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| 1 | Impact of a clinical pathway on treatment outcome in patients with acute pancreatitis显示文摘AIM:To determine the impact of a clinical pathway(CP) on acute pancreatitis(AP) treatment outcome.METHODS:A retrospective analysis of medical records was performed. We compared the results of AP treatment outcome over two time periods in our centre,before(2006-2007) and after(2010-2012) the implementation of a CP. The CP comprised the following indicators of quality:performance of all laboratory tests on admission(including lipids and carbohydrate deficient transferrin),determination of AP aetiology,abdomen ultrasound(US) within the first 24 h after admission,contrast-enhanced computed tomography of the abdomen in all cases of suspected pancreatic necrosis,appropriately selected and sufficiently used antibiotic therapy(if necessary),pain control,adequate hydration,control of haemodynamic parameters and transfer to the Intensive Care Unit(ICU)(if necessary),endoscopic retrograde cholangiopancreatography(ERCP) in biliary AP,surgical treatment(if necessary),and advice on outpatient follow-up after discharge. A comparison of the length of stay with that in other Slovenian hospitals was also performed.RESULTS:There were 139 patients treated in the three-year period after the introduction of a CP,of which 81(58.3%) were male and 58(41.7%) female. The patients' mean age was 59.6 ± 17.3 years. The most common aetiologies were alcoholism and gallstones(38.8% each),followed by unexplained(11.5%),drug-induced,hypertriglyceridemia,post ERCP(2.9% each) and tumours(2.2%). Antibiotic therapy was prescribed in 72(51.8%) patients. Abdominal US was performed in all patients within the first 24 h after admission. Thirty-two(23.0%) patients were treated in the ICU. Four patients died(2.9%). In comparison to 2006-2007,we found an increased number of alcoholic and biliary AP and an associateddecrease in the number of unexplained aetiology cases. The use of antibiotics also significantly decreased after the implementation of a CP(from 70.3% to 51.8%; P = 0.003). There was no statistically significant difference in mortality(1.8% vs 2.9%). The length of stay was significantly shorter when compared to the Slovenian average(P = 0.018).CONCLUSION:The introduction of a CP has improved the treatment of patients with AP,as assessed by all of the observed parameters. | Miroslav Vujasinovic Jana Makuc Bojan Tepes Apolon Marolt Zdenko Kikec Nace Robac | 2015 | World Journal of Gastroenterology2015，21，30： | 13 |
| 2 | Pancreatic exocrine insufficiency, diabetes mellitus and serum nutritional markers after acute pancreatitis显示文摘AIM:To investigate impairment and clinical significance of exocrine and endocrine pancreatic function in patients after acute pancreatitis(AP).METHODS:Patients with AP were invited to participate in the study.Severity of AP was determined by the Atlanta classification and definitions revised in2012.Pancreatic exocrine insufficiency(PEI)was diagnosed by the concentration of fecal elastase-1.An additional work-up,including laboratory testing of serum nutritional markers for determination ofmalnutrition,was offered to all patients with low levels of fecal elastase-1 FE.Hemoglobin A1c or oral glucose tolerance tests were also performed in patients without prior diabetes mellitus,and type 3c diabetes mellitus(T3c DM)was diagnosed according to American Diabetes Association criteria.RESULTS:One hundred patients were included in the study:75%(75/100)of patients had one attack of AP and 25%(25/100)had two or more attacks.The most common etiology was alcohol.Mild,moderately severe and severe AP were present in 67,15 and 18%of patients,respectively.The mean time from attack of AP to inclusion in the study was 2.7 years.PEI was diagnosed in 21%(21/100)of patients and T3c DM in14%(14/100)of patients.In all patients with PEI,at least one serologic nutritional marker was below the lower limit of normal.T3c DM was more frequently present in patients with severe AP(P=0.031),but was also present in some patients with mild and moderately severe AP.PEI was present in all degrees of severity of AP.There were no statistically significantly differences according to gender,etiology and number of AP attacks.CONCLUSION:As exocrine and endocrine pancreatic insufficiency can develop after AP,routine follow-up of patients is necessary,for which serum nutritional panel measurements can be useful. | Miroslav Vujasinovic Bojan Tepes Jana Makuc Sasa Rudolf Jelka Zaletel Tjasa Vidmar Maja Seruga Bostjan Birsa | 2014 | World Journal of Gastroenterology2014，20，48： | 10 |
| 3 | Modified Helicobacter test using a new test meal and a 13C-urea breath test in Helicobacter pylori positive and negative dyspepsia patients on proton pump inhibitors显示文摘AIM To determine the sensitivity and specificity of the ^(13)C-urea breath test(UBT) in patients taking proton pump inhibitors(PPIs), using a new test meal Refex. METHODS One hundred and fourteen consecutive patients with dyspepsia, 53 Helicobacter pylori(H. pylori) positive, 49 H. pylori negative, were included in the study. The patients were then given esomeprazole 40 mg for 29 consecutive days, and the ^(13)C-UBT with the new test meal was performed the next morning. RESULTS The sensitivity of the ^(13)C-UBT with a cut off 2.5‰ was92.45%(95%CI: 81.79%-97.91%) by per-protocol(PP) analysis and 78.13 %(95%CI: 66.03%-87.49%) by intention-to-treat(ITT) analysis. The specificity of the ^(13)C-UBT test was 96.00 % in the ITT population(95%CI: 86.29%-99.51%) and 97.96% in the PP population(95%CI: 89.15%-99.95%).CONCLUSION The new test meal based ^(13)C-UBT is highly accurate in patients on PPIs and can be used in those unable to stop their PPI treatment. | Bojan Tepes Peter Malfertheiner Joachim Labenz Sitke Aygen | 2017 | World Journal of Gastroenterology2017，23，32： | 5 |
| 4 | Effect of column in batch distillation显示文摘 | PIGFORD R L TEPE JB GARRAHAN C J | 1951 | IndEng Chem1951，43，11： | 1 |
| 5 | Screening of the antioxidativc and antimicrobial properties of the essential oils of Pimpinella anisetum and Pimpinella flabellifolia from Turkey 显示文摘 | Tepe B Akpulat HA Sokmen M | 2006 | Food Chem2006，97，： | 1 |
| 6 | Prophylaxis of restenosis with ( 186)re-labeled stents in a rabbit model显示文摘 | Tepe G Dinkelborg L M Brehme U | 2001 | Circulation2001，104，4： | 1 |
| 7 | Antimicrobial and antioxidative activities of the essential oils and methanol extracts of Salvia cryptantha(Montbret et Aucher ex Benth)and Salvia multicaulis(Vahl)显示文摘 | TEPE B DONMEZ E UNLU M | | 0，，04： | 1 |
| 8 | Minimum energy hierarchical dynamic source routing for mobile ad hoc networks显示文摘 | Tarique M Tepe K | 2009 | Ad Hoc Networks2009，7，6： | 1 |
| 9 | Low and high adrenergic receptors differentially affect cardiac hypertrophy and function in Gaq overexpressing mice显示文摘 | DORN G W Ⅱ TEPE N M LORENZ J N | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 10 | Survey of multipath rou-ting protocols for mobile ad hoc networks显示文摘 | Tarique M Tepe K E Adibi S | 2009 | Journal of Net-work and Computer Applications2009，32，6： | 1 |
| 11 | Intraocular pressure during comeal flap preparation:comparison among four femtosecond lasers in porcine eyes显示文摘 | Vetter JM Holzer MP Teping C | | 0，，： | 1 |
| 12 | In vitro amoebicidal activities of Satureja cuneifolia and Melissa officinalis on Acanthamoeba castellanii cysts and trophozoites显示文摘 | E. Malatyali B. Tepe S. Degerli S. Berk | 2012 | Parasitology Research2012，，： | 1 |
| 13 | Evaluation of metal concentration and antioxidant ac-tivity of three edible mushrooms from Mugla,Turkey显示文摘 | Cengiz Sarikurkcu Bektas Tepe Deniz Karslfi Semiz etal | 2010 | Food and Chemical Toxicology2010，48，5： | 1 |
| 14 | Effect of refining processeson the total and individual tocopherol content in sunflower oil显示文摘 | ALPASLAN M TEPE S SIMSEK O | 2001 | International Journal of Food Science and Technology2001，36，7： | 1 |
| 15 | Acute kidney injuryin the elderly hospitalized patients显示文摘 | Kayatas K Sahin G Tepe M | 2014 | Renal Fail-ure2014，36，8： | 1 |
| 16 | Complication after embolization of a complex renal vascular malformation显示文摘 | Wiesinger B Schber W Tepe G | 2005 | Nephrol Dial Transplant2005，20，8： | 1 |
| 17 | Combined NT–pro-BNP and CW-Doppler ultrasound cardiac output monitoring (USCOM) in epirubicin and liposomal doxorubicin therapy显示文摘 | K. Knobloch J. Tepe D. Rossner R. Lichtinghagen H.J. Luck K.H. Busch P.M. Vogt | 2007 | International Journal of Cardiology2007，，3： | 1 |
| 18 | Effects of DNA immunization formulated with bupivacaine in murine and guinea pig models of genital herpes simplex virus infection显示文摘 | Tepe ER Mester JC | 1999 | Vaccine1999，9，： | 1 |
| 19 | Spinal canal remodeling in burst fractures of the thoracolumbar spine : a computerized tomographic comparison between operative and nonoperative treatment 显示文摘 | Yazici M Atilla B Tepe S | 1996 | J Spinal Disord1996，9，5： | 1 |
| 20 | Prophylaxis of restenosis with lS6Re-labeled stents in a rabbit model显示文摘 | Tepe G Dinkelborg LM Brehme U | 2001 | Circulation2001，104，4： | 1 |
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