
| 4 | Comparison of estimators of variance for forest inventories with systematic sampling-results from artificial populations显示文摘Background:Large area forest inventories often use regular grids(with a single random start)of sample locations to ensure a uniform sampling intensity across the space of the surveyed populations.A design-unbiased estimator of variance does not exist for this design.Oftentimes,a quasi-default estimator applicable to simple random sampling(SRS)is used,even if it carries with it the likely risk of overestimating the variance by a practically important margin.To better exploit the precision of systematic sampling we assess the performance of five estimators of variance,including the quasi default.In this study,simulated systematic sampling was applied to artificial populations with contrasting covariance structures and with or without linear trends.We compared the results obtained with the SRS,Matern’s,successive difference replication,Ripley’s,and D’Orazio’s variance estimators.Results:The variances obtained with the four alternatives to the SRS estimator of variance were strongly correlated,and in all study settings consistently closer to the target design variance than the estimator for SRS.The latter always produced the greatest overestimation.In populations with a near zero spatial autocorrelation,all estimators,performed equally,and delivered estimates close to the actual design variance.Conclusion:Without a linear trend,the SDR and DOR estimators were best with variance estimates more narrowly distributed around the benchmark;yet in terms of the least average absolute deviation,Matern’s estimator held a narrow lead.With a strong or moderate linear trend,Matern’s estimator is choice.In large populations,and a low sampling intensity,the performance of the investigated estimators becomes more similar. | Steen Magnussen Ronald EMcRoberts Johannes Breidenbach Thomas Nord-Larsen Göran Ståhl Lutz Fehrmann Sebastian Schnell | 2020 | Forest Ecosystems2020，7，2： | 2 |
| 5 | Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial显示文摘 | Robert J Motzer Bernard Escudier Stéphane Oudard Thomas E Hutson Camillo Porta Sergio Bracarda Viktor Grünwald John A Thompson Robert A Figlin Norbert Hollaender Gladys Urbanowitz William J Berg Andrea Kay David Lebwohl Alain Ravaud | 2008 | The Lancet2008，，9637： | 2 |
| 6 | Estimating the Global Public Health Implications of Electricity and Coal Consumption显示文摘 | Gohlke Julia M Thomas Reuben Woodward Alistair Campbell-Lendrum Diarmid Prüss-üstün Annette Hales Simon Portier Christopher J | 2011 | Environmental Health Perspectives2011，，6： | 2 |
| 7 | T-lymphoblastic lymphoma with cutaneous involvement显示文摘To study dermatological manifestation of T-lymphoblastic lymphoma and to help clinicians in the diagnosis, we report here the case of a 75-year-old patient who presented with violaceous nodules acquired during the last 4 wk and affecting the scalp and right arm. The diagnosis of systemic lymphoma was suggested upon the appearance of cutaneous tumors, palpable lymph nodes and general symptoms including asthenia and weight-loss. The pathology features: positive immunostaining for CD3 and terminal deoxynucleotidyl transferase(Td T) and staging, led us to the final diagnosis of T-lymphoblastic lymphoma(T-LBL) with cutaneous involvement. He received a CHOP regimen as first-line treatment. Unfortunately, the patient relapsed and died 8 mo after the treatment initiation. T-LBL may be diagnosed by skin lesions. Additional immunostaining including Td T and experienced histopathologists are needed to correctly classify this aggressive disease and discuss the correct management including bone-marrow transplantation where appropriate. | Emmanuelle Ginoux Fanny Julia Brigitte Balme Luc Thomas Stéphane Dalle | 2015 | World Journal of Clinical Cases2015，3，8： | 2 |
| 8 | New flexible endoscopic controlled stapler technique for the treatment of Zenker's diverticulum:A case series显示文摘AIM To report about the combination and advantages of a tapler-assisted diverticulotomy performed by flexible endoscopy.METHODS From November 2014 till December 2015 17 patients(8 female, 9 male, average age 69.8 years) with a symptomatic Zenker diverticulum(mean size 3.5 cm) were treated by inserting a new 5 mm fully rotatable surgical stapler(Micro Cutter30 Xchange, Cardica Inc.) next to an ultrathin flexible endoscope through an overtube. The Patients were under conscious sedation with the head reclined in left position, the stapler placed centrally and pushed forward to the bottom of the diverticulum. The septum was divided by the staple rows under flexible endoscopic control.RESULTS In eleven patients(64.7%) the stapler successfully divided the septum completely. Mean procedure time was 21 min, medium size of the septum was 2.8 cm(range 1.5 cm to 4 cm). In four patients the septum was shorter than 3 cm, in seven longer than 3 cm. To divide the septum, averagely 1.3 stapler cartridges were used. Two minor bleedings occurred. Major adverse events like perforation or secondary haemorrhage did not occur. After an average time of two days patients were discharged from the hospital. In 6 patients(35.3%) the stapler failed due to a thick septum or insufficient reclination of the head. Follow up endoscopy was performed after an average of two months in 9 patients; 4 patients(44.4%) were free of symptoms, 5 patients(55.6%) stated an improvement. A relapse of symptoms did not occur. CONCLUSION Flexible endoscopic Zenker diverticulotomy by using a surgical stapler is a new, safe and efficient treatment modality. A simultaneously tissue opening and occlusion prevents major complications. | Johanna Wilmsen Robert Baumbach Dietmar Stüker Vincens Weingart Frank Neser Stefan Karl Golder Christof Pfundstein Ellen Claudia Notzel Thomas Rosch Siegbert Faiss | 2017 | World Journal of Gastroenterology2017，23，17： | 2 |
| 9 | Lake of antibody practioner fol-lowing immunization in old age:association with CD8+CD28-T cellclonal expansions and an imbalance in the prauction of Thl and Th2显示文摘 | Maria ST Thomas LL Florentine M | 2002 | J Immunol2002，169，6： | 1 |
| 10 | Distance sampling显示文摘 | Thomas L Buckland ST Burnham KP | 2002 | Encyclopedia of Environmetrics2002，1，： | 1 |
| 11 | Next-generation sequencing of small RNAs from HIV-infeeted cells identifies phased mieroRNA expression patterns and candidate novel microRNAs differentially expressed upon infection显示文摘 | Chang ST Thomas MJ | 2013 | mBio2013，4，1： | 1 |
| 12 | Plastic ity in the injured brain: more than molecules matter显示文摘 | Overman J J Carmichael ST Thomas Carmichael | 2014 | Neuroscientist2014，20，1： | 1 |
| 13 | Compression bandage system evaluation 显示文摘 | Thomas ST Fram P | 2003 | Nursing Times2003，99，40： | 1 |
| 14 | Mobilization of CD34^+CD38^- hematopoietic stem cells after priming in acute myeloid leukemia显示文摘AIM: To evaluate quantitatively and qualitatively the different CD34+cell subsets after priming by chemotherapy granulocyte colony-stimulating factor(± G-CSF)in patients with acute myeloid leukemia.METHODS: Peripheral blood and bone marrow sampleswere harvested in 8 acute myeloid leukemia patients during and after induction chemotherapy. The CD34/CD38 cell profile was analyzed by multi-parameter flow cytometry. Adhesion profile was made using CXC chemokine receptor 4(CXCR4)(CD184), VLA-4(CD49d/CD29) and CD47.RESULTS: Chemotherapy ± G-CSF mobilized immature cells(CD34+CD38 population), while the more mature cells(CD34+CD38lowand CD34+CD38+populations) decreased progressively after treatment. Circulating CD34+cells tended to be more sensitive to chemotherapy after priming with G-CSF. CD34+cell mobilization was correlated with a gradual increase in CXCR4 and CD47expression, suggesting a role in cell protection and the capacity of homing back to the marrow.CONCLUSION: Chemotherapy ± G-CSF mobilizes into the circulation CD34+bone marrow cells, of which, the immature CD34+CD38-cell population. Further manipulations of these interactions may be a means with which to control the trafficking of leukemia stem cells to improve patients' outcomes. | Adriana Plesa Eve Mattei Charles Dumontet Youcef Chelghoum Hélène Labussière Giovanna Cannas Mauricette Michallet Xavier Thomas Mohamed Elhamri Stéphane Morisset Inès Tagoug | 2013 | World Journal of Stem Cells2013，5，4： | 1 |
| 15 | Two-step chromatographic procedure for the preparation of hen egg white ovotransferrin显示文摘 | Thomas Croguennec Fran?oise Nau Stéphane Pezennec Michel Piot Gérard Brulé | 2001 | European Food Research and Technology2001，，3： | 1 |
| 16 | The relationship of the U wave to the 10-year incidence of myocardial infarction显示文摘 | Weiss ST Thomas HE | 1983 | Am J Epidemiol1983，117，： | 1 |
| 17 | Compression Bandage system Eraluation 显示文摘 | Thomas ST Fram P | 2003 | NurSing Times2003，99，40： | 1 |
| 18 | Receptors for prostaglandin E2 that regulate cellular responses in the mouse显示文摘 | Thomas DW Tilley ST | 2001 | J Clin Invest2001，108，： | 1 |
| 19 | 查看详情显示文摘 | Bonard Jean-Marc St(o)ckli Thomas Noury Olivier | | 0，，： | 1 |
| 20 | Sediment capping in eutrophic lakes – efficiency of undisturbed calcite barriers to immobilize phosphorus显示文摘 | Ute Berg Thomas Neumann Dietfried Donnert Rolf Nüesch Doris Stüben | 2004 | Applied Geochemistry2004，，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员