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| 1 | Association between fifteen risk factors and progressing ischemic stroke in the Han population of northeast China显示文摘与进行的 ischemic 联系的死亡和残疾摸的背景比一般 ischemic 击高得多。这研究被进行决定为进行的 ischemic 的因素在有在 24 个小时以内的 ischemic 击的 2511 个病人的一个总数承认了到神经病学的部门的东北 China.Methods 的汉人口摸的风险,哈尔滨医药大学的首先隶属于的医院被学习,从 2007 年 11 月到 2009 年 5 月。所有病人被分类进根据斯堪的纳维亚的神经病学的击规模的分数进行或非进行的组。十五个通常认为的风险因素被评估。为进行的 ischemic 击的风险因素的影响与简单逻辑分析,多重逻辑分析,和逐步的逻辑回归模型被分析。所有统计分析被 SAS 9.1 .Results 完全执行 359 (14.3%) 病人们为进行的 ischemic 满足了标准击。逻辑分析显示出那年龄,家庭中风历史,吸烟历史,录取上的高血压,在在到医院的录取以后的血压的落下,录取上的高浆液葡萄糖,并且发烧与在有这些因素的 ischemic 中风的东北 China.Conclusion 人的汉人口的进行的 ischemic 击有关是更可能的发展进行 ischemic 击。 | YANG Shan-shan TENG Da YOU Ding-yun SU Zhi-qiang LI Fang ZHAO Ji-yang | 2010 | Chinese Medical Journal2010，，11： | 11 |
| 2 | Impact of Ownership Types on R&D Intensity and Innovation Performance--Evidence from Transitional China显示文摘这份报纸在公司 R&D 紧张和革新性能上检验所有权类型的效果,用从 2005 ~ 2007 的 357,857 个中国公司的一件样品。这研究以 R&D 紧张和革新性能在中国国内企业之中发现可观的分叉。,我们发现中央政府拥有的公司是为公司 R&D 活动的关键司机本地管理,私人、外国的所有权是否定地与 R&D 紧张和革新性能有关。这份报纸在政府所有权范畴以内发现重要分叉并且主张瓷器机构的变化与资源天赋的不同层次产生改变的政府所有权组,它接着影响公司 R&D 活动。 | Da Teng Jingtao Yi | 2017 | Frontiers of Business Research in China2017，11，1： | 7 |
| 3 | Room temperature ferromagnetism in ultra-thin van der Waals crystals of 1T-CrTe2显示文摘Although many emerging new phenomena have been unraveled in two dimensional(2D)materials with long-range spin orderings,the usually low critical temperature in van der Waals(vdW)magnetic material has thus far hindered the related practical applications.Here,we show that ferromagnetism can hold above 300 K in a metallic phase of 1T-CrTe2 down to the ultra-thin limit.It thus makes CrTe2 so far the only known exfoliated ultra-thin vdW magnets with intrinsic long-range magnetic ordering above room temperature.An in-plane room-temperature negative anisotropic magnetoresistance(AMR)was obtained in ultra-thin CrTe2 devices,with a sign change in the AMR at lower temperature,with−0.6%and+5%at 300 and 10 K,respectively.Our findings provide insights into magnetism in ultra-thin CrTe2,expanding the vdW crystals toolbox for future room-temperature spintronic applications. | Xingdan Sun Wanying Li Xiao Wang Qi Sui Tongyao Zhang Zhi Wang Long Liu Da Li Shun Feng Siyu Zhong Hanwen Wang Vincent Bouchiat Manuel Nunez Regueiro Nicolas Rougemaille Johann Coraux Anike Purbawati Abdellali Hadj-Azzem Zhenhua Wang Baojuan Dong Xing Wu Teng Yang Guoqiang Yu Bingwu Wang Zheng Han Xiufeng Han Zhidong Zhang | 2020 | Nano Research2020，13，12： | 6 |
| 4 | Expression of Aspergillus niger 9891 Endoinulinase in Pichia pastoris显示文摘An endoinulinase gene from Aspergillus niger 9891 (CGMCC0991) has been expressed in Pichia pastoris GS115 using pPIC9 vector. The recombinant endoinulinase was highly expressed and the optimization of the expression in a 7 liter of fermentor has been investigated. In fermented broth, the concentration of protein secreted is 2.15 mg/ml. The activity of endoinulinase is 1501 U/ml with sucrose as substrate and 291 U/ml with inulin as substrate, 105 and 273 times higher than that from the original strain respectively. | 王建华 TENG Da YAO Yi Yang Yalin Zhang Fan | 2004 | High Technology Letters2004，10，4： | 6 |
| 5 | Phase recovery and holographic image reconstruction using deep learning in neural networks显示文摘Phase recovery from intensity-only measurements forms the heart of coherent imaging techniques and holography.In this study,we demonstrate that a neural network can learn to perform phase recovery and holographic image reconstruction after appropriate training.This deep learning-based approach provides an entirely new framework to conduct holographic imaging by rapidly eliminating twin-image and self-interference-related spatial artifacts.This neural network-based method is fast to compute and reconstructs phase and amplitude images of the objects using only one hologram,requiring fewer measurements in addition to being computationally faster.We validated this method by reconstructing the phase and amplitude images of various samples,including blood and Pap smears and tissue sections.These results highlight that challenging problems in imaging science can be overcome through machine learning,providing new avenues to design powerful computational imaging systems. | Yair Rivenson Yibo Zhang Harun Günaydın Da Teng Aydogan Ozcan | 2017 | Light(Science & Applications)2017，6，1： | 5 |
| 6 | Structural impairment patterns in peripapillary retinal fiber layer and retinal ganglion cell layer in mitochondrial optic neuropathies显示文摘AIM:To evaluate the structural injure patterns in peripapillary retinal fiber layer (pRNFL), retinal ganglion cell layer (RGCL) and their correlations to visual function in various mitochondrial optic neuropathies (MON) to offer help to their differential diagnosis.METHODS:Totally 32 MON patients (60 eyes) were recruited within 6mo after clinical onsets, including 20 Leber hereditary optic neuropathy (LHON) patients (37eyes), 12 ethambutol-induced optic neuropathy (EON)patients (23 eyes), and 41 age-gender matched healthy controls (HC, 82 eyes). All subjects had pRNFL and RGCL examinations with optic coherence tomography (OCT) and visual function tests.RESULTS:In the early stages of MON, the temporal pRNFL thickness decreased (66.09±22.57μm), but increased in other quadrants, compared to HC (76.95±14.81μm). The other quadrants remaining stable for LHON and EON patients besides the second hour sector of pRNFL thickness reduced and the temporal pRNFL decreased (56.78±15.87μm) for EON. Total macular thickness in MON reduced remarkably(279.25±18.90μm; P=0.015), which mainly occurring in the inner circle (3 mm diameter of circle) and the nasal temporal sectors in the outer circle (5.5 mm diameter of circle), in contrast to those in HC. RGCL thickness reduced in each sector of the macula (61.90±8.73μm; P≤0.001). It strongly showed the correlationship of best corrected visual acuity (R=0.50, P=0.0003) and visual field injury (R=0.54,P=0.0002) in MON patients.CONCLUSION:OCT is a potential tool for detecting structural alterations in the optic nerves of various MON. Different types of MON may have different damage patterns. | Da Teng Chun-Xia Peng Hai-Yan Qian Li Li Wei Wang Jun-Qing Wang Bing Chen Huan-Fen Zhou Shi-Hui Wei | 2018 | International Journal of Ophthalmology(English edition)2018，11，10： | 5 |
| 7 | A spirocyclic oxindole analogue:Synthesis and antitumor activities显示文摘spirocyclic oxindole 类似物 spiro 的新合成[piperidine-4,3-pyrrolo [2,3-b ] 吡啶]-2(1H)-one 1 被描述。关键步由羧基的酰胺和芳基氯化物的 intramolecular BuchwaldHartwig amidation 包含 arylacetonitrile 的 dialkylation 和 azaoxindole 戒指的环合。一个小图书馆被 1 的减少的胺化作用与各种各样的醛获得并且对人的肺癌症房间 A549,人的肝癌症房间 BEL7402,和人的结肠癌房间 HCT-8 被屏蔽。结果显示出 2 有的图书馆混合物的那个大多数一些禁止的活动。2-(Trifluoromethoxy ) benzylic 代替了 spirocyclic azaoxindole 2e 对人的肺癌症房间 A-549 作为一个 nanomolar 禁止者被识别(IC50 = 50 nmol/L ) 。 | Hui Hong Long Jiang Huang Da Wei Teng | 2011 | Chinese Chemical Letters2011，22，9： | 5 |
| 8 | Granular porous calcium carbonate particles for scalable and high-performance solar-driven thermochemical heat storage显示文摘Calcium carbonate is promising thermochemical heat storage material for next-generation solar power systems due to its high energy storage density,low cost,and high operation temperature.Researchers have tried to improve energy storage performances of calcium carbonate recently,but most researches focus on powders,which are not suitable for scalable applications.Here,novel granular porous calcium carbonate particles with very high solar absorptance,energy storage density,abrasive resistances,and energy storage rate are proposed for direct solar thermochemical heat storage.The average solar absorptance is improved by 234%compared with ordinary particles.Both cycle stability and abrasive resistances are excellent with almost no decay of energy storage density over 25 cycles nor apparent particle weight loss over 24 h of continuous operation insides a planetary ball mill.In addition,the decomposition temperature is reduced by 2.8%–5.6%while the reaction rate of heat storage is enhanced by 80%–205%depending on the CO_(2) partial pressure.The decomposition process of doped granular porous CaCO_(3) particles is found to involve three overlapping processes.This work provides new routes to achieve scalable direct solar thermochemical heat storage for next-generation high-temperature solar power systems. | SONG Chao LIU XiangLei XUAN YiMin ZHENG HangBin GAO Ke TENG Liang DA Yun LI Chuan LI YongLiang DING YuLong | 2021 | Science China(Technological Sciences)2021，64，10： | 4 |
| 9 | Novel Kriging-Based Decomposed-Coordinated Approach for Estimating the Clearance Reliability of Assembled Structures显示文摘Turbine blisks are assembled using blades,disks and casings.They can endure complex loads at a high temperature,high pressure and high speed.The safe operation of assembled structures depends on the reliability of each component.Monte Carlo(MC)simulation is commonly used to analyze structural reliability,but this method needs to run thousands of computations.In order to assess the clearance reliability of assembled structures in an efficient and precise manner,the novel Kriging-based decomposed-coordinated(DC)(DCNK)approach is proposed by integrating the DC strategy,the Kriging model and the importance sampling-based Markov chain(MCIS)technique.In this method,the DC strategy is used to decompose a multi-objective problem into many single-objective problems.The relationships between these many single-objectives and the overall objective are then coordinated.The Kriging model is applied to establish the limit state functions of the single-objectives and multi-objective problems,while the MCIS method is used to assess the structural assembled clearance reliability.Moreover,a highly nonlinear complex compound function is first utilized to verify the DCNK model from a mathematical perspective.Then,the reliability of an aeroengine high-pressure turbine(HPT)blade-tip radial running clearance(BTRRC)is analyzed to validate the DCNK approach by considering thermo-structural interaction.The analytical results show that the reliability is 0.9976 when the allowance value of the BTTRC is 1.7650×10^(−3)m.Compared with different methodologies(including direct simulation,the classical Kriging model,and the weighted response surface method(WRSM)),the proposed method holds obvious advantages in computing time and precision,as well as simulation efficiency and precision.The efforts of this paper provide a useful approach to analyzing assembled clearance reliability and contribute to the development of structural reliability theory. | Da Teng Yunwen Feng Cheng Lu Chengwei Fei Jiaqi Liu Xiaofeng Xue | 2021 | Computer Modeling in Engineering & Sciences2021，，11： | 2 |
| 10 | An improved and scalable process for 3,8-diazabicyclo[3.2.1]-octane analogues显示文摘一改善并且为代替的 3,8-diazabicyclo 的可伸缩的过程[3.2.1 ] 辛烷被开发。N-Benzyl-2,5-dicarbethoxy-pyrrolidine 2 被归结为 N-benzyl-2,5-dihydroxymethylpyrrolidine 9 并且随后负担得起 N-Boc-2,5-dihydroxymethylpyrrolidine 10 的 debenzylated。在 diol 的 mesylation 以后 10 并且有 benzylamine 的环合,多种支架, 3,8-diazabicyclo [3.2.1 ] 辛烷类似物 12 在五步在 42% 的全部的收益被获得。 | Long Jiang Huang Da Wei Teng | 2011 | Chinese Chemical Letters2011，22，5： | 2 |
| 11 | circBIRC6 contributes to the development of non-small cell lung cancer via regulating microRNA-217/amyloid beta precursor protein binding protein 2 axis显示文摘Background:Circular RNAs(circRNAs)are considered to be important regulators in cancer biology.In this study,we focused on the effect of circRNA baculoviral inhibitor of apoptosis protein(IAP)repeat containing 6(circBIRC6)on non-small cell lung cancer(NSCLC)progression.Methods:The NSCLC and adjacent non-tumor tissues were collected at Shanghai Ninth People's Hospital.Quantitative real-time polymerase chain reaction was conducted for assessing the levels of circBIRC6,amyloid beta precursor protein binding protein 2(APPBP2)messenger RNA(mRNA),baculoviral IAP repeat containing 6 mRNA(BIRC6),and microRNA-217(miR-217).Western blot assay was adopted for measuring the protein levels of APPBP2,E-cadherin,N-cadherin,and vimentin.Colony formation assay,transwell assay,and flow cytometry analysis were utilized for evaluating cell colony formation,metastasis,and apoptosis.Dualluciferase reporter assay and RNA immunoprecipitation assay were carried out to determine the interaction between miR-217 and circBIRC6 and APPBP2 in NSCLC tissues.The murine xenograft model assay was used to investigate the function of circBIRC6 in tumor formation in vivo.Differences were analyzed via Student's t test or one-way analysis of variance.Pearson's correlation coefficient analysis was used to analyze linear correlation.Results:CircBIRC6 was overexpressed in NSCLC tissues and cells.Knockdown of circBIRC6 repressed the colony formation and metastasis and facilitated apoptosis of NSCLC cells in vitro and restrained tumorigenesis in vivo.Mechanically,circBIRC6 functioned as miR-217 sponge to promote APPBP2 expression in NSCLC cells.MiR-217 inhibition rescued circBIRC6 knockdown-mediated effects on NSCLC cell colony formation,metastasis,and apoptosis.Overexpression of miR-217 inhibited the malignant phenotypes of NSCLC cells,while the effects were abrogated by elevating APPBP2.Conclusion:CircBIRC6 aggravated NSCLC cell progression by elevating APPBP2 via sponging miR-217,which might provide a fresh perspective on NSCLC therapy. | Da Ni Jiping Teng Youshuang Cheng Zhijun Zhu Bufeng Zhuang Zhiyin Yang | 2022 | Chinese Medical Journal2022，，6： | 2 |
| 12 | Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells:the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways显示文摘 | Moerman EJ Teng K Lipschitz DA | 2004 | Aging Cell2004，3，6： | 1 |
| 13 | Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/ stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/ BMP signaling pathways显示文摘 | Moerman EJ Teng K Lipschitz DA | 2004 | Aging Cell2004，3，6： | 1 |
| 14 | Aging activates adipogenic and suppresses osteogenic programs in mesen-chymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways 显示文摘 | Moerman E J Teng K Lipschitz DA | 2004 | Aging Cell2004，3，6： | 1 |
| 15 | Multimerization and fusion expression of bovine lactoferricin derivative LfcinB 15-W4, 10 in Escherichia coli显示文摘 | TIAN Zigang TENG Da YANG Yalin | 2007 | Appl Microbiol Biotechnol2007，75，1： | 1 |
| 16 | High-level production of a candidacidal peptide lactoferrampin in Escherichia coli by fusion expression显示文摘 | YANG Yalin TIAN Zigang TENG Da | 2009 | J Biotechnol2009，139，4： | 1 |
| 17 | Profiling the pattern of the human T-cell receptorγδcomplementary determinant region 3 repertoire in patients with lung carcinoma via high-throughput sequencing analysis显示文摘γδT cells function as sentinels in early host responses to infections and malignancies.Specifically,γδT cells recognize tumor-associated stress antigens via T-cell receptor(TCR)γδand play important roles in the antitumor immune response.In this study,we characterized the pattern of the human TCRγδcomplementary determinant region 3(CDR3)repertoire in patients with lung carcinoma(LC)via high-throughput sequencing.The results showed that the diversity of CDR3δwas significantly reduced,and that of CDR3γwas unchanged in LC patients compared with healthy individuals;in addition,LC patients shared significantly more CDR3δsequences with each other than healthy individuals.The CDR3 length distribution and N-addition length distribution did not significantly differ between LC patients and healthy individuals.In addition,the CDR3 repertoire tended to use more Vδ2 and fewer Vδ1 germline gene fragments among LC patients.Moreover,we found a combination of four TCRγδrepertoire features that focus on CDR3δand can be used as a biomarker for LC diagnosis.Our research suggests that the TCRγδCDR3 repertoire changed in LC patients due to the antitumor immune response byγδT cells in vivo,and these changes primarily focus on the amplification of certain tumor-specific CDR3δclones among patients.This study demonstrates the role ofγδT cells from the TCRγδCDR3 repertoire in tumor immunity and lays the foundation for elucidating the mechanism underlying the function ofγδT cells in antitumor immunity. | Hui Chen Mingjin Zou Da Teng Yu Hu Jianmin Zhang Wei He | 2019 | Cellular & Molecular Immunology2019，16，3： | 1 |
| 18 | Deciphering the chromatin spatial organization landscapes during BMMSC differentiation显示文摘The differentiation imbalance in bone marrow mesenchymal stem cells(BMMSCs)is critical for the development of bone density diseases as the population ages.BMMSCs are precursor cells for osteoblasts and adipocytes;however,the chromatin organization landscapes during BMMSC differentiation remain elusive.In this study,we systematically delineate the four-dimensional genome and dynamic epigenetic atlas of BMMSCs by RNA sequencing,assay for transposase-accessible chromatin sequencing,and highthroughput chromosome conformation capture.The structure analyses reveal 17.5%common and28.5%-30%specific loops among BMMSCs,osteoblasts,and adipocytes.The subsequent correlation of genome-wide association studies and expression quantitative trait locus(e QTL)data with multi-omics analysis reveal 274 genes and 3634 single nucleotide polymorphisms(SNPs)associated with bone degeneration and osteoporosis(OP).We hypothesize that SNP mutations affect transcription factor(TF)binding sites,thereby affecting changes in gene expression.Furthermore,26 motifs,260 TFs,and 291SNPs are identified to affect the e QTL.Among these genes,DAAM2,TIMP2,and TMEM241 are found to be essential for diseases such as bone degeneration and OP and may serve as potential drug targets. | Zhaowei Teng Yun Zhu Da Lin Qinggang Hao Qiaoning Yue Xiaochao Yu Shuo Sun Lihong Jiang Sheng Lu | 2023 | Journal of Genetics and Genomics2023，50，4： | 1 |
| 19 | Muhimerization and fusion ex- pression of bovine lactoferricin derivative LfcinBl5-W4, 10 in Escherichia coli 显示文摘 | Tian Zigang Teng Da Yang Yalin | 2007 | Appl Microbiol Biotechnol2007，，75： | 1 |
| 20 | The exploitation of volatile oil显示文摘 | MENG Teng ZHANG Da | 2009 | Journal of Northeast Agricultural University2009，6，17： | 1 |
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