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1Neuroprotective effect of systemic and/or intravitreal rosuvastatin administration in rat glaucoma model显示文摘AIM:To evaluate the neuroprotective effect of rosuvastatin,in a rat experimental glaucoma model.· METHODS:Ocular hypertension was induced in right eyes of Long-Evans rats(n=30) by cauterization of three episcleral veins.Left eyes were defined as controls.Rats were divided into five groups:oral rosuvastatin,intravitreal rosuvastatin,oral +intravitreal rosuvastatin,intravitreal sham and glaucoma without intervention.Rats were sacrificed at day 14.Retinal ganglion cell(RGC) number was assessed by histopathological analysis.Terminal deoxynucleotidyl transferase-mediated dUTP-nick end-labeling(TUNEL) staining and the expression of glial fibrillary acidic protein(GFAP) in RGC layer was also examined.· RESULTS:A significant intraocular pressure(IOP)elevation was seen(P=0.002).Elevated IOP resulted in a significant decrease in number of RGCs in group 5(70.33±8.2 cells/mm^2) when compared with controls(92.50±13.72 cells/mm^2;P=0.03).The RGC number in group 1(92.4±7.3 cells/mm^2) was significantly higher than group 5(P=0.03).The numbers of RGC in groups 2,3(57.3±8.2 cells/mm^2,60.5±12.9 cells/mm^2) were comparable with that of group 5(P=0.18 and P=0.31).The apoptosis rates with TUNEL staining were also parallel to RGC number.Animals with experimentally induced glaucoma showed an increase in retinal GFAP immunoreactivity.· CONCLUSION:Decrease in RGC loss and apoptosis suggest the neuroprotective potential of oral rosuvastatin treatment in a rat model of ocular hypertension.However intravitreal rosuvastatin showed a contrary effect and further studies are required.Metin Unlu Zeynep Aktas Pinar Uyar Gocun Sevil Ozger Ilhan Murat Hasanreisoglu Berati Hasanreisoglu 2016International Journal of Ophthalmology(English edition)2016,9,3:7
2Dividend policy, creditor rights, and the agency costs of debt显示文摘Paul Brockman Emre Unlu 2009Journal of Financial Economics2009,,2:2
3Effect of Poisson’s ratio on the normalized radial displacements occurring around the face of a circular tunnel显示文摘T. Unlu H. Gercek 2003Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2003,,5:2
4The evaluation of eustachian tube function in patients with chronic otitis media显示文摘Yuceturk AV Unlu HH Okumus M 1997Clin Otolaryngol1997,22,:1
5Comparison of surgical outcomes in primary endoscopic dacryocystorhinostomy with and without silicone intubation显示文摘Unlu HH Toprak B Aslan A 2002Ann Otol Rhinol Laryngol2002,111,8:1
6Evaluation of retinoic acid ophthalmic emulsion in dry eye显示文摘Selek H Unlu N Orhan M Irkec M 2000Eur J Ophthalmol2000,10,2:1
7Effect of home bleaching agents on the mierohardness of human enamel and dentin显示文摘Unlu N Cobankara F K Altinoz C 2004J Oral Rehabil2004,31,1:1
8Leptin and TNF-αlpha levels in pa-tients with chronic obstructive pulmonary disease and their relationship to nutritional parameters显示文摘Calikoglu M Sahin G Unlu A 2004Respiration2004,71,1:1
9I-123-mIBG myocardial imaging for assessment of risk for a major cardiac event in heart failure patients: insights from a retrospective European multicenter study显示文摘Denis Agostini Hein J. Verberne Wolfgang Burchert Juhani Knuuti Pavol Povinec Gianmario Sambuceti Mustafa Unlu Montserrat Estorch Gopa Banerjee Arnold F. Jacobson 2008European Journal of Nuclear Medicine and Molecular Imaging2008,,3:1
10Evaluation of tumor angiogenesis with contrast-enhanced dynamic magnetic resonance mammography显示文摘Tuncbilek N Unlu E Karakas HM 2003Breast J2003,9,5:1
11MMP-9 and TIMP-1 levels in the sputum of patients with chronic obstructive pulmonary disease and asthma显示文摘Calikoglu M Unlu A Tamer L 2006Tuberk Toraks2006,54,2:1
12MRI findings of Wernicke encephalopathy revisited due to hunger strike显示文摘Unlu E Cakir B Asil T 2006Eur J Radiol2006,57,1:1
13Using cuffed and tunneled central venous catheters as permanent vascular access for hemodialysis:A prospective sduty显示文摘Cetinkaya R Odabas A Unlu Y 2003Ren Fail2003,25,:1
14Antimicrobial and antioxidative activities of the essential oils and methanol extracts of Salvia cryptantha(Montbret et Aucher ex Benth)and Salvia multicaulis(Vahl)显示文摘TEPE B DONMEZ E UNLU M 0,,04:1
15Predictors of mortality in elderly patients with an intertrochanteric or a femoral neck fracture显示文摘Kesmezacar H Ayhan E Unlu MC 2010J Trauma2010,68,:1
16Lycopene from heat-in- duced cis-isomer-rich tomato sauce is more bioavailable than from all-trans-rich tomato sauce in human subjects显示文摘UNLU N Z BOHN T FRANCIS D M 2007Brit J Nutr2007,98,1:1
17Importance of the cell block technique in diagnosing patients with non-small cell carcinoma accompanied by pleural effeusion显示文摘Ugurluoglu C Kurtipek E Unlu Y etal 2015Asian Pac J Cancer Prev2015,16,7:1
18The relationship between leptin and lipids in atherosclerosis显示文摘Tamer L Ercan B Unlu A 2002Indian Heart2002,54,6:1
19RTD in twin- screw food extrusion 显示文摘Unlu E FaUer J F 2002J Food Eng2002,53,:1
20Internal spatial modes in glass microring resonators显示文摘 Goldberg B B Unlu M S Chu S T Little B 2000IEEE Journal on Selected Topics in Quantum Electronics2000,,:1
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