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103篇 您的检索式:作者名="Thomas AB"
    题名 作者 年代 出处 被引量
1Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism显示文摘AIM:To investigate if and how the proinflammatory cytokine interferon γ(IFNγ) affects ghrelin expression in mice.METHODS:The plasma concentration of ghrelin,andgastric ghrelin and somatostatin expression,were examined in wild-type mice and mice infected with Helicobacter pylori(H.pylori).Furthermore,ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth.To study the effect of IFNγ alone,mice were given a subcutaneous infusion of IFNγ for 7 d.Finally,the influence of IFNγ and somatostatin on the ghrelin promoter was characterized.RESULTS:H.pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration.Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models.Subcutaneous infusion of IFNγ suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations.Finally,we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFNγ.CONCLUSION:Gastric infection and inflammation is associated with increased IFNγ expression and reduced ghrelin expression.IFNγ does not directly control ghrelin expression but inhibits it indirectly via somatostatin.Jesper AB Strickertsson Kristina BV DΦssing Anna JM Aabakke Hans-Olof Nilsson Thomas VO Hansen Ulrich Knigge Andreas Kjr Torkel Wadstrm Lennart Friis-Hansen 2011World Journal of Gastroenterology2011,17,26:2
2Myeloid Leukemia Cutis: a Histologic and ImmunohistoehemicaI Review 显示文摘Cibull TL Thomas AB O Malley DP 2008J Cutan Pathol2008,35,2:1
3Substituted Tetrahydropyrrolo oxazol- 5 ( 6H )- ones and Tetrahydropyrrolothiazol-5 (6H)-ones as Hypoglycemic Agents显示文摘 Bork Balkan Philip AB 1998J Med Chem1998,41,23:1
4Norgren RB:magnetic resonance imaging of neural transplants in rat brain using a superparamagnetic contrast agent显示文摘Norman AB Thomas SR Pratt RG 1992Brain Res1992,594,:1
5Mitochondrial autophagy-an essential quality control mechanism for myocardial homeostasis显示文摘Thomas RL Gustafsson AB 0,,10:1
6NCCN Clinical Practice Guidelines in Oncology:rectal cancer 显示文摘Engstrom PF Arnoletti JP Benson AB 3rd Chen YJ Choti MA Cooper HS Covey A Dilawari RA Early DS Enzinger PC Fakih MG Fleshman J Jr Fuchs C Greta JL Kiel K Knol JA Leong LA Lin E Mulcahy MF Rao S Ryan DP Saltz L Shibata D Skibber JM Sofocleous C Thomas J Venook AP Willett C 2009J Natl Compr Canc Netw2009,7,:1
7Biologi- cal activities of curcumin and its analogues (congeners) made by man and mother nature 显示文摘ANAND THOMAS S KUNNUMAKKARA AB 2008Biochem Pharmacol2008,76,11:1
8Magnetic Resonance Imaging of Neural Transplants in Rat Brain Using a Superparamagnetic Contrast Agent显示文摘Norman AB Thomas SR Pratt RG 1992Brain Res1992,594,2:1
9PPAR-γ agonists inhibit TGF-β induced pulmonary myofibroblast differentiation and collagen production 显示文摘Heather AB Louis ED Thomas HT 2005Physiol Lung Cell Mol Physiol2005,288,:1
10Brow-lift suhgaleal vs subpe riosteal flap adherence in the rabbit model显示文摘Thomas JR Lee AS Patel AB 2007Arch Facial Plast Surg2007,9,2:1
11Bnip3-mediated defects in oxidative phosphorylation promote mitophagy 显示文摘Thomas RL Kubli DA Gustafsson AB 2011Autophagy2011,7,7:1
12Novel,potent aidose reductase inhibitors:3,4-dihydro-4-oxo-3-methyl]-1-phthalazineacetic acid(Zopolrestat)and congeners显示文摘Anavara LM Eric RL Thomas AB 1991J Med Chem1991,34,1:1
13Endoscopic reconstruction of the cranial base using a pedicled nasoseptal flap显示文摘Kassam AB Thomas A Carrau RL 2008Neurosurgery2008,63,1:1
14Extending and applying the demand-control model: the role of soldier's coping on a peacekeeping deployment 显示文摘Ippolito J Adler AB Thomas JL 2005J Oceup Health Psychol2005,10,4:1
15Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X)显示文摘Thomas D Hammerling BC Wimmer AB 2004Cardiovasc Res2004,64,3:1
16Rapid prototyping: the future of trauma surgery显示文摘George AB Keikhosrow F Thomas AD etal 2003Journal of Bone and Joint Surgery2003,4,:1
17Environmental occurrence and shallow ground water detection of the antibiotic monensin from dairy farms 显示文摘Naoko W Thomas HH Brian AB 2008J Environ Qual2008,37,:1
18Endoscopic endona- sal pituitary transposition for a transdorsum sellae approach to the interpeduncular cistern 显示文摘Kassam AB Prevedello DM Thomas A 2008Neurosurgery2008,62,31:1
19Effects of anesthesia on echocardiographic assessment of left ventricular structure and function in rats显示文摘 Tiwari S Thomas P 2007Basic Res Cardiol2007,102,:1
20Comparative analyses of multi-species sequences from targeted genomic regions显示文摘Thomas JW Touchman JW Blakesley RW Bouffard GG Beckstrom-Sternberg SM Margulies EH Blanchette M Siepel AC Thomas PJ McDowell JC Maskeri B Hansen NF Schwartz MS Weber RJ Kent WJ Karolchik D Bruen TC Bevan R Cutler DJ Schwartz S Elnitski L Idol JR Prasad AB 0,,6950:1
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