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| 1 | Potential roles of tumor suppressor genes and microsatellite instability in hepatocellular carcinogenesis in southern African blacks显示文摘MAJOR POINTS OF THE COMMENTED ARTICLECumulative loss of heterozygosity(LOH)ofchromosomal regions and tumor suppressor geneshas been reported in hepatocellular carcinomas(HCCs) from China,Japan,and Korea.In thisissue of the World Journal of Gastroenterology,Martins et al report an analysis of LOH andmicrosatellite instability in HCCs from a group of | Roberts LR LaRusso NF | 2000 | World Journal of Gastroenterology2000，6，1： | 13 |
| 2 | Gamma knife stereotactic radiosurgery for the management of incidentally-identified brain metastasis from non-small cell lung cancer显示文摘 | Marko NF Suh JH Chao ST Barnett GH Vogelbaum MA Toms S Well R J Angelov L | 2011 | 中国神经肿瘤杂志2011，9，1： | 4 |
| 3 | Stereotactic radiosurgery as single-modality treatment of incidentally identified renal cell carcinoma brain metastases显示文摘 | Marko NF Angelov L Toms SA Suh JH Chao ST Vogelbaum MA Barnett GH Weil RJ | 2010 | 中国神经肿瘤杂志2010，8，3： | 4 |
| 4 | 非甾体抗炎药应用中,环氧合酶2、不对称二甲基精氨酸与心血管危害的关系显示文摘已有大规模、安慰剂对照试验确定了非甾体类抗炎药(nonsteroidal anti—inflammatory drugs,NSAIDs)具有心血管危害性:这归因于环氧合酶2(cyclooxygenase,COX-2)的心脏保护产物受到抑制,尤其是前列环素(prostacyclin,PG12)。NSAID降低心脏保护作用的另一种机制可能是通过增强肾脏中甲基精氨酸的形成来限制一氧化氮在整个脉管系统中的作用。 | Ricciotti E Castro C Tang SY Briggs WTE West JA Malik D Rhoades SD Meng H Li X Lahens NF Sparks JA Karlson EW Weljie AM Griffin JL FitzGerald GA6 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 3 |
| 5 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 6 | L3T4 CD4+ cells that mediate contact sensitivity to trinitrochlorobenzene express I-A determinants显示文摘 | Gautam SC Matriano JA Chikkala NF Edinger MG Tubbs R | 1991 | Cell Immunol1991，135，1： | 2 |
| 7 | 有氧运动联合阻抗运动对难治性高血压患者动态血压的降低作用更为持久:一项随机交叉试验显示文摘该研究比较有氧运动、阻抗运动及联合运动对难治性高血压(refractory hypertension,RH)和非难治性高血压(NON-RH)患者血压的短期影响。方法:招募患者20例(RH 10例和NON-RH 10例),随机进行三种运动训练或对照训练。试验训练结束后监测24h动态血压。结果:RH患者在有氧运动、阻抗运动及联合运动后动态血压降低。联合运动后日间和夜间动态血压均降低。有氧运动对日间血压的影响更为显著,而阻抗运动降低夜间血压的幅度较大。仅阻抗运动降低NON-RH患者的收缩压,三种运动均可降低舒张压。 | 袁源(摘译) 练桂丽(审校) Pires NF Coelho-Júnior HJ Gambassi BB deFaria APC Ritter AMV de Andrade Barboza C Ferreira-Melo SE Rodrigues B Júnior HM | 2021 | 中华高血压杂志2021，29，1： | 2 |
| 8 | Oxidative stress as a therapeutic target in diabetes: revisiting the controversy显示文摘 | NF Wiernsperger | 2003 | Diabetes and Metabolism2003，，6： | 2 |
| 9 | Human intestinal and biliary cryptosporidiosis显示文摘 | Chen XM LaRusso NF | 1999 | World Journal of Gastroenterology1999，5，5： | 2 |
| 10 | Fractures attributable to osteoporosis:report from the National Osteoporosis Foundation显示文摘 | Melton LJ 3rd Thamer M Ray NF | 1997 | J Bone Miner Res1997，12，1： | 1 |
| 11 | Pulmonary vein antrum isolation for treatment of atrial fibrillation in patients with valvular heart disease or prior open heart surgery显示文摘 | Khaykin Y Marrouche NF Saliba W | 2004 | Heart Rhythm2004，1，1： | 1 |
| 12 | PVN lesions prevent the endothelinl-induced increase in arterial pressure and vasopressin显示文摘 | Rossi NF Chen H | 2001 | Am J Physiol Endocrinol Metab2001，280，： | 1 |
| 13 | Pulmonary hamartoma CT findings显示文摘 | Siegelman SS Khouri NF Scott WW Jr | 1996 | Radiology1996，160，2： | 1 |
| 14 | Mode of initiation and ablation of velatricular fibrillation storms in patients with ischemic cardiomyopathy 显示文摘 | Marrouche NF Verma A Wazni O | 2004 | J Am Coll Cardiol2004，43，9： | 1 |
| 15 | Microsphere formation in a series of derivatized α-amino acid:properties,molecular modeling,and oral delivery of salmon calcitonin显示文摘 | McInnes C Wang NF | 1995 | J Med Chem1995，38，： | 1 |
| 16 | Dection of anticentromere antibodies using cloned autoantigen CENP-B显示文摘 | Whitaker D Bordwell B | 1987 | Athritis Rheum1987，30，12： | 1 |
| 17 | Histological changes in the normal rat brain after gamma irradiation显示文摘 | Kassell NF Thai QA | 1996 | Acta Neurochir (Wien)1996，138，： | 1 |
| 18 | Electropharmacological effects of berberine on canine cardiac Purkinje fibers and ventricular muscle and atrial muscle of the rabbit显示文摘 | Ricciopo NF | 1993 | Br J Pharmacol1993，108，： | 1 |
| 19 | Nutrient Adequacy and Diet Quality in Non-Overweight and Overweight Hispanic Children of Low Socioeconomic Status:The Viva la Familia Study显示文摘 | WILSON TA ADOLPH AL BUTTE NF | 2009 | Journal of the American Dietetic Association2009，109，6： | 1 |
| 20 | Phospholipase B in the brains and meninges of nonsensitized and sensitized rats after challenge with Angiostrongylus cantonensis显示文摘 | Ottolenghi A Weatherly NF Jr Larsh JE | 1980 | Infect Immun1980，29，2： | 1 |
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